Marcelle Nascimento,
Professor
Department:
DN-OPERATIVE DIVISION
Business Phone:
(352) 273-5858
Business Email:
mnascimento@dental.ufl.edu
About Marcelle Nascimento
I joined the University of Florida College of Dentistry (UFCD) in 2007 as an Assistant Professor in the Department of Operative Dentistry. In 2015, I was promoted to Associate Professor with tenure, and in 2022, I was promoted to Full Professor. Cariology research and teaching are my main professional assignments at UFCD. I have been conducting several research projects in the areas of Cariology, Oral Microbiology, Pediatric Dentistry, and Dental Education. I am the director of the Cariology and Preventive Dentistry course offered to our 1DN students. I am also actively engaged in the teaching of preclinical and clinical Cariology and Operative Dentistry for both undergraduate and graduate programs. I have served as President of the IADR Cariology Research group (2015-2016), I am the current chair of the ADEA Cariology section, and I serve as a member of the American Academy of Cariology Board of Directors as Chair of the Research Section Pillar.
Accomplishments
Elected Faculty Advisor by the UFCD Class of 2022
2019
·
University of Florida College of Dentistry
IADR Cariology Research Group Award
2019
·
International Association for Dental Research (IADR)
Sustained Excellence in Teaching Award
2019
·
University of Florida College of Dentistry
UF Research Foundation Professorship Award
2019
·
University of Florida
Elected to serve in the AAC Board of Directors
2018
·
American Academy of Cariology (AAC)
UF Term Professorship Award
2018
·
University of Florida
Consultant to the ADA Council on Scientific Affairs (CSA)
2017
·
American Dental Association (ADA)
Elected Officer of the ADEA Cariology section
2017
·
American Dental Education Association (ADEA)
Faculty Inductee, OKU National Dental Honor Society
2016
·
Omicron Kappa Upsilon (OKU)
Joseph Lister Award for New Investigators
2016
·
International Association for Dental Research (IADR)
Faculty of Color Tuition Award for Professional Development
2015
·
American Dental Education Association (ADEA)/ AAL
Promotion to Associate Professor with Tenure by UF Board of Trustees
2015
·
University of Florida
Academy of Research Excellence
2014
·
University of Florida /CTSI
President-elect of the IADR Cariology Research Group
2014
·
International Association for Dental Research (IADR)
Elected Faculty Advisor by the UFCD Class of 2012
2009
·
University of Florida College of Dentistry
Teaching Profile
Courses Taught
2011-2013,2015-2022,2020-2023
DEN8748L Clin Operative Den 5
2020
DEN7016 Prof Care/Prac Man 2
2011-2017,2020-2023,2023
DEN5404C Den Anat and Stmtgnthcs
2011-2013,2015-2022,2020-2023
DEN7745L Clin Operative Den 2
2009-2016,2020-2024
DEN5405C Preclin Oper Bio 1
2017-2024
DEN5502C Cariology Prev Dent
2018,2022-2023
DEN6302C Intro Cli Diag/Trtmnt
2011-2013,2016-2023,2021-2023
DEN7744L Clin Operative Den 1
2011-2012,2016
DEN6502 Preventive Dentistry
2012-2016
DEN7961L Clinical Examinaton 1
2011-2016,2021-2023
DEN6407C Preclin Operative 2
2011-2013,2015-2023,2021-2023
DEN8747L Clin Operative Den 4
2014,2016
DEN8960L Clinical Examinatio 2
2011-2015,2021-2023,2023
DEN6408C PreClinical Operative Dentistry 3
2013-2014
DEN8290 Special Topics
2014
DEN5210 Dev Biol Psychosoc 1
2012-2014
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2011-2014,2021-2024
DEN8749L Clin Operative Den 6
2011-2014,2021-2024
DEN7746L Clin Operative Den 3
2011
GMS6160 Introduction to Oral Biology I
Clinical Profile
Specialties
- Dentistry
Areas of Interest
- Dental cavities
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9536-0038
Publications
2024
Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species.
Microbiology spectrum.
12(4)
[DOI] 10.1128/spectrum.01445-23.
[PMID] 38411054.
2023
Direct materials for restoring caries lesions: Systematic review and meta-analysis-a report of the American Dental Association Council on Scientific Affairs.
Journal of the American Dental Association (1939).
154(2):e1-e98
[DOI] 10.1016/j.adaj.2022.09.012.
[PMID] 36610925.
2023
Evidence-based clinical practice guideline on restorative treatments for caries lesions: A report from the American Dental Association.
Journal of the American Dental Association (1939).
154(7):551-566.e51
[DOI] 10.1016/j.adaj.2023.04.011.
[PMID] 37380250.
2022
Optimization and Evaluation of the 30S-S11 rRNA Gene for Taxonomic Profiling of Oral Streptococci.
Applied and environmental microbiology.
88(13)
[DOI] 10.1128/aem.00453-22.
[PMID] 35730938.
2022
Prepregnancy BMI, gestational weight gain and offspring caries experience: Avon longitudinal study of parents and children.
PloS one.
17(3)
[DOI] 10.1371/journal.pone.0266247.
[PMID] 35358251.
2021
Incorporation of Arginine to Commercial Orthodontic Light-Cured Resin Cements-Physical, Adhesive, and Antibacterial Properties.
Materials (Basel, Switzerland).
14(16)
[DOI] 10.3390/ma14164391.
[PMID] 34442914.
2021
Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study.
BMC oral health.
21(1)
[DOI] 10.1186/s12903-021-01597-x.
[PMID] 33964928.
2020
Accuracy of Maternal Reports of Young Children’s Dental Disease Status: Avon Longitudinal Study of Parents and Children.
Dentistry journal.
8(1)
[DOI] 10.3390/dj8010008.
[PMID] 31936716.
2020
Prenatal smoking and the risk of early childhood caries: A prospective cohort study.
Preventive medicine reports.
20
[DOI] 10.1016/j.pmedr.2020.101201.
[PMID] 33083206.
2020
Site-Specific Profiling of the Dental Mycobiome Reveals Strong Taxonomic Shifts during Progression of Early-Childhood Caries.
Applied and environmental microbiology.
86(7)
[DOI] 10.1128/AEM.02825-19.
[PMID] 31953340.
2020
Temporary Tooth Separation to Improve Assessment of Approximal Caries Lesions: A School-Based Study.
Operative dentistry.
45(6):581-588
[DOI] 10.2341/19-221-C.
[PMID] 32516382.
2019
Approaches to Modulate Biofilm Ecology.
Dental clinics of North America.
63(4):581-594
[DOI] 10.1016/j.cden.2019.07.002.
[PMID] 31470914.
2019
Arginine Metabolism in Supragingival Oral Biofilms as a Potential Predictor of Caries Risk.
JDR clinical and translational research.
4(3):262-270
[DOI] 10.1177/2380084419834234.
[PMID] 31039043.
2019
Dental Caries: Evidence and Interdisciplinary Person-Centered Care Considerations for Management Over Time.
Dental clinics of North America.
63(4):xiii-xv
[DOI] 10.1016/j.cden.2019.07.003.
[PMID] 31470928.
2019
Metabolic Profile of Supragingival Plaque Exposed to Arginine and Fluoride.
Journal of dental research.
98(11):1245-1252
[DOI] 10.1177/0022034519869906.
[PMID] 31454264.
2019
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis.
Journal of dental research.
98(1):14-26
[DOI] 10.1177/0022034518800014.
[PMID] 30290130.
2019
Novel Probiotic Mechanisms of the Oral Bacterium Streptococcus sp. A12 as Explored with Functional Genomics.
Applied and environmental microbiology.
85(21)
[DOI] 10.1128/AEM.01335-19.
[PMID] 31420345.
2018
Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.
Caries research.
52(1-2):88-101
[DOI] 10.1159/000479091.
[PMID] 29258070.
2018
Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association.
Journal of the American Dental Association (1939).
149(10):837-849.e19
[DOI] 10.1016/j.adaj.2018.07.002.
[PMID] 30261951.
2018
Influence of Preparatory Workshops on Dental Students’ Academic Performance and Stress on Their First Operative Dentistry Psychomotor Exam.
Journal of dental education.
82(6):608-613
[DOI] 10.21815/JDE.018.068.
[PMID] 29858257.
2018
Potential Uses of Arginine in Dentistry.
Advances in dental research.
29(1):98-103
[DOI] 10.1177/0022034517735294.
[PMID] 29355411.
2018
Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci.
mSystems.
3(6)
[DOI] 10.1128/mSystems.00158-18.
[PMID] 30574560.
2017
A new arginine-based dental adhesive system: formulation, mechanical and anti-caries properties.
Journal of dentistry.
63:72-80
[DOI] 10.1016/j.jdent.2017.05.024.
[PMID] 28587978.
2017
Exploring How U.S. Dental Schools Teach Removal of Carious Tissues During Cavity Preparations.
Journal of dental education.
81(1):5-13
[PMID] 28049672.
2017
Microbiomes of Site-Specific Dental Plaques from Children with Different Caries Status
Infection and Immunity.
85(8)
[DOI] 10.1128/iai.00106-17.
2017
Oral microbiota transplant: a potential new therapy for oral diseases.
Journal of the California Dental Association.
45(10):565-568
[PMID] 29497269.
2017
Second Era of OMICS in Caries Research: Moving Past the Phase of Disillusionment.
Journal of dental research.
96(7):733-740
[DOI] 10.1177/0022034517701902.
[PMID] 28384412.
2016
A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans.
Applied and environmental microbiology.
82(7):2187-201
[DOI] 10.1128/AEM.03887-15.
[PMID] 26826230.
2016
Abfraction lesions: etiology, diagnosis, and treatment options.
Clinical, cosmetic and investigational dentistry.
8:79-87
[DOI] 10.2147/CCIDE.S63465.
[PMID] 27217799.
2016
Clinical assessment in Operative Dentistry
.
2016
Insights into the Virulence Traits of Streptococcus mutans in Dentine Carious Lesions of Children with Early Childhood Caries.
Caries research.
50(3):279-87
[DOI] 10.1159/000445256.
[PMID] 27160402.
2016
Microbial profile of supragingival and subgingival plaque of patients with glycogen storage disease
Journal of Inborn Errors of Metabolism and Screening.
4:1-6
[DOI] 10.1177/2326409816682765.
2016
The impact of an infant oral health program in pre-doctoral dental education
Journal of Dental Education.
80(11):1328-1336
2016
The Impact of an Infant Oral Health Program on Dental Students’ Knowledge and Attitudes.
Journal of dental education.
80(11):1328-1336
[PMID] 27803205.
2015
Anticipated and Actual Implementation of Case-Based Learning by Dental Faculty Members During and After Training.
Journal of dental education.
79(9):1049-60
[PMID] 26329029.
2015
Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms.
Caries research.
49(2):165-76
[DOI] 10.1159/000365296.
[PMID] 25634570.
2014
Caries prevention by arginine metabolism in oral biofilms: translating science into clinical success
Current Oral Health Reports.
1(1):79-85
[DOI] 10.1007/s40496-013-0007-2.
2014
The effect of arginine on oral biofilm communities.
Molecular oral microbiology.
29(1):45-54
[DOI] 10.1111/omi.12044.
[PMID] 24289808.
2013
Oral arginine metabolism may decrease the risk for dental caries in children.
Journal of dental research.
92(7):604-8
[DOI] 10.1177/0022034513487907.
[PMID] 23640952.
2013
The combined use of chlorhexidine and fluoride therapy can reduce the risk for dental caries.
The journal of evidence-based dental practice.
13(3):123-4
[DOI] 10.1016/j.jebdp.2013.07.015.
[PMID] 24011013.
2012
Functional amyloid formation by Streptococcus mutans
Journal of Microbiology.
158(12):2903-2916
2012
Functional amyloid formation by Streptococcus mutans.
Microbiology (Reading, England).
158(Pt 12):2903-2916
[DOI] 10.1099/mic.0.060855-0.
[PMID] 23082034.
2012
Progress dissecting the oral microbiome in caries and health.
Advances in dental research.
24(2):77-80
[DOI] 10.1177/0022034512449462.
[PMID] 22899685.
2012
Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.
International journal of oral science.
4(3):135-40
[DOI] 10.1038/ijos.2012.54.
[PMID] 22996271.
2011
Restoration of noncarious tooth defects by dentists in The Dental Practice-Based Research Network.
Journal of the American Dental Association (1939).
142(12):1368-75
[PMID] 22130438.
2010
Concordance between preoperative and postoperative assessments of primary caries lesion depth: results from the Dental PBRN.
Operative dentistry.
35(4):389-96
[DOI] 10.2341/09-363-C.
[PMID] 20672722.
2010
Reasons for placement of restorations on previously unrestored tooth surfaces by dentists in The Dental Practice-Based Research Network.
Journal of the American Dental Association (1939).
141(4):441-8
[PMID] 20354094.
2010
The effect of sucrose on plaque and saliva urease levels in vivo.
Archives of oral biology.
55(3):249-54
[DOI] 10.1016/j.archoralbio.2009.12.007.
[PMID] 20096398.
2009
Correlations of oral bacterial arginine and urea catabolism with caries experience.
Oral microbiology and immunology.
24(2):89-95
[DOI] 10.1111/j.1399-302X.2008.00477.x.
[PMID] 19239634.
2009
Distribution, regulation and role of the agmatine deiminase system in mutans streptococci.
Oral microbiology and immunology.
24(1):79-82
[DOI] 10.1111/j.1399-302X.2008.00459.x.
[PMID] 19121075.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research.
21(1):17-20
[DOI] 10.1177/0895937409335593.
[PMID] 19710079.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology.
190(7):2340-9
[DOI] 10.1128/JB.01237-07.
[PMID] 18223086.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology.
190(15):5291-9
[DOI] 10.1128/JB.00288-08.
[PMID] 18539745.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology.
190(1):28-36
[PMID] 17951382.
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology.
65(6):1568-81
[PMID] 17714452.
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology.
186(19):6383-90
[PMID] 15375118.
2004
Streptococcus mutans genotypes isolated from root and coronal caries.
Caries research.
38(5):454-63
[PMID] 15316190.
Grants
Jun 2023
ACTIVE
Restorative dental materials with wavelength-controlled release and recharge of L-arginine
Role: Other
Funding: COLGATE-PALMOLIVE CO
Apr 2021
ACTIVE
A Phase 2 randomized, double-blind, active-controlled multi-center
clinical trial to assess the safety and the anti-caries efficacy of COL
101 (arginine) non-fluoride dentifrices with 1.5%, 4.0% and 8.0%
arginine each in comparison with 0.24% sodium fluoride (1100 ppm
F) dentifrice control in 10 to 14-year-old children.
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Sep 2020
ACTIVE
Arginine metabolism in periodontal health and diseases
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2019
ACTIVE
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Mar 2016
– Feb 2023
Probiotics that moderate PH and antagonize pathogens to promote oral health
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2015
– Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Nov 2015
– Nov 2017
The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Apr 2014
– Sep 2019
Oral alkali production and caries prevention in children
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2012
– Feb 2017
Functional Amyloid Formation in Streptococcus mutans
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Education
PhD – Cariology
2005
·
Dental School of Piracicaba, State University of Campinas (UNICAMP), Piracicaba, SP, Brazil
Master of Dental Sciences – Cariology
2002
·
Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
Doctor of Dental Science
2000
·
Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
Contact Details
Phones:
- Business:
- (352) 273-5858
Emails:
- Business:
- mnascimento@dental.ufl.edu
Addresses:
- Business Mailing:
-
1395 CENTER DR RM D9 6
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610