Edward K Chan

Edward K Chan,

PROFESSOR

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8849
Business Email: echan@ufl.edu

Accomplishments

Master
2020 · American College of Rheumatology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3938-9503

Areas of Interest
  • Autoantibody
  • Autoimmune Disease
  • Oral cancer
  • microRNA

Publications

2021
Corrigendum to “Anti-rods/rings autoantibody and IMPDH filaments: An update after fifteen years of discovery” [AUTREV 19-10 (2020) 102643].
Autoimmunity reviews. 20(3) [DOI] 10.1016/j.autrev.2021.102766. [PMID] 33514492.
2021
Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein
Clinical Chemistry and Laboratory Medicine (CCLM). 59(1):197-207 [DOI] 10.1515/cclm-2020-0981. [PMID] 32776893.
2021
Fusobacteria modulate oral carcinogenesis and promote cancer progression
Journal of Oral Microbiology. 13(1) [DOI] 10.1080/20002297.2020.1849493. [PMID] 33391626.
2021
How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative.
Immunologic research. [DOI] 10.1007/s12026-021-09233-0. [PMID] 34625914.
2021
Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study.
BMC oral health. 21(1) [DOI] 10.1186/s12903-021-01597-x. [PMID] 33964928.
2021
The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation.
Auto- immunity highlights. 12(1) [DOI] 10.1186/s13317-020-00146-w. [PMID] 33640027.
2020
Anti-DFS70 Antibodies Among Patient and Healthy Population Cohorts in China: Results From a Multicenter Training Program Showing Spontaneous Abortion and Pediatric Systemic Autoimmune Rheumatic Diseases Are Common in Anti-DFS70 Positive Patients.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.562138. [PMID] 33133072.
2020
Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery.
Autoimmunity reviews. 19(10) [DOI] 10.1016/j.autrev.2020.102643. [PMID] 32805424.
2020
Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey.
Auto- immunity highlights. 11(1) [DOI] 10.1186/s13317-020-00139-9. [PMID] 33228811.
2020
Increasing Prevalence of Antinuclear Antibodies in the United States.
Arthritis & rheumatology (Hoboken, N.J.). 72(6):1026-1035 [DOI] 10.1002/art.41214. [PMID] 32266792.
2020
Response to ‘Decision making value of nuclear dense fine speckled pattern in systemic autoimmune rheumatic disease: trick or treat?’ by Deng et al.
Annals of the rheumatic diseases. 79(8) [DOI] 10.1136/annrheumdis-2019-215640. [PMID] 31092413.
2020
Response to: ‘The utility of the HEp-2000 antinuclear antibody substrate’ by Lee et al.
Annals of the rheumatic diseases. 79(6) [DOI] 10.1136/annrheumdis-2019-215610. [PMID] 31088789.
2019
Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective.
Annals of the rheumatic diseases. 78(7):879-889 [DOI] 10.1136/annrheumdis-2018-214436. [PMID] 30862649.
2019
Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.
Clinical chemistry and laboratory medicine. 57(11):1754-1763 [DOI] 10.1515/cclm-2019-0087. [PMID] 31005948.
2019
Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs
Antiviral Research. 162:130-135 [DOI] 10.1016/j.antiviral.2018.12.017.
2019
Unending story of the indirect immunofluorescence assay on HEp-2 cells: old problems and new solutions?
Annals of the rheumatic diseases. 78(6) [DOI] 10.1136/annrheumdis-2018-213440. [PMID] 29666046.
2018
CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.
Oral oncology. 78:145-150 [DOI] 10.1016/j.oraloncology.2018.01.024. [PMID] 29496042.
2018
CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening.
Biosensors & bioelectronics. 117:68-74 [DOI] 10.1016/j.bios.2018.04.016. [PMID] 29886188.
2018
Clarification Needed Regarding Anti-Topoisomerase I as a Biomarker for Non-Small Cell Lung Cancer.
The Annals of thoracic surgery. 106(3) [DOI] 10.1016/j.athoracsur.2018.03.037. [PMID] 29679532.
2018
Emerging microRNAs in cancer diagnosis, progression, and immune surveillance
Cancer Letters. 438:126-132 [DOI] 10.1016/j.canlet.2018.09.019.
2018
Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-34698-9. [PMID] 30385810.
2018
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.02789. [PMID] 30555474.
2018
International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns.
Clinical chemistry and laboratory medicine. 56(10):1799-1802 [DOI] 10.1515/cclm-2018-0052. [PMID] 29634478.
2018
International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I.
Clinical chemistry and laboratory medicine. 56(10):1783-1788 [DOI] 10.1515/cclm-2018-0188. [PMID] 29813025.
2018
Prescription medication use and antinuclear antibodies in the United States, 1999–2004
Journal of Autoimmunity. 92:93-103 [DOI] 10.1016/j.jaut.2018.05.006. [PMID] 29779929.
2018
Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies.
Clinical chemistry and laboratory medicine. 56(10):1789-1798 [DOI] 10.1515/cclm-2017-1152. [PMID] 29478040.
2017
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Clinical reviews in allergy & immunology. 52(1):1-19 [DOI] 10.1007/s12016-015-8510-y. [PMID] 26424665.
2017
Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
International journal of molecular sciences. 18(4) [DOI] 10.3390/ijms18040875. [PMID] 28425970.
2017
Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).
PloS one. 12(10) [DOI] 10.1371/journal.pone.0185977. [PMID] 29016697.
2017
Biomarkers and Pathogenic Mechanisms in Autoimmunity.
Immunologic research. 65(1):296-298 [DOI] 10.1007/s12026-016-8864-0. [PMID] 27647146.
2017
Dr Eng M. Tan: a tribute to an enduring legacy in autoimmunity.
Lupus. 26(2):208-217 [DOI] 10.1177/0961203316664598. [PMID] 27539991.
2016
A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14.
Autoimmunity. 49(5):347-56 [DOI] 10.1080/08916934.2016.1196676. [PMID] 27328271.
2016
Anti-Rods/Rings Autoantibody Generation in Hepatitis C Patients During Interferon-Alpha/Ribavirin Therapy
World Journal of Gastroenterology. 22(6):1966-1974 [DOI] 10.3748/wjg.v22.i6.1966. [PMID] 26877604.
2016
Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection.
Auto- immunity highlights. 7(1) [PMID] 27844412.
View on: PubMed
2016
Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004.
Environmental health perspectives. 124(4):426-36 [DOI] 10.1289/ehp.1409345. [PMID] 26252071.
2016
Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies.
Clinical immunology (Orlando, Fla.). 173:149-156 [DOI] 10.1016/j.clim.2016.10.004. [PMID] 27746381.
2016
From autoantibody research to standardized diagnostic assays in the management of human diseases – report of the 12th Dresden Symposium on Autoantibodies.
Lupus. 25(8):787-96 [DOI] 10.1177/0961203316644337. [PMID] 27252254.
2016
International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results.
Auto- immunity highlights. 7(1) [DOI] 10.1007/s13317-016-0075-0. [PMID] 26831867.
2016
Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells.
PloS one. 11(10) [DOI] 10.1371/journal.pone.0165162. [PMID] 27798680.
2016
MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.
Arthritis & rheumatology (Hoboken, N.J.). 68(9):2232-43 [DOI] 10.1002/art.39725. [PMID] 27111096.
2016
MicroRNA-375 as a biomarker for malignant transformation in oral lesions.
Oral surgery, oral medicine, oral pathology and oral radiology. 122(6):743-752.e1 [DOI] 10.1016/j.oooo.2016.07.022. [PMID] 27720656.
2016
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-1056-4. [PMID] 27405639.
2016
Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015.
Lupus. 25(8):797-804 [DOI] 10.1177/0961203316640920. [PMID] 27252255.
2016
Rod and Ring formation from IMP dehydrogenase is regulated via the one-carbon metabolic pathway
Journal of Cell Science. [DOI] 10.1242/jcs.183400.
2016
Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-1010-5. [PMID] 27184054.
2015
Anti-cancer drugs reactivate tumor suppressor miR-375 expression in tongue cancer cells.
Journal of cellular biochemistry. 116(5):836-43 [DOI] 10.1002/jcb.25039. [PMID] 25521291.
2015
Anti-rods/rings: a human model of drug-induced autoantibody generation.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00041. [PMID] 25699057.
2015
Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction.
Journal of genetics and genomics = Yi chuan xue bao. 42(6):287-99 [DOI] 10.1016/j.jgg.2015.04.002. [PMID] 26165495.
2015
CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.
Molecular bioSystems. 11(1):105-14 [DOI] 10.1039/c4mb00513a. [PMID] 25325377.
2015
Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands
Journal of Innate Immunity. 7(4):428-440 [DOI] 10.1159/000371517. [PMID] 25896300.
2015
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures.
Cell & bioscience. 5(1) [DOI] 10.1186/2045-3701-5-1. [PMID] 25601894.
2015
miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer.
Oral oncology. 51(2):151-7 [DOI] 10.1016/j.oraloncology.2014.11.019. [PMID] 25500095.
2015
Our Journey from the Study of Human Autoantibodies to the microRNA World.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00110. [PMID] 25814992.
2015
Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00412. [PMID] 26347739.
2015
The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00181. [PMID] 25954274.
2014
Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests.
The Journal of rheumatology. 41(7):1334-43 [DOI] 10.3899/jrheum.131450. [PMID] 24931955.
2014
Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4448. [PMID] 24451065.
2014
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Cellular and molecular life sciences : CMLS. 71(15):2963-73 [DOI] 10.1007/s00018-014-1567-6. [PMID] 24477477.
2014
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies.
Annals of the rheumatic diseases. 73(1):17-23 [DOI] 10.1136/annrheumdis-2013-203863. [PMID] 24126457.
2014
miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.
Molecular cancer. 13 [DOI] 10.1186/1476-4598-13-80. [PMID] 24708873.
2014
Molecular cell biology and immunobiology of mammalian rod/ring structures.
International review of cell and molecular biology. 308:35-74 [DOI] 10.1016/B978-0-12-800097-7.00002-6. [PMID] 24411169.
2014
Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology. 34(2):171-80 [DOI] 10.1007/s10875-013-9973-3. [PMID] 24292724.
2014
Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis.
Clinical and experimental rheumatology. 32(6):891-7 [PMID] 25151986.
View on: PubMed
2014
Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4451. [PMID] 24460726.
2014
Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 23(11):2492-502 [DOI] 10.1158/1055-9965.EPI-14-0429. [PMID] 25086100.
2014
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α.
Immunologic research. 60(1):38-49 [DOI] 10.1007/s12026-014-8515-2. [PMID] 24845459.
2013
An SNP in the trinucleotide repeat region of the TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182.
Advances in experimental medicine and biology. 768:243-59 [DOI] 10.1007/978-1-4614-5107-5_14. [PMID] 23224974.
2013
Antinuclear antibody test: when to order?
The American journal of medicine. 126(10) [DOI] 10.1016/j.amjmed.2013.04.022. [PMID] 24054962.
2013
Autoantibodies to Argonaute 2 (Su antigen).
Advances in experimental medicine and biology. 768:45-59 [DOI] 10.1007/978-1-4614-5107-5_4. [PMID] 23224964.
2013
Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients.
Journal of clinical immunology. 33(2):420-6 [DOI] 10.1007/s10875-012-9827-4. [PMID] 23100146.
2013
Function of GW182 and GW bodies in siRNA and miRNA pathways.
Advances in experimental medicine and biology. 768:71-96 [DOI] 10.1007/978-1-4614-5107-5_6. [PMID] 23224966.
2013
Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4207. [PMID] 23557279.
2013
Introduction: the GW body story as an example of autoantibodies with significant impacts to molecular cell biology.
Advances in experimental medicine and biology. 768:1-4 [DOI] 10.1007/978-1-4614-5107-5_1. [PMID] 23224961.
2013
MicroRNA-146a in autoimmunity and innate immune responses.
Annals of the rheumatic diseases. 72 Suppl 2:ii90-5 [DOI] 10.1136/annrheumdis-2012-202203. [PMID] 23253933.
2013
Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research.
Advances in experimental medicine and biology. 768:261-70 [DOI] 10.1007/978-1-4614-5107-5_15. [PMID] 23224975.
2013
Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.
Journal of immunology (Baltimore, Md. : 1950). 190(3):1250-63 [DOI] 10.4049/jimmunol.1103060. [PMID] 23264652.
2013
Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4210. [PMID] 23587095.
2013
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.
Cancer discovery. 3(2):182-97 [DOI] 10.1158/2159-8290.CD-12-0292. [PMID] 23306062.
2013
Stress, Coping, Vegf and Mortality in Women With Endometrial Cancer
Psychosomatic Medicine. 75(3)
2013
The discovery of GW bodies.
Advances in experimental medicine and biology. 768:5-21 [DOI] 10.1007/978-1-4614-5107-5_2. [PMID] 23224962.
2013
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.
Molecular biology of the cell. 24(11):1638-48, S1 [DOI] 10.1091/mbc.E12-12-0891. [PMID] 23552692.
2012
A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis.
Arthritis research & therapy. 14(3) [DOI] 10.1186/ar3858. [PMID] 22643159.
2012
Anti-Mj/Nxp-2 Antibodies Are the Most Common Specifcity in a Cohort of Adult Caucasian Patients With Dermatomyositis
Annals of the Rheumatic Diseases. 71(Suppl 1):A49-A49 [DOI] 10.1136/annrheumdis-2011-201235.17.
2012
Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis.
Arthritis research & therapy. 14(2) [DOI] 10.1186/ar3822. [PMID] 22546500.
2012
Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis.
Arthritis research & therapy. 14(2) [DOI] 10.1186/ar3802. [PMID] 22513056.
2012
CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0033209. [PMID] 22461891.
2012
Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lupus. 21(1):68-74 [DOI] 10.1177/0961203311422712. [PMID] 22025191.
2012
Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders.
Clinical reviews in allergy & immunology. 42(1):16-25 [DOI] 10.1007/s12016-011-8286-7. [PMID] 22083460.
2012
Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C.
Antiviral therapy. 17(5):805-11 [DOI] 10.3851/IMP1993. [PMID] 22293655.
2012
Defining a new role of GW182 in maintaining miRNA stability.
EMBO reports. 13(12):1102-8 [DOI] 10.1038/embor.2012.160. [PMID] 23090477.
2012
Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer.
The Journal of biological chemistry. 287(35):29261-72 [DOI] 10.1074/jbc.M112.366518. [PMID] 22761427.
2012
Longitudinal study of a human drug-induced model of autoantibody to cytoplasmic rods/rings following HCV therapy with ribavirin and interferon-α.
PloS one. 7(9) [DOI] 10.1371/journal.pone.0045392. [PMID] 23028980.
2012
MicroRNAs and autoimmunity.
Current opinion in immunology. 24(6):686-91 [DOI] 10.1016/j.coi.2012.07.011. [PMID] 22902047.
2012
Prevalence and sociodemographic correlates of antinuclear antibodies in the United States.
Arthritis and rheumatism. 64(7):2319-27 [DOI] 10.1002/art.34380. [PMID] 22237992.
2012
Role of environmental factors in autoantibody production – importance of a detailed analysis in a small cohort.
Arthritis research & therapy. 14(1) [DOI] 10.1186/ar3739. [PMID] 22380573.
2011
A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren’s syndrome.
Arthritis and rheumatism. 63(10):3116-25 [DOI] 10.1002/art.30450. [PMID] 21567383.
2011
Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity.
European journal of immunology. 41(7):2029-39 [DOI] 10.1002/eji.201040757. [PMID] 21469088.
2011
Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS).
Autoimmunity. 44(2):90-7 [DOI] 10.3109/08916934.2010.499886. [PMID] 20695766.
2011
Atypical clinical presentation of a subset of patients with anti-RNA polymerase III–non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining.
Arthritis research & therapy. 13(4) [DOI] 10.1186/ar3422. [PMID] 21781293.
2011
Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.
Arthritis and rheumatism. 63(7):1972-8 [DOI] 10.1002/art.30349. [PMID] 21425128.
2011
Congenital Heart Block With and Without Anti-Ro/La Antibodies
Clinical and Experimental Rheumatology. 29
2011
Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism. 63
2011
Divergent GW182 functional domains in the regulation of translational silencing.
Nucleic acids research. 39(7):2534-47 [DOI] 10.1093/nar/gkq1099. [PMID] 21131274.
2011
Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3334. [PMID] 21569292.
2011
Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.
Clinical rheumatology. 30(10):1333-9 [DOI] 10.1007/s10067-011-1751-0. [PMID] 21523365.
2011
High resolution of microRNA signatures in human whole saliva.
Archives of oral biology. 56(12):1506-13 [DOI] 10.1016/j.archoralbio.2011.05.015. [PMID] 21704302.
2011
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0029690. [PMID] 22220215.
2011
Lupus T cells switched on by DNA hypomethylation via microRNA?
Arthritis and rheumatism. 63(5):1177-81 [DOI] 10.1002/art.30192. [PMID] 21538310.
2011
Mapping of Ago2-GW182 functional interactions.
Methods in molecular biology (Clifton, N.J.). 725:45-62 [DOI] 10.1007/978-1-61779-046-1_4. [PMID] 21528446.
2011
Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling.
Journal of immunology (Baltimore, Md. : 1950). 186(3):1723-34 [DOI] 10.4049/jimmunol.1002311. [PMID] 21178010.
2011
MicroRNA in TLR signaling and endotoxin tolerance.
Cellular & molecular immunology. 8(5):388-403 [DOI] 10.1038/cmi.2011.26. [PMID] 21822296.
2011
MicroRNAs in rheumatoid arthritis.
FEBS letters. 585(23):3667-74 [DOI] 10.1016/j.febslet.2011.05.020. [PMID] 21600203.
2011
MicroRNAs in systemic rheumatic diseases.
Arthritis research & therapy. 13(4) [DOI] 10.1186/ar3377. [PMID] 21787439.
2011
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon.
Fish & shellfish immunology. 30(4-5):1080-6 [DOI] 10.1016/j.fsi.2011.02.006. [PMID] 21316456.
2011
Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease.
Infection and immunity. 79(4):1597-605 [DOI] 10.1128/IAI.01062-10. [PMID] 21263019.
2010
Anti-Th/To Antibodies in Italian Scleroderma Patients: Clinical and Immunological Correlations and Comparison With Patients With Anti-Centromere Antibodies
Annals of the Rheumatic Diseases. 69(Suppl 2):A9-A9 [DOI] 10.1136/ard.2010.129577v.
2010
Anti-Th/To are common antinucleolar autoantibodies in Italian patients with scleroderma.
The Journal of rheumatology. 37(10):2071-5 [DOI] 10.3899/jrheum.100316. [PMID] 20682663.
2010
Autoantibodies to a miRNA-binding protein Argonaute2 (Su antigen) in patients with hepatitis C virus infection.
Clinical and experimental rheumatology. 28(6):842-8 [PMID] 21122261.
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2010
CIP2A expression and localization in oral carcinoma and dysplasia.
Cancer biology & therapy. 10(7):694-9 [DOI] 10.4161/cbt.10.7.12895. [PMID] 21068540.
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology. 88(2):205-12 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2010
High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus.
Arthritis research & therapy. 12(1) [DOI] 10.1186/ar2905. [PMID] 20064217.
2010
Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.
Brain, behavior, and immunity. 24(2):210-4 [DOI] 10.1016/j.bbi.2009.08.008. [PMID] 19716411.
2010
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells.
Genes, chromosomes & cancer. 49(6):549-59 [DOI] 10.1002/gcc.20765. [PMID] 20232482.
2009
Antibody reactivity to alpha-enolase in mothers of children with congenital heart block.
The Journal of rheumatology. 36(3):565-9 [DOI] 10.3899/jrheum.080860. [PMID] 19208599.
2009
Autoantibody to NA14 is an independent marker primarily for Sjogren’s syndrome.
Frontiers in bioscience (Landmark edition). 14:3733-9 [PMID] 19273306.
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2009
Cell Cycle Proteins To Monitor Cancer of Salivary Glands
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2009
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology. 36(12):2682-90 [DOI] 10.3899/jrheum.090338. [PMID] 19884269.
2009
Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases.
Modern rheumatology. 19(3):219-28 [DOI] 10.1007/s10165-009-0155-3. [PMID] 19277826.
2009
Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis.
Cell biology international. 33(2):148-57 [DOI] 10.1016/j.cellbi.2008.10.016. [PMID] 19000931.
2009
Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases.
The Journal of rheumatology. 36(8):1744-8 [DOI] 10.3899/jrheum.080737. [PMID] 19567621.
2009
Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need?
Arthritis and rheumatism. 60(4):912-5 [DOI] 10.1002/art.24421. [PMID] 19333929.
2009
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
Journal of medicinal chemistry. 52(16):5144-51 [DOI] 10.1021/jm900277z. [PMID] 19630402.
2009
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s syndrome before disease onset.
Immunology and cell biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
2009
MicroRNA in autoimmunity and autoimmune diseases.
Journal of autoimmunity. 32(3-4):189-94 [DOI] 10.1016/j.jaut.2009.02.012. [PMID] 19303254.
2009
miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY.
The Journal of biological chemistry. 284(50):34590-9 [DOI] 10.1074/jbc.M109.056317. [PMID] 19840932.
2009
Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P bodies.
Nature protocols. 4(5):674-85 [DOI] 10.1038/nprot.2009.34. [PMID] 19373232.
2009
Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies.
Arthritis research & therapy. 11(1) [DOI] 10.1186/ar2621. [PMID] 19232124.
2009
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.
RNA (New York, N.Y.). 15(5):804-13 [DOI] 10.1261/rna.1229409. [PMID] 19324964.
2008
Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism. 58:S372-S373
2008
Differential anti-Golgi complex autoantibody production following murine lactate dehydrogenase-elevating virus infection.
Immunopharmacology and immunotoxicology. 30(1):13-25 [DOI] 10.1080/08923970701812191 . [PMID] 18306101.
2008
Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing.
Journal of cell science. 121(Pt 24):4134-44 [DOI] 10.1242/jcs.036905. [PMID] 19056672.
2008
MicroRNAs and their emerging roles in immunology.
Annals of the New York Academy of Sciences. 1143:226-39 [DOI] 10.1196/annals.1443.009. [PMID] 19076353.
2008
Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.
Arthritis and rheumatism. 58(6):1576-81 [DOI] 10.1002/art.23514. [PMID] 18512773.
2008
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients.
Arthritis research & therapy. 10(4) [DOI] 10.1186/ar2493. [PMID] 18759964.
2008
Vaccination-Induced Systemic Autoimmunity in Farmed Atlantic Salmon
Arthritis and Rheumatism. 58
2007
Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma
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2007
AutoAbSC.Org — Autoantibody Standardization Committee in 2006.
Autoimmunity Reviews. 6(8) [DOI] 10.1016/j.autrev.2007.05.001. [PMID] 17854752.
2007
CIP2A inhibits PP2A in human malignancies.
Cell. 130(1):51-62 [PMID] 17632056.
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2007
Clinical and serological features of patients with autoantibodies to GW/P bodies.
Clinical immunology (Orlando, Fla.). 125(3):247-56 [PMID] 17870671.
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2007
Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert review of clinical immunology. 3(5):721-38 [DOI] 10.1586/1744666X.3.5.721. [PMID] 20477023.
2007
Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies.
Journal of neuroscience research. 85(16):3619-31 [PMID] 17663465.
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2007
Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells
Molecular Biology of the Cell. 18(2):394-403
2007
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.
Molecular biology of the cell. 18(9):3375-87 [PMID] 17596515.
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2007
The role of GW/P-bodies in RNA processing and silencing.
Journal of cell science. 120(Pt 8):1317-23 [PMID] 17401112.
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2006
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy. 8(4) [PMID] 16846524.
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2006
Autoimmune targeting of key components of RNA interference.
Arthritis research & therapy. 8(4) [PMID] 16684366.
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2006
Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody.
Journal of immunological methods. 317(1-2):38-44 [PMID] 17054975.
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2006
Formation of GW bodies is a consequence of microRNA genesis.
EMBO reports. 7(9):904-10 [PMID] 16906129.
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2006
GW bodies, microRNAs and the cell cycle.
Cell cycle (Georgetown, Tex.). 5(3):242-5 [PMID] 16418578.
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2006
Ninth International Workshop on Autoantibodies and Autoimmunity
Autoimmunity Reviews. 6(5):365-366
2006
Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies.
Arthritis and rheumatism. 54(9):3051-6 [PMID] 16948135.
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2006
Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis.
Arthritis and rheumatism. 54(6):2004-9 [PMID] 16732549.
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2005
Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma.
International journal of oncology. 27(4):1079-85 [PMID] 16142326.
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2005
Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection
Cancer Detection and Prevention. 29(2):241-248
2005
Disruption of GW bodies impairs mammalian RNA interference.
Nature cell biology. 7(12):1267-74 [PMID] 16284622.
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2005
Identification of kinectin as a novel Behçet’s disease autoantigen.
Arthritis research & therapy. 7(5):R1133-9 [PMID] 16207330.
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2005
Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens.
The Prostate. 63(3):252-8 [PMID] 15538718.
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2005
Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma.
International journal of oncology. 26(2):311-7 [PMID] 15645114.
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2005
Unique and shared features of Golgi complex autoantigens.
Autoimmunity reviews. 4(1):35-41 [PMID] 15652777.
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2004
Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies.
Clinical immunology (Orlando, Fla.). 110(1):30-44 [PMID] 14962794.
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2004
Autoimmune response in mothers of children with congenital and postnatally diagnosed isolated heart block: a population based study.
The Journal of rheumatology. 31(1):183-9 [PMID] 14705240.
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2004
Giantin is the major Golgi autoantigen in human anti-Golgi complex sera.
Arthritis research & therapy. 6(2):R95-102 [PMID] 15059272.
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2004
GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.
Journal of cell science. 117(Pt 23):5567-78 [PMID] 15494374.
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2004
Identification of RANTES as a novel immunomodulator of the maternal allogeneic response
Clinical Immunology. 110(1):71-80
2004
Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block.
Acta paediatrica (Oslo, Norway : 1992). 93(6):803-9 [PMID] 15244231.
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2003
A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182
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A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182.
Hybridoma and hybridomics. 22(2):79-86 [PMID] 12831532.
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2003
Anti-Golgi antibodies in adult Still’s disease.
Clinical and experimental rheumatology. 21(2):275-6 [PMID] 12747298.
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2003
Autoantibodies to tissue transglutaminase in Sjögren’s syndrome and related rheumatic diseases.
The Journal of rheumatology. 30(12):2613-9 [PMID] 14719202.
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2003
Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182
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Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182.
Journal of molecular medicine (Berlin, Germany). 81(12):811-8 [PMID] 14598044.
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2003
Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens
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2003
Recursive partitioning as an approach to selection of immune markers for tumor diagnosis
Clinical Cancer Research. 9(14):5120-5126
2003
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.
RNA (New York, N.Y.). 9(10):1171-3 [PMID] 13130130.
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2002
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.
Molecular biology of the cell. 13(4):1338-51 [PMID] 11950943.
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2002
Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma.
Autoimmunity reviews. 1(3):146-53 [PMID] 12849008.
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2002
Autoantibody responses in Chinese hepatocellular carcinoma.
Journal of clinical immunology. 22(2):98-105 [PMID] 11998899.
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2002
Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.
Arthritis and rheumatism. 46(3):726-34 [PMID] 11920408.
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2002
Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block.
Journal of autoimmunity. 19(1-2):79-86 [PMID] 12367562.
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2002
Cloning and characterization of a novel 90 kDa ‘companion’ auto-antigen of p62 overexpressed in cancer.
Oncogene. 21(32):5006-15 [PMID] 12118381.
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2002
Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis.
Arthritis research. 4(4) [PMID] 12106502.
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2002
The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein.
The Journal of biological chemistry. 277(43):41282-6 [PMID] 12196535.
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2001
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis
The American Journal Of Pathology. 159(2):945-953
2001
Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies
Clinical Immunology. 100(2):149-156
2001
De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma.
Clinical and experimental immunology. 125(1):3-9 [PMID] 11472419.
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2001
Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function
International Journal of Biochemistry and Cell Biology. 33(9):924-934
2001
Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis
Experimental Cell Research. 267(1):45-60
2001
Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product.
The Journal of cell biology. 154(2):293-307 [PMID] 11470819.
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2001
SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus.
The Journal of clinical investigation. 108(6):861-9 [PMID] 11560955.
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2001
The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment.
Nature cell biology. 3(12):1101-13 [PMID] 11781572.
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2001
Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats.
Experimental cell research. 269(2):312-21 [PMID] 11570823.
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2000
Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-α by macrophages
Journal of Immunology. 165(9):5345-5351
2000
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
Journal of Allergy and Clinical Immunology. 105(6):1211-1220
2000
Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen.
Journal of autoimmunity. 14(2):179-87 [PMID] 10677249.
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2000
Identification and characterization of a novel Golgi protein, golgin-67.
The Journal of biological chemistry. 275(6):4137-44 [PMID] 10660574.
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2000
Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4)
Genome Biology. 1(1)
2000
Structure and characterization of the murine p80 coilin gene, Coil
Journal of Structural Biology. 129(2-3):269-277
2000
Vesicular traffic and Golgi apparatus dynamics during mammalian spermatogenesis: implications for acrosome architecture
Biology of reproduction. 63(1):89-98
1999
A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma
Journal of Experimental Medicine. 189(7):1101-1110
1999
Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies.
The Journal of clinical investigation. 104(9):1265-75 [PMID] 10545525.
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1999
mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure
Pediatric Research. 45(2)
1998
Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes.
Journal of immunology (Baltimore, Md. : 1950). 161(9):5061-9 [PMID] 9794444.
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1998
Advances in autoantibodies in SLE.
Lupus. 7(8):507-14 [PMID] 9863891.
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1998
Environmental Estrogens Increase Expression of SS‐A/Ro Autoantigen in Normal Human Epidermal Keratinocytes
Journal of Dermatology. 25(8):558-560
1998
Genetic and physical mapping of theLpsLocus: identification of the Toll-4 receptor as a candidate gene in the critical region
Blood Cells, Molecules & Diseases. 24(3):340-355
1998
Golgins: coiled-coil-rich proteins associated with the Golgi complex
Electronic Journal of Biotechnology. 1(2):1-20
1998
Immunological characterization of heterochromatin protein p25β autoantibodies and relationship with centromere autoantibodies and pulmonary fibrosis in systemic scleroderma
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1998
Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model.
Journal of immunology (Baltimore, Md. : 1950). 161(11):5886-92 [PMID] 9834068.
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1998
Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P.
Nucleic acids research. 26(2):439-45 [PMID] 9421497.
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1998
Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells
Proceedings of the National Academy of Sciences. 95(16):9167-9171
1997
Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency
Journal of Allergy and Clinical Immunology. 134-146
1997
Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development.
Arthritis and rheumatism. 40(4):655-60 [PMID] 9125247.
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1997
cDNA library protocols (Methods in Molecular Biology, Vol. 69): edited by Ian G. Cowell and Caroline A. Austin Humana Press, 1996. $69.50 hbk (x and 321 pages) ISBN 0 89603 383 X
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1997
Diversity of antinuclear antibody responses in hepatocellular carcinoma.
Journal of hepatology. 26(6):1255-65 [PMID] 9210612.
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Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis.
Chromosoma. 106(1):11-9 [PMID] 9169582.
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1997
Immune response to cyclin B1 in hepatocellular carcinoma
Hepatology. 25(1):75-80
1997
Molecular Cloning of the RNA Polymerase I Transcription Factor hUBF/NOR-90 (UBTF) Gene and Localization to 17q21. 3 by Fluorescencein SituHybridization and Radiation Hybrid Mapping
Genomics. 41(1):135-138
1997
The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex.
Arthritis and rheumatism. 40(5):936-44 [PMID] 9153557.
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1996
17-β-Estradiol increases expression of 52-kDa and 60-kDa SS-A/Ro autoantigens in human keratinocytes and breast cancer cell line MCF-7
Journal of Investigative Dermatology. 107(4):610-614
1996
Biographical sketch and scientific contributions of Eng M. Tan
Molecular Biology Reports. 23(3):129-130
1996
cDNA cloning and characterization of a novel nucleolar protein.
Molecular biology of the cell. 7(7):1015-24 [PMID] 8862517.
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1996
Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro
Molecular Biology Reports. 23(3-4):205-210
1996
Comparison of protocols for depleting anti-E. coli antibody in immunoblotting of recombinant antigens
Journal of Immunological Methods. 190(1):143-145
1996
Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block.
The Journal of rheumatology. 23(5):925-32 [PMID] 8724310.
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1995
52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
The Journal of experimental medicine. 182(4):983-92 [PMID] 7561701.
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1995
A Cell-Cycle Nuclear Autoantigen Containing Wd-40 Motifs Expressed Mainly in S and G2-Phase Cells
Biochemical and Biophysical Research Communications. 107(3):1029-1037
1995
Formation of nuclear bodies in hepatocytes of estrogen-treated roosters.
Molecular biology of the cell. 6(3):345-56 [PMID] 7612968.
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1995
Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature.
The Journal of biological chemistry. 270(52):31262-8 [PMID] 8537393.
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1995
Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.
Clinical and experimental immunology. 100(1):67-74 [PMID] 7697925.
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1995
p80-coilin: a component of coiled bodies and interchromatin granule-associated zones
Journal of Cell Science. 108(3):1143-1153
1994
A microscale method for depleting cross-reactive anti-antibodies used in indirect immunofluorescence microscopy.
Journal of immunological methods. 176(2):271-3 [PMID] 7983385.
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1994
Autoantibody responses to the “native” 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren’s syndrome.
Journal of immunology (Baltimore, Md. : 1950). 152(7):3675-84 [PMID] 7511655.
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1994
Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization
Genomics. 23(1)
1994
Immunocytochemical characterization of human NOR-90 (upstream binding factor) and associated antigens reactive with autoimmune sera. Two MR forms of NOR-90/hUBF autoantigens.
Molecular biology reports. 19(2):115-24 [PMID] 8072492.
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1994
Is the coiled body involved in nucleolar functions?
Experimental Cell Research. 211(2):415-419
1994
Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block.
The Journal of rheumatology. 21(10):1943-50 [PMID] 7837164.
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1994
Structure, expression and chromosomal localization of human p80-coilin gene
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Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice.
Clinical immunology and immunopathology. 68(3):350-6 [PMID] 8370186.
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1993
Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjögren’s syndrome
Journal of Immunology. 150(8):3615-3623
1993
Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America. 90(5):1947-51 [PMID] 8446613.
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1993
Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La.
Arthritis and rheumatism. 36(11):1588-98 [PMID] 8240435.
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1993
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Journal of virology. 67(7):3798-807 [PMID] 8389906.
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1993
Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.
The Journal of experimental medicine. 178(1):49-62 [PMID] 8315394.
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1993
Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma
The Journal Of Clinical Investigation. 92(5):2419-2426
1992
Antinuclear antibodies in Sjögren’s syndrome.
Rheumatic diseases clinics of North America. 18(3):551-70 [PMID] 1496161.
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Laboratory evaluation of patients with Sjögren’s syndrome.
Clinical biochemistry. 25(3):213-22 [PMID] 1633637.
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1991
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.
The Journal of experimental medicine. 173(6):1407-19 [PMID] 2033369.
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1991
Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor.
The Journal of experimental medicine. 174(5):1239-44 [PMID] 1940801.
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1991
Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies.
Experimental cell research. 195(1):27-37 [PMID] 2055273.
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1991
Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex.
The Journal of experimental medicine. 173(4):941-52 [PMID] 2007859.
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1991
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
The Journal of clinical investigation. 87(1):68-76 [PMID] 1985112.
View on: PubMed
1990
Association between the nucleolus and the coiled body.
Journal of structural biology. 104(1-3):120-7 [PMID] 2088441.
View on: PubMed
1990
Effective separation of the 52 kDa SSA/Ro polypeptide from the 48 kDa SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis
Journal of Immunological Methods. 129(2):207-210
1990
In vitro posttranslational modification of lamin B cloned from a human T-cell line
Molecular And Cellular Biology. 10(5):2164-2175
1989
Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögren’s syndrome.
Current opinion in rheumatology. 1(3):376-81 [PMID] 2484307.
View on: PubMed
1989
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding
Nucleic Acids Research. 17(6):2233-2244
1989
Sjögren’s syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes.
Journal of autoimmunity. 2(4):321-7 [PMID] 2476998.
View on: PubMed
1989
Viral genomes in lymphomas of patients with Sjögren’s syndrome.
Journal of autoimmunity. 2(4):449-55 [PMID] 2571338.
View on: PubMed
1988
A 52-kD protein is a novel component of the SS-A/Ro antigenic particle.
The Journal of experimental medicine. 167(5):1560-71 [PMID] 3367095.
View on: PubMed
1988
Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity.
Clinical immunology and immunopathology. 47(2):121-41 [PMID] 3280190.
View on: PubMed
1988
Treatment of primary Sjögren’s syndrome with hydroxychloroquine
The American journal of medicine. 85(4):62-67
1987
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies
Journal of Experimental Medicine. 166(6):1627-1640
1987
Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease.
Clinical immunology and immunopathology. 44(1):31-40 [PMID] 3496180.
View on: PubMed
1987
The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons
Molecular And Cellular Biology. 7(7):2588-2591
1986
Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs.
Virology. 152(1):87-99 [PMID] 3012876.
View on: PubMed
1986
Epitopes and structural domains of a RNA-binding nuclear protein, SS-B/La: similarities with adenovirus DNA-binding protein
Scandinavian journal of rheumatology. 61:102-105
1986
Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein.
Journal of immunology (Baltimore, Md. : 1950). 136(10):3744-9 [PMID] 2422260.
View on: PubMed
1986
IgG subclasses of autoantibodies in systemic lupus erythematosus, Sjogren’s syndrome, and drug-induced autoimmunity.
Journal of immunology (Baltimore, Md. : 1950). 137(8):2528-34 [PMID] 3760566.
View on: PubMed
1985
Characterization and purification of lupus antigen La, and RNA-binding protein
Molecular And Cellular Biology. 5(3):586-590
1980
Preparation of covalently linked immune complexes of specific composition
Journal of Immunological Methods. 33(1):55-61

Grants

Dec 2019 ACTIVE
Dominant microRNAs as biomarkers in innate immunity and periodontitis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jun 2016 – May 2019
Influence of Innate Immunity on Xenobiotic-lnduced Systemic Autoimmunity
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via NATL INST OF HLTH NIEHS
Dec 2015 – Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2015 – Sep 2017
Antinuclear Antibodies by Immunofluorescence
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Jun 2015 – May 2017
Dr. Chan
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Jun 2015 – May 2016
Influence of Innate Immunity on Xenobiotic-Induced Systemic Autoimmunity
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST via NATL INST OF HLTH NIEHS
Feb 2015 – Jan 2020
UF Health Cancer Center Collaborative Cancer Related Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2012 – Dec 2016
Ethnic heterogeneity in microRNA expression as a biomarker in rheumatoid arthritis
Role: Principal Investigator
Funding: PFIZER INC
Sep 2012 ACTIVE
DSR Matching Support – Support for NSF Fellowship
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jun 2012 – May 2017
Functional Elucidation of Aberrant MicroRNA Expresstion in Oral Cancer
Role: Principal Investigator
Funding: UF FOU
Jul 2010 – Jun 2016
Expression and function of microRNA in autoimmune Sjogren's Syndrome
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Teaching Profile

Courses Taught
2011-2017,2019-2021
DEN6128 Host Defense
2014,2016-2020,2020-2021
GMS6421 Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2007-2011,2013-2018,2015-2018,2017-2018
GMS5905 Special Topics in Biomedical Sciences
2007-2008,2016
DEN8290 Special Topics
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2015
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2014
DEN5210 Dev Biol Psychosoc 1
2011-2012
IDH4905 Individual Work
2011-2012
GMS6161 Introduction to Oral Biology II
2009-2010
IDH4917 Undergrad Research
2009
GMS6030 Autoimmunity
2006-2009
GMS6006 Fund Immunol/Microbio

Contact Details

Phones:
Business:
(352) 273-8849
Emails:
Business:
echan@ufl.edu