Marcelle Nascimento

Marcelle Nascimento,

Associate Professor

Department: DN-OPERATIVE DIVISION
Business Phone: (352) 273-5858
Business Email: mnascimento@dental.ufl.edu

About Marcelle Nascimento

I joined the University of Florida College of Dentistry (UFCD) in 2007 as an Assistant Professor in the Department of Operative Dentistry. In 2015, I was promoted to Associate Professor with tenure. Cariology research and teaching are my main professional assignments at UFCD. I have been conducting several research projects in the areas of Cariology, Oral Microbiology, Pediatric Dentistry, and Dental Education. I am the director of the Cariology and Preventive Dentistry course offered to our 1DN students. I am also actively engaged in the teaching of preclinical and clinical Cariology and Operative Dentistry for both undergraduate and graduate programs. I have served as President of the IADR Cariology Research group (2015-2016), I am the current chair of the ADEA Cariology section, and I serve as a member of the American Academy of Cariology Board of Directors as Chair of the Research Section Pillar.

Accomplishments

Elected Faculty Advisor by the UFCD Class of 2022
2019 · University of Florida College of Dentistry
IADR Cariology Research Group Award
2019 · International Association for Dental Research (IADR)
Sustained Excellence in Teaching Award
2019 · University of Florida College of Dentistry
UF Research Foundation Professorship Award
2019 · University of Florida
Elected to serve in the AAC Board of Directors
2018 · American Academy of Cariology (AAC)
UF Term Professorship Award
2018 · University of Florida
Consultant to the ADA Council on Scientific Affairs (CSA)
2017 · American Dental Association (ADA)
Elected Officer of the ADEA Cariology section
2017 · American Dental Education Association (ADEA)
Faculty Inductee, OKU National Dental Honor Society
2016 · Omicron Kappa Upsilon (OKU)
Joseph Lister Award for New Investigators
2016 · International Association for Dental Research (IADR)
Faculty of Color Tuition Award for Professional Development
2015 · American Dental Education Association (ADEA)/ AAL
Promotion to Associate Professor with Tenure by UF Board of Trustees
2015 · University of Florida
Academy of Research Excellence
2014 · University of Florida /CTSI
President-elect of the IADR Cariology Research Group
2014 · International Association for Dental Research (IADR)
Elected Faculty Advisor by the UFCD Class of 2012
2009 · University of Florida College of Dentistry

Clinical Profile

Specialties
  • Dentistry
Areas of Interest
  • Dental cavities

Publications

2021
Incorporation of Arginine to Commercial Orthodontic Light-Cured Resin Cements-Physical, Adhesive, and Antibacterial Properties.
Materials (Basel, Switzerland). 14(16) [DOI] 10.3390/ma14164391. [PMID] 34442914.
2021
Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study.
BMC oral health. 21(1) [DOI] 10.1186/s12903-021-01597-x. [PMID] 33964928.
2020
Accuracy of Maternal Reports of Young Children’s Dental Disease Status: Avon Longitudinal Study of Parents and Children.
Dentistry journal. 8(1) [DOI] 10.3390/dj8010008. [PMID] 31936716.
2020
Prenatal smoking and the risk of early childhood caries: A prospective cohort study.
Preventive medicine reports. 20 [DOI] 10.1016/j.pmedr.2020.101201. [PMID] 33083206.
2020
Site-Specific Profiling of the Dental Mycobiome Reveals Strong Taxonomic Shifts during Progression of Early-Childhood Caries.
Applied and environmental microbiology. 86(7) [DOI] 10.1128/AEM.02825-19. [PMID] 31953340.
2020
Temporary Tooth Separation to Improve Assessment of Approximal Caries Lesions: A School-Based Study.
Operative dentistry. 45(6):581-588 [DOI] 10.2341/19-221-C. [PMID] 32516382.
2019
Approaches to Modulate Biofilm Ecology.
Dental clinics of North America. 63(4):581-594 [DOI] 10.1016/j.cden.2019.07.002. [PMID] 31470914.
2019
Arginine Metabolism in Supragingival Oral Biofilms as a Potential Predictor of Caries Risk.
JDR clinical and translational research. 4(3):262-270 [DOI] 10.1177/2380084419834234. [PMID] 31039043.
2019
Dental Caries: Evidence and Interdisciplinary Person-Centered Care Considerations for Management Over Time.
Dental clinics of North America. 63(4):xiii-xv [DOI] 10.1016/j.cden.2019.07.003. [PMID] 31470928.
2019
Metabolic Profile of Supragingival Plaque Exposed to Arginine and Fluoride.
Journal of dental research. 98(11):1245-1252 [DOI] 10.1177/0022034519869906. [PMID] 31454264.
2019
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis.
Journal of dental research. 98(1):14-26 [DOI] 10.1177/0022034518800014. [PMID] 30290130.
2019
Novel Probiotic Mechanisms of the Oral Bacterium Streptococcus sp. A12 as Explored with Functional Genomics.
Applied and environmental microbiology. 85(21) [DOI] 10.1128/AEM.01335-19. [PMID] 31420345.
2018
Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.
Caries research. 52(1-2):88-101 [DOI] 10.1159/000479091. [PMID] 29258070.
2018
Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association.
Journal of the American Dental Association (1939). 149(10):837-849.e19 [DOI] 10.1016/j.adaj.2018.07.002. [PMID] 30261951.
2018
Influence of Preparatory Workshops on Dental Students’ Academic Performance and Stress on Their First Operative Dentistry Psychomotor Exam.
Journal of dental education. 82(6):608-613 [DOI] 10.21815/JDE.018.068. [PMID] 29858257.
2018
Potential Uses of Arginine in Dentistry.
Advances in dental research. 29(1):98-103 [DOI] 10.1177/0022034517735294. [PMID] 29355411.
2018
Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci.
mSystems. 3(6) [DOI] 10.1128/mSystems.00158-18. [PMID] 30574560.
2017
A new arginine-based dental adhesive system: formulation, mechanical and anti-caries properties.
Journal of dentistry. 63:72-80 [DOI] 10.1016/j.jdent.2017.05.024. [PMID] 28587978.
2017
Exploring How U.S. Dental Schools Teach Removal of Carious Tissues During Cavity Preparations.
Journal of dental education. 81(1):5-13 [PMID] 28049672.
View on: PubMed
2017
Microbiomes of Site-Specific Dental Plaques from Children with Different Caries Status.
Infection and immunity. 85(8) [DOI] 10.1128/IAI.00106-17. [PMID] 28507066.
2017
Oral microbiota transplant: a potential new therapy for oral diseases.
Journal of the California Dental Association. 45(10):565-568 [PMID] 29497269.
View on: PubMed
2017
Second Era of OMICS in Caries Research: Moving Past the Phase of Disillusionment.
Journal of dental research. 96(7):733-740 [DOI] 10.1177/0022034517701902. [PMID] 28384412.
2016
A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans.
Applied and environmental microbiology. 82(7):2187-201 [DOI] 10.1128/AEM.03887-15. [PMID] 26826230.
2016
Abfraction lesions: etiology, diagnosis, and treatment options.
Clinical, cosmetic and investigational dentistry. 8:79-87 [DOI] 10.2147/CCIDE.S63465. [PMID] 27217799.
2016
Clinical assessment in Operative Dentistry
.
2016
Insights into the Virulence Traits of Streptococcus mutans in Dentine Carious Lesions of Children with Early Childhood Caries.
Caries research. 50(3):279-87 [DOI] 10.1159/000445256. [PMID] 27160402.
2016
Microbial profile of supragingival and subgingival plaque of patients with glycogen storage disease
Journal of Inborn Errors of Metabolism and Screening. 4:1-6 [DOI] 10.1177/2326409816682765.
2016
The impact of an infant oral health program in pre-doctoral dental education
Journal of Dental Education. 80(11):1328-1336
2016
The Impact of an Infant Oral Health Program on Dental Students’ Knowledge and Attitudes.
Journal of dental education. 80(11):1328-1336 [PMID] 27803205.
View on: PubMed
2015
Anticipated and Actual Implementation of Case-Based Learning by Dental Faculty Members During and After Training.
Journal of dental education. 79(9):1049-60 [PMID] 26329029.
View on: PubMed
2015
Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms.
Caries research. 49(2):165-76 [DOI] 10.1159/000365296. [PMID] 25634570.
2014
Caries prevention by arginine metabolism in oral biofilms: translating science into clinical success
Current Oral Health Reports. 1(1):79-85 [DOI] 10.1007/s40496-013-0007-2.
2014
The effect of arginine on oral biofilm communities.
Molecular oral microbiology. 29(1):45-54 [DOI] 10.1111/omi.12044. [PMID] 24289808.
2013
Oral arginine metabolism may decrease the risk for dental caries in children.
Journal of dental research. 92(7):604-8 [DOI] 10.1177/0022034513487907. [PMID] 23640952.
2013
The combined use of chlorhexidine and fluoride therapy can reduce the risk for dental caries.
The journal of evidence-based dental practice. 13(3):123-4 [DOI] 10.1016/j.jebdp.2013.07.015. [PMID] 24011013.
2012
Functional amyloid formation by Streptococcus mutans
Journal of Microbiology. 158(12):2903-2916
2012
Functional amyloid formation by Streptococcus mutans.
Microbiology (Reading, England). 158(Pt 12):2903-2916 [DOI] 10.1099/mic.0.060855-0. [PMID] 23082034.
2012
Progress dissecting the oral microbiome in caries and health.
Advances in dental research. 24(2):77-80 [DOI] 10.1177/0022034512449462. [PMID] 22899685.
2012
Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.
International journal of oral science. 4(3):135-40 [DOI] 10.1038/ijos.2012.54. [PMID] 22996271.
2011
Restoration of noncarious tooth defects by dentists in The Dental Practice-Based Research Network.
Journal of the American Dental Association (1939). 142(12):1368-75 [PMID] 22130438.
View on: PubMed
2010
Concordance between preoperative and postoperative assessments of primary caries lesion depth: results from the Dental PBRN.
Operative dentistry. 35(4):389-96 [DOI] 10.2341/09-363-C. [PMID] 20672722.
2010
Reasons for placement of restorations on previously unrestored tooth surfaces by dentists in The Dental Practice-Based Research Network.
Journal of the American Dental Association (1939). 141(4):441-8 [PMID] 20354094.
View on: PubMed
2010
The effect of sucrose on plaque and saliva urease levels in vivo.
Archives of oral biology. 55(3):249-54 [DOI] 10.1016/j.archoralbio.2009.12.007. [PMID] 20096398.
2009
Correlations of oral bacterial arginine and urea catabolism with caries experience.
Oral microbiology and immunology. 24(2):89-95 [DOI] 10.1111/j.1399-302X.2008.00477.x. [PMID] 19239634.
2009
Distribution, regulation and role of the agmatine deiminase system in mutans streptococci.
Oral microbiology and immunology. 24(1):79-82 [DOI] 10.1111/j.1399-302X.2008.00459.x. [PMID] 19121075.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research. 21(1):17-20 [DOI] 10.1177/0895937409335593. [PMID] 19710079.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology. 190(7):2340-9 [DOI] 10.1128/JB.01237-07. [PMID] 18223086.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology. 190(15):5291-9 [DOI] 10.1128/JB.00288-08. [PMID] 18539745.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology. 190(1):28-36 [PMID] 17951382.
View on: PubMed
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology. 65(6):1568-81 [PMID] 17714452.
View on: PubMed
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology. 186(19):6383-90 [PMID] 15375118.
View on: PubMed
2004
Streptococcus mutans genotypes isolated from root and coronal caries.
Caries research. 38(5):454-63 [PMID] 15316190.
View on: PubMed

Grants

Sep 2020 ACTIVE
Arginine metabolism in periodontal health and diseases
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2016 ACTIVE
Probiotics that moderate PH and antagonize pathogens to promote oral health
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2015 – Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Nov 2015 – Nov 2017
The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Apr 2014 – Sep 2019
Oral alkali production and caries prevention in children
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2012 – Feb 2017
Functional Amyloid Formation in Streptococcus mutans
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR

Patents

Published March 2018
Arginine-Containing Restorative Dental Materials and Methods of preventing and Controlling Carier Associated with Dental Work
#US-2018-0243175-A1
Issued May 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions
#9,655,839
Published January 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions (CIP of 13295)
#US-2017-0136074-A1

Education

PhD – Cariology
2005 · Dental School of Piracicaba, State University of Campinas (UNICAMP), Piracicaba, SP, Brazil
Master of Dental Sciences – Cariology
2002 · Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
Doctor of Dental Science
2000 · Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil

Teaching Profile

Courses Taught
2011-2013,2015-2021,2020-2021
DEN8748L Clin Operative Den 5
2020
DEN7016 Prof Care/Prac Man 2
2011-2017,2020
DEN5404C Den Anat and Stmtgnthcs
2011-2013,2015-2021,2020-2021
DEN7745L Clin Operative Den 2
2009-2016,2020-2021
DEN5405C Preclin Oper Bio 1
2017-2021
DEN5502C Cariology Prev Dent
2018
DEN6302C Intro Cli Diag/Trtmnt
2011-2013,2016-2021,2021
DEN7744L Clin Operative Den 1
2011-2012,2016
DEN6502 Preventive Dentistry
2012-2016
DEN7961L Clinical Examinaton 1
2011-2016,2021
DEN6407C Preclin Operative 2
2011-2013,2015-2021,2021
DEN8747L Clin Operative Den 4
2014,2016
DEN8960L Clinical Examinatio 2
2011-2015
DEN6408C Preclin Operative 3
2013-2014
DEN8290 Special Topics
2014
DEN5210 Dev Biol Psychosoc 1
2012-2014
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2011-2014,2021
DEN8749L Clin Operative Den 6
2011-2014,2021
DEN7746L Clin Operative Den 3
2011
GMS6160 Introduction to Oral Biology I

Contact Details

Phones:
Business:
(352) 273-5858
Emails: