Sasanka S Chukkapalli

Sasanka S Chukkapalli,

Research Assistant Professor

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8864
Business Email: schukkapalli@dental.ufl.edu

Publications

2021
Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.
Journal of cellular physiology. 236(8):5715-5724 [DOI] 10.1002/jcp.30256. [PMID] 33400284.
2021
Porphyromonas gingivalis (W83) Infection Induces Alzheimer’s Disease-Like Pathophysiology in Obese and Diabetic Mice.
Journal of Alzheimer's disease : JAD. 82(3):1259-1275 [DOI] 10.3233/JAD-210465. [PMID] 34151813.
2021
Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells.
Journal of periodontology. 92(7):54-65 [DOI] 10.1002/JPER.20-0444. [PMID] 33128253.
2020
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Journal of oral microbiology. 13(1) [DOI] 10.1080/20002297.2020.1849493. [PMID] 33391626.
2020
Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease.
Journal of Alzheimer's disease reports. 4(1):501-511 [DOI] 10.3233/ADR-200250. [PMID] 33532698.
2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and disease. 76(8) [DOI] 10.1093/femspd/fty076. [PMID] 30351354.
2018
Periodontal cell mechanotransduction.
Open biology. 8(9) [DOI] 10.1098/rsob.180053. [PMID] 30209038.
2017
A Novel Rat Model of Polymicrobial Peri-Implantitis: A Preliminary Study.
Journal of periodontology. 88(2):e32-e41 [DOI] 10.1902/jop.2016.160273. [PMID] 27786620.
2017
Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
International journal of molecular sciences. 18(4) [DOI] 10.3390/ijms18040875. [PMID] 28425970.
2017
Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice.
Journal of Alzheimer's disease : JAD. 60(2):359-369 [DOI] 10.3233/JAD-170304. [PMID] 28800332.
2017
Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE-/- mice brains.
Journal of oral microbiology. 9(1) [DOI] 10.1080/20002297.2016.1270602. [PMID] 28326151.
2017
Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection.
Molecular oral microbiology. 32(3):211-225 [DOI] 10.1111/omi.12165. [PMID] 27224005.
2017
Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice.
Pathogens and disease. 75(1) [DOI] 10.1093/femspd/ftx003. [PMID] 28104616.
2016
Apolipoprotein E Related Co-Morbidities and Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 51(4):935-48 [DOI] 10.3233/JAD150690. [PMID] 26923007.
2016
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-1056-4. [PMID] 27405639.
2016
Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease.
Anaerobe. 38:70-75 [DOI] 10.1016/j.anaerobe.2015.10.005. [PMID] 26481834.
2015
Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains.
Journal of Alzheimer's disease : JAD. 43(1):67-80 [DOI] 10.3233/JAD-140315. [PMID] 25061055.
2015
Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers.
Pathogens and disease. 73(3) [DOI] 10.1093/femspd/ftv009. [PMID] 25663343.
2015
Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(null) Mice.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0129795. [PMID] 26079509.
2015
Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice.
Infection and immunity. 83(12):4582-93 [DOI] 10.1128/IAI.01077-15. [PMID] 26371120.
2015
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.
Journal of periodontology. 86(1):137-45 [DOI] 10.1902/jop.2014.140302. [PMID] 25101489.
2015
Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0129885. [PMID] 26111153.
2015
Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.
PloS one. 10(11) [DOI] 10.1371/journal.pone.0143291. [PMID] 26619277.
2014
Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0097811. [PMID] 24836175.
2014
Active Invasion of Periodontal Bacteria Into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice.
Arthritis & Rheumatology. 66(10, SI)
2014
Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0092119. [PMID] 24638087.
2014
Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.
Infection and immunity. 82(5):1959-67 [DOI] 10.1128/IAI.01511-14. [PMID] 24566627.
2014
Microrna Expression Signature in Human Thoracic and Abdominal Aortic Aneurysms
Atherosclerosis. 235(2)
2014
Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice.
PloS one. 9(10) [DOI] 10.1371/journal.pone.0111353. [PMID] 25354050.
2013
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0057178. [PMID] 23451182.

Grants

Mar 2020 – Jun 2021
Integrated transcriptomics and metabolomics approach to define pathogenicity of P.gingivalis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Contact Details

Phones:
Business:
(352) 273-8864
Emails: