David Culp,
Professor Of Oral Biology
Teaching Profile
Courses Taught
2013-2014,2016-2021
DEN8510L Gen Dent Practice 1
2014-2016,2018-2021
DEN8511L Gen Dent Practice 2
2011,2014-2016,2016-2021,2021
DEN6128 Host Defense
2013-2021
DEN6681 Craniofacial Pathobiology
2012-2018,2020
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2016
DEN6416C Basic Sciences Rev
2011,2013-2015
DEN8290 Special Topics
2015
DEN5221 Oral Hlth Manage
2014
DEN6251 Clin Manage Dent Pain
2011-2012
GMS6161 Introduction to Oral Biology II
2007,2011
GMS6160 Introduction to Oral Biology I
2011
IDH4905 Individual Work
Publications
2022
Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo.
Molecular microbiology.
117(2):375-393
[DOI] 10.1111/mmi.14854.
[PMID] 34862691.
2022
Testing of candidate probiotics to prevent dental caries induced by Streptococcus mutans in a mouse model.
Journal of applied microbiology.
132(5):3853-3869
[DOI] 10.1111/jam.15516.
[PMID] 35262250.
2021
In Vivo Colonization with Candidate Oral Probiotics Attenuates Colonization and Virulence of Streptococcus mutans.
Applied and environmental microbiology.
87(4)
[DOI] 10.1128/AEM.02490-20.
[PMID] 33277269.
2021
Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries.
Frontiers in physiology.
12
[DOI] 10.3389/fphys.2021.699104.
[PMID] 34276419.
2020
Understanding LrgAB Regulation of Streptococcus mutans Metabolism.
Frontiers in microbiology.
11
[DOI] 10.3389/fmicb.2020.02119.
[PMID] 33013773.
2020
VIP and muscarinic synergistic mucin secretion by salivary mucous cells is mediated by enhanced PKC activity via VIP-induced release of an intracellular Ca2+ pool.
Pflugers Archiv : European journal of physiology.
472(3):385-403
[DOI] 10.1007/s00424-020-02348-7.
[PMID] 31932898.
2019
Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren’s syndrome.
Oral diseases.
25(5):1325-1334
[DOI] 10.1111/odi.13098.
[PMID] 30920100.
2018
Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159.
mSphere.
3(1)
[DOI] 10.1128/mSphere.00031-18.
[PMID] 29435491.
2015
Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva.
The Journal of biological chemistry.
290(5):2993-3008
[DOI] 10.1074/jbc.M114.597906.
[PMID] 25512380.
2013
Establishment and characterization of a telomerase immortalized human gingival epithelial cell line.
Journal of periodontal research.
48(6):713-21
[DOI] 10.1111/jre.12059.
[PMID] 23441958.
2013
The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay.
The Journal of biological chemistry.
288(21):14742-55
[DOI] 10.1074/jbc.M113.468645.
[PMID] 23580649.
2011
Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva.
Biochimica et biophysica acta.
1812(12):1567-76
[DOI] 10.1016/j.bbadis.2011.09.006.
[PMID] 21945428.
2011
Role of calcium and PKC in salivary mucous cell exocrine secretion.
Journal of dental research.
90(12):1469-76
[DOI] 10.1177/0022034511422817.
[PMID] 21933938.
2010
Tissue distibution of murine Muc19/smgc gene products.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
58(2):141-56
[DOI] 10.1369/jhc.2009.954891.
[PMID] 19826070.
2009
Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
57(4):383-96
[DOI] 10.1369/jhc.2008.952853.
[PMID] 19110483.
2005
A mouse caries model and evaluation of aqp5-/- knockout mice.
Caries research.
39(6):448-54
[PMID] 16251788.
2004
Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
52(5):671-81
[PMID] 15100244.
2004
The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc.
Physiological genomics.
19(3):303-18
[PMID] 15340121.
2003
The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression.
Physiological genomics.
14(2):95-106
[PMID] 12847143.
2001
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
American journal of physiology. Cell physiology.
280(4):C884-96
[PMID] 11245606.
1998
In vitro studies of the regulation of mucous gland secretion.
European journal of morphology.
36 Suppl:219-21
[PMID] 9825926.
1997
Biochemical and immunological studies and assay of rat sublingual mucins.
Archives of oral biology.
42(2):161-72
[PMID] 9134128.
1996
Both M1 and M3 receptors regulate exocrine secretion by mucous acini.
The American journal of physiology.
271(6 Pt 1):C1963-72
[PMID] 8997199.
1996
Cell lines expressing the adenovirus E1A 12S protein derived from rat sublingual glands.
In vitro cellular & developmental biology. Animal.
32(3):123-6
[PMID] 8925132.
1996
Regulation of mucous acinar exocrine secretion with age.
Journal of dental research.
75(1):575-80
[PMID] 8655762.
1995
Composition of human airway mucins and effects after inhalation of acid aerosol.
The American journal of physiology.
269(3 Pt 1):L358-70
[PMID] 7573470.
1995
Persistence of a perinatal cellular phenotype in submandibular glands of adult rat.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
43(12):1203-15
[PMID] 8537636.
1994
Muscarinic cholinergic receptor subtypes in rat sublingual glands.
The American journal of physiology.
266(2 Pt 1):C335-42
[PMID] 8141247.
1993
Mucinlike glycoproteins from cat tracheal gland cells in primary culture.
The American journal of physiology.
265(3 Pt 1):L260-9
[PMID] 8214086.
1991
Rat sublingual gland as a model to study glandular mucous cell secretion.
The American journal of physiology.
260(6 Pt 1):C1233-44
[PMID] 2058654.
1989
Light and electron microscopic immunolocalization of rat submandibular gland mucin glycoprotein and glutamine/glutamic acid-rich proteins.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
37(4):515-28
[PMID] 2926128.
1989
The effect of chronic atropine treatment on salivary composition and caries in rats.
Journal of dental research.
68(12):1739-45
[PMID] 2600253.
1988
Influenza virus infection of tracheal gland cells in culture.
Journal of virology.
62(5):1524-9
[PMID] 3357204.
1983
Muscarinic receptors and guanylate cyclase in mammalian gastric glandular cells.
The American journal of physiology.
245(6):G760-8
[PMID] 6140859.
Grants
Apr 2016
– Mar 2022
Streptococcus mutans adaptation to oxidative stress by the Cid/Lrg system
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Mar 2016
– Feb 2023
Probiotics that moderate PH and antagonize pathogens to promote oral health
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Jul 2012
– Jun 2018
Faculty Development Supporting Academic Dental Institution Curriculum for the 21st Century
Role: Project Manager
Funding: US HLTH RESOURCES AND SERV ADMN
Contact Details
Phones:
- Business:
- (352) 273-8853
Emails:
- Business:
- dculp@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100424
GAINESVILLE FL 32610 - Business Street:
-
1395 CENTER DR RM DG 32
GAINESVILLE FL 32610