Jia Chang, DDS
Associate Professor
About Jia Chang
Dr. Jia Chang is an Associate Professor with tenure in the Department of Periodontology at the University of Florida. Dr. Chang completed his D.D.S. and Oral & Maxillofacial surgery resident training in China in 2003. He completed his periodontal resident training at the University of Michigan in 2014. He is a Diplomat of the American Board of Periodontology since 2015. His research interests are in bone biology and tissue engineering to repair bone loss in inflammatory diseases, such as periodontitis and periimplantitis. Dr. Chang has published more than 30 articles related to bone inflammation and tissue regeneration in the top dental and medical journals such as Nature Medicine, PNAS, and Journal of Dental Research. Dr. Chang is involved in teaching periodontal residents and D.M.D. students and is part of intramural faculty practice.
Accomplishments
Volpe Basic Science Fellowship
2019
·
American Academy of Periodontology
Teaching Profile
Courses Taught
2015-2018,2020-2023
DEN6421C Perio Tx Plan
2014-2015,2017-2022
DEN8838L Comp Perio Tx 5
2016-2017,2020-2023
DEN7422C Perio Surgery
2014-2015,2017-2021,2020-2023
DEN7835L Comp Perio Tx 2
2017-2023
DEN8423 Perio in Gen Pract
2015-2018,2020-2024
DEN8839L Comp Perio Tx 6
2016-2024
DEN7836L Comp Perio Tx 3
2015,2018-2021,2021-2023,2023
DEN8837L Comp Perio Tx 4
2014-2015,2019-2022,2021-2023
DEN7834L Comp Perio Tx 1
2018
VME7979 Advanced Research
2017
DEN8960L Clinical Examinatio 2
2016
DEN7961L Clinical Examinaton 1
2016,2021-2024,2024
DEN8651L Clinical Periodontics
2016,2021
DEN6658 Treatment Planning in Periodontal Therapy
2016
DEN6655 Review of Periodontics Literature IV
2021
DEN6656 Introduction to Advanced Periodontology
2021
DEN6940 Supervised Teaching
2021,2024
DEN6971 Research for Master’s Thesis
Board Certifications
-
PeriodontistAmerican Board of Periodontology
Clinical Profile
Specialties
- Dentistry
Subspecialties
- Periodontology
Areas of Interest
- Dental Implants
- Periodontal Disease / Gum Disease
- Periodontitis
Research Profile
Anti-inflammatory treatment in periodontal bone regeneration and disease prevention; bone and gingival soft tissue engineering in periodontics and implantology; effect of antidepressant medication on periodontal and implant stability
Open Researcher and Contributor ID (ORCID)
0000-0003-0592-5750
Areas of Interest
- Bone Regeneration
- Dental Implantology
- Inflammation biology
- Mesenchymal stem cells
- Periodontal disease
Publications
2023
FBXO11 regulates bone development.
Bone.
170
[DOI] 10.1016/j.bone.2023.116709.
[PMID] 36863499.
2022
Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress
Cells.
11(14)
[DOI] 10.3390/cells11142208.
[PMID] 35883651.
2021
A Clinical Case Report of a Potential Acute Allergic Reaction with Titanium Dental Implant.
Case reports in dentistry.
2021
[DOI] 10.1155/2021/5592934.
[PMID] 33953988.
2021
Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study.
Journal of periodontal research.
[DOI] 10.1111/jre.12939.
2021
Effects of different antidepressant classes on dental implant failure: A retrospective clinical study.
Journal of periodontology.
92(2):196-204
[DOI] 10.1002/JPER.19-0714.
[PMID] 32725908.
2021
Multiple channels with interconnected pores in a bioceramic scaffold promote bone tissue formation.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-00024-z.
[PMID] 34650074.
2019
The impact of simvastatin intervention on the healing of bone, soft tissue, and TMJ cartilage in dentistry: a systematic review and meta-analysis.
International journal of implant dentistry.
5(1)
[DOI] 10.1186/s40729-019-0168-4.
[PMID] 30963362.
2018
Channels in a porous scaffold: a new player for vascularization.
Regenerative medicine.
13(6):705-715
[DOI] 10.2217/rme-2018-0022.
[PMID] 30246614.
2018
Current Understanding of the Pathophysiology of Osteonecrosis of the Jaw.
Current osteoporosis reports.
16(5):584-595
[DOI] 10.1007/s11914-018-0474-4.
[PMID] 30155844.
2015
Juxtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration.
Bone research.
3
[DOI] 10.1038/boneres.2015.14.
[PMID] 26558138.
2014
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.
Nature medicine.
20(9):1009-17
[DOI] 10.1038/nm.3586.
[PMID] 25108526.
2013
NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.
Proceedings of the National Academy of Sciences of the United States of America.
110(23):9469-74
[DOI] 10.1073/pnas.1300532110.
[PMID] 23690607.
2012
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Cell stem cell.
11(1):50-61
[DOI] 10.1016/j.stem.2012.04.009.
[PMID] 22770241.
2010
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America.
107(4):1431-6
[DOI] 10.1073/pnas.0911409107.
[PMID] 20080598.
2010
Novel functions for NFκB: inhibition of bone formation.
Nature reviews. Rheumatology.
6(10):607-11
[DOI] 10.1038/nrrheum.2010.133.
[PMID] 20703218.
2009
Inhibition of osteoblastic bone formation by nuclear factor-kappaB
Nature Medicine.
2008
Inhibition of human dental pulp stem cell differentiation by Notch signaling.
Journal of dental research.
87(3):250-5
[PMID] 18296609.
2008
Wnt/beta-catenin inhibits dental pulp stem cell differentiation.
Journal of dental research.
87(2):126-30
[PMID] 18218837.
2007
Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK.
The Journal of biological chemistry.
282(42):30938-48
[PMID] 17720811.
2007
Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair.
Journal of periodontology.
78(2):273-81
[PMID] 17274716.
2005
Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines.
Cancer research.
65(12):5063-9
[PMID] 15958549.
2005
NF-kappaB activation in human dental pulp stem cells by TNF and LPS.
Journal of dental research.
84(11):994-8
[PMID] 16246929.
2004
[Study on the characteristics of apoptosis in the condyles of osteoarthritic temporomandibular joints].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.
22(5):353-6
[PMID] 15562640.
2004
[Study on the metabolism of cartilage matrix by the chondrocytes in osteoarthritic condylar cartilage].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.
39(4):309-12
[PMID] 15454017.
2003
[Alteration of the expression of cartilage matrix molecule in the cartilage by the chondrocytes from rabbit temporomandibular joint with experimental osteoarthritis and its response to interleukin-1 beta].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
35(5):521-4
[PMID] 14601312.
2002
Application of alginate three-dimensional culture system for in vitro culture of mandibular condylar chondrocytes from human osteoarthritic temporomandibular joint.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.
37(4):246-8
[PMID] 12411167.
Grants
May 2020
ACTIVE
Molecular control of bone development and inflammation by FBXO11
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2019
ACTIVE
Dominant microRNAs as biomarkers in innate immunity and periodontitis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2015
– Mar 2018
Start-up funds for Dr. Jia Chang
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Education
MS in Periodontics
2014
·
University of Michigan School of Dentistry
Specialty certificate in Periodontics
2014
·
University of Michigan School of Dentistry
Postdoc
2007
·
University of Michigan School of Dentistry
Doctor degree in Oral & Maxillofacial Surgery
2002
·
Peking University School of Stomatology
DDS in General Dentistry
1995
·
Wuhan University School of Stomatology
Contact Details
Phones:
- Business:
- (352) 273-8366
Emails:
- Business:
- jchang@dental.ufl.edu
Addresses:
- Business Mailing:
-
College of Dentistry
GAINESVILLE FL 326100434 - Business Street:
-
1395 Center Dr.
GAINESVILLE FL 32610