Edward K Chan,
PROFESSOR
About Edward K Chan
Related Links:
Accomplishments
Carl R. Jolliff Award for Outstanding Achievement in Clinical or Diagnostic Medicine
2024
·
Association for Diagnostics & Laboratory Medicine (ADLM, formerly AACC)
Master
2020
·
American College of Rheumatology
Teaching Profile
Courses Taught
2011-2017,2019-2022
DEN6128 Host Defense
2014,2016-2020,2020-2022
GMS6421 Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2007-2011,2013-2018,2015-2018,2017-2018
GMS5905 Special Topics in Biomedical Sciences
2007-2008,2016
DEN8290 Special Topics
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2015
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2014
DEN5210 Dev Biol Psychosoc 1
2011-2012
IDH4905 Individual Work
2011-2012
GMS6161 Introduction to Oral Biology II
2009-2010
IDH4917 Undergrad Research
2009
GMS6030 Autoimmunity
2006-2009
GMS6006 Fund Immunol/Microbio
Clinical Profile
Specialties
- Dentistry
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-3938-9503
Areas of Interest
- Autoantibody
- Autoimmune Disease
- Oral cancer
- microRNA
Publications
2024
Adopting the International Consensus on ANA Patterns (ICAP) classification for reporting: the experience of Italian clinical laboratories.
Clinical chemistry and laboratory medicine.
62(5):830-834
[DOI] 10.1515/cclm-2023-0752.
[PMID] 37852014.
2024
Dr. Eng Meng Tan August 26, 1926 – March 9, 2024 La Jolla, California.
Lupus.
[DOI] 10.1177/09612033241252038.
[PMID] 38770549.
2024
Eng Meng Tan
Annals of the Rheumatic Diseases.
ard-2024
[DOI] 10.1136/ard-2024-226025.
2024
Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop.
Autoimmunity reviews.
[DOI] 10.1016/j.autrev.2024.103608.
[PMID] 39187221.
2024
Streptococcus gordonii Supragingival Bacterium Oral Infection-Induced Periodontitis and Robust miRNA Expression Kinetics.
International journal of molecular sciences.
25(11)
[DOI] 10.3390/ijms25116217.
[PMID] 38892405.
2023
Analytical aspects of the antinuclear antibody test by HEp-2 indirect immunofluorescence: EFLM report on an international survey.
Clinical chemistry and laboratory medicine.
61(7):1199-1208
[DOI] 10.1515/cclm-2023-0210.
[PMID] 36989428.
2023
Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1186439.
[PMID] 37426660.
2023
Correction to: The International Consensus on ANA Patterns (ICAP) in 2021—the 6th Workshop and Current Perspectives
The Journal of Applied Laboratory Medicine.
8(2):419-419
[DOI] 10.1093/jalm/jfac013.
2023
Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP.
Clinical chemistry and laboratory medicine.
61(7):1167-1198
[DOI] 10.1515/cclm-2023-0209.
[PMID] 36989417.
2023
Editorial: Contemporary challenges in immunologic testing in clinical and research laboratories.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1259823.
[PMID] 37575258.
2023
Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis.
International journal of molecular sciences.
24(15)
[DOI] 10.3390/ijms241512105.
[PMID] 37569480.
2023
Specific microRNA Signature Kinetics in Porphyromonas gingivalis-Induced Periodontitis.
International journal of molecular sciences.
24(3)
[DOI] 10.3390/ijms24032327.
[PMID] 36768651.
2023
Unique miRomics Expression Profiles in Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning
International Journal of Molecular Sciences.
24(22)
[DOI] 10.3390/ijms242216393.
[PMID] 38003583.
2022
Anti-Ro52 Autoantibody Is Common in Systemic Autoimmune Rheumatic Diseases and Correlating with Worse Outcome when Associated with interstitial lung disease in Systemic Sclerosis and Autoimmune Myositis.
Clinical reviews in allergy & immunology.
63(2):178-193
[DOI] 10.1007/s12016-021-08911-z.
[PMID] 35040083.
2022
Expanded assessment of xenobiotic associations with antinuclear antibodies in the United States, 1988-2012.
Environment international.
166
[DOI] 10.1016/j.envint.2022.107376.
[PMID] 35785669.
2022
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).
Neoplasia (New York, N.Y.).
31
[DOI] 10.1016/j.neo.2022.100813.
[PMID] 35834946.
2022
Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression.
International journal of molecular sciences.
23(9)
[DOI] 10.3390/ijms23095107.
[PMID] 35563501.
2022
Increasing Prevalence of Antinuclear Antibodies in the United States.
Arthritis & rheumatology (Hoboken, N.J.).
74(12):2032-2041
[DOI] 10.1002/art.42330.
[PMID] 36054084.
2022
The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives
The Journal of Applied Laboratory Medicine.
7(1):322-330
[DOI] 10.1093/jalm/jfab140.
2021
Corrigendum to “Anti-rods/rings autoantibody and IMPDH filaments: An update after fifteen years of discovery” [AUTREV 19-10 (2020) 102643].
Autoimmunity reviews.
20(3)
[DOI] 10.1016/j.autrev.2021.102766.
[PMID] 33514492.
2021
Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein
Clinical Chemistry and Laboratory Medicine (CCLM).
59(1):197-207
[DOI] 10.1515/cclm-2020-0981.
[PMID] 32776893.
2021
Fusobacteria modulate oral carcinogenesis and promote cancer progression
Journal of Oral Microbiology.
13(1)
[DOI] 10.1080/20002297.2020.1849493.
[PMID] 33391626.
2021
How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative.
Immunologic research.
69(6):594-608
[DOI] 10.1007/s12026-021-09233-0.
[PMID] 34625914.
2021
Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.730102.
[PMID] 34675922.
2021
Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study.
BMC oral health.
21(1)
[DOI] 10.1186/s12903-021-01597-x.
[PMID] 33964928.
2021
The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation.
Auto- immunity highlights.
12(1)
[DOI] 10.1186/s13317-020-00146-w.
[PMID] 33640027.
2020
Anti-DFS70 Antibodies Among Patient and Healthy Population Cohorts in China: Results From a Multicenter Training Program Showing Spontaneous Abortion and Pediatric Systemic Autoimmune Rheumatic Diseases Are Common in Anti-DFS70 Positive Patients.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.562138.
[PMID] 33133072.
2020
Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery.
Autoimmunity reviews.
19(10)
[DOI] 10.1016/j.autrev.2020.102643.
[PMID] 32805424.
2020
Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey.
Auto- immunity highlights.
11(1)
[DOI] 10.1186/s13317-020-00139-9.
[PMID] 33228811.
2020
Increasing Prevalence of Antinuclear Antibodies in the United States.
Arthritis & rheumatology (Hoboken, N.J.).
72(6):1026-1035
[DOI] 10.1002/art.41214.
[PMID] 32266792.
2020
Response to ‘Decision making value of nuclear dense fine speckled pattern in systemic autoimmune rheumatic disease: trick or treat?’ by Deng et al.
Annals of the rheumatic diseases.
79(8)
[DOI] 10.1136/annrheumdis-2019-215640.
[PMID] 31092413.
2020
Response to: ‘The utility of the HEp-2000 antinuclear antibody substrate’ by Lee et al.
Annals of the rheumatic diseases.
79(6)
[DOI] 10.1136/annrheumdis-2019-215610.
[PMID] 31088789.
2019
Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective.
Annals of the rheumatic diseases.
78(7):879-889
[DOI] 10.1136/annrheumdis-2018-214436.
[PMID] 30862649.
2019
Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.
Clinical chemistry and laboratory medicine.
57(11):1754-1763
[DOI] 10.1515/cclm-2019-0087.
[PMID] 31005948.
2019
Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs
Antiviral Research.
162:130-135
[DOI] 10.1016/j.antiviral.2018.12.017.
2019
Unending story of the indirect immunofluorescence assay on HEp-2 cells: old problems and new solutions?
Annals of the rheumatic diseases.
78(6)
[DOI] 10.1136/annrheumdis-2018-213440.
[PMID] 29666046.
2018
CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.
Oral oncology.
78:145-150
[DOI] 10.1016/j.oraloncology.2018.01.024.
[PMID] 29496042.
2018
CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening.
Biosensors & bioelectronics.
117:68-74
[DOI] 10.1016/j.bios.2018.04.016.
[PMID] 29886188.
2018
Clarification Needed Regarding Anti-Topoisomerase I as a Biomarker for Non-Small Cell Lung Cancer.
The Annals of thoracic surgery.
106(3)
[DOI] 10.1016/j.athoracsur.2018.03.037.
[PMID] 29679532.
2018
Emerging microRNAs in cancer diagnosis, progression, and immune surveillance
Cancer Letters.
438:126-132
[DOI] 10.1016/j.canlet.2018.09.019.
2018
Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-34698-9.
[PMID] 30385810.
2018
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.02789.
[PMID] 30555474.
2018
International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns.
Clinical chemistry and laboratory medicine.
56(10):1799-1802
[DOI] 10.1515/cclm-2018-0052.
[PMID] 29634478.
2018
International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I.
Clinical chemistry and laboratory medicine.
56(10):1783-1788
[DOI] 10.1515/cclm-2018-0188.
[PMID] 29813025.
2018
Prescription medication use and antinuclear antibodies in the United States, 1999–2004
Journal of Autoimmunity.
92:93-103
[DOI] 10.1016/j.jaut.2018.05.006.
[PMID] 29779929.
2018
Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies.
Clinical chemistry and laboratory medicine.
56(10):1789-1798
[DOI] 10.1515/cclm-2017-1152.
[PMID] 29478040.
2017
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Clinical reviews in allergy & immunology.
52(1):1-19
[DOI] 10.1007/s12016-015-8510-y.
[PMID] 26424665.
2017
Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
International journal of molecular sciences.
18(4)
[DOI] 10.3390/ijms18040875.
[PMID] 28425970.
2017
Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).
PloS one.
12(10)
[DOI] 10.1371/journal.pone.0185977.
[PMID] 29016697.
2017
Biomarkers and Pathogenic Mechanisms in Autoimmunity.
Immunologic research.
65(1):296-298
[DOI] 10.1007/s12026-016-8864-0.
[PMID] 27647146.
2017
Dr Eng M. Tan: a tribute to an enduring legacy in autoimmunity.
Lupus.
26(2):208-217
[DOI] 10.1177/0961203316664598.
[PMID] 27539991.
2016
A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14.
Autoimmunity.
49(5):347-56
[DOI] 10.1080/08916934.2016.1196676.
[PMID] 27328271.
2016
Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy.
World journal of gastroenterology.
22(6):1966-74
[DOI] 10.3748/wjg.v22.i6.1966.
[PMID] 26877604.
2016
Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection.
Auto- immunity highlights.
7(1)
[PMID] 27844412.
2016
Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004.
Environmental health perspectives.
124(4):426-36
[DOI] 10.1289/ehp.1409345.
[PMID] 26252071.
2016
Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies.
Clinical immunology (Orlando, Fla.).
173:149-156
[DOI] 10.1016/j.clim.2016.10.004.
[PMID] 27746381.
2016
From autoantibody research to standardized diagnostic assays in the management of human diseases – report of the 12th Dresden Symposium on Autoantibodies.
Lupus.
25(8):787-96
[DOI] 10.1177/0961203316644337.
[PMID] 27252254.
2016
International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results.
Auto- immunity highlights.
7(1)
[DOI] 10.1007/s13317-016-0075-0.
[PMID] 26831867.
2016
Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells.
PloS one.
11(10)
[DOI] 10.1371/journal.pone.0165162.
[PMID] 27798680.
2016
MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.
Arthritis & rheumatology (Hoboken, N.J.).
68(9):2232-43
[DOI] 10.1002/art.39725.
[PMID] 27111096.
2016
MicroRNA-375 as a biomarker for malignant transformation in oral lesions.
Oral surgery, oral medicine, oral pathology and oral radiology.
122(6):743-752.e1
[DOI] 10.1016/j.oooo.2016.07.022.
[PMID] 27720656.
2016
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Arthritis research & therapy.
18(1)
[DOI] 10.1186/s13075-016-1056-4.
[PMID] 27405639.
2016
Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients.
Arthritis research & therapy.
18(1)
[DOI] 10.1186/s13075-016-1010-5.
[PMID] 27184054.
2016
‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway
Journal of Cell Science.
129(15):3042-3052
[DOI] 10.1242/jcs.183400.
2015
Anti-cancer drugs reactivate tumor suppressor miR-375 expression in tongue cancer cells.
Journal of cellular biochemistry.
116(5):836-43
[DOI] 10.1002/jcb.25039.
[PMID] 25521291.
2015
Anti-rods/rings: a human model of drug-induced autoantibody generation.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00041.
[PMID] 25699057.
2015
Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction.
Journal of genetics and genomics = Yi chuan xue bao.
42(6):287-99
[DOI] 10.1016/j.jgg.2015.04.002.
[PMID] 26165495.
2015
CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.
Molecular bioSystems.
11(1):105-14
[DOI] 10.1039/c4mb00513a.
[PMID] 25325377.
2015
Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands
Journal of Innate Immunity.
7(4):428-440
[DOI] 10.1159/000371517.
[PMID] 25896300.
2015
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures.
Cell & bioscience.
5(1)
[DOI] 10.1186/2045-3701-5-1.
[PMID] 25601894.
2015
miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer.
Oral oncology.
51(2):151-7
[DOI] 10.1016/j.oraloncology.2014.11.019.
[PMID] 25500095.
2015
Our Journey from the Study of Human Autoantibodies to the microRNA World.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00110.
[PMID] 25814992.
2015
Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00412.
[PMID] 26347739.
2015
The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00181.
[PMID] 25954274.
2014
Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests.
The Journal of rheumatology.
41(7):1334-43
[DOI] 10.3899/jrheum.131450.
[PMID] 24931955.
2014
Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy.
16(1)
[DOI] 10.1186/ar4448.
[PMID] 24451065.
2014
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Cellular and molecular life sciences : CMLS.
71(15):2963-73
[DOI] 10.1007/s00018-014-1567-6.
[PMID] 24477477.
2014
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies.
Annals of the rheumatic diseases.
73(1):17-23
[DOI] 10.1136/annrheumdis-2013-203863.
[PMID] 24126457.
2014
miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.
Molecular cancer.
13
[DOI] 10.1186/1476-4598-13-80.
[PMID] 24708873.
2014
Molecular cell biology and immunobiology of mammalian rod/ring structures.
International review of cell and molecular biology.
308:35-74
[DOI] 10.1016/B978-0-12-800097-7.00002-6.
[PMID] 24411169.
2014
Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology.
34(2):171-80
[DOI] 10.1007/s10875-013-9973-3.
[PMID] 24292724.
2014
Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis.
Clinical and experimental rheumatology.
32(6):891-7
[PMID] 25151986.
2014
Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy.
16(1)
[DOI] 10.1186/ar4451.
[PMID] 24460726.
2014
Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
23(11):2492-502
[DOI] 10.1158/1055-9965.EPI-14-0429.
[PMID] 25086100.
2014
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α.
Immunologic research.
60(1):38-49
[DOI] 10.1007/s12026-014-8515-2.
[PMID] 24845459.
2013
An SNP in the trinucleotide repeat region of the TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182.
Advances in experimental medicine and biology.
768:243-59
[DOI] 10.1007/978-1-4614-5107-5_14.
[PMID] 23224974.
2013
Antinuclear antibody test: when to order?
The American journal of medicine.
126(10)
[DOI] 10.1016/j.amjmed.2013.04.022.
[PMID] 24054962.
2013
Autoantibodies to Argonaute 2 (Su antigen).
Advances in experimental medicine and biology.
768:45-59
[DOI] 10.1007/978-1-4614-5107-5_4.
[PMID] 23224964.
2013
Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients.
Journal of clinical immunology.
33(2):420-6
[DOI] 10.1007/s10875-012-9827-4.
[PMID] 23100146.
2013
Function of GW182 and GW bodies in siRNA and miRNA pathways.
Advances in experimental medicine and biology.
768:71-96
[DOI] 10.1007/978-1-4614-5107-5_6.
[PMID] 23224966.
2013
Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara.
Arthritis research & therapy.
15(2)
[DOI] 10.1186/ar4207.
[PMID] 23557279.
2013
Introduction: the GW body story as an example of autoantibodies with significant impacts to molecular cell biology.
Advances in experimental medicine and biology.
768:1-4
[DOI] 10.1007/978-1-4614-5107-5_1.
[PMID] 23224961.
2013
MicroRNA-146a in autoimmunity and innate immune responses.
Annals of the rheumatic diseases.
72 Suppl 2(Suppl 2):ii90-5
[DOI] 10.1136/annrheumdis-2012-202203.
[PMID] 23253933.
2013
Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research.
Advances in experimental medicine and biology.
768:261-70
[DOI] 10.1007/978-1-4614-5107-5_15.
[PMID] 23224975.
2013
Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212.
Journal of immunology (Baltimore, Md. : 1950).
190(3):1250-63
[DOI] 10.4049/jimmunol.1103060.
[PMID] 23264652.
2013
Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.
Arthritis research & therapy.
15(2)
[DOI] 10.1186/ar4210.
[PMID] 23587095.
2013
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.
Cancer discovery.
3(2):182-97
[DOI] 10.1158/2159-8290.CD-12-0292.
[PMID] 23306062.
2013
The discovery of GW bodies.
Advances in experimental medicine and biology.
768:5-21
[DOI] 10.1007/978-1-4614-5107-5_2.
[PMID] 23224962.
2013
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.
Molecular biology of the cell.
24(11):1638-48, S1
[DOI] 10.1091/mbc.E12-12-0891.
[PMID] 23552692.
2012
A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis.
Arthritis research & therapy.
14(3)
[DOI] 10.1186/ar3858.
[PMID] 22643159.
2012
Anti-Mj/Nxp-2 Antibodies Are the Most Common Specifcity in a Cohort of Adult Caucasian Patients With Dermatomyositis
Annals of the Rheumatic Diseases.
71(Suppl 1):A49-A49
[DOI] 10.1136/annrheumdis-2011-201235.17.
2012
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[PMID] 9210612.
1997
Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis.
Chromosoma.
106(1):11-9
[PMID] 9169582.
1997
Immune response to cyclin B1 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.).
25(1):75-80
[PMID] 8985268.
1997
Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping.
Genomics.
41(1):135-8
[PMID] 9126496.
1997
The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex.
Arthritis and rheumatism.
40(5):936-44
[PMID] 9153557.
1996
17-beta-estradiol increases expression of 52-kDa and 60-kDa SS-A/Ro autoantigens in human keratinocytes and breast cancer cell line MCF-7.
The Journal of investigative dermatology.
107(4):610-4
[PMID] 8823369.
1996
Biographical sketch and scientific contributions of Eng M. Tan
Molecular Biology Reports.
23(3):129-130
1996
cDNA cloning and characterization of a novel nucleolar protein.
Molecular biology of the cell.
7(7):1015-24
[PMID] 8862517.
1996
Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro.
Molecular biology reports.
23(3-4):205-10
[PMID] 9112230.
1996
Comparison of protocols for depleting anti-E. coli antibody in immunoblotting of recombinant antigens.
Journal of immunological methods.
190(1):143-5
[PMID] 8601707.
1996
Exon 1 sequence of the human B2 bradykinin receptor gene and its transcript.
Immunopharmacology.
33(1-3):90-2
[PMID] 8856121.
1996
Simplifying 5’RACE in the hunt for full-length cDNAs.
Trends in genetics : TIG.
12(10):389-91
[PMID] 8909129.
1996
Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block.
The Journal of rheumatology.
23(5):925-32
[PMID] 8724310.
1995
52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
The Journal of experimental medicine.
182(4):983-92
[PMID] 7561701.
1995
A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells.
Biochemical and biophysical research communications.
207(3):1029-37
[PMID] 7864889.
1995
Formation of nuclear bodies in hepatocytes of estrogen-treated roosters.
Molecular biology of the cell.
6(3):345-56
[PMID] 7612968.
1995
Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature.
The Journal of biological chemistry.
270(52):31262-8
[PMID] 8537393.
1995
Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.
Clinical and experimental immunology.
100(1):67-74
[PMID] 7697925.
1995
p80-coilin: a component of coiled bodies and interchromatin granule-associated zones.
Journal of cell science.
108 ( Pt 3):1143-53
[PMID] 7622600.
1994
A microscale method for depleting cross-reactive anti-antibodies used in indirect immunofluorescence microscopy.
Journal of immunological methods.
176(2):271-3
[PMID] 7983385.
1994
Autoantibody responses to the “native” 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren’s syndrome.
Journal of immunology (Baltimore, Md. : 1950).
152(7):3675-84
[PMID] 7511655.
1994
Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization.
Genomics.
23(1):298-300
[PMID] 7829096.
1994
Immunocytochemical characterization of human NOR-90 (upstream binding factor) and associated antigens reactive with autoimmune sera. Two MR forms of NOR-90/hUBF autoantigens.
Molecular biology reports.
19(2):115-24
[PMID] 8072492.
1994
Is the coiled body involved in nucleolar functions?
Experimental Cell Research.
211(2):415-419
1994
Structure, expression and chromosomal localization of human p80-coilin gene
.
22(21):4462-4469
1993
Autoantibodies in viral hepatitis-related hepatocellular carcinoma.
Intervirology.
35(1-4):73-85
[PMID] 8407252.
1993
Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice.
Clinical immunology and immunopathology.
68(3):350-6
[PMID] 8370186.
1993
Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjögren’s syndrome
Journal of Immunology.
150(8):3615-3623
1993
Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America.
90(5):1947-51
[PMID] 8446613.
1993
Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La.
Arthritis and rheumatism.
36(11):1588-98
[PMID] 8240435.
1993
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Journal of virology.
67(7):3798-807
[PMID] 8389906.
1993
Molecular biology of autoantigens and new insights into autoimmunity.
The Clinical investigator.
71(4):327-30
[PMID] 7682458.
1993
Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.
The Journal of experimental medicine.
178(1):49-62
[PMID] 8315394.
1993
Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.
The Journal of clinical investigation.
92(5):2419-26
[PMID] 8227358.
1992
Antinuclear antibodies in Sjögren’s syndrome.
Rheumatic diseases clinics of North America.
18(3):551-70
[PMID] 1496161.
1991
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.
The Journal of experimental medicine.
173(6):1407-19
[PMID] 2033369.
1991
Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor.
The Journal of experimental medicine.
174(5):1239-44
[PMID] 1940801.
1991
Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies.
Experimental cell research.
195(1):27-37
[PMID] 2055273.
1991
Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex.
The Journal of experimental medicine.
173(4):941-52
[PMID] 2007859.
1991
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
The Journal of clinical investigation.
87(1):68-76
[PMID] 1985112.
1990
Association between the nucleolus and the coiled body.
Journal of structural biology.
104(1-3):120-7
[PMID] 2088441.
1990
Effective separation of the 52 kDa SSA/Ro polypeptide from the 48 kDa SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis.
Journal of immunological methods.
129(2):207-10
[PMID] 2351837.
1990
In vitro posttranslational modification of lamin B cloned from a human T-cell line.
Molecular and cellular biology.
10(5):2164-75
[PMID] 2325650.
1989
Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögren’s syndrome.
Current opinion in rheumatology.
1(3):376-81
[PMID] 2484307.
1989
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.
Nucleic acids research.
17(6):2233-44
[PMID] 2468131.
1989
Sjögren’s syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes.
Journal of autoimmunity.
2(4):321-7
[PMID] 2476998.
1989
Viral genomes in lymphomas of patients with Sjögren’s syndrome.
Journal of autoimmunity.
2(4):449-55
[PMID] 2571338.
1988
A 52-kD protein is a novel component of the SS-A/Ro antigenic particle.
The Journal of experimental medicine.
167(5):1560-71
[PMID] 3367095.
1988
Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity.
Clinical immunology and immunopathology.
47(2):121-41
[PMID] 3280190.
1988
Treatment of primary Sjögren’s syndrome with hydroxychloroquine
The American journal of medicine.
85(4):62-67
1987
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.
The Journal of experimental medicine.
166(6):1627-40
[PMID] 2445893.
1987
Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease.
Clinical immunology and immunopathology.
44(1):31-40
[PMID] 3496180.
1987
The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons.
Molecular and cellular biology.
7(7):2588-91
[PMID] 2441242.
1986
Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs.
Virology.
152(1):87-99
[PMID] 3012876.
1986
Epitopes and structural domains of a RNA-binding nuclear protein, SS-B/La: similarities with adenovirus DNA-binding protein.
Scandinavian journal of rheumatology. Supplement.
61:102-5
[PMID] 2438757.
1986
Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein.
Journal of immunology (Baltimore, Md. : 1950).
136(10):3744-9
[PMID] 2422260.
1986
IgG subclasses of autoantibodies in systemic lupus erythematosus, Sjogren’s syndrome, and drug-induced autoimmunity.
Journal of immunology (Baltimore, Md. : 1950).
137(8):2528-34
[PMID] 3760566.
1985
Characterization and purification of lupus antigen La, and RNA-binding protein
Molecular And Cellular Biology.
5(3):586-590
1980
Preparation of covalently linked immune complexes of specific composition
Journal of Immunological Methods.
33(1):55-61
Grants
Jun 2016
– May 2019
Influence of Innate Immunity on Xenobiotic-lnduced Systemic Autoimmunity
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST
via NATL INST OF HLTH NIEHS
Dec 2015
– Feb 2019
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2015
– Sep 2017
Antinuclear Antibodies by Immunofluorescence
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Jun 2015
– May 2017
Dr. Chan
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Jun 2015
– May 2016
Influence of Innate Immunity on Xenobiotic-Induced Systemic Autoimmunity
Role: Principal Investigator
Funding: SCRIPPS RESEARCH INST
via NATL INST OF HLTH NIEHS
Feb 2015
– Jan 2020
UF Health Cancer Center Collaborative Cancer Related Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2012
– Dec 2016
Ethnic heterogeneity in microRNA expression as a biomarker in rheumatoid arthritis
Role: Principal Investigator
Funding: PFIZER INC
Sep 2012
– Aug 2022
DSR Matching Support – Support for NSF Fellowship
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jun 2012
– May 2017
Functional Elucidation of Aberrant MicroRNA Expresstion in Oral Cancer
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2010
– Jun 2016
Expression and function of microRNA in autoimmune Sjogren's Syndrome
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Jul 2006
– Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS
Contact Details
Phones:
- Business:
- (352) 273-8849
Emails:
- Business:
- echan@ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 100424
DEPARTMENT OF ORAL BIOLOGY
GAINESVILLE FL 326100424 - Business Street:
-
PO BOX 100424
D5-22
GAINESVILLE FL 326100424