John K Neubert

John K Neubert, D.D.S.

Professor

Department: DN-ORTHODONTICS RESEARCH
Business Phone: (352) 273-5687
Business Email: jneubert@dental.ufl.edu

About John K Neubert

Dr. Neubert graduated from the University of California Santa Barbara (1990) and received his D.D.S. (1994) from the University of California Los Angles (UCLA). He has earned specialty certificates in both Orofacial Pain Management from UCLA (1996) and Orthodontics and Dentofacial Orthopedics from the University of Florida (2013). Dr. Neubert continues to treat both patients in need of orthodontics and those with orofacial pain. Dr. Neubert has been a faculty member at the University of Florida since 2003 and currently serves as the Director of pre-doctoral orthodontic education. Dr. Neubert is also an established translational researcher and his work is recognized worldwide.

Clinical Profile

Specialties
  • Dentistry
Subspecialties
  • Orthodontics

Publications

2021
Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors.
Molecules (Basel, Switzerland). 26(4) [DOI] 10.3390/molecules26040983. [PMID] 33673320.
2020
Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration.
Frontiers in pharmacology. 11 [DOI] 10.3389/fphar.2020.527495. [PMID] 33343340.
2018
Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats.
Archives of oral biology. 92:18-24 [DOI] 10.1016/j.archoralbio.2018.04.013. [PMID] 29738922.
2018
Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-34698-9. [PMID] 30385810.
2018
Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.
The Journal of clinical investigation. 128(4):1657-1670 [DOI] 10.1172/JCI94331. [PMID] 29408808.
2017
Effects of cocoa-enriched diet on orofacial pain in a murine model.
Orthodontics & craniofacial research. 20 Suppl 1:157-161 [DOI] 10.1111/ocr.12149. [PMID] 28643911.
2017
Effects of High-Dose Capsaicin on TMD Subjects: A Randomized Clinical Study.
JDR clinical and translational research. 2(1):58-65 [DOI] 10.1177/2380084416675837. [PMID] 28879245.
2017
Exosomes: novel regulators of bone remodelling and potential therapeutic agents for orthodontics.
Orthodontics & craniofacial research. 20 Suppl 1:95-99 [DOI] 10.1111/ocr.12165. [PMID] 28643924.
2017
Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons.
PloS one. 12(5) [DOI] 10.1371/journal.pone.0176753. [PMID] 28472061.
2016
Analgesic Activity of Tramadol and Buprenorphine after Voluntary Ingestion by Rats (Rattus norvegicus).
Journal of the American Association for Laboratory Animal Science : JAALAS. 55(1):74-82 [PMID] 26817983.
View on: PubMed
2016
Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI).
Neuropharmacology. 107:27-39 [DOI] 10.1016/j.neuropharm.2016.03.016. [PMID] 26972829.
2015
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
Journal of neuroscience methods. 248:1-6 [DOI] 10.1016/j.jneumeth.2015.03.022. [PMID] 25823368.
2015
Assessment of an Orofacial Operant Pain Assay as a Preclinical Tool for Evaluating Analgesic Efficacy in Rodents.
Journal of the American Association for Laboratory Animal Science : JAALAS. 54(4):426-32 [PMID] 26224444.
View on: PubMed
2015
Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry.
Journal of materials chemistry. B. 3(43):8492-8498 [DOI] 10.1039/c5tb00674k. [PMID] 32262689.
2015
Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.
The Journal of pharmacology and experimental therapeutics. 355(3):496-505 [DOI] 10.1124/jpet.115.227629. [PMID] 26377910.
2014
Gabapentin hybrid peptides and bioconjugates.
Bioorganic & medicinal chemistry. 22(4):1479-86 [DOI] 10.1016/j.bmc.2013.12.017. [PMID] 24468631.
2014
Operant assays for assessing pain in preclinical rodent models: highlights from an orofacial assay.
Current topics in behavioral neurosciences. 20:121-45 [DOI] 10.1007/7854_2014_332. [PMID] 25103871.
2014
The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device.
PloS one. 9(2) [DOI] 10.1371/journal.pone.0089137. [PMID] 24558480.
2013
Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A.
Pain. 154(11):2547-2553 [DOI] 10.1016/j.pain.2013.07.041. [PMID] 23933181.
2013
Assessment of the sigma-1 receptor antagonist (SR1A): a model approach for preclinical analgesic drug discovery.
European journal of pain (London, England). 17(6):789-90 [DOI] 10.1002/j.1532-2149.2013.00292.x. [PMID] 23658072.
2013
Bis-enoxacin inhibits bone resorption and orthodontic tooth movement.
Journal of dental research. 92(10):925-31 [DOI] 10.1177/0022034513501876. [PMID] 23958763.
2013
Effects of diet-induced obesity on motivation and pain behavior in an operant assay.
Neuroscience. 235:87-95 [DOI] 10.1016/j.neuroscience.2013.01.019. [PMID] 23333672.
2013
Use of the Operant Orofacial Pain Assessment Device (OPAD) to measure changes in nociceptive behavior.
Journal of visualized experiments : JoVE. (76) [DOI] 10.3791/50336. [PMID] 23792907.
2012
Characterization of bilateral trigeminal constriction injury using an operant facial pain assay.
Neuroscience. 224:294-306 [DOI] 10.1016/j.neuroscience.2012.08.015. [PMID] 22909425.
2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry. 287(21):17894-17904 [DOI] 10.1074/jbc.M111.280511. [PMID] 22474295.
2012
Evaluation of An Operant Thermal Assay for the Assessment of Analgesic Efficacy in Rats
Journal of the American Association for Laboratory Animal Science. 51:638-639
2012
Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay.
Journal of oral rehabilitation. 39(1):63-72 [DOI] 10.1111/j.1365-2842.2011.02236.x. [PMID] 21793870.
2012
Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-D-aspartate receptor 1 splice variants in the amygdala.
Neuroscience. 223:45-55 [DOI] 10.1016/j.neuroscience.2012.07.037. [PMID] 22863572.
2012
Morphine and MK-801 administration leads to alternative N-methyl-D-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay.
Neuroscience. 214:14-27 [DOI] 10.1016/j.neuroscience.2012.04.032. [PMID] 22531378.
2012
Placebo-induced analgesia in an operant pain model in rats.
Pain. 153(10):2009-2016 [DOI] 10.1016/j.pain.2012.04.026. [PMID] 22871471.
2011
Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain.
Behavioural brain research. 217(2):477-80 [DOI] 10.1016/j.bbr.2010.10.022. [PMID] 20974188.
2011
Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning.
Behavioural brain research. 216(2):723-5 [DOI] 10.1016/j.bbr.2010.08.023. [PMID] 20797411.
2011
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
Nature neuroscience. 14(12):1569-73 [DOI] 10.1038/nn.2941. [PMID] 22019732.
2010
Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin.
The journal of pain. 11(9):838-46 [DOI] 10.1016/j.jpain.2010.05.007. [PMID] 20620120.
2009
Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats.
The journal of pain. 10(6):646-53 [DOI] 10.1016/j.jpain.2009.01.002. [PMID] 19409862.
2009
Effects of hot and cold stimulus combinations on the thermal preference of rats.
Behavioural brain research. 203(2):240-6 [DOI] 10.1016/j.bbr.2009.05.009. [PMID] 19454295.
2008
Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior.
Molecular pain. 4 [DOI] 10.1186/1744-8069-4-43. [PMID] 18828909.
2008
Effects of environmental enrichment on thermal sensitivity in an operant orofacial pain assay.
Behavioural brain research. 187(2):478-82 [PMID] 17976833.
View on: PubMed
2008
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.
Molecular pain. 4 [DOI] 10.1186/1744-8069-4-3. [PMID] 18199335.
2008
Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat.
The journal of pain. 9(8):739-49 [DOI] 10.1016/j.jpain.2008.03.008. [PMID] 18486556.
2008
Toothache or trigeminal neuralgia: treatment dilemmas.
The journal of pain. 9(9):767-70 [DOI] 10.1016/j.jpain.2008.07.001. [PMID] 18722958.
2007
Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors.
Behavioral and brain functions : BBF. 3 [PMID] 17883847.
View on: PubMed
2007
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
BMC neuroscience. 8 [PMID] 17493276.
View on: PubMed
2006
Characterization of cold sensitivity and thermal preference using an operant orofacial assay.
Molecular pain. 2 [PMID] 17166284.
View on: PubMed
2006
Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay.
Behavioural brain research. 170(2):308-15 [PMID] 16675039.
View on: PubMed
2005
Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy.
Brain research. Brain research protocols. 15(3):119-26 [PMID] 16024266.
View on: PubMed
2005
Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity.
Pain. 116(3):386-395 [DOI] 10.1016/j.pain.2005.05.011. [PMID] 15982812.
2004
Comparison of experimental and acute clinical pain responses in humans as pain phenotypes.
The journal of pain. 5(7):377-84 [PMID] 15501195.
View on: PubMed
2004
Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.
The Journal of clinical investigation. 113(9):1344-52 [PMID] 15124026.
View on: PubMed
2004
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.
Pain. 109(3):488-496 [DOI] 10.1016/j.pain.2004.02.027. [PMID] 15157710.
2003
Peripherally induced resiniferatoxin analgesia.
Pain. 104(1-2):219-28 [PMID] 12855332.
View on: PubMed
2003
Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.
Neuroscience. 118(2):535-45 [PMID] 12699788.
View on: PubMed
2002
Microdialysis in trigeminal ganglia.
Brain research. Brain research protocols. 10(2):102-8 [PMID] 12431709.
View on: PubMed
2001
Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo.
Brain research. 915(2):248-55 [PMID] 11595216.
View on: PubMed
2000
Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.
Brain research. 871(2):181-91 [PMID] 10899285.
View on: PubMed
1996
Histochemical investigations on the influence of long-term altered gravity on the CNS of developing cichlid fish: results from the 2nd German Spacelab Mission D-2.
Advances in space research : the official journal of the Committee on Space Research (COSPAR). 17(6-7):281-4 [PMID] 11538630.
View on: PubMed

Grants

Jul 2021 ACTIVE
Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging
Role: Other
Funding: NATL INST OF HLTH OD
Sep 2020 ACTIVE
Opioid and cannabinoid interactions in pain and reward
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jun 2019 ACTIVE
Opioid and cannabinoid interactions in pain and reward
Role: Principal Investigator
Funding: UF RESEARCH
May 2019 ACTIVE
Acute Effects of Alcohol Use on Chronic Orofacial Pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAAA
May 2019 ACTIVE
Evaluation of a cellular therapeutic for the treatment of trigeminal pain
Role: Principal Investigator
Funding: UF FOU via THE FACIAL PAIN RESEARCH FOU
Sep 2017 – Jan 2019
Operant behavioral instrument for measuring trigeminal neuropathic pain in rodent
Role: Principal Investigator
Funding: CODA BIOTHERAPEUTICS
Jul 2016 – Jun 2017
Operant behavioral instrument for measuring trigeminal neuropathic pain in rodent
Role: Principal Investigator
Funding: AMER ASSO OF ORTHODONTISTS FOU
Sep 2015 – Mar 2017
Operant behavioral instrument for measuring trigeminal neuropathic pain in rodent
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Jul 2015 ACTIVE
Effects of genetics on the expectation and experience of orthodontic pain
Role: Principal Investigator
Funding: AMER ASSO OF ORTHODONTISTS FOU
Feb 2015 ACTIVE
Mapping Towards a Cure Identification of Neurophysiologic Signatures of Trigeminal Neuralgia Pain
Role: Principal Investigator
Funding: UF FOU via THE FACIAL PAIN RESEARCH FOU

Teaching Profile

Courses Taught
2018,2020-2021
DEN6940 Supervised Teaching
2011,2016-2020
DEN8290 Special Topics
2011-2018,2020-2021
DEN6251 Clin Manage Dent Pain
2013-2020
DEN7819L Clinic Orthodontics 3
2012-2021
DEN7450C Orthodont Gen Pract
2011-2020
DEN5120C Physiology
2014,2018
DEN6905 Individual Study
2011-2014,2018
DEN6971 Research for Master’s Thesis
2011-2014,2018
DEN6910 Supervised Research
2015,2018
GMS6711 Neurobiology of Pain
2011,2016-2018,2018
DEN8263 Adv Oral/Med Cl Pharm
2016
DEN5013 Found Professionalism
2014
IDH4905 Individual Work
2012,2014
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2011,2013-2014
DEN7540 Special Topics
2013-2014
DEN6681 Craniofacial Pathobiology
2012-2013
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2011-2012
GMS6161 Introduction to Oral Biology II
2011
GMS6160 Introduction to Oral Biology I
2011
DEN6675 Craniofacial Pain

Contact Details

Phones:
Business:
(352) 273-5687
Emails: