Sasanka S Chukkapalli,
Research Assistant Professor
Department:
DN-ORAL BIOLOGY
Business Phone:
(352) 273-8864
Business Email:
schukkapalli@dental.ufl.edu
Publications
Academic Articles
2024
Cinnamaldehyde Protects against P. gingivalis Induced Intestinal Epithelial Barrier Dysfunction in IEC-6 Cells via the PI3K/Akt-Mediated NO/Nrf2 Signaling Pathway.
International journal of molecular sciences.
25(9)
[DOI] 10.3390/ijms25094734.
[PMID] 38731952.
2024
Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization.
Nature communications.
15(1)
[DOI] 10.1038/s41467-024-54577-4.
[PMID] 39578439.
2024
Periodontal disease and emerging point-of-care technologies for its diagnosis.
Lab on a chip.
24(14):3326-3346
[DOI] 10.1039/d4lc00295d.
[PMID] 38874483.
2023
Rho activation drives luminal collapse and eversion in epithelial acini.
Biophysical journal.
122(18):3630-3645
[DOI] 10.1016/j.bpj.2023.01.005.
[PMID] 36617192.
2022
Porphyromonas gingivalis Conditioned Medium Induces Amyloidogenic Processing of the Amyloid-β Protein Precursor upon in vitro Infection of SH-SY5Y Cells.
Journal of Alzheimer's disease reports.
6(1):577-587
[DOI] 10.3233/ADR-220029.
[PMID] 36275415.
2022
VBNC, previously unrecognized in the life cycle of Porphyromonas gingivalis?
Journal of oral microbiology.
14(1)
[DOI] 10.1080/20002297.2021.1952838.
[PMID] 35035782.
2021
Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.
Journal of cellular physiology.
236(8):5715-5724
[DOI] 10.1002/jcp.30256.
[PMID] 33400284.
2021
Porphyromonas gingivalis (W83) Infection Induces Alzheimer’s Disease-Like Pathophysiology in Obese and Diabetic Mice.
Journal of Alzheimer's disease : JAD.
82(3):1259-1275
[DOI] 10.3233/JAD-210465.
[PMID] 34151813.
2021
Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells.
Journal of periodontology.
92(7):54-65
[DOI] 10.1002/JPER.20-0444.
[PMID] 33128253.
2020
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Journal of oral microbiology.
13(1)
[DOI] 10.1080/20002297.2020.1849493.
[PMID] 33391626.
2020
Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease.
Journal of Alzheimer's disease reports.
4(1):501-511
[DOI] 10.3233/ADR-200250.
[PMID] 33532698.
2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and disease.
76(8)
[DOI] 10.1093/femspd/fty076.
[PMID] 30351354.
2018
Periodontal cell mechanotransduction.
Open biology.
8(9)
[DOI] 10.1098/rsob.180053.
[PMID] 30209038.
2017
A Novel Rat Model of Polymicrobial Peri-Implantitis: A Preliminary Study.
Journal of periodontology.
88(2):e32-e41
[DOI] 10.1902/jop.2016.160273.
[PMID] 27786620.
2017
Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
International journal of molecular sciences.
18(4)
[DOI] 10.3390/ijms18040875.
[PMID] 28425970.
2017
Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice.
Journal of Alzheimer's disease : JAD.
60(2):359-369
[DOI] 10.3233/JAD-170304.
[PMID] 28800332.
2017
Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE-/- mice brains.
Journal of oral microbiology.
9(1)
[DOI] 10.1080/20002297.2016.1270602.
[PMID] 28326151.
2017
Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection.
Molecular oral microbiology.
32(3):211-225
[DOI] 10.1111/omi.12165.
[PMID] 27224005.
2017
Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice.
Pathogens and disease.
75(1)
[DOI] 10.1093/femspd/ftx003.
[PMID] 28104616.
2016
Apolipoprotein E Related Co-Morbidities and Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD.
51(4):935-48
[DOI] 10.3233/JAD150690.
[PMID] 26923007.
2016
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Arthritis research & therapy.
18(1)
[DOI] 10.1186/s13075-016-1056-4.
[PMID] 27405639.
2016
Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease.
Anaerobe.
38:70-75
[DOI] 10.1016/j.anaerobe.2015.10.005.
[PMID] 26481834.
2015
Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains.
Journal of Alzheimer's disease : JAD.
43(1):67-80
[DOI] 10.3233/JAD-140315.
[PMID] 25061055.
2015
Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers.
Pathogens and disease.
73(3)
[DOI] 10.1093/femspd/ftv009.
[PMID] 25663343.
2015
Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(null) Mice.
PloS one.
10(6)
[DOI] 10.1371/journal.pone.0129795.
[PMID] 26079509.
2015
Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice.
Infection and immunity.
83(12):4582-93
[DOI] 10.1128/IAI.01077-15.
[PMID] 26371120.
2015
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.
Journal of periodontology.
86(1):137-45
[DOI] 10.1902/jop.2014.140302.
[PMID] 25101489.
2015
Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression.
PloS one.
10(6)
[DOI] 10.1371/journal.pone.0129885.
[PMID] 26111153.
2015
Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.
PloS one.
10(11)
[DOI] 10.1371/journal.pone.0143291.
[PMID] 26619277.
2014
Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis.
PloS one.
9(5)
[DOI] 10.1371/journal.pone.0097811.
[PMID] 24836175.
2014
Active Invasion of Periodontal Bacteria Into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice.
Arthritis & Rheumatology.
66(10, SI)
2014
Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis.
PloS one.
9(3)
[DOI] 10.1371/journal.pone.0092119.
[PMID] 24638087.
2014
Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.
Infection and immunity.
82(5):1959-67
[DOI] 10.1128/IAI.01511-14.
[PMID] 24566627.
2014
Microrna Expression Signature in Human Thoracic and Abdominal Aortic Aneurysms
Atherosclerosis.
235(2)
2014
Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice.
PloS one.
9(10)
[DOI] 10.1371/journal.pone.0111353.
[PMID] 25354050.
2013
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice.
PloS one.
8(2)
[DOI] 10.1371/journal.pone.0057178.
[PMID] 23451182.
Grants
Mar 2020
– Jun 2021
Integrated transcriptomics and metabolomics approach to define pathogenicity of P.gingivalis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Contact Details
Phones:
- Business:
- (352) 273-8864
Emails:
- Business:
- schukkapalli@dental.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100424
GAINESVILLE FL 32610 - Business Street:
-
DG-51E
1395 Center Drive DG-51E
GAINESVILLE FL 32610