Zsolt Toth

Zsolt Toth,

AST PROF

Department: DN-ORAL BIOLOGY
Business Phone: (352) 294-8461
Business Email: ztoth@dental.ufl.edu

Publications

2021
Clinical Manifestations and Epigenetic Regulation of Oral Herpesvirus Infections.
Viruses. 13(4) [DOI] 10.3390/v13040681. [PMID] 33920978.
2021
Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7.
PLoS pathogens. 17(1) [DOI] 10.1371/journal.ppat.1009179. [PMID] 33471866.
2021
KDM2B Overexpression Facilitates Lytic De Novo KSHV Infection by Inducing AP-1 Activity Through Interaction with the SCF E3 Ubiquitin Ligase Complex.
Journal of virology. [DOI] 10.1128/JVI.00331-21. [PMID] 33692209.
2020
Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway.
Virology. 541:160-173 [DOI] 10.1016/j.virol.2019.12.011. [PMID] 32056714.
2020
Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV.
PLoS pathogens. 16(1) [DOI] 10.1371/journal.ppat.1008268. [PMID] 31923286.
2019
Characterization of de novo lytic infection of dermal lymphatic microvascular endothelial cells by Kaposi’s sarcoma-associated herpesvirus.
Virology. 536:27-31 [DOI] 10.1016/j.virol.2019.07.028. [PMID] 31394409.
2019
Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi’s Sarcoma-Associated Herpesvirus Lytic Reactivation.
Journal of virology. 93(5) [DOI] 10.1128/JVI.01978-18. [PMID] 30541837.
2018
LL-37 disrupts the Kaposi’s sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells.
Antiviral research. 158:25-33 [DOI] 10.1016/j.antiviral.2018.07.025. [PMID] 30076864.
2017
Inhibition of the lytic cycle of Kaposi’s sarcoma-associated herpesvirus by cohesin factors following de novo infection.
Virology. 512:25-33 [DOI] 10.1016/j.virol.2017.09.001. [PMID] 28898712.
2016
LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection.
PLoS pathogens. 12(9) [DOI] 10.1371/journal.ppat.1005878. [PMID] 27606464.
2015
Association of Kaposi’s Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression.
Journal of virology. 89(11):6148-54 [DOI] 10.1128/JVI.00272-15. [PMID] 25810551.
2014
Kaposi’s sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication.
Journal of virology. 88(16):9335-49 [DOI] 10.1128/JVI.00873-14. [PMID] 24899205.
2014
Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.
Journal of virology. 88(4):2183-94 [DOI] 10.1128/JVI.02106-13. [PMID] 24335298.
2013
Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection.
PLoS pathogens. 9(12) [DOI] 10.1371/journal.ppat.1003813. [PMID] 24367262.
2013
The chromatin landscape of Kaposi’s sarcoma-associated herpesvirus.
Viruses. 5(5):1346-73 [DOI] 10.3390/v5051346. [PMID] 23698402.
2013
The product of Kaposi’s sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1.
Journal of virology. 87(22):12069-79 [DOI] 10.1128/JVI.01900-13. [PMID] 23986581.
2012
Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2.
Cancer research. 72(14):3582-92 [DOI] 10.1158/0008-5472.CAN-11-2876. [PMID] 22593192.
2012
Construction and manipulation of a new Kaposi’s sarcoma-associated herpesvirus bacterial artificial chromosome clone.
Journal of virology. 86(18):9708-20 [DOI] 10.1128/JVI.01019-12. [PMID] 22740391.
2012
Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi’s sarcoma-associated herpesvirus lytic gene expression.
Journal of virology. 86(18):9696-707 [DOI] 10.1128/JVI.01012-12. [PMID] 22740393.
2012
Novel Phosphorylations of IKKγ/NEMO.
mBio. 3(6):e00411-12 [DOI] 10.1128/mBio.00411-12. [PMID] 23131831.
2011
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.
Nature structural & molecular biology. 18(12):1336-44 [DOI] 10.1038/nsmb.2142. [PMID] 22056774.
2011
Inhibition of RIG-I-mediated signaling by Kaposi’s sarcoma-associated herpesvirus-encoded deubiquitinase ORF64.
Journal of virology. 85(20):10899-904 [DOI] 10.1128/JVI.00690-11. [PMID] 21835791.
2011
TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.
PloS one. 6(1) [DOI] 10.1371/journal.pone.0016205. [PMID] 21267413.
2010
Epigenetic analysis of KSHV latent and lytic genomes.
PLoS pathogens. 6(7) [DOI] 10.1371/journal.ppat.1001013. [PMID] 20661424.
2009
Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.
Journal of virology. 83(13):6739-47 [DOI] 10.1128/JVI.02353-08. [PMID] 19369353.

Grants

Jul 2021 ACTIVE
Forkhead factor regulation in oral viral infection
Role: Other
Funding: NATL INST OF HLTH NIDCR
Dec 2020 ACTIVE
Immune evasion mechanisms by a tumor herpesvirus in the oral cavity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jan 2019 ACTIVE
Controlling the Establishment of Oncogenic Herpesviral Infection
Role: Principal Investigator
Funding: AMER CANCER SOC
Jun 2018 ACTIVE
Viral and host strategies for regulation of KSHV infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2017 – May 2019
OR-DRPD-ROF2017: Immune evasion mechanisms during oral infection by an oncogenic herpesvirus
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Jun 2016 – Jun 2018
Regulation of KSHV lytic replication in oral epithelial cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jun 2016 – May 2018
Epigenetic role of LANA in the establishment of KSHV latent infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL

Teaching Profile

Courses Taught
2017-2021
DEN5127 Infectious Diseases
2018-2020
DEN8290 Special Topics
2018
GMS7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 294-8461
Emails: