Shannon Holliday

Shannon Holliday,

ASSOCIATE PROFESSOR

Department: DN-ORTHODONTICS RESEARCH
Business Phone: (352) 273-5689
Business Email: holl@ufl.edu

Publications

2017
Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions.
Molecular medicine (Cambridge, Mass.). 23:57-69 [DOI] 10.2119/molmed.2016.00170. [PMID] 28332697.
2016
Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model
Human Gene Therapy. 27(9):679-686 [DOI] 10.1089/hum.2016.029.
2016
Characterization of Regulatory Extracellular Vesicles from Osteoclasts.
Journal of dental research. 95(6):673-9 [DOI] 10.1177/0022034516633189. [PMID] 26908631.
2016
Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth.
The Angle orthodontist. 86(2):187-92 [DOI] 10.2319/032415-195.1. [PMID] 26154939.
2015
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.
Journal of periodontology. 86(1):137-45 [DOI] 10.1902/jop.2014.140302. [PMID] 25101489.
2014
Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0092119. [PMID] 24638087.
2014
Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.
Acta biomaterialia. 10(1):494-507 [DOI] 10.1016/j.actbio.2013.10.010. [PMID] 24140612.
2014
Propolis decreases lipopolysaccharide-induced inflammatory mediators in pulp cells and osteoclasts.
Dental traumatology : official publication of International Association for Dental Traumatology. 30(5):362-367 [DOI] 10.1111/edt.12096. [PMID] 24502251.
2013
Bis-enoxacin inhibits bone resorption and orthodontic tooth movement.
Journal of dental research. 92(10):925-31 [DOI] 10.1177/0022034513501876. [PMID] 23958763.
2012
Differentiation and Characteristics of Undifferentiated Mesenchymal Stem Cells Originating From Adult Premolar Periodontal Ligaments
Korean Journal of Orthodontics. 42(6):307-317 [DOI] 10.4041/kjod.2012.42.6.307. [PMID] 23323245.
2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry. 287(21):17894-17904 [DOI] 10.1074/jbc.M111.280511. [PMID] 22474295.
2012
Rational Identification of Enoxacin as a Novel V-Atpase-Directed Osteoclast Inhibitor
. 13:180-191
2012
Vacuolar H+-Atpase: Targeting a “Housekeeping” Enzyme for Drug Development
. 13:105-106
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology. 88(2):205-12 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2009
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
Journal of medicinal chemistry. 52(16):5144-51 [DOI] 10.1021/jm900277z. [PMID] 19630402.
2009
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents.
Bone. 44(2):266-74 [DOI] 10.1016/j.bone.2008.10.041. [PMID] 19013265.
2009
Osteoclast polarization and orthodontic tooth movement.
Orthodontics & craniofacial research. 12(2):105-12 [DOI] 10.1111/j.1601-6343.2009.01443.x. [PMID] 19419453.
2009
Propolis inhibits osteoclast maturation.
Dental traumatology : official publication of International Association for Dental Traumatology. 25(6):584-588 [DOI] 10.1111/j.1600-9657.2009.00821.x. [PMID] 19843135.
2009
Regulation of vacuolar H(+)-ATPase in microglia by RANKL.
Biochemical and biophysical research communications. 389(1):193-7 [DOI] 10.1016/j.bbrc.2009.08.122. [PMID] 19715671.
2008
Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.
The Journal of experimental biology. 211(Pt 7):1102-8 [DOI] 10.1242/jeb.013672. [PMID] 18344484.
2005
Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts.
Journal of bioenergetics and biomembranes. 37(6):419-23 [PMID] 16691476.
View on: PubMed
2003
Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 95(3):348-54 [PMID] 12627109.
View on: PubMed
2003
Effects of echistatin and an RGD peptide on orthodontic tooth movement.
Journal of dental research. 82(9):682-6 [PMID] 12939350.
View on: PubMed
2003
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
Calcified tissue international. 72(3):206-14 [PMID] 12522662.
View on: PubMed
2003
The synergistic effect of peptidoglycan and lipopolysaccaride on osteoclast formation.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 96(6):738-43 [PMID] 14676766.
View on: PubMed
2002
The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function.
The Journal of biological chemistry. 277(41):38409-15 [PMID] 12163484.
View on: PubMed
2001
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.
The Journal of biological chemistry. 276(32):30407-13 [PMID] 11399750.
View on: PubMed
2000
The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.
The Journal of biological chemistry. 275(41):32331-7 [PMID] 10915794.
View on: PubMed

Grants

Sep 2018 – Aug 2021
Development of an exosome-based diagnostic platform for periodontal disease and root resorption
Role: Principal Investigator
Funding: STATE UNIV OF NEW YORK STONY BROOK via NATL INST OF HLTH NIDCR
Jul 2017 – Dec 2019
Biomimetic Bone for Load-Bearing Bioresorbable Nanostructured Bone Substitutes
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2014 – Jul 2016
Exosomes in alveolar bone remodeling and root resorption
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Patents

Published October 2011
Novel V-ATPase-Directed Bone Anabolic Agents
#US-2012-0046246-A1

Teaching Profile

Courses Taught
2012-2013,2020-2021
DEN6935 Special Topics in Dentistry
2013-2014,2016-2021
GMS6001 Fundamentals of Biomedical Sciences I
2011-2017,2020-2021
DEN6128 Host Defense
2014,2018
DEN8290 Special Topics
2011-2014,2018
DEN6910 Supervised Research
2011-2014,2018
DEN6971 Research for Master’s Thesis
2014,2016-2018
GMS6421 Cell Biology
2017-2018
GMS5905 Special Topics in Biomedical Sciences
2014-2016
DEN5210 Dev Biol Psychosoc 1
2016
DEN7413C Rem Part Pros Techniq
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2014-2015
DEN6251 Clin Manage Dent Pain
2012-2015
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2014
DEN6905 Individual Study
2006,2009-2012,2012-2021,2021
DEN6610 Biology of Tooth Movement: Part I
2011-2012
GMS6161 Introduction to Oral Biology II
2011
GMS6160 Introduction to Oral Biology I
2011
IDH4905 Individual Work
2009-2010
IDH4917 Undergrad Research
2007
DEN6611 Biol Tooth Movemnt 2

Contact Details

Phones:
Business:
(352) 273-5689
Emails:
Business:
holl@ufl.edu