Jia Chang

Jia Chang, D.D.S.

Assistant Professor

Department: DN-PERIODONTICS
Business Phone: (352) 273-8366
Business Email: jchang@dental.ufl.edu

About Jia Chang

Dr. Jia Chang is an Assistant Professor in the Department of Periodontology at the University of Florida. Dr. Chang completed his D.D.S. and Oral & Maxillofacial surgery resident training in China, and his periodontal resident training at the University of Michigan. He is a Diplomat of the American Board of Periodontology. His research interests are in the bone biology and tissue engineering to repair the bone loss in the inflammatory disease, such as periodontitis and periimplantitis. Dr. Chang has published more than 20 articles related to the bone inflammation and tissue regeneration in the top dental and medical journals such as Nature Medicine, PNAS, and Journal of Dental Research. Dr. Chang is involved in teaching periodontal residents and D.M.D. students, and is part of intramural faculty practice.

Accomplishments

Volpe Basic Science Fellowship
2019 · American Academy of Periodontology

Board Certifications

  • Periodontist
    American Board of Periodontology

Clinical Profile

Specialties
  • Dentistry
Subspecialties
  • Periodontology
Areas of Interest
  • Dental Implants
  • Periodontal Disease / Gum Disease
  • Periodontitis

Research Profile

Anti-inflammatory treatment in periodontal bone regeneration and disease prevention; bone and gingival soft tissue engineering in periodontics and implantology; effect of antidepressant medication on periodontal and implant stability

Open Researcher and Contributor ID (ORCID)

0000-0003-0592-5750

Publications

2021
A Clinical Case Report of a Potential Acute Allergic Reaction with Titanium Dental Implant.
Case reports in dentistry. 2021 [DOI] 10.1155/2021/5592934. [PMID] 33953988.
2021
Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study.
Journal of periodontal research. [DOI] 10.1111/jre.12939. [PMID] 34622954.
2021
Effects of different antidepressant classes on dental implant failure: A retrospective clinical study
Journal of Periodontology. 92(2):196-204 [DOI] 10.1002/jper.19-0714.
2021
Multiple channels with interconnected pores in a bioceramic scaffold promote bone tissue formation
Scientific Reports. 11(1) [DOI] 10.1038/s41598-021-00024-z. [PMID] 34650074.
2019
The impact of simvastatin intervention on the healing of bone, soft tissue, and TMJ cartilage in dentistry: a systematic review and meta-analysis.
International journal of implant dentistry. 5(1) [DOI] 10.1186/s40729-019-0168-4. [PMID] 30963362.
2018
Channels in a porous scaffold: a new player for vascularization.
Regenerative medicine. 13(6):705-715 [DOI] 10.2217/rme-2018-0022. [PMID] 30246614.
2018
Current Understanding of the Pathophysiology of Osteonecrosis of the Jaw.
Current osteoporosis reports. 16(5):584-595 [DOI] 10.1007/s11914-018-0474-4. [PMID] 30155844.
2015
Juxtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration
Bone Research.
2014
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-kappaB
Nature Medicine.
2013
NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs
Cell Stem Cell.
2010
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Novel functions for NFkappaB: inhibition of bone formation
Nature reviews. Rheumatology.
2009
Inhibition of osteoblastic bone formation by nuclear factor-kappaB
Nature Medicine.
2008
Inhibition of human dental pulp stem cell differentiation by Notch signaling
Journal of dental research.
2008
Wnt/beta-catenin inhibits dental pulp stem cell differentiation
Journal of dental research.
2007
Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK
Journal of Biological Chemistry.
2007
Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair
Journal of Periodontology.
2005
Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines.
Cancer Research.
2005
NF-kappaB activation in human dental pulp stem cells by TNF and LPS
Journal of dental research.
2004
[Study on the characteristics of apoptosis in the condyles of osteoarthritic temporomandibular joints].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 22(5):353-6 [PMID] 15562640.
View on: PubMed
2004
[Study on the metabolism of cartilage matrix by the chondrocytes in osteoarthritic condylar cartilage].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. 39(4):309-12 [PMID] 15454017.
View on: PubMed
2003
[Alteration of the expression of cartilage matrix molecule in the cartilage by the chondrocytes from rabbit temporomandibular joint with experimental osteoarthritis and its response to interleukin-1 beta].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 35(5):521-4 [PMID] 14601312.
View on: PubMed
2002
Application of alginate three-dimensional culture system for in vitro culture of mandibular condylar chondrocytes from human osteoarthritic temporomandibular joint.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. 37(4):246-8 [PMID] 12411167.
View on: PubMed

Grants

May 2020 ACTIVE
Molecular control of bone development and inflammation by FBXO11
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Dec 2019 ACTIVE
Dominant microRNAs as biomarkers in innate immunity and periodontitis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Mar 2015 – Mar 2018
Start-up funds for Dr. Jia Chang
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM

Education

MS in Periodontics
2014 · University of Michigan School of Dentistry
Specialty certificate in Periodontics
2014 · University of Michigan School of Dentistry
Postdoc
2007 · University of Michigan School of Dentistry
Doctor degree in Oral & Maxillofacial Surgery
2002 · Peking University School of Stomatology
DDS in General Dentistry
1995 · Wuhan University School of Stomatology

Teaching Profile

Courses Taught
2015-2018,2020
DEN6421C Perio Tx Plan
2014-2015,2017-2021
DEN8838L Comp Perio Tx 5
2016-2017,2020
DEN7422C Perio Surgery
2014-2015,2017-2021,2020-2021
DEN7835L Comp Perio Tx 2
2017-2021
DEN8423 Perio in Gen Pract
2015-2018,2020-2021
DEN8839L Comp Perio Tx 6
2016-2021
DEN7836L Comp Perio Tx 3
2015,2018-2021,2021
DEN8837L Comp Perio Tx 4
2014-2015,2019-2021,2021
DEN7834L Comp Perio Tx 1
2018
VME7979 Advanced Research
2017
DEN8960L Clinical Examinatio 2
2016
DEN7961L Clinical Examinaton 1
2016,2021
DEN8651L Clinical Periodontics
2016,2021
DEN6658 Treatment Planning in Periodontal Therapy
2016
DEN6655 Review of Periodontics Literature IV
2021
DEN6656 Introduction to Advanced Periodontology
2021
DEN6940 Supervised Teaching
2021
DEN6971 Research for Master’s Thesis

Contact Details

Phones:
Business:
(352) 273-8366
Emails: