Robert P Yezierski

Robert P Yezierski,

PROF & PRG DIR

Department: DN-PAIN CENTER
Business Phone: (352) 392-4081
Business Email: ryezierski@dental.ufl.edu

Publications

2018
Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
The journal of pain. 19(6):571-588 [DOI] 10.1016/j.jpain.2017.12.261. [PMID] 29307749.
2016
Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat.
Neuroscience. 319:23-34 [DOI] 10.1016/j.neuroscience.2016.01.038. [PMID] 26812034.
2015
A preclinical model of hyperalgesia following spinal stenosis/compression.
European journal of pain (London, England). 19(8):1158-67 [DOI] 10.1002/ejp.640. [PMID] 25573023.
2015
Comparison of operant escape and reflex tests of nociceptive sensitivity.
Neuroscience and biobehavioral reviews. 51:223-42 [DOI] 10.1016/j.neubiorev.2015.01.022. [PMID] 25660956.
2014
‘Inhibition of IL-6 signaling: a novel therapeutic approach to treating spinal cord injury pain’ by Guptarak et al.
Pain. 155(1):197-198 [DOI] 10.1016/j.pain.2013.10.012. [PMID] 24157894.
2013
Discovery versus translation: do we need different strategies?
Pain management. 3(4):249-52 [DOI] 10.2217/pmt.13.21. [PMID] 24654807.
2013
Effects of gabapentin on thermal sensitivity following spinal nerve ligation or spinal cord compression.
Behavioural pharmacology. 24(7):598-609 [DOI] 10.1097/FBP.0b013e3283656d9b. [PMID] 23969615.
2013
Excitotoxic injury to thoracolumbar gray matter alters sympathetic activation and thermal pain sensitivity.
Experimental brain research. 231(1):19-26 [DOI] 10.1007/s00221-013-3666-2. [PMID] 23925342.
2013
Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.
Neuroscience letters. 544:62-7 [DOI] 10.1016/j.neulet.2013.03.042. [PMID] 23570732.
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Nucleus Tractus Solitaries and Oxidative Stress in the Hypothalamus in Rats
Journal of Neurotrauma. 29
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Rat Adrenal Medulla
The FASEB's Journal. 26
2012
International Spinal Cord Injury Pain (ISCIP) Classification: Part 2. Initial validation using vignettes.
Spinal cord. 50(6):404-12 [DOI] 10.1038/sc.2012.2. [PMID] 22310319.
2012
International spinal cord injury pain classification: part I. Background and description. March 6-7, 2009.
Spinal cord. 50(6):413-7 [DOI] 10.1038/sc.2011.156. [PMID] 22182852.
2012
The effects of age on pain sensitivity: preclinical studies.
Pain medicine (Malden, Mass.). 13 Suppl 2:S27-36 [DOI] 10.1111/j.1526-4637.2011.01311.x. [PMID] 22497745.
2011
Effects of analgesics on orthodontic pain.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 139(1):e53-8 [DOI] 10.1016/j.ajodo.2010.07.017. [PMID] 21195257.
2011
Interview: Pathways to discovery: reflections on an ongoing journey.
Pain management. 1(4):307-9 [DOI] 10.2217/pmt.11.26. [PMID] 24645657.
2011
Sex differences in effects of excitotoxic spinal injury on below-level pain sensitivity.
Brain research. 1419:85-96 [DOI] 10.1016/j.brainres.2011.08.072. [PMID] 21943508.
2011
Should the hot-plate test be reincarnated?
The journal of pain. 12(8):936-7; author reply 938 [DOI] 10.1016/j.jpain.2011.05.003. [PMID] 21816354.
2010
Effects of Age On Thermal Sensitivity in the Rat
Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 65(5):353-362 [DOI] 10.1093/gerona/glp024. [PMID] 19304940.
2010
Effects of age on thermal sensitivity in the rat.
The journals of gerontology. Series A, Biological sciences and medical sciences. 65(4):353-62 [DOI] 10.1093/gerona/glq024. [PMID] 20185437.
2010
Effects of age on thermal sensitivity in the rat.
Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 65(4) [DOI] 10.1093/gerona/glq024. [PMID] 20185437.
2010
Involvement of ERK2 in traumatic spinal cord injury.
Journal of neurochemistry. 113(1):131-42 [DOI] 10.1111/j.1471-4159.2010.06579.x. [PMID] 20067580.
2010
Pain as a stressor: effects of prior nociceptive stimulation on escape responding of rats to thermal stimulation.
European journal of pain (London, England). 14(1):11-6 [DOI] 10.1016/j.ejpain.2009.01.009. [PMID] 19261494.
2010
Reflex and pain behaviors are not equivalent: lessons from spinal cord injury.
Pain. 151(3):569-570 [DOI] 10.1016/j.pain.2010.09.012. [PMID] 20888692.
2009
Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats.
The journal of pain. 10(6):646-53 [DOI] 10.1016/j.jpain.2009.01.002. [PMID] 19409862.
2009
Effects of preoperative ibuprofen on pain after separator placement.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 136(4):510-7 [DOI] 10.1016/j.ajodo.2007.09.018. [PMID] 19815152.
2009
Rnai Approach Reveals a Specific Role of Erk2 in the Deleterious Consequences of Spinal Cord Injury
Journal of Neurotrauma. 26
2009
Social defeat stress potentiates thermal sensitivity in operant models of pain processing.
Brain research. 1251:112-20 [DOI] 10.1016/j.brainres.2008.11.042. [PMID] 19059227.
2009
Spinal cord injury pain: spinal and supraspinal mechanisms.
Journal of rehabilitation research and development. 46(1):95-107 [PMID] 19533523.
View on: PubMed
2008
Clinical and pre-clinical pain assessment: are we measuring the same thing?
Pain. 135(1-2):7-10 [DOI] 10.1016/j.pain.2007.12.008. [PMID] 18215466.
2008
Dermatomal scratching after intramedullary quisqualate injection: correlation with cutaneous denervation.
The journal of pain. 9(11):999-1005 [DOI] 10.1016/j.jpain.2008.05.010. [PMID] 18619906.
2008
Evaluation of prescription opioids using operant-based pain measures in rats.
Experimental and clinical psychopharmacology. 16(5):367-75 [DOI] 10.1037/a0013520. [PMID] 18837633.
2008
Long-lasting hyperalgesia and sympathetic dysregulation after formalin injection into the rat hind paw.
Neuroscience. 153(2):501-6 [DOI] 10.1016/j.neuroscience.2008.02.027. [PMID] 18378404.
2008
Targeting Erk2 With Lentiviral Shrna Improves Tissue Sparing and Locomotor Function After Spinal Cord Injury
Journal of Neurotrauma. 25
2007
Opioid modulation of reflex versus operant responses following stress in the rat.
Neuroscience. 147(1):174-82 [PMID] 17521823.
View on: PubMed
2006
Chapter 21 Pain following spinal cord injury: central mechanisms.
Handbook of clinical neurology. 81:293-V [DOI] 10.1016/S0072-9752(06)80025-4. [PMID] 18808843.
2006
Spinal cord injury.
The journal of pain. 7(12):871-7 [PMID] 17157772.
View on: PubMed
2005
Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury.
Brain research. Molecular brain research. 138(2):244-55 [PMID] 15922485.
View on: PubMed
2005
Comment on: Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesis, Dey et al., Pain 113 (2005) 233-237.
Pain. 115(3):419-420 [DOI] 10.1016/j.pain.2005.03.019. [PMID] 15878800.
2005
Differences in forebrain activation in two strains of rat at rest and after spinal cord injury.
Experimental neurology. 196(2):413-21 [PMID] 16182286.
View on: PubMed
2005
Evaluation of the pathologic characteristics of excitotoxic spinal cord injury with MR imaging.
AJNR. American journal of neuroradiology. 26(7):1612-22 [PMID] 16091503.
View on: PubMed
2005
Spinal cord injury: a model of central neuropathic pain.
Neuro-Signals. 14(4):182-93 [PMID] 16215301.
View on: PubMed
2005
Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord.
Molecular pain. 1 [PMID] 15987503.
View on: PubMed
2004
Spinal neurons involved in the generation of at-level pain following spinal injury in the rat.
Neuroscience letters. 361(1-3):232-6 [PMID] 15135936.
View on: PubMed
2004
Understanding chronic pain.
Nursing. 34(4):22-3 [PMID] 15247653.
View on: PubMed
2003
Differential effects of stress on escape and reflex responses to nociceptive thermal stimuli in the rat.
Brain research. 987(2):214-22 [PMID] 14499966.
View on: PubMed
2003
Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats.
The journal of pain. 4(3):129-40 [PMID] 14622710.
View on: PubMed
2003
N-methyl-D-aspartate receptor subunit expression and phosphorylation following excitotoxic spinal cord injury in rats.
Neuroscience letters. 349(1):37-40 [PMID] 12946581.
View on: PubMed
2002
Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury.
AJNR. American journal of neuroradiology. 23(6):901-5 [PMID] 12063213.
View on: PubMed
2001
Chronic pain after spinal injury: interference with sleep and daily activities.
Archives of physical medicine and rehabilitation. 82(11):1571-7 [PMID] 11689978.
View on: PubMed
2001
Conditions affecting the onset, severity, and progression of a spontaneous pain-like behavior after excitotoxic spinal cord injury.
The journal of pain. 2(4):229-40 [PMID] 14622821.
View on: PubMed
2001
Detrimental effects of systemic hyperthermia on locomotor function and histopathological outcome after traumatic spinal cord injury in the rat.
Neurosurgery. 49(1):152-8; discussion 158 [PMID] 11440437.
View on: PubMed
2001
Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat.
Experimental neurology. 168(1):144-54 [PMID] 11170729.
View on: PubMed
2001
Relationships among clinical characteristics of chronic pain after spinal cord injury.
Archives of physical medicine and rehabilitation. 82(9):1191-7 [PMID] 11552190.
View on: PubMed
2001
The role of neuroinflammation and neuroimmune activation in persistent pain.
Pain. 90(1-2):1-6 [PMID] 11166964.
View on: PubMed
2000
Agmatine improves locomotor function and reduces tissue damage following spinal cord injury.
Neuroreport. 11(14):3203-7 [PMID] 11043549.
View on: PubMed
2000
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.
Proceedings of the National Academy of Sciences of the United States of America. 97(19):10584-9 [PMID] 10984543.
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2000
Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats.
Journal of neurosurgery. 93(1 Suppl):85-93 [PMID] 10879763.
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2000
Chronic, selective forebrain responses to excitotoxic dorsal horn injury.
Experimental neurology. 161(1):220-6 [PMID] 10683288.
View on: PubMed
2000
Cytokine involvement in dynorphin-induced allodynia.
Pain. 84(2-3):159-67 [PMID] 10666520.
View on: PubMed
2000
Pain following spinal cord injury: animal models and mechanistic studies.
Pain. 89(1):1-5 [DOI] 10.1016/S0304-3959(00)00463-2. [PMID] 11113287.
2000
Pain following spinal cord injury: pathophysiology and central mechanisms.
Progress in brain research. 129:429-49 [PMID] 11098709.
View on: PubMed
2000
Posttraumatic hypothermia reduces polymorphonuclear leukocyte accumulation following spinal cord injury in rats.
Journal of neurotrauma. 17(4):321-32 [PMID] 10776915.
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1999
Diffusion-weighted MR imaging in a rat model of syringomyelia after excitotoxic spinal cord injury.
AJNR. American journal of neuroradiology. 20(8):1422-8 [PMID] 10512223.
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1999
Neuroprotective effects of basic fibroblast growth factor following spinal cord contusion injury in the rat.
Journal of neurotrauma. 16(5):347-56 [PMID] 10369555.
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1999
Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury.
Experimental neurology. 159(2):484-93 [PMID] 10506519.
View on: PubMed
1999
Perceived difficulty in dealing with consequences of spinal cord injury.
Archives of physical medicine and rehabilitation. 80(5):580-6 [PMID] 10326925.
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1998
Effects of adrenal medullary transplants on pain-related behaviors following excitotoxic spinal cord injury.
Brain research. 798(1-2):83-92 [PMID] 9666085.
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1998
Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat.
Journal of neurotrauma. 15(7):473-83 [PMID] 9674551.
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1998
Traumatic spinal cord injury induces nuclear factor-kappaB activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(9):3251-60 [PMID] 9547234.
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1997
NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord.
Brain research. 756(1-2):160-7 [PMID] 9187327.
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1996
Neuronal damage following intraspinal injection of a nitric oxide synthase inhibitor in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 16(5):996-1004 [PMID] 8784245.
View on: PubMed
1996
Pain following spinal cord injury: the clinical problem and experimental studies.
Pain. 68(2-3):185-94 [PMID] 9121805.
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1995
A combined behavioral-physiological method for the assessment of thermal sensibility in the rat.
Journal of neuroscience methods. 63(1-2):185-95 [PMID] 8788063.
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1994
Syringomyelia: clinical observations and experimental studies.
Journal of neurotrauma. 11(3):241-54 [PMID] 7996579.
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1993
Glutaminase-like immunoreactivity in rat spinomesencephalic tract cells.
Brain research. 624(1-2):304-8 [PMID] 8252406.
View on: PubMed
1993
Neuronal degeneration and spinal cavitation following intraspinal injections of quisqualic acid in the rat.
Journal of neurotrauma. 10(4):445-56 [PMID] 8145267.
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1993
The mechanosensitivity of spinal sensory neurons following intraspinal injections of quisqualic acid in the rat.
Neuroscience letters. 157(1):115-9 [PMID] 8233021.
View on: PubMed
1992
Effects of dorsal column demyelination on evoked potentials in nucleus gracilis.
Journal of neurotrauma. 9(3):231-44 [PMID] 1474610.
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1991
Effects of glutamate and gamma-aminobutyric acid on spontaneously active intraocular spinal cord graft neurons.
Journal of neural transplantation & plasticity. 2(2):101-11 [PMID] 1684114.
View on: PubMed
1991
Functional properties of spinomesencephalic tract (SMT) cells in the upper cervical spinal cord of the cat.
Pain. 45(2):187-196 [DOI] 10.1016/0304-3959(91)90187-3. [PMID] 1876427.
1991
Spinal distribution and collateral projections of rat spinomesencephalic tract cells.
Neuroscience. 44(1):113-30 [PMID] 1722887.
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1990
Effects of midbrain and medullary stimulation on spinomesencephalic tract cells in the cat.
Journal of neurophysiology. 63(2):240-55 [PMID] 2313343.
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1990
Intraocular grafts of fetal rat spinal cord: a Golgi study of neuronal morphology and organization.
Experimental neurology. 108(2):122-9 [PMID] 1692285.
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1988
Spinomesencephalic tract: projections from the lumbosacral spinal cord of the rat, cat, and monkey.
The Journal of comparative neurology. 267(1):131-46 [PMID] 2449474.
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1987
Response properties of spinal neurons projecting to midbrain or midbrain-thalamus in the monkey.
Brain research. 437(1):165-70 [PMID] 2827865.
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1986
Response and receptive-field properties of spinomesencephalic tract cells in the cat.
Journal of neurophysiology. 55(1):76-96 [PMID] 3950687.
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1984
Inhibition of primate spinothalamic tract neurons by stimulation in periaqueductal gray or adjacent midbrain reticular formation.
Journal of neurophysiology. 51(3):450-66 [PMID] 6699675.
View on: PubMed
1984
Primate raphe- and reticulospinal neurons: effects of stimulation in periaqueductal gray or VPLc thalamic nucleus.
Journal of neurophysiology. 51(3):467-80 [PMID] 6422009.
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1983
A further examination of effects of cortical stimulation on primate spinothalamic tract cells.
Journal of neurophysiology. 49(2):424-41 [PMID] 6834085.
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1983
Inhibition of primate spinothalamic tract neurons by stimulation in ventral posterior lateral (VPLc) thalamic nucleus: possible mechanisms.
Journal of neurophysiology. 49(2):406-23 [PMID] 6834084.
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1983
Midbrain nuclei projecting to the medial medulla oblongata in the monkey.
The Journal of comparative neurology. 214(1):93-102 [PMID] 6841679.
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1982
Cells of origin of the spinoreticular tract in the monkey.
The Journal of comparative neurology. 207(1):61-74 [PMID] 7096639.
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1982
Serotonergic projections to the caudal brain stem: a double label study using horseradish peroxidase and serotonin immunocytochemistry.
Brain research. 239(1):258-64 [PMID] 6178465.
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1982
The effects of serotonin antagonists on the inhibition of primate spinothalamic tract cells produced by stimulation in nucleus raphe magnus or periaqueductal gray.
The Journal of pharmacology and experimental therapeutics. 220(2):266-77 [PMID] 7057392.
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1981
A retrograde double label tracing technique using horseradish peroxidase and the fluorescent dye 4′-,6-diamidino-2-phenylindole 2HC1 (DAPI).
Journal of neuroscience methods. 4(1):53-62 [PMID] 6166816.
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1981
Inhibition of primate spinothalamic tract neurons by stimulation in ipsilateral or contralateral ventral posterior lateral (VPLc) thalamic nucleus.
Brain research. 229(2):514-9 [PMID] 6272944.
View on: PubMed
1981
Inhibitory receptive fields of primate spinothalamic tract cells.
Journal of neurophysiology. 46(6):1309-25 [PMID] 7320747.
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1981
Postsynaptic inhibition of primate spinothalamic neurons by stimulation in nucleus raphe magnus.
Brain research. 204(1):184-8 [PMID] 7248744.
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1981
Spinothalamic tract neurons that project to medial and/or lateral thalamic nuclei: evidence for a physiologically novel population of spinal cord neurons.
Journal of neurophysiology. 46(6):1285-308 [PMID] 7320746.
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1980
Cells of origin of propriospinal connections to cat lumbosacral gray as determined with horseradish peroxidase.
Experimental neurology. 69(3):493-512 [PMID] 7409061.
View on: PubMed
1979
Cross-correlation analysis of connectivities among cat lumbosacral dorsal horn cells.
Journal of neurophysiology. 42(5):1199-1211 [PMID] 490195.
View on: PubMed

Grants

Jul 2010 – Jan 2016
Integrative and translational training in pain research
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2002 – Dec 2018
02052305
Role: Project Manager
Funding: FINE SCIENCE TOOLS (USA) INC

Teaching Profile

Courses Taught
2011-2016
DEN6251 Clin Manage Dent Pain
2015
GMS6711 Neurobiology of Pain
2008-2010
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 392-4081
Emails: