Clay B Walker

Clay B Walker,

Associate Dean For Faculty Affairs

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8866
Business Email: cwalker@dental.ufl.edu

Teaching Profile

Courses Taught
2006-2007,2009-2017
DEN5127 Infectious Diseases
2011-2012,2014
DEN6416C Basic Sciences Rev
2013-2014
DEN6681 Craniofacial Pathobiology
2011-2012
GMS6161 Introduction to Oral Biology II
2009
DEN8290 Special Topics
2007
DEN5121 Biochm Molec Cell Bio

Publications

2023
Smoking-induced subgingival dysbiosis precedes clinical signs of periodontal disease.
Scientific reports. 13(1) [DOI] 10.1038/s41598-023-30203-z. [PMID] 36882425.
2021
Bacterial Biofilm Growth on Various Dental Stabilization Systems for Avulsed and Luxated Teeth
Applied Sciences-Basel. 11(19) [DOI] 10.3390/app11198982.
2021
Stability of healthy subgingival microbiome across space and time.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-03479-2. [PMID] 34907334.
2018
The subgingival microbiome in patients with established rheumatoid arthritis.
Rheumatology (Oxford, England). 57(7):1162-1172 [DOI] 10.1093/rheumatology/key052. [PMID] 29562298.
2016
Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases.
International dental journal. 66(3):127-35 [DOI] 10.1111/idj.12221. [PMID] 27009489.
2015
Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis.
Applied and environmental microbiology. 81(2):783-93 [DOI] 10.1128/AEM.02712-14. [PMID] 25398868.
2014
Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis.
Arthritis & rheumatology (Hoboken, N.J.). 66(5):1090-100 [DOI] 10.1002/art.38348. [PMID] 24782175.
2013
Pathogenicity of exopolysaccharide-producing Actinomyces oris isolated from an apical abscess lesion.
International endodontic journal. 46(2):145-54 [DOI] 10.1111/j.1365-2591.2012.02099.x. [PMID] 22900599.
2013
Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.
Journal of periodontology. 84(12):1801-8 [DOI] 10.1902/jop.2013.130002. [PMID] 23537121.
2012
Microbiological characterization in children with aggressive periodontitis.
Journal of dental research. 91(10):927-33 [PMID] 22863892.
2012
Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine.
Journal of oral microbiology. 4 [DOI] 10.3402/jom.v4i0.19227. [PMID] 23071896.
2011
A comparative evaluation of the sealing ability of 2 root-end filling materials: an in vitro leakage study using Enterococcus faecalis.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 112(2):e74-7 [DOI] 10.1016/j.tripleo.2011.01.030. [PMID] 21507688.
2011
Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms.
BMC infectious diseases. 11 [DOI] 10.1186/1471-2334-11-228. [PMID] 21864411.
2011
Reduction of two red complex bacteria by sustained-release doxycycline and correlation to improvement in mean pocket depth.
Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995). 32(3):e32-7 [PMID] 23738858.
2010
Comparison of bacterial reduction in straight and curved canals using erbium, chromium:yttrium-scandium-gallium-garnet laser treatment versus a traditional irrigation technique with sodium hypochlorite.
Journal of endodontics. 36(4):725-8 [DOI] 10.1016/j.joen.2009.11.017. [PMID] 20307752.
2010
Genetic analysis of mobile tetQ elements in oral Prevotella species.
Anaerobe. 16(6):604-9 [DOI] 10.1016/j.anaerobe.2010.08.008. [PMID] 20826220.
2010
Perpetuation of Subgingival Biofilms in An in Vitro Model
Molecular oral microbiology. 25(1):81-87 [DOI] 10.1111/j.2041-1014.2009.00549.x. [PMID] 20331796.
2010
Treating chronic periodontitis: current status, challenges, and future directions.
Clinical, cosmetic and investigational dentistry. 2:79-91 [PMID] 23662085.
2009
Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17.
BMC microbiology. 9 [DOI] 10.1186/1471-2180-9-11. [PMID] 19146705.
2009
Microbial testing in periodontics: value, limitations and future directions.
Periodontology 2000. 50:25-38 [DOI] 10.1111/j.1600-0757.2008.00285.x. [PMID] 19388951.
2009
Preliminary assessment of safety and effectiveness in humans of ProBiora3, a probiotic mouthwash.
Journal of applied microbiology. 107(2):682-90 [DOI] 10.1111/j.1365-2672.2009.04243.x. [PMID] 19486429.
2008
Matrix metalloproteinase levels in children with aggressive periodontitis.
Journal of periodontology. 79(5):819-26 [DOI] 10.1902/jop.2008.070513. [PMID] 18454660.
2008
Modified-release subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease.
Journal of periodontology. 79(3):440-52 [DOI] 10.1902/jop.2008.070375. [PMID] 18315426.
2007
An in vitro biofilm model of subgingival plaque.
Oral microbiology and immunology. 22(3):152-61 [PMID] 17488440.
2007
Microbiologic changes following administration of locally delivered doxycycline in smokers: a 15-month follow-up.
Journal of periodontology. 78(11):2143-9 [PMID] 17970681.
2007
Subantimicrobial dose doxycycline effects on osteopenic bone loss: microbiologic results.
Journal of periodontology. 78(8):1590-601 [PMID] 17668979.
2005
Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis.
FEMS microbiology letters. 242(2):319-24 [PMID] 15621454.
2005
Long-term treatment with sub-antimicrobial dose doxycycline has no antibacterial effect on intestinal flora.
Journal of clinical periodontology. 32(11):1163-9 [PMID] 16212578.
2004
Chemotherapeutics: antibiotics and other antimicrobials.
Periodontology 2000. 36:146-65 [PMID] 15330947.
2004
Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review.
Journal of clinical periodontology. 31(9):697-707 [PMID] 15312090.
2004
Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial.
Journal of periodontology. 75(8):1068-76 [PMID] 15455733.
2003
Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne.
Archives of dermatology. 139(4):459-64 [PMID] 12707093.
2002
Rationale for use of antibiotics in periodontics.
Journal of periodontology. 73(10):1188-96 [PMID] 12416778.
2000
Long-term treatment with subantimicrobial dose doxycycline exerts no antibacterial effect on the subgingival microflora associated with adult periodontitis.
Journal of periodontology. 71(9):1465-71 [PMID] 11022777.
2000
The effects of sustained release doxycycline on the anaerobic flora and antibiotic-resistant patterns in subgingival plaque and saliva.
Journal of periodontology. 71(5):768-74 [PMID] 10872958.
1997
Antibiotic resistance in an oral isolate of Prevotella intermedia.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 25 Suppl 2:S281-3 [PMID] 9310707.
1996
Detection and prevalence of the tetracycline resistance determinant Tet Q in the microbiota associated with adult periodontitis.
Oral microbiology and immunology. 11(4):282-8 [PMID] 9002882.
1996
Refractory periodontitis or recurrence of disease.
Journal of clinical periodontology. 23(3 Pt 2):289-92 [PMID] 8707992.
1996
Selected antimicrobial agents: mechanisms of action, side effects and drug interactions.
Periodontology 2000. 10:12-28 [PMID] 9567935.
1996
The acquisition of antibiotic resistance in the periodontal microflora.
Periodontology 2000. 10:79-88 [PMID] 9567938.
1994
Treatment of subjects with refractory periodontal disease.
Journal of clinical periodontology. 21(9):628-37 [PMID] 7806681.
1993
A role for antibiotics in the treatment of refractory periodontitis.
Journal of periodontology. 64(8 Suppl):772-81 [PMID] 8410617.
1993
A Role for Antibiotics in the Treatment of Refractory Periodontitis.
Journal of periodontology. 64 Suppl 8S:772-781 [DOI] 10.1902/jop.1993.64.8s.772. [PMID] 29539756.
1993
Comparative analysis between a modified ultrasonic tip and hand instruments on clinical parameters of periodontal disease.
Journal of periodontology. 64(8):694-700 [PMID] 8410606.
1993
Current Status of Systemic Antibiotic Usage in Destructive Periodontal Disease.
Journal of periodontology. 64 Suppl 8S:760-771 [DOI] 10.1902/jop.1993.64.8s.760. [PMID] 29539750.
1993
Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
Antimicrobial agents and chemotherapy. 37(9):2037-41 [PMID] 7916585.
1992
Identification of a streptomycin resistance gene and a partial Tn3 transposon coding for a beta-lactamase in a periodontal strain of Eikenella corrodens.
Antimicrobial agents and chemotherapy. 36(4):740-3 [PMID] 1323951.
1992
Phenotypic characteristics and DNA relatedness in Prevotella intermedia and similar organisms.
Oral microbiology and immunology. 7(1):60-4 [PMID] 1528627.
1992
The effect of 3 mouthrinses on plaque and gingivitis development.
Journal of clinical periodontology. 19(1):19-23 [PMID] 1310096.
1991
Clinical, microbiological and immunological characteristics of subjects with “refractory” periodontal disease.
Journal of clinical periodontology. 18(5):291-9 [PMID] 2066442.
1990
Localization and identification of root canal bacteria in clinically asymptomatic periapical pathosis.
Journal of endodontics. 16(11):534-8 [PMID] 2084210.
1989
Effect of non-surgical periodontal therapy combined with adjunctive antibiotics in subjects with “refractory” periodontal disease. (I). Clinical results.
Journal of clinical periodontology. 16(10):647-53 [PMID] 2693498.
1989
Efficacy of Perimed antibacterial system on established gingivitis. (I). Clinical results.
Journal of clinical periodontology. 16(10):630-5 [PMID] 2693495.
1988
Microbiological effects of mouthrinses containing antimicrobials.
Journal of clinical periodontology. 15(8):499-505 [PMID] 3053791.
1985
Antibiotic Susceptibilities of Periodontal Bacteria: In Vitro Susceptibilities to Eight Antimicrobial Agents.
Journal of periodontology. 56 Suppl 11S:67-74 [DOI] 10.1902/jop.1985.56.11s.67. [PMID] 29538943.
1985
Efficacy of Clindamycin Hydrochloride in Refractory Periodontitis: 12-Month Results.
Journal of periodontology. 56 Suppl 11S:75-80 [DOI] 10.1902/jop.1985.56.11s.75. [PMID] 29538955.

Grants

Mar 2015 – Mar 2017
An examination of the oral microflora of arthritic subjects
Role: Principal Investigator
Funding: US DEPT OF VET AFF NEBRASKA-WESTERN IA
Nov 2014 – Jun 2017
Microbiota associated with arthritic patients with and without periodontitis
Role: Principal Investigator
Funding: UNIV OF NEBRASKA

Contact Details

Phones:
Business:
(352) 273-8866
Emails:
Addresses:
Business Mailing:
PO Box 100424
OFC DG 48
GAINESVILLE FL 32610
Business Street:
DG-48 JHMHC
GAINESVILLE FL 32611