Jeffrey D Hillman

Jeffrey D Hillman,

PROFESSOR EMERITUS

Department: DN-ORAL BIOLOGY
Business Email: jhillman@ufl.edu

Publications

2019
Complete synthesis of the bicyclic ring of a mutacin analog with orthogonally protected lanthionine via solid-phase intracyclization.
Journal of peptide science : an official publication of the European Peptide Society. 25(11) [DOI] 10.1002/psc.3214. [PMID] 31721375.
2013
Site-directed mutations in the lanthipeptide mutacin 1140.
Applied and environmental microbiology. 79(13):4015-23 [DOI] 10.1128/AEM.00704-13. [PMID] 23603688.
2012
Identification of genes expressed in cultures of E. coli lysogens carrying the Shiga toxin-encoding prophage Φ24B.
BMC microbiology. 12 [DOI] 10.1186/1471-2180-12-42. [PMID] 22439817.
2010
Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 41(5):658-64 [DOI] 10.1016/j.ejps.2010.09.005. [PMID] 20869439.
2010
Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140.
Journal of pharmaceutical sciences. 99(5):2521-8 [DOI] 10.1002/jps.22015. [PMID] 20039385.
2009
A spontaneous lactate dehydrogenase deficient mutant of Streptococcus rattus for use as a probiotic in the prevention of dental caries.
Journal of applied microbiology. 107(5):1551-8 [DOI] 10.1111/j.1365-2672.2009.04333.x. [PMID] 19426263.
2009
Development and validation of a LC-MS quantification method for the lantibiotic MU1140 in rat plasma.
Journal of pharmaceutical and biomedical analysis. 49(4):970-5 [DOI] 10.1016/j.jpba.2008.12.022. [PMID] 19269770.
2009
Pharmacodynamic Activity of the Lantibiotic Mu1140
International Journal of Antimicrobial Agents. 33(1):70-74 [DOI] 10.1016/j.ijantimicag.2008.07.028. [PMID] 18835136.
2009
Preliminary assessment of safety and effectiveness in humans of ProBiora3, a probiotic mouthwash.
Journal of applied microbiology. 107(2):682-90 [DOI] 10.1111/j.1365-2672.2009.04243.x. [PMID] 19486429.
2009
Safety assessment of ProBiora3, a probiotic mouthwash: subchronic toxicity study in rats.
International journal of toxicology. 28(5):357-67 [DOI] 10.1177/1091581809340705. [PMID] 19815843.
2008
Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis.
PloS one. 3(3) [DOI] 10.1371/journal.pone.0001824. [PMID] 18350160.
2008
Elucidation of the antimicrobial mechanism of mutacin 1140.
Biochemistry. 47(10):3308-14 [DOI] 10.1021/bi701262z. [PMID] 18266322.
2007
Identification of Tannerella forsythia antigens specifically expressed in patients with periodontal disease.
FEMS microbiology letters. 275(2):344-52 [PMID] 17868359.
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2007
Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials.
Journal of applied microbiology. 102(5):1209-19 [PMID] 17448156.
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2006
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.
Science (New York, N.Y.). 313(5793):1636-7 [PMID] 16973881.
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2006
In vivo induced antigen technology (IVIAT) and change mediated antigen technology (CMAT).
Infectious disorders drug targets. 6(3):327-34 [PMID] 16918490.
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2005
Identification of group A Streptococcus antigenic determinants upregulated in vivo.
Infection and immunity. 73(9):6026-38 [PMID] 16113323.
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2005
In vivo induced antigen technology (IVIAT).
Cellular microbiology. 7(1):1-9 [PMID] 15617518.
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2005
In vivo induced genes in human diseases.
Periodontology 2000. 38:123-34 [PMID] 15853939.
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2005
Microarray analysis of quorum-sensing-regulated genes in Porphyromonas gingivalis.
Infection and immunity. 73(7):4146-54 [PMID] 15972504.
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2005
Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection.
Infection and immunity. 73(5):2665-79 [PMID] 15845468.
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2004
In vivo induced antigenic determinants of Actinobacillus actinomycetemcomitans.
FEMS microbiology letters. 237(1):97-103 [PMID] 15268943.
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2003
Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients.
Infection and immunity. 71(10):5461-71 [PMID] 14500463.
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2003
Identification of Candida albicans genes induced during thrush offers insight into pathogenesis.
Molecular microbiology. 48(5):1275-88 [PMID] 12787355.
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2003
In vivo expression of bacterial genes during human infections.
Methods in molecular medicine. 71:225-42 [PMID] 12374023.
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2003
Structure and dynamics of the lantibiotic mutacin 1140.
Biochemistry. 42(35):10372-84 [PMID] 12950164.
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2003
Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America. 100(14):8508-13 [PMID] 12826608.
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2002
Genes of periodontopathogens expressed during human disease.
Annals of periodontology. 7(1):38-42 [PMID] 16013215.
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2002
Genetically modified Streptococcus mutans for the prevention of dental caries.
Antonie van Leeuwenhoek. 82(1-4):361-6 [PMID] 12369203.
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2002
Identification and testing of Porphyromonas gingivalis virulence genes with a pPGIVET system.
Infection and immunity. 70(2):928-37 [PMID] 11796628.
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2000
Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries.
Infection and immunity. 68(2):543-9 [PMID] 10639415.
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2000
Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics.
European journal of biochemistry. 267(23):6810-6 [PMID] 11082191.
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2000
IVIAT: a novel method to identify microbial genes expressed specifically during human infections.
Trends in microbiology. 8(7):336-9 [PMID] 10878769.
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2000
Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes.
FEMS microbiology letters. 182(1):149-54 [PMID] 10612747.
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1999
Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress.
Microbiology (Reading, England). 145 ( Pt 2):357-366 [DOI] 10.1099/13500872-145-2-357. [PMID] 10075418.
1998
Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans.
Infection and immunity. 66(6):2743-9 [PMID] 9596742.
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1997
Cloning and characterization of a Prevotella melaninogenica hemolysin.
Infection and immunity. 65(7):2765-71 [PMID] 9199448.
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1997
Genetic and physiologic analysis of a formyl-tetrahydrofolate synthetase mutant of Streptococcus mutans.
Journal of bacteriology. 179(5):1563-72 [PMID] 9045814.
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1996
Genetic and physiological analysis of the lethal effect of L-(+)-lactate dehydrogenase deficiency in Streptococcus mutans: complementation by alcohol dehydrogenase from Zymomonas mobilis.
Infection and immunity. 64(10):4319-23 [PMID] 8926105.
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1996
Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements.
Journal of bacteriology. 178(14):4166-75 [PMID] 8763945.
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1996
Principles of microbial ecology and their application to xerostomia-associated opportunistic infections of the oral cavity.
Advances in dental research. 10(1):66-8 [PMID] 8934928.
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1996
The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector.
Infection and immunity. 64(11):4802-10 [PMID] 8890242.
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1994
Evidence that L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans.
Infection and immunity. 62(1):60-4 [PMID] 8262650.
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1994
L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans.
Journal of bacteriology. 176(5):1542-5 [PMID] 8113201.
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1993
Characterization of hemolytic bacteria in subgingival plaque.
Journal of periodontal research. 28(3):173-9 [PMID] 8496781.
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1991
DNA sequence and in vitro mutagenesis of the gene encoding the fructose-1,6-diphosphate-dependent L-(+)-lactate dehydrogenase of Streptococcus mutans.
Infection and immunity. 59(11):3930-4 [PMID] 1937751.
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1990
Cloning and expression of the gene encoding the fructose-1,6-diphosphate-dependent L-(+)-lactate dehydrogenase of Streptococcus mutans.
Infection and immunity. 58(5):1290-5 [PMID] 2323817.
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1989
The specific pathogen-free human: a new frontier in oral infectious disease research.
Advances in dental research. 3(1):58-68 [PMID] 2532515.
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1988
Interaction between wild-type, mutant and revertant forms of the bacterium Streptococcus sanguis and the bacterium Actinobacillus actinomycetemcomitans in vitro and in the gnotobiotic rat.
Archives of oral biology. 33(6):395-401 [PMID] 3228385.
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1987
Acetoin production by wild-type strains and a lactate dehydrogenase-deficient mutant of Streptococcus mutans.
Infection and immunity. 55(6):1399-402 [PMID] 3570471.
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1987
Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin.
Journal of dental research. 66(6):1092-4 [PMID] 3476580.
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1987
Replacement therapy of the prevention of dental disease.
Advances in dental research. 1(1):119-25 [PMID] 3326613.
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1985
Colonization of the human oral cavity by a strain of Streptococcus mutans.
Journal of dental research. 64(11):1272-4 [PMID] 3912416.
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1984
Isolation of a Streptococcus mutans strain producing a novel bacteriocin.
Infection and immunity. 44(1):141-4 [PMID] 6706403.
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1982
Bacterial interference in the oral ecology of Actinobacillus actinomycetemcomitans and its relationship to human periodontosis.
Archives of oral biology. 27(1):75-7 [PMID] 6951532.
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1982
Competitive properties of lactate dehydrogenase mutants of the oral bacterium Streptococcus mutans in the rat.
Archives of oral biology. 27(6):513-6 [PMID] 6956265.
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1982
Lactate dehydrogenase-deficient mutants of Streptococcus mutans.
Basic life sciences. 19:371-81 [PMID] 7066010.
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1980
Cariogenic potential in vitro in man and in vivo in the rat of lactate dehydrogenase mutants of Streptococcus mutans.
Archives of oral biology. 25(11-12):707-13 [PMID] 6943990.
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1980
Replacement therapy for the control of dental caries.
The New dentist : the official journal of the American Student Dental Association. 10(6):24-7 [PMID] 6934471.
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1978
Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization.
Infection and immunity. 21(1):206-12 [PMID] 30695.
View on: PubMed

Patents

Issued April 2014
Identification of Porphyromonas Gingivalis Virulence Polynucleotides for Diagnosis, Treatment and Monitoring of Periodontal Diseases (CON)
#8,703,436
Issued April 2013
Identification of Actinobacillus Actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases (DIV of 13622)
#8,420,340
Issued July 2011
Identification of Actinobacillus Actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases (DIV)
#7,981,631
Issued December 2010
Identification of Actinobacillus Actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases (DIV)
#7,851,171
Issued March 2009
Identification of Actinobacillus Actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases (DIV)
#7,498,143
Issued August 2008
Identification of Porphyromonas Gingivalis Virulence Polynucleotides for Diagnosis, Treatment and Monitoring of Periodontal Diseases
#7,416,852
Issued June 2006
Novel Antimicrobial Polypeptide And Methods Of Use (DIV of 10838, 10216, 1712)
#7,067,125
Issued May 2006
Identification of Actinobacillus Actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases
#7,052,860
Published April 2006
Novel Antimicrobial Polypeptide and Methods of Use
#US-2006-0198793-A1
Issued November 2005
Antimicrobial Polypeptide, Nucleic Acid, and Methods of Use (CIP of 1712 and 10216)
#6,964,760
Issued November 2002
Novel Antimicrobial Polypeptide And Methods Of Use (DIV of 1712 & 10216)
#6,475,771
Issued May 2002
Novel Antimicrobial Polypeptide and Methods of use (DIV of 1712)
#6,391,285
Issued August 1999
Novel Anti-Microbial Polypeptides & Compositions and Methods of Use
#5,932,469
Issued March 1997
Replacement Therapy for Dental Caries Administering Recombinant Streptococcus Mutans Strains Deficient in Lactic Acid Production and Producing Recombinant Alcohol Dehydrogenase
#5,607,672

Contact Details

Emails:
Business:
jhillman@ufl.edu