Shannon Holliday,
ASSOCIATE PROFESSOR
Teaching Profile
Courses Taught
2012-2013,2020-2024
DEN6935 Special Topics in Dentistry
2013-2014,2016-2024
GMS6001 Fundamentals of Biomedical Sciences I
2011-2017,2020-2023
DEN6128 Host Defense
2014,2018
DEN8290 Special Topics
2011-2014,2018-2023,2023
DEN6910 Supervised Research
2011-2014,2018-2023,2023
DEN6971 Research for Master’s Thesis
2014,2016-2022,2022-2024
GMS6421 Cell Biology
2017-2018
GMS5905 Special Topics in Biomedical Sciences
2014-2016
DEN5210 Dev Biol Psychosoc 1
2016
DEN7413C Rem Part Pros Techniq
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2014-2015
DEN6251 Clin Manage Dent Pain
2012-2015
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2014
DEN6905 Individual Study
2006,2009-2012,2012-2022,2021-2024
DEN6610 Biology of Tooth Movement: Part I
2011-2012
GMS6161 Introduction to Oral Biology II
2011
GMS6160 Introduction to Oral Biology I
2011
IDH4905 Individual Work
2009-2010
IDH4917 Undergrad Research
2007
DEN6611 Biol Tooth Movemnt 2
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-0844-1965
Publications
2023
Characterization of 3D printed biodegradable piezoelectric scaffolds for bone regeneration
Clinical and Experimental Dental Research.
9(2):398-408
[DOI] 10.1002/cre2.712.
[PMID] 36779270.
2023
Conditioned Media from Human Pulp Stem Cell Cultures Improve Bone Regeneration in Rat Calvarial Critical-Size Defects
Journal of Functional Biomaterials.
14(8)
[DOI] 10.3390/jfb14080396.
[PMID] 37623641.
2023
Metabolomic signatures distinguish extracellular vesicles from osteoclasts and odontoclasts
Orthodontics & Craniofacial Research.
26(4):632-641
[DOI] 10.1111/ocr.12658.
[PMID] 36997279.
2023
Towards resorbable 3D‐printed scaffolds for craniofacial bone regeneration
Orthodontics & Craniofacial Research.
26(S1):188-195
[DOI] 10.1111/ocr.12645.
2022
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Respiratory research.
23(1)
[DOI] 10.1186/s12931-022-02161-z.
[PMID] 36068572.
2022
Effects of Alendronate and Dexamethasone on Osteoclast Gene Expression and Bone Resorption in Mouse Marrow Cultures.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
70(2):169-179
[DOI] 10.1369/00221554211063519.
[PMID] 34915746.
2022
Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney.
Frontiers in molecular biosciences.
9
[DOI] 10.3389/fmolb.2022.874186.
[PMID] 35601831.
2021
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-88665-y.
[PMID] 33911158.
2021
Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw.
Clinical pharmacology and therapeutics.
110(6):1558-1569
[DOI] 10.1002/cpt.2397.
[PMID] 34390503.
2021
Orthodontic retention: what’s on the horizon?
British dental journal.
230(11):760-764
[DOI] 10.1038/s41415-021-2937-8.
[PMID] 34117435.
2021
Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone.
International journal of molecular sciences.
22(18)
[DOI] 10.3390/ijms221810097.
[PMID] 34576260.
2021
RANKL and RANK in extracellular vesicles: surprising new players in bone remodeling.
Extracellular vesicles and circulating nucleic acids.
2:18-28
[DOI] 10.20517/evcna.2020.02.
[PMID] 33982033.
2021
SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
36(2):347-356
[DOI] 10.1002/jbmr.4185.
[PMID] 32967053.
2020
Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo.
Cell communication and signaling : CCS.
18(1)
[DOI] 10.1186/s12964-020-00648-0.
[PMID] 32887613.
2019
Actin and Actin-Associated Proteins in Extracellular Vesicles Shed by Osteoclasts
International Journal of Molecular Sciences.
21(1)
[DOI] 10.3390/ijms21010158.
[PMID] 31881680.
2019
Clastic cells in orthodontic treatment: Translational challenges and recent advances
Orthodontics & Craniofacial Research.
22(S1):180-185
[DOI] 10.1111/ocr.12285.
2019
Extracellular vesicle identification in tooth movement models
Orthodontics & Craniofacial Research.
22(S1):101-106
[DOI] 10.1111/ocr.12287.
[PMID] 31074148.
2017
Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions.
Molecular medicine (Cambridge, Mass.).
23:57-69
[DOI] 10.2119/molmed.2016.00170.
[PMID] 28332697.
2017
Exosomes: novel regulators of bone remodelling and potential therapeutic agents for orthodontics
Orthodontics & Craniofacial Research.
20(S1):95-99
[DOI] 10.1111/ocr.12165.
[PMID] 28643924.
2017
The use of cell culture platforms to identify novel markers of bone and dentin resorption
Orthodontics & Craniofacial Research.
20(S1):89-94
[DOI] 10.1111/ocr.12162.
[PMID] 28643914.
2016
Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model
Human Gene Therapy.
27(9):679-686
[DOI] 10.1089/hum.2016.029.
2016
Characterization of Regulatory Extracellular Vesicles from Osteoclasts.
Journal of dental research.
95(6):673-9
[DOI] 10.1177/0022034516633189.
[PMID] 26908631.
2016
Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth.
The Angle orthodontist.
86(2):187-92
[DOI] 10.2319/032415-195.1.
[PMID] 26154939.
2015
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.
Journal of periodontology.
86(1):137-45
[DOI] 10.1902/jop.2014.140302.
[PMID] 25101489.
2014
Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis.
PloS one.
9(3)
[DOI] 10.1371/journal.pone.0092119.
[PMID] 24638087.
2014
Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.
Acta biomaterialia.
10(1):494-507
[DOI] 10.1016/j.actbio.2013.10.010.
[PMID] 24140612.
2014
Propolis decreases lipopolysaccharide-induced inflammatory mediators in pulp cells and osteoclasts.
Dental traumatology : official publication of International Association for Dental Traumatology.
30(5):362-367
[DOI] 10.1111/edt.12096.
[PMID] 24502251.
2013
Bis-enoxacin inhibits bone resorption and orthodontic tooth movement.
Journal of dental research.
92(10):925-31
[DOI] 10.1177/0022034513501876.
[PMID] 23958763.
2012
Differentiation and characteristics of undifferentiated mesenchymal stem cells originating from adult premolar periodontal ligaments.
Korean journal of orthodontics.
42(6):307-17
[DOI] 10.4041/kjod.2012.42.6.307.
[PMID] 23323245.
2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry.
287(21):17894-17904
[DOI] 10.1074/jbc.M111.280511.
[PMID] 22474295.
2012
Rational Identification of Enoxacin as a Novel V-Atpase-Directed Osteoclast Inhibitor
.
13:180-191
2012
Vacuolar H+-Atpase: Targeting a “Housekeeping” Enzyme for Drug Development
.
13:105-106
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology.
88(2):205-12
[DOI] 10.1038/icb.2009.84.
[PMID] 19918258.
2009
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
Journal of medicinal chemistry.
52(16):5144-51
[DOI] 10.1021/jm900277z.
[PMID] 19630402.
2009
In vitro and in vivo evidence for stimulation of bone resorption by an EP4 receptor agonist and basic fibroblast growth factor: Implications for their efficacy as bone anabolic agents.
Bone.
44(2):266-74
[DOI] 10.1016/j.bone.2008.10.041.
[PMID] 19013265.
2009
Osteoclast polarization and orthodontic tooth movement.
Orthodontics & craniofacial research.
12(2):105-12
[DOI] 10.1111/j.1601-6343.2009.01443.x.
[PMID] 19419453.
2009
Regulation of vacuolar H(+)-ATPase in microglia by RANKL.
Biochemical and biophysical research communications.
389(1):193-7
[DOI] 10.1016/j.bbrc.2009.08.122.
[PMID] 19715671.
2008
Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.
The Journal of experimental biology.
211(Pt 7):1102-8
[DOI] 10.1242/jeb.013672.
[PMID] 18344484.
2005
Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts.
Journal of bioenergetics and biomembranes.
37(6):419-23
[PMID] 16691476.
2003
Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
95(3):348-54
[PMID] 12627109.
2003
Effects of echistatin and an RGD peptide on orthodontic tooth movement.
Journal of dental research.
82(9):682-6
[PMID] 12939350.
2003
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
Calcified tissue international.
72(3):206-14
[PMID] 12522662.
2003
The synergistic effect of peptidoglycan and lipopolysaccaride on osteoclast formation.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
96(6):738-43
[PMID] 14676766.
2002
The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function.
The Journal of biological chemistry.
277(41):38409-15
[PMID] 12163484.
2000
The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.
The Journal of biological chemistry.
275(41):32331-7
[PMID] 10915794.
Grants
Sep 2021
– Sep 2023
Toward a Precision Medicine Approach to Medication-Related Osteonecrosis of the Jaw
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Sep 2018
– Aug 2021
Development of an exosome-based diagnostic platform for periodontal disease and root resorption
Role: Principal Investigator
Funding: STATE UNIV OF NEW YORK STONY BROOK
via NATL INST OF HLTH NIDCR
Jul 2017
– Dec 2019
Biomimetic Bone for Load-Bearing Bioresorbable Nanostructured Bone Substitutes
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2014
– Jul 2016
Exosomes in alveolar bone remodeling and root resorption
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Contact Details
Phones:
- Business:
- (352) 273-5689
Emails:
- Business:
- holl@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100444
GAINESVILLE FL 32610 - Business Street:
-
COLLEGE OF DENTISTRY
1600 SW ARCHER RD., D7-18
ORTHODONTICS DEPARTMENT
GAINESVILLE FL 326100444