Seunghee Cha

Seunghee Cha, D.D.S., Ph.D.

Professor

Department: DN-ORAL MEDICINE
Business Phone: (352) 273-5849
Business Email: scha@dental.ufl.edu

Clinical Profile

Specialties
  • Dentistry
Subspecialties
  • Oral and Maxillofacial Diagnostic Sciences
Areas of Interest
  • Burning Mouth Syndrome
  • Oral cancer
  • Sjögren syndrome

Publications

2021
Labial salivary gland assessment in idiopathic pulmonary fibrosis patients with sicca symptoms.
Oral surgery, oral medicine, oral pathology and oral radiology. 132(4):434-440 [DOI] 10.1016/j.oooo.2021.03.014. [PMID] 34274288.
2021
Localization and characterization of human papillomavirus-16 in oral squamous cell carcinoma
Oral Diseases. [DOI] 10.1111/odi.13920. [PMID] 34022097.
2021
The Diagnostic Performance of Early Sjögren’s Syndrome Autoantibodies in Juvenile Sjögren’s Syndrome: The University of Florida Pediatric Cohort Study.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.704193. [PMID] 34249010.
2020
Childhood Sjögren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria.
Rheumatology (Oxford, England). [DOI] 10.1093/rheumatology/keaa757. [PMID] 33280020.
2020
Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sjögren’s syndrome.
Clinical and experimental rheumatology. [PMID] 33124573.
View on: PubMed
2020
Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study.
BMJ open. 10(9) [DOI] 10.1136/bmjopen-2019-033542. [PMID] 32998913.
2020
Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors.
International journal of molecular sciences. 21(23) [DOI] 10.3390/ijms21239055. [PMID] 33260559.
2020
The first case of monozygotic twin boys with nearly identical features of Sjögren’s syndrome.
Rheumatology (Oxford, England). 59(3):687-688 [DOI] 10.1093/rheumatology/kez428. [PMID] 31566227.
2019
HPV-related oral dysplasia in a multiple myeloma patient after stem cell transplantation.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 39(1):51-55 [DOI] 10.1111/scd.12344. [PMID] 30431178.
2019
MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells
International Journal of Molecular Sciences. 20(3) [DOI] 10.3390/ijms20030767. [PMID] 30759717.
2019
Novel Discovery of LINE-1 in a Korean Individual by a Target Enrichment Method
Molecules and Cells. 42(1):87-95 [DOI] 10.14348/molcells.2018.0351. [PMID] 30699287.
2018
Increased expression of interferon-λ in minor salivary glands of patients with primary Sjögren’s syndrome and its synergic effect with interferon-α on salivary gland epithelial cells.
Clinical and experimental rheumatology. 36 Suppl 112(3):31-40 [PMID] 28421993.
View on: PubMed
2018
Low-power laser irradiation decreases lipid droplet accumulation in the parotid glands of diabetic rats.
Journal of biophotonics. 11(4) [DOI] 10.1002/jbio.201700179. [PMID] 29112328.
2018
MicroRNAs in Autoimmune Sjögren’s Syndrome.
Genomics & informatics. 16(4) [DOI] 10.5808/GI.2018.16.4.e19. [PMID] 30602080.
2017
The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System.
Current drug delivery. 14(4):581-586 [DOI] 10.2174/1567201813666161013150648. [PMID] 27739377.
2017
Uncovering stem cell differentiation factors for salivary gland regeneration by quantitative analysis of differential proteomes.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0169677. [PMID] 28158262.
2016
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren’s syndrome.
Journal of immunological methods. 437:28-36 [DOI] 10.1016/j.jim.2016.07.003. [PMID] 27460476.
2016
Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease.
Anaerobe. 38:70-75 [DOI] 10.1016/j.anaerobe.2015.10.005. [PMID] 26481834.
2016
Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review.
Stem cells international. 2016 [DOI] 10.1155/2016/9305986. [PMID] 26798366.
2016
Sjögren’s syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-0987-0. [PMID] 27142093.
2015
Comparison of Pen-Implant Bone Formation Around Injection-Molded and Machined Surface Zirconia Implants in Rabbit Tibiae
Dental Materials Journal. 34(4):508-515 [DOI] 10.4012/dmj.2015-024. [PMID] 26235717.
2015
Dysregulated co-stimulatory molecule expression in a Sjögren’s syndrome mouse model with potential implications by microRNA-146a.
Molecular immunology. 68(2 Pt C):606-16 [DOI] 10.1016/j.molimm.2015.09.027. [PMID] 26505653.
2015
Epigenetic alteration of the purinergic type 7 receptor in salivary epithelial cells.
Biochemical and biophysical research communications. 466(4):704-10 [DOI] 10.1016/j.bbrc.2015.09.095. [PMID] 26399685.
2015
Mouse Models of Primary Sjogren’s Syndrome
Current Pharmaceutical Design. 21(18):2350-2364
2014
Akt2 Deficiency as a Therapeutic Strategy Protects Against Acute Lung Injury
Immunotherapy. 6(4):377-380 [DOI] 10.2217/imt.14.5. [PMID] 24815778.
2014
Identification of regulatory factors for mesenchymal stem cell-derived salivary epithelial cells in a co-culture system.
PloS one. 9(11) [DOI] 10.1371/journal.pone.0112158. [PMID] 25402494.
2014
Microrna-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule Cd80 Expression and Increases Autoreactive T Cell Activation in Sjogren’s Syndrome.
Arthritis & Rheumatology. 66(10, SI)
2013
Autoantibodies Against Muscarinic Type 3 Receptor in Sjogren’s Syndrome Inhibit Aquaporin 5 Trafficking
PLoS One. 8(1) [DOI] 10.1371/journal.pone.0053113. [PMID] 23382834.
2013
Interleukin-7 enhances the Th1 response to promote the development of Sjögren’s syndrome-like autoimmune exocrinopathy in mice.
Arthritis and rheumatism. 65(8):2132-42 [DOI] 10.1002/art.38007. [PMID] 23666710.
2012
Animal Models in Autoimmune Diseases: Lessons Learned From Mouse Models for Sjogren’S Syndrome
Clinical Reviews in Allergy & Immunology. 42(1):35-44 [DOI] 10.1007/s12016-011-8288-5. [PMID] 22105703.
2012
Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
Molecular pharmacology. 82(1):115-24 [DOI] 10.1124/mol.111.077354. [PMID] 22511543.
2011
A Secretagogue-Small Interfering Rna Conjugate Confers Resistance To Cytotoxicity in a Cell Model of Sjogren’S Syndrome
Arthritis and Rheumatism. 63(10):3116-3125 [DOI] 10.1002/art.30450. [PMID] 21567383.
2011
Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity.
European journal of immunology. 41(7):2029-39 [DOI] 10.1002/eji.201040757. [PMID] 21469088.
2011
Ligneous gingivitis associated with plasminogen deficiency: a challenge in diagnosis.
Journal of investigative and clinical dentistry. 2(3):207-11 [DOI] 10.1111/j.2041-1626.2011.00066.x. [PMID] 25426793.
2011
Loss of Pkc Delta Results in Characteristics of Sjogren’S Syndrome Including Salivary Gland Dysfunction
Oral Diseases. 17(6):601-609 [DOI] 10.1111/j.1601-0825.2011.01819.x. [PMID] 21702866.
2011
miRNA-146a in rheumatoid arthritis: a new therapeutic strategy.
Immunotherapy. 3(7):829-31 [DOI] 10.2217/imt.11.70. [PMID] 21751952.
2011
Presence of Porphyromonas Gingivalis in Gingival Squamous Cell Carcinoma
International Journal of Oral Science. 3(4):209-215 [DOI] 10.4248/IJOS11075. [PMID] 22010579.
2010
Cip2a Expression and Localization in Oral Carcinoma and Dysplasia
Cancer biology & therapy. 10(7):694-699 [DOI] 10.4161/cbt.10.7.12895. [PMID] 21068540.
2010
Epigenetics in autoimmune disorders: highlights of the 10th Sjögren’s syndrome symposium.
Autoimmunity reviews. 9(9):627-30 [DOI] 10.1016/j.autrev.2010.05.011. [PMID] 20452464.
2010
Formation of Gw/P Bodies as Marker for Microrna-Mediated Regulation of Innate Immune Signaling in Thp-1 Cells
Immunology and Cell Biology. 88(2):205-212 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2010
Gingival Rage Expression in Calorie-Restricted Versus Ad Libitum-Fed Rats
Journal of Periodontology. 81(10):1481-1487 [DOI] 10.1902/jop.2010.100019. [PMID] 20572766.
2010
Periodontal Disease and the Oral-Systemic Connection: “Is It All the Rage?”
Quintessence International. 41:229-237
2010
Periodontal disease and the oral-systemic connection: “is it all the RAGE?”.
Quintessence International. 41(3):229-37 [PMID] 20213024.
View on: PubMed
2009
Inflammatory Caspases Are Critical for Enhanced Cell Death in the Target Tissue of Sjogren’s Syndrome Before Disease Onset
Immunology and Cell Biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
2009
Microrna in Autoimmunity and Autoimmune Diseases
Journal of Autoimmunity. 32(3-4):189-194 [DOI] 10.1016/j.jaut.2009.02.012. [PMID] 19303254.
2009
Rage Expression and Nf-Kappa B Activation Attenuated By Extracellular Domain of Rage in Human Salivary Gland Cell Line
Journal of Cellular Physiology. 221(2):430-434 [DOI] 10.1002/jcp.21873. [PMID] 19591173.
2008
Decreased Levels of Soluble Receptor for Advanced Glycation End Products in Patients With Primary Sjogren’S Syndrome
Rheumatology International. 28(8):771-776 [DOI] 10.1007/s00296-008-0529-4. [PMID] 18231794.
2008
Salivary Dysfunction and Quality of Life in Sjogren Syndrome – a Critical Oral-Systemic Connection
Journal of the American Dental Association. 139:291-299
2008
Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association (1939). 139(3):291-9; quiz 358 [PMID] 18310733.
View on: PubMed
2002
Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 13(1):5-16 [PMID] 12097234.
View on: PubMed
2002
Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren’s syndrome) on a healthy murine background.
Arthritis and rheumatism. 46(5):1390-8 [PMID] 12115247.
View on: PubMed
1989
Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
The Journal of infectious diseases. 159(5):959-65 [PMID] 2540249.
View on: PubMed

Grants

Sep 2021 ACTIVE
Cytoplasmic mitochondrial dsRNA in pediatric Sj?grens syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2021 ACTIVE
Innate Immunity in the Sj?grens syndrome mouse model
Role: Principal Investigator
Funding: MITOBRIDGE
Mar 2021 ACTIVE
Targeting P2 receptors to restore salivary and lacrimal gland function in sjogren's syndrome
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NIDCR
Oct 2020 – Sep 2021
STING in Sjogren's syndrome
Role: Principal Investigator
Funding: MITOBRIDGE
Sep 2020 ACTIVE
Integrated transcriptomic profiling of recurrent parotitis in pediatric Sj?grens syndrome for assessment of mitochondrial RNA regulators
Role: Principal Investigator
Funding: SJOGRENS SYNDROME FOU
Sep 2020 – Aug 2021
Mechanisms and therapeutic modulation of T cell autoimmune responses in Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Sep 2016 – Aug 2020
Facilitation of stem cell differentiation in severely injured salivary glands
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2020
Regulation and Function of Interleukin-7 in Primary Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2017
IDENTIFICATION OF SALIVARY EPITHELIAL PRECURSOR INDUCINGFACTORS
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Jul 2010 – Jun 2016
Expression and function of microRNA in autoimmune Sjogren's Syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Teaching Profile

Courses Taught
2014-2021
DEN8767L Clin Oncology and Path
2018-2021
DEN5120C Physiology
2011-2014,2016-2021
DEN6260 Oral Med/Den Pharmaco
2018
DEN6971 Research for Master’s Thesis
2018
GMS7979 Advanced Research
2009,2011-2017,2017
IDH4905 Individual Work
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014
DEN7540 Special Topics
2011-2013
DEN8765L Cln Radiol 2 Interpre
2011-2013
DEN7762L Cln Rad 1 Radiograph
2011-2012
GMS6161 Introduction to Oral Biology II
2009
DEN8290 Special Topics

Contact Details

Phones:
Business:
(352) 273-5849
Emails: