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Marcelle Nascimento, D.D.S., M.S., Ph.D.

Marcelle NascimentoDepartment of Restorative Dental Sciences

Division of Operative Dentistry

Associate Professor

Dental Science Building, Rm D9-5
P.O. Box 100415
Gainesville, FL 32610-0424
Phone: 352-273-5858
Email: mnascimento@dental.ufl.edu

Education

  • Postdoctoral (2005–2007): Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Fla., USA.
  • Ph.D. in Cariology (2002–2005): School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.
  • M.S. in Cariology (2000–2002): School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.
  • D.D.S.(1996–2000): School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.

Professional Experience

2015 to present
Associate Professor with Tenure
Department of Restorative Dental Sciences, Division of Operative Dentistry, College of Dentistry, University of Florida, Gainesville, Fla., USA
2007–2015
Assistant Professor
Department of Operative Dentistry, College of Dentistry, University of Florida, Gainesville, Fla., USA
2006–2007
Adjunct Clinical Assistant Professor
Department of Operative Dentistry, College of Dentistry, University of Florida, Gainesville, Fla., USA
2005–2007
Post-Doctoral Associate
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Fla., USA
2004–2005
Assistant Professor
Department of Microbiology, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil

Publications

Monographs
  • Nascimento, M.M. Physiologic and genetic characterization of Streptococcus sobrinus. 2005. School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.
  • Nascimento, M.M. Clinical and microbiological aspects of root caries. 2002. School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.
Referred Publications (most recent)

1.       Behar-Horenstein L, Catalanotto FA, Nascimento MM. Anticipated and Actual Implementation of Case-Based Learning by Dental Faculty Members During and After Training. Journal of Dental Education, 2015; 79(9):1049-1060.

2.       Huang X, Schulte RM, Burne RA, Nascimento MM. Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms. Caries Research, 2015; 49:165-176.

3.       Nascimento MM, Burne RA. Caries prevention by arginine metabolism in oral biofilms: translating science into clinical success. Current Oral Health Reports, 2014; 1(1):79-85.

4.       Nascimento MM, Browngardt c, Xiaohui X, Klepac-Ceraj V, Paster BJ, Burne RA. The effect of arginine on oral biofilm communities. Molecular Oral Microbiology, 2014; 29(1):45-54.

5.       Nascimento MM. The combined use of chlorhexidine and fluoride therapy can reduce the risk for dental caries. Journal of Evidence-Based Dental Practice, 2013;13(3):123-124.

6.       Nascimento MM, Liu Y, Kalra R, Perry S, Adewumi A, Xu X, Primosch RE, Burne RA. Oral arginine metabolism may decrease the risk for dental caries in children. Journal of Dental Research, 2013; 92(7):604-608.

7.       Oli MW, Otoo HN, Crowley PJ, Heim KP, Nascimento MM, Ramsool CB, Lipke PN, Brady LJ. Functional amyloid formation by Streptococcus mutans. Microbiology, 2012; 158(12): 2903-16.

8.       Liu Y, Nascimento MM, Burne, RA. Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries. International Journal of Oral Science, 2012; 4(3):135-140.

9.       Burne RA, Zeng L, Ahn S, Palmer S, Yaling L, Lefebure T, Stanhope M, Nascimento MM. Progress dissecting the oral microbiome in caries and health. Advances in Dental Research, 2012; 24: 77-80.

10.    Nascimento MM, Gordan VA, Qvist V, Bader JD, Rindal DB, Williams OD, Gewartowski D, Fellows JL, Litaker MS, Gilbert GH, for the DPBRN Collaborative Group. Restoration of noncarious tooth defects by dentists in The Dental Practice-Based Research Network. Journal of the American Dental Association, 2011; 142(12): 1368-75.

11.    Nascimento MM, Bader JD, Qvist V, Litaker MS, Williams OD, Rindal DB, Gilbert GH, Gordan VA, for the DPBRN Collaborative Group. Concordance between pre-operative and post-operative assessments of primary caries lesion depth: results from The Dental PBRN. Operative Dentistry, 2010; 35(4): 389-96.

12.    Nascimento MM, Gordan VA, Mjor IA, Qvist V, Litaker, MS, Williams OD, Rindal DB; Fellows JL, Ritchie LkJr, McClelland J, Gilbert GH, for the DPBRN Collaborative Group. Reasons for placement of restorations on previously unrestored tooth surfaces by Dental PBRN Dentists. Journal of the American Dental Association, 2010; 141(4): 441-8.

13.    Toro E, Nascimento MM, Suarez-Perez E, Burne RA, Elias-Boneta A, Morou-Bermudez E. The effect of sucrose on plaque and saliva urease levels in vivo. Archives of Oral Biology, 2010; 55: 249-54.

14.    Burne RA, Ahn S, Wen ZT, Zeng L, Lemos JA, Abranches J, Nascimento MM. Opportunities for disrupting cariogenic biofilms. Advances in Dental Research, 2009; 21(1): 17-20.

15.    Nascimento MM, Gordan VA, Garvan CW, Browngardt C, Burne RA. Correlations of oral bacteria arginine and urea catabolism with caries experience. Oral Microbiology and Immunology, 2009; 24(2): 89-95.

16.    Griswold AR, Nascimento MM, Burne RA. Distribution, regulation and role of the agmatine deiminase system in mutans streptococci. Oral Microbiology and Immunology, 2009; 24(1): 79-82.

17.    Lemos JA, Nascimento MM, Lin VK5, Abranches J, Burne RA. Global regulation by (p)ppGpp and CodY in Streptococcus mutans. Journal of Bacteriology, 2008; 190(15): 5291-9.

18.    Abranches J*, Nascimento MM*, Zeng L*, Browngardt CM, Wen ZT, Rivera MF, Burne RA. CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. Journal of Bacteriology, 2008; 190(7): 2340-9. (*equal contribution as 1st authors)

19.    Nascimento MM, Lemos JA, Abranches J, Lin VK, Burne RA. Role of RelA of Streptococcus mutans in global control of gene expression. Journal of Bacteriology, 2008; 190(1): 28-36.

20.    Lemos JA, Lin VK, Nascimento MM, Abranches J, Burne RA. Three gene products govern (p)ppGpp production by Streptococcus mutans. Molecular Microbiology, 2007; 65(6): 1568-81.

21.    Nascimento MM, Lemos JA, Abranches J, Gonçalves RB, Burne RA. The adaptive acid tolerance response of Streptococcus sobrinus. Journal of Bacteriology, 2004; 186(19): 6383-90.

22.    Nascimento MM, Hofling JF, Gonçalves RB. Streptococcus mutans genotypes isolated from root and coronal caries. Caries Research, 2004; 38(5): 454- 63.

 

Research Grants

  • NIH/NIDCR – K23 DE023579: 2014-2019
    “Alkali production and Caries Prevention in Children”
    Role: Principal Investigator
  • Colgate-Palmolive: 2015-2016 “The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride”        Role: Principal Investigator
  • Colgate-Palmolive: 2009-2015 “The Microbiology of Caries Resistance”
    Role: Principal Investigator
  • NIH/NIDCR – R01 DE021789: 2012-2016
    “Functional Amyloid Formation in Streptococcus mutans
    Role: Investigator
  • NIH/NIDCR-DE10362: 2010-2013
    “Molecular Biology of Oral Alkali Generation”
    Role: Investigator
  • NIH/ NIDCR-R21 DE018392: 2008-2009
    “Alkali production in human plaque and saliva as predictor of caries risk”
    Role: Co-Principal Investigator
  • NIH/ NIDCR-U01-DE 16746 and U01-DE 16747: 2007-2009
    “DPBRN: Reasons for placement of the first restoration”
    Role: Investigator
  • FAPESP-Brazil: 2002-2004
    Doctoral fellowship: “Physiologic and genetic characterization of Streptococcus sobrinus.”
    Role: Principal Investigator
  • FAPESP-Brazil: 2003
    Postgraduate exchange fellowship: “The adaptive acid tolerance response of    Streptococcus sobrinus
    Role: Principal Investigator
  • FAPESP-Brazil: 2000-2002
    Master fellowship: “Clinical and microbiological aspects of root caries”
    Role: Principal Investigator
  • FAPESP-Brazil: 1999-2000
    Undergraduate research fellowship: “Quantitative analysis of microlinkage in posterior         teeth restored with composite using different insertions techniques”
    Role: Principal Investigator
  • CNPq-Brazil: 1996–1998
    Undergraduate research fellowship – University of Campinas, São Paulo, Brazil.
    “Morphological study of the Tropidurus torquatus specie tooth structure”
    Role: Principal Investigator