Seunghee Cha

Seunghee Cha, DDS, PhD

Professor

Department: DN-ORAL MEDICINE

About Seunghee Cha

Additional Positions:
Director
2018 – Current · Center for Orphaned Autoimmune Disorders

Accomplishments

FEO award for Leadership in Health and Wellbeing
2022-2023 · University of Florida
Distinguished Professorship Award
2018-2021 · University of Florida Research Foundation
Term Professorship Award
2017-2020 · University of Florida
Distinguished Mentor Award
2014 · Howard Hughes Medical Institute and UF
Excellence Aawrd for Assistant Professor
2012 · University of Florida
Outstanding Abstract Award
2010 · Sjogren's Syndrome Foundation
Award for Outstanding Academic Achievement
1998 · The Office of International Studies and Programs at the University of Florida
Valedictorian
1993 · Yonsei University College of Dentistry

Teaching Profile

Courses Taught
2014-2024
DEN8767L Clin Oncology and Path
2018-2022
DEN5120C Physiology
2011-2014,2016-2022
DEN6260 Oral Med/Den Pharmaco
2018
DEN6971 Research for Master’s Thesis
2018
GMS7979 Advanced Research
2009,2011-2017,2017
IDH4905 Individual Work
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014
DEN7540 Special Topics
2011-2013
DEN8765L Cln Radiol 2 Interpre
2011-2013
DEN7762L Cln Rad 1 Radiograph
2011-2012
GMS6161 Introduction to Oral Biology II
2009
DEN8290 Special Topics
2022
PHC7918 Independent Study

Clinical Profile

Specialties
  • Dentistry
Subspecialties
  • Oral Medicine
  • Oral and Maxillofacial Diagnostic Sciences
Areas of Interest
  • Head and Neck Cancer
  • Salivary gland disorders
  • Sjögren syndrome

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3772-1832

Areas of Interest
  • Autoimmune Disease
  • Clinical outcomes studies
  • Clinical therapeutic studies
  • Clustering and classification
  • biomarker discovery

Publications

2024
Increased prevalence of erythema multiforme in patients with COVID-19 infection or vaccination
Scientific Reports. 14(1) [DOI] 10.1038/s41598-024-52099-z. [PMID] 38307870.
2023
A lower prevalence of malignant lymphoma in Sjögren’s syndrome patients: A cross‐sectional study
Oral Diseases. 29(8):3313-3324 [DOI] 10.1111/odi.14435.
2023
Dens Evaginatus of Bilateral Permanent Mandibular Premolars with Pulpal Involvement: A Case Report
Open Access Journal of Dental and Oral Surgery (OAJDOS). 4(2):1-3 [DOI] 10.54026/oajdos/1059.
2023
Intraoperative Visualization and Treatment of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients Using Contrast-Enhanced Ultrasound Sialendoscopy (CEUSS)
Journal of Clinical Medicine. 12(12) [DOI] 10.3390/jcm12124152. [PMID] 37373845.
2023
Lichen planus after COVID‐19 infection and vaccination
Oral Diseases. [DOI] 10.1111/odi.14834.
2023
Localization and characterization of human papillomavirus-16 in oral squamous cell carcinoma.
Oral diseases. 29(2):436-444 [DOI] 10.1111/odi.13920. [PMID] 34022097.
2023
Long-term efficacy of sialendoscopy in treating childhood Sjögren’s disease with chronological monitoring by salivary gland ultrasonography: A novel approach.
Pediatric rheumatology online journal. 21(1) [DOI] 10.1186/s12969-023-00870-3. [PMID] 37574559.
2023
Review for “The minimally important difference for the Xerostomia Inventory among Sjögren’s disease patients”
. [DOI] 10.1111/odi.14841/v2/review2.
2023
The minimally important difference for the Xerostomia Inventory among Sjögren’s disease patients.
Oral diseases. [DOI] 10.1111/odi.14841. [PMID] 38148483.
2023
Therapeutic potential for P2Y2 receptor antagonism
Purinergic Signalling. 19(2):401-420 [DOI] 10.1007/s11302-022-09900-3. [PMID] 36219327.
2022
Diagnosis of Sjögren’s disease
Clinical Dentistry Reviewed. 6(1) [DOI] 10.1007/s41894-022-00124-7.
2022
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome.
Molecular therapy. Nucleic acids. 30:257-269 [DOI] 10.1016/j.omtn.2022.09.020. [PMID] 36284513.
2022
The inflammatory signature in monocytes of Sjögren’s syndrome and systemic lupus erythematosus, revealed by the integrated Reactome and drug target analysis.
Genes & genomics. 44(10):1215-1229 [DOI] 10.1007/s13258-022-01308-y. [PMID] 36040684.
2021
Labial salivary gland assessment in idiopathic pulmonary fibrosis patients with sicca symptoms
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 132(4):434-440 [DOI] 10.1016/j.oooo.2021.03.014.
2021
Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies
Journal of Clinical Advances in Dentistry. 5(1):005-011 [DOI] 10.29328/journal.jcad.1001024.
2021
The Diagnostic Performance of Early Sjögren’s Syndrome Autoantibodies in Juvenile Sjögren’s Syndrome: The University of Florida Pediatric Cohort Study.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.704193. [PMID] 34249010.
2020
Childhood Sjögren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria.
Rheumatology (Oxford, England). [DOI] 10.1093/rheumatology/keaa757. [PMID] 33280020.
2020
Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sjögren’s syndrome.
Clinical and experimental rheumatology. [PMID] 33124573.
2020
Questionable Reliability of Malondialdehyde to Measure Oxidative Stress in Sjögren’s Syndrome: Preliminary Study
Journal of Oral Medicine and Pain. 45(4):89-96 [DOI] 10.14476/jomp.2020.45.4.89.
2019
HPV-related oral dysplasia in a multiple myeloma patient after stem cell transplantation.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 39(1):51-55 [DOI] 10.1111/scd.12344. [PMID] 30431178.
2019
MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells
International Journal of Molecular Sciences. 20(3) [DOI] 10.3390/ijms20030767. [PMID] 30759717.
2019
Novel Discovery of LINE-1 in a Korean Individual by a Target Enrichment Method
Molecules and Cells. 42(1):87-95 [DOI] 10.14348/molcells.2018.0351. [PMID] 30699287.
2018
Increased expression of interferon-λ in minor salivary glands of patients with primary Sjögren’s syndrome and its synergic effect with interferon-α on salivary gland epithelial cells.
Clinical and experimental rheumatology. 36 Suppl 112(3):31-40 [PMID] 28421993.
2018
MicroRNAs in Autoimmune Sjögren’s Syndrome
Genomics & Informatics. 16(4) [DOI] 10.5808/gi.2018.16.4.e19.
2017
The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System.
Current drug delivery. 14(4):581-586 [DOI] 10.2174/1567201813666161013150648. [PMID] 27739377.
2017
Uncovering stem cell differentiation factors for salivary gland regeneration by quantitative analysis of differential proteomes.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0169677. [PMID] 28158262.
2016
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren’s syndrome.
Journal of immunological methods. 437:28-36 [DOI] 10.1016/j.jim.2016.07.003. [PMID] 27460476.
2016
Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease.
Anaerobe. 38:70-75 [DOI] 10.1016/j.anaerobe.2015.10.005. [PMID] 26481834.
2016
Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review.
Stem cells international. 2016 [DOI] 10.1155/2016/9305986. [PMID] 26798366.
2016
Sjögren’s syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-0987-0. [PMID] 27142093.
2015
Comparison of peri-implant bone formation around injection-molded and machined surface zirconia implants in rabbit tibiae.
Dental materials journal. 34(4):508-15 [DOI] 10.4012/dmj.2015-024. [PMID] 26235717.
2015
Mouse Models of Primary Sjogren’s Syndrome
Current Pharmaceutical Design. 21(18):2350-2364
2014
Identification of regulatory factors for mesenchymal stem cell-derived salivary epithelial cells in a co-culture system.
PloS one. 9(11) [DOI] 10.1371/journal.pone.0112158. [PMID] 25402494.
2014
Microrna-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule Cd80 Expression and Increases Autoreactive T Cell Activation in Sjogren’s Syndrome.
Arthritis & Rheumatology. 66(10, SI)
2013
Autoantibodies Against Muscarinic Type 3 Receptor in Sjogren’s Syndrome Inhibit Aquaporin 5 Trafficking
PLoS One. 8(1) [DOI] 10.1371/journal.pone.0053113. [PMID] 23382834.
2013
Interleukin-7 enhances the Th1 response to promote the development of Sjögren’s syndrome-like autoimmune exocrinopathy in mice.
Arthritis and rheumatism. 65(8):2132-42 [DOI] 10.1002/art.38007. [PMID] 23666710.
2012
Animal models in autoimmune diseases: lessons learned from mouse models for Sjögren’s syndrome.
Clinical reviews in allergy & immunology. 42(1):35-44 [DOI] 10.1007/s12016-011-8288-5. [PMID] 22105703.
2012
Muscarinic Type 3 Receptor Induces Cytoprotective Signaling in Salivary Gland Cells Through Epidermal Growth Factor Receptor Transactivation
Molecular Pharmacology. 82(1):115-124 [DOI] 10.1124/mol.111.077354. [PMID] 22511543.
2011
A Secretagogue-Small Interfering Rna Conjugate Confers Resistance To Cytotoxicity in a Cell Model of Sjogren’S Syndrome
Arthritis and Rheumatism. 63(10):3116-3125 [DOI] 10.1002/art.30450. [PMID] 21567383.
2011
Ligneous gingivitis associated with plasminogen deficiency: a challenge in diagnosis.
Journal of investigative and clinical dentistry. 2(3):207-11 [DOI] 10.1111/j.2041-1626.2011.00066.x. [PMID] 25426793.
2011
Loss of PKCδ results in characteristics of Sjögren’s syndrome including salivary gland dysfunction.
Oral diseases. 17(6):601-9 [DOI] 10.1111/j.1601-0825.2011.01819.x. [PMID] 21702866.
2010
CIP2A expression and localization in oral carcinoma and dysplasia.
Cancer biology & therapy. 10(7):694-9 [DOI] 10.4161/cbt.10.7.12895. [PMID] 21068540.
2010
Epigenetics in autoimmune disorders: highlights of the 10th Sjögren’s syndrome symposium.
Autoimmunity reviews. 9(9):627-30 [DOI] 10.1016/j.autrev.2010.05.011. [PMID] 20452464.
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology. 88(2):205-12 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2010
Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats.
Journal of periodontology. 81(10):1481-7 [DOI] 10.1902/jop.2010.100019. [PMID] 20572766.
2010
Periodontal Disease and the Oral-Systemic Connection: “Is It All the Rage?”
Quintessence International. 41:229-237
2010
Periodontal disease and the oral-systemic connection: “is it all the RAGE?”.
Quintessence international (Berlin, Germany : 1985). 41(3):229-37 [PMID] 20213024.
2009
Inflammatory Caspases Are Critical for Enhanced Cell Death in the Target Tissue of Sjogren’s Syndrome Before Disease Onset
Immunology and Cell Biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
2009
MicroRNA in autoimmunity and autoimmune diseases.
Journal of autoimmunity. 32(3-4):189-94 [DOI] 10.1016/j.jaut.2009.02.012. [PMID] 19303254.
2009
Rage Expression and Nf-Kappa B Activation Attenuated By Extracellular Domain of Rage in Human Salivary Gland Cell Line
Journal of Cellular Physiology. 221(2):430-434 [DOI] 10.1002/jcp.21873. [PMID] 19591173.
2008
Decreased Levels of Soluble Receptor for Advanced Glycation End Products in Patients With Primary Sjogren’S Syndrome
Rheumatology International. 28(8):771-776 [DOI] 10.1007/s00296-008-0529-4. [PMID] 18231794.
2008
Salivary Dysfunction and Quality of Life in Sjogren Syndrome – a Critical Oral-Systemic Connection
Journal of the American Dental Association. 139:291-299
2008
Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association (1939). 139(3):291-9; quiz 358 [PMID] 18310733.
2002
Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.
Critical Reviews in Oral Biology and Medicine. 13(1):5-16 [PMID] 12097234.
1989
Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
The Journal of infectious diseases. 159(5):959-65 [PMID] 2540249.
In Print
The novel Florida Scoring System for stratifying children suspected of Sjögren’s disease: the first data-driven analysis applied to a rare prospective pediatric cohort
The Lancet Rheumatology.
In Print
Unveiling novel transcriptomic profiles and interplay of immune subsets in rare condition of autoimmune childhood Sjögren’s disease
Communications Biology.

Grants

Sep 2023 ACTIVE
PKR sensing of mitochondrial dsRNA in childhood Sjogrens disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2022 ACTIVE
Phase I/IIa Clinical Trial Using Localized and Systemic Delivery of the P2X7 Receptor Antagonist AZD9056 for the Treatment of Salivary Gland Dysfunction in Sj?grens Syndrome Patients
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NIAID
Sep 2021 ACTIVE
Cytoplasmic mitochondrial dsRNA in pediatric Sj?grens syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2021 – Jul 2023
Innate Immunity in the Sj?grens syndrome mouse model
Role: Principal Investigator
Funding: MITOBRIDGE
Mar 2021 ACTIVE
Targeting P2 receptors to restore salivary and lacrimal gland function in sjogren's syndrome
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NIDCR
Oct 2020 – Sep 2021
STING in Sjogren's syndrome
Role: Principal Investigator
Funding: MITOBRIDGE
Sep 2020 – Dec 2023
Integrated transcriptomic profiling of recurrent parotitis in pediatric Sj?grens syndrome for assessment of mitochondrial RNA regulators
Role: Principal Investigator
Funding: SJOGRENS SYNDROME FOU
Sep 2020 – Aug 2022
Mechanisms and therapeutic modulation of T cell autoimmune responses in Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Sep 2016 – Aug 2020
Facilitation of stem cell differentiation in severely injured salivary glands
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2020
Regulation and Function of Interleukin-7 in Primary Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2017
IDENTIFICATION OF SALIVARY EPITHELIAL PRECURSOR INDUCINGFACTORS
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Jul 2010 – Jun 2016
Expression and function of microRNA in autoimmune Sjogren's Syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Education

Health and wellbeing coach
2023 · Duke University
Clinical Fellowship in Oral Oncology and Oral Medicine
2012 · University of Florida
PhD in Biomedical Sciences w/ Immunology Conc.
2001 · University of Florida
DDS
1993 · Yonsei University College of Dentistry

Contact Details

Student Assistant:
Addresses:
Business Mailing:
PO Box 100414
GAINESVILLE FL 32610
Business Street:
1395 Center Drive, R#D8-42
GAINESVILLE FL 32610