Ann Progulske-Fox

Ann Progulske-Fox, PhD

Distinguished Professor & Program Director

Department: DN-MICROBIOLOGY
Business Phone: (352) 273-8835
Business Email: apfox@dental.ufl.edu

Teaching Profile

Courses Taught
2011-2022
DEN5127 Infectious Diseases
2018
GMS7980 Research for Doctoral Dissertation
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2013-2016
IDH4905 Individual Work
2011-2012
GMS6161 Introduction to Oral Biology II
2011
DEN8290 Special Topics
2009
ALS4905 Problems in Agricul
2021
GMS6162 Oral Microbiology and Immunology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-5911-5935

Publications

2022
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).
Neoplasia (New York, N.Y.). 31 [DOI] 10.1016/j.neo.2022.100813. [PMID] 35834946.
2022
VBNC, previously unrecognized in the life cycle of Porphyromonas gingivalis?
Journal of oral microbiology. 14(1) [DOI] 10.1080/20002297.2021.1952838. [PMID] 35035782.
2021
A Novel Regulation of K-antigen Capsule Synthesis in Porphyromonas gingivalis Is Driven by the Response Regulator PG0720-Directed Antisense RNA.
Frontiers in oral health. 2 [DOI] 10.3389/froh.2021.701659. [PMID] 35048039.
2021
Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study.
BMC oral health. 21(1) [DOI] 10.1186/s12903-021-01597-x. [PMID] 33964928.
2020
A Uniquely Altered Oral Microbiome Composition Was Observed in Pregnant Rats With Porphyromonas gingivalis Induced Periodontal Disease.
Frontiers in cellular and infection microbiology. 10 [DOI] 10.3389/fcimb.2020.00092. [PMID] 32211345.
2020
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Journal of oral microbiology. 13(1) [DOI] 10.1080/20002297.2020.1849493. [PMID] 33391626.
2020
Porphyromonas gingivalis W83 traffics via ICAM1 in microvascular endothelial cells and alters capillary organization in vivo.
Journal of oral microbiology. 12(1) [DOI] 10.1080/20002297.2020.1742528. [PMID] 32341760.
2019
Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B.
Data in brief. 22:964-970 [DOI] 10.1016/j.dib.2018.12.087. [PMID] 30740479.
2019
The Importance of Being an Antagonist as Well as Persistent.
Journal of bacteriology. 201(11) [DOI] 10.1128/JB.00146-19. [PMID] 30910810.
2019
Tribute: Edward ‘Ned’ Lally.
Molecular oral microbiology. 34(6):235-236 [DOI] 10.1111/omi.12269. [PMID] 31637856.
2018
Deletion of a conserved transcript PG_RS02100 expressed during logarithmic growth in Porphyromonas gingivalis results in hyperpigmentation and increased tolerance to oxidative stress.
PloS one. 13(11) [DOI] 10.1371/journal.pone.0207295. [PMID] 30419070.
2018
Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B.
Journal of periodontology. 89(3):361-369 [DOI] 10.1002/JPER.17-0366. [PMID] 29543996.
2018
Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B.
International journal of molecular sciences. 19(12) [DOI] 10.3390/ijms19123923. [PMID] 30544510.
2018
Porphyromonas gingivalis and adverse pregnancy outcome.
Journal of oral microbiology. 10(1) [DOI] 10.1080/20002297.2017.1374153. [PMID] 29291034.
2018
Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat.
Biology of reproduction. 99(5):1045-1056 [DOI] 10.1093/biolre/ioy119. [PMID] 29788108.
2017
Genome Sequence of Porphyromonas gingivalis Strain 381.
Genome announcements. 5(2) [DOI] 10.1128/genomeA.01467-16. [PMID] 28082501.
2017
Genome Sequence of Porphyromonas gingivalis Strain A7A1-28.
Genome announcements. 5(10) [DOI] 10.1128/genomeA.00021-17. [PMID] 28280013.
2016
Biofilm Formation by Mycobacterium abscessus in a Lung Cavity.
American journal of respiratory and critical care medicine. 193(6):692-3 [DOI] 10.1164/rccm.201508-1586IM. [PMID] 26731090.
2016
Introduction to the Mark Wilson Conference Special Issue.
Molecular oral microbiology. 31(1):1-2 [DOI] 10.1111/omi.12148. [PMID] 26754252.
2016
Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome.
PloS one. 11(1) [DOI] 10.1371/journal.pone.0146157. [PMID] 26731111.
2015
Genome Sequence of Porphyromonas gingivalis Strain A7436.
Genome announcements. 3(5) [DOI] 10.1128/genomeA.00927-15. [PMID] 26404590.
2015
Genome Sequence of Porphyromonas gingivalis Strain AJW4.
Genome announcements. 3(6) [DOI] 10.1128/genomeA.01304-15. [PMID] 26543127.
2015
Invasion of Porphyromonas gingivalis strains into vascular cells and tissue.
Journal of oral microbiology. 7 [DOI] 10.3402/jom.v7.28788. [PMID] 26329158.
2015
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
Infection and immunity. 83(5):2001-10 [DOI] 10.1128/IAI.03022-14. [PMID] 25733523.
2014
Expression of Porphyromonas gingivalis small RNA in response to hemin availability identified using microarray and RNA-seq analysis.
FEMS microbiology letters. 351(2):202-8 [DOI] 10.1111/1574-6968.12320. [PMID] 24245974.
2014
Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.
Scientific reports. 4 [DOI] 10.1038/srep03904. [PMID] 24473528.
2013
Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.
Scientific reports. 3 [DOI] 10.1038/srep01232. [PMID] 23390582.
2013
Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells.
PloS one. 8(9) [DOI] 10.1371/journal.pone.0074230. [PMID] 24069284.
2013
Development of a novel ex vivo porcine skin explant model for the assessment of mature bacterial biofilms.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 21(5):704-14 [DOI] 10.1111/wrr.12074. [PMID] 23927831.
2013
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology.
Journal of clinical periodontology. 40 Suppl 14:S30-50 [DOI] 10.1111/jcpe.12079. [PMID] 23627333.
2013
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology.
Journal of periodontology. 84(4 Suppl):S30-50 [DOI] 10.1902/jop.2013.1340012. [PMID] 23631583.
2013
Transforming women’s oral-systemic health through discovery, development, and delivery.
Journal of women's health (2002). 22(4):299-302 [DOI] 10.1089/jwh.2012.4197. [PMID] 23540329.
2012
Both the unique and repeat regions of the Porphyromonas gingivalis hemagglutin A are involved in adhesion and invasion of host cells.
Anaerobe. 18(1):128-34 [DOI] 10.1016/j.anaerobe.2011.10.005. [PMID] 22100486.
2012
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy. 8(4):445-544 [PMID] 22966490.
2012
Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells.
International journal of antimicrobial agents. 40(1):75-9 [DOI] 10.1016/j.ijantimicag.2012.03.007. [PMID] 22578747.
2012
Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice.
Journal of dental research. 91(3):255-60 [DOI] 10.1177/0022034511435101. [PMID] 22262633.
2012
Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0052606. [PMID] 23300720.
2010
Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.
Future microbiology. 5(1):115-25 [DOI] 10.2217/fmb.09.107. [PMID] 20020833.
2010
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.
PloS one. 5(7) [DOI] 10.1371/journal.pone.0011714. [PMID] 20668524.
2009
A member of the peptidase M48 superfamily of Porphyromonas gingivalis is associated with virulence in vitro and in vivo.
Journal of oral microbiology. 1 [DOI] 10.3402/jom.v1i0.2021. [PMID] 21523206.
2009
Analysis of a band 7/MEC-2 family gene of Porphyromonas gingivalis.
Journal of dental research. 88(1):34-8 [DOI] 10.1177/0022034508328381. [PMID] 19131314.
2009
Identification of Compounds That Enhance and Suppress Autophagy
Autophagy. 5:910-911
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology. 24(2):141-5 [DOI] 10.1111/j.1399-302X.2008.00487.x. [PMID] 19239641.
2008
Colonization of maternal and fetal tissues by Porphyromonas gingivalis is strain-dependent in a rodent animal model.
American journal of obstetrics and gynecology. 199(1):86.e1-7 [DOI] 10.1016/j.ajog.2007.11.067. [PMID] 18355778.
2008
Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis.
Infection and immunity. 76(12):5714-20 [DOI] 10.1128/IAI.00997-08. [PMID] 18852241.
2008
Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.
Immunology and cell biology. 86(8):643-9 [DOI] 10.1038/icb.2008.56. [PMID] 18711400.
2008
Invasive differences among Porphyromonas gingivalis strains from healthy and diseased periodontal sites.
Journal of periodontal research. 43(5):524-30 [DOI] 10.1111/j.1600-0765.2007.01064.x. [PMID] 18544120.
2008
Porphyromonas gingivalis and the autophagic pathway: an innate immune interaction?
Frontiers in bioscience : a journal and virtual library. 13:178-87 [PMID] 17981536.
2008
Porphyromonas gingivalis htrA is involved in cellular invasion and in vivo survival.
Microbiology (Reading, England). 154(Pt 4):1161-1169 [DOI] 10.1099/mic.0.2007/015131-0. [PMID] 18375808.
2007
Conjugal transfer of chromosomal DNA contributes to genetic variation in the oral pathogen Porphyromonas gingivalis.
Journal of bacteriology. 189(17):6382-8 [PMID] 17573478.
2007
Genetic manipulation of Porphyromonas gingivalis.
Current protocols in microbiology. Chapter 13 [DOI] 10.1002/9780471729259.mc13c02s05. [PMID] 18770611.
2007
Identification of Tannerella forsythia antigens specifically expressed in patients with periodontal disease.
FEMS microbiology letters. 275(2):344-52 [PMID] 17868359.
2007
In vitro activity of amoxicillin, clindamycin, doxycycline, metronidazole, and moxifloxacin against oral Actinomyces.
Journal of endodontics. 33(5):557-60 [PMID] 17437871.
2007
The Porphyromonas gingivalis clpB gene is involved in cellular invasion in vitro and virulence in vivo.
FEMS immunology and medical microbiology. 51(2):388-98 [PMID] 17854400.
2006
Antimicrobial efficacy of medicated root canal filling materials.
Journal of endodontics. 32(2):148-51 [PMID] 16427466.
2006
Autophagy: a highway for Porphyromonas gingivalis in endothelial cells.
Autophagy. 2(3):165-70 [PMID] 16874051.
2006
Detection of bacterial DNA in atheromatous plaques by quantitative PCR.
Microbes and infection. 8(3):687-93 [PMID] 16513386.
2005
Dentinal tubule disinfection using three calcium hydroxide formulations.
Journal of endodontics. 31(1):50-2 [PMID] 15614007.
2005
Distinct transcriptional profiles characterize oral epithelium-microbiota interactions.
Cellular microbiology. 7(6):811-23 [PMID] 15888084.
2005
Gene expression profile analysis of Porphyromonas gingivalis during invasion of human coronary artery endothelial cells.
Infection and immunity. 73(9):6169-73 [PMID] 16113342.
2005
Hemagglutinin B is involved in the adherence of Porphyromonas gingivalis to human coronary artery endothelial cells.
Infection and immunity. 73(11):7267-73 [PMID] 16239522.
2005
Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
Arteriosclerosis, thrombosis, and vascular biology. 25(3):e17-8 [PMID] 15662025.
2005
In vivo induced genes in human diseases.
Periodontology 2000. 38:123-34 [PMID] 15853939.
2005
Microarray analysis of quorum-sensing-regulated genes in Porphyromonas gingivalis.
Infection and immunity. 73(7):4146-54 [PMID] 15972504.
2005
Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection.
Infection and immunity. 73(5):2665-79 [PMID] 15845468.
2004
In vivo induced antigenic determinants of Actinobacillus actinomycetemcomitans.
FEMS microbiology letters. 237(1):97-103 [PMID] 15268943.
2003
Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients.
Infection and immunity. 71(10):5461-71 [PMID] 14500463.
2003
Identification of Candida albicans genes induced during thrush offers insight into pathogenesis.
Molecular microbiology. 48(5):1275-88 [PMID] 12787355.
2003
Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America. 100(14):8508-13 [PMID] 12826608.
2002
Bacterial interactions with the autophagic pathway.
Cellular microbiology. 4(1):1-10 [PMID] 11856168.
2002
Genes of periodontopathogens expressed during human disease.
Annals of periodontology. 7(1):38-42 [PMID] 16013215.
2002
Identification and testing of Porphyromonas gingivalis virulence genes with a pPGIVET system.
Infection and immunity. 70(2):928-37 [PMID] 11796628.
2002
Invasion of vascular cells in vitro by Porphyromonas endodontalis.
International endodontic journal. 35(4):366-71 [PMID] 12059938.
2001
Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease.
Microbial pathogenesis. 30(4):179-92 [PMID] 11312612.
2001
Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells.
Infection and immunity. 69(9):5698-708 [PMID] 11500446.
2001
The effect of monoclonal antibody and route of immunization on the humoral immune response against Porphyromonas gingivalis.
Oral microbiology and immunology. 16(3):153-62 [PMID] 11358537.
2000
Expression and immunogenicity of hemagglutinin A from Porphyromonas gingivalis in an avirulent Salmonella enterica serovar typhimurium vaccine strain.
Infection and immunity. 68(2):732-9 [PMID] 10639440.
2000
Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis.
FEMS microbiology letters. 187(2):139-44 [PMID] 10856647.
2000
IVIAT: a novel method to identify microbial genes expressed specifically during human infections.
Trends in microbiology. 8(7):336-9 [PMID] 10878769.
2000
Long-term immunological memory induced by recombinant oral Salmonella vaccine vectors.
Infection and immunity. 68(7):4370-3 [PMID] 10858264.
1999
Invasion of human coronary artery cells by periodontal pathogens.
Infection and immunity. 67(11):5792-8 [PMID] 10531230.
1999
Porphyromonas gingivalis virulence factors and invasion of cells of the cardiovascular system.
Journal of periodontal research. 34(7):393-9 [PMID] 10685367.
1998
Invasion of human oral epithelial cells by Prevotella intermedia.
Infection and immunity. 66(12):6054-7 [PMID] 9826397.
1998
The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains.
Infection and immunity. 66(10):4721-5 [PMID] 9746569.
1998
The porphyromonas gingivalis prtP/kgp homologue exists as two open reading frames in strain 381.
Oral diseases. 4(3):170-9 [PMID] 9972167.
1996
Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis.
Journal of bacteriology. 178(10):2734-41 [PMID] 8631659.
1996
Construction and preliminary characterization of three hemagglutinin mutants of Porphyromonas gingivalis.
Infection and immunity. 64(4):1467-72 [PMID] 8606121.
1996
Duplication and differential expression of hemagglutinin genes in Porphyromonas gingivalis.
Oral microbiology and immunology. 11(2):65-78 [PMID] 8941757.
1996
The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats.
Infection and immunity. 64(10):4000-7 [PMID] 8926061.
1996
The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector.
Infection and immunity. 64(11):4802-10 [PMID] 8890242.
1995
Expression and immunogenicity of a cloned Porphyromonas gingivalis hemagglutinin in Salmonella typhimurium.
Advances in experimental medicine and biology. 371B:1119-21 [PMID] 7502765.
1995
Restriction fragment length polymorphism analysis of two hemagglutinin loci, serotyping and agglutinating activity of Porphyromonas gingivalis isolates.
Oral microbiology and immunology. 10(1):1-7 [PMID] 7644268.
1995
The cloning, expression and sequence analysis of a second Porphyromonas gingivalis gene that codes for a protein involved in hemagglutination.
Oral microbiology and immunology. 10(5):311-8 [PMID] 8596675.
1994
Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin.
Infection and immunity. 62(5):1652-7 [PMID] 8168925.
1993
Cloning and sequencing of two type 4 (N-methylphenylalanine) pilin genes from Eikenella corrodens.
Journal of general microbiology. 139(3):651-60 [PMID] 8473871.
1993
Development of a genetic system for Eikenella corrodens: transfer of plasmids pFM739 and pLES2.
Plasmid. 30(3):289-95 [PMID] 8302938.
1993
Isolation and characterization of a cloned Porphyromonas gingivalis hemagglutinin from an avirulent strain of Salmonella typhimurium.
Infection and immunity. 61(3):940-6 [PMID] 8381773.
1993
Molecular characterization of hemagglutinin genes of periodontopathic bacteria.
Journal of periodontal research. 28(6 Pt 2):473-4 [PMID] 8263716.
1993
Sequence divergence in two tandemly located pilin genes of Eikenella corrodens.
Infection and immunity. 61(5):1909-16 [PMID] 8478080.
1993
Sequencing of a tet(Q) gene isolated from Bacteroides fragilis 1126.
Antimicrobial agents and chemotherapy. 37(9):2037-41 [PMID] 7916585.
1992
Evidence for independent molecular identity and functional interaction of the haemagglutinin and cysteine proteinase (gingivain) of Porphyromonas gingivalis.
Journal of medical microbiology. 36(4):239-44 [PMID] 1313881.
1991
Identification and sequence analysis of a methylase gene in Porphyromonas gingivalis.
Nucleic acids research. 19(15):4189-92 [PMID] 1870972.
1990
Cloning and inactivation of the gene responsible for a major surface antigen on Streptococcus mutans.
Archives of oral biology. 35 Suppl:15S-23S [PMID] 2088219.
1989
Construction and characterization of isogenic mutants of Streptococcus mutans deficient in major surface protein antigen P1 (I/II).
Infection and immunity. 57(11):3306-13 [PMID] 2807526.
1989
Sequence analysis of the cloned streptococcal cell surface antigen I/II.
FEBS letters. 258(1):127-32 [PMID] 2687020.
1989
The expression and function of a Bacteroides gingivalis hemagglutinin gene in Escherichia coli.
Oral microbiology and immunology. 4(3):121-31 [PMID] 2700777.
1989
Transfer of plasmid pE5-2 from Escherichia coli to Bacteroides gingivalis and B. intermedius.
Oral microbiology and immunology. 4(3):132-4 [PMID] 2700778.
1988
Molecular cloning and expression of a Streptococcus mutans major surface protein antigen, P1 (I/II), in Escherichia coli.
Infection and immunity. 56(8):2114-9 [PMID] 3135272.
1987
The effect of Eikenella corrodens endotoxin on periapical bone.
Journal of endodontics. 13(12):559-65 [PMID] 3329211.
1975
The 6-hydroxydopamine rotational model for the detection of dopamine agonist activity: reliability of effect from different locations of 6-hydroxydopamine.
The Journal of pharmacy and pharmacology. 27(12):943-6 [PMID] 2668.

Grants

Jan 2021 ACTIVE
Oral Immunology/Microbiology research group annual meeting
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2019 ACTIVE
Investigating the viable but not culturable (VBNC) state in P. gingivalis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2019 – Dec 2020
Analysis of Mab61BG1.3 reactivity with strains of P. gingivalis.
Role: Principal Investigator
Funding: KEYSTONE BIO
Aug 2019 – Aug 2020
Analysis of antigen reactivity
Role: Principal Investigator
Funding: SALVDX
Jun 2017 – Dec 2018
Clinical effectiveness of Next Science oral rinse in controlling plaque and gingival inflammation
Role: Principal Investigator
Funding: NEXT SCIENCE LLC
Dec 2015 – Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Apr 2015 – Mar 2021
P. gingivalis mediated disruption of autophagy in endothelial dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2014 – Jul 2017
Porphyromonas gingivalis strain specific effects on the deep placental bed
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
Jul 2013 – Dec 2016
Internalization of S. mutans in vascular endothelial cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2011 – May 2017
Periodontal Pathogens and Cardiovascular Disease
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR

Contact Details

Phones:
Business:
(352) 273-8835
Emails:
Addresses:
Business Mailing:
PO Box 100424
GAINESVILLE FL 32610
Business Street:
DG-50 DSB
GAINESVILLE FL 32611