Seunghee Cha

Seunghee Cha, DDS, PhD

Professor

Department: DN-ORAL MEDICINE

About Seunghee Cha

Additional Positions:
Director
2018 – Current · Center for Orphaned Autoimmune Disorders

Accomplishments

FEO award for Leadership in Health and Wellbeing
2022-2023 · University of Florida
Distinguished Professorship Award
2018-2021 · University of Florida Research Foundation
Term Professorship Award
2017-2020 · University of Florida
Distinguished Mentor Award
2014 · Howard Hughes Medical Institute and UF
Excellence Aawrd for Assistant Professor
2012 · University of Florida
Outstanding Abstract Award
2010 · Sjogren's Syndrome Foundation
Award for Outstanding Academic Achievement
1998 · The Office of International Studies and Programs at the University of Florida
Valedictorian
1993 · Yonsei University College of Dentistry

Teaching Profile

Courses Taught
2014-2025
DEN8767L Clin Oncology and Path
2018-2022
DEN5120C Physiology
2011-2014,2016-2022
DEN6260 Oral Med/Den Pharmaco
2018
DEN6971 Research for Master’s Thesis
2018
GMS7979 Advanced Research
2009,2011-2017,2017
IDH4905 Individual Work
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014
DEN7540 Special Topics
2011-2013
DEN8765L Cln Radiol 2 Interpre
2011-2013
DEN7762L Cln Rad 1 Radiograph
2011-2012
GMS6161 Introduction to Oral Biology II
2009
DEN8290 Special Topics
2022
PHC7918 Independent Study

Clinical Profile

Specialties
  • Dentistry
Subspecialties
  • Oral Medicine
  • Oral and Maxillofacial Diagnostic Sciences
Areas of Interest
  • Head and Neck Cancer
  • Salivary gland disorders
  • Sjögren syndrome

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3772-1832

Areas of Interest
  • Autoimmune Disease
  • Clinical outcomes studies
  • Clinical therapeutic studies
  • Clustering and classification
  • biomarker discovery

Publications

2024
Increased prevalence of erythema multiforme in patients with COVID-19 infection or vaccination
Scientific Reports. 14(1) [DOI] 10.1038/s41598-024-52099-z. [PMID] 38307870.
2024
Opportunities in childhood Sjögren’s disease: results from collaborative roundtable discussions
Rheumatology. [DOI] 10.1093/rheumatology/keae258.
2023
A lower prevalence of malignant lymphoma in Sjögren’s syndrome patients: A cross‐sectional study
Oral Diseases. 29(8):3313-3324 [DOI] 10.1111/odi.14435.
2023
Dens Evaginatus of Bilateral Permanent Mandibular Premolars with Pulpal Involvement: A Case Report
Open Access Journal of Dental and Oral Surgery (OAJDOS). 4(2):1-3 [DOI] 10.54026/oajdos/1059.
2023
Intraoperative Visualization and Treatment of Salivary Gland Dysfunction in Sjögren’s Syndrome Patients Using Contrast-Enhanced Ultrasound Sialendoscopy (CEUSS)
Journal of Clinical Medicine. 12(12) [DOI] 10.3390/jcm12124152. [PMID] 37373845.
2023
Lichen planus after COVID‐19 infection and vaccination
Oral Diseases. [DOI] 10.1111/odi.14834.
2023
Long-term efficacy of sialendoscopy in treating childhood Sjögren’s disease with chronological monitoring by salivary gland ultrasonography: A novel approach.
Pediatric rheumatology online journal. 21(1) [DOI] 10.1186/s12969-023-00870-3. [PMID] 37574559.
2023
Review for “The minimally important difference for the Xerostomia Inventory among Sjögren’s disease patients”
. [DOI] 10.1111/odi.14841/v2/review2.
2023
The minimally important difference for the Xerostomia Inventory among Sjögren’s disease patients.
Oral diseases. [DOI] 10.1111/odi.14841. [PMID] 38148483.
2023
Therapeutic potential for P2Y2 receptor antagonism
Purinergic Signalling. 19(2):401-420 [DOI] 10.1007/s11302-022-09900-3. [PMID] 36219327.
2022
Diagnosis of Sjögren’s disease
Clinical Dentistry Reviewed. 6(1) [DOI] 10.1007/s41894-022-00124-7.
2022
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome.
Molecular therapy. Nucleic acids. 30:257-269 [DOI] 10.1016/j.omtn.2022.09.020. [PMID] 36284513.
2022
The inflammatory signature in monocytes of Sjögren’s syndrome and systemic lupus erythematosus, revealed by the integrated Reactome and drug target analysis.
Genes & genomics. 44(10):1215-1229 [DOI] 10.1007/s13258-022-01308-y. [PMID] 36040684.
2021
Labial salivary gland assessment in idiopathic pulmonary fibrosis patients with sicca symptoms
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 132(4):434-440 [DOI] 10.1016/j.oooo.2021.03.014.
2021
Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies
Journal of Clinical Advances in Dentistry. 5(1):005-011 [DOI] 10.29328/journal.jcad.1001024.
2020
Childhood Sjögren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria.
Rheumatology (Oxford, England). [DOI] 10.1093/rheumatology/keaa757. [PMID] 33280020.
2020
Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sjögren’s syndrome.
Clinical and experimental rheumatology. [PMID] 33124573.
2020
Questionable Reliability of Malondialdehyde to Measure Oxidative Stress in Sjögren’s Syndrome: Preliminary Study
Journal of Oral Medicine and Pain. 45(4):89-96 [DOI] 10.14476/jomp.2020.45.4.89.
2019
HPV-related oral dysplasia in a multiple myeloma patient after stem cell transplantation.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 39(1):51-55 [DOI] 10.1111/scd.12344. [PMID] 30431178.
2019
MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells
International Journal of Molecular Sciences. 20(3) [DOI] 10.3390/ijms20030767. [PMID] 30759717.
2019
Novel Discovery of LINE-1 in a Korean Individual by a Target Enrichment Method
Molecules and Cells. 42(1):87-95 [DOI] 10.14348/molcells.2018.0351. [PMID] 30699287.
2018
Increased expression of interferon-λ in minor salivary glands of patients with primary Sjögren’s syndrome and its synergic effect with interferon-α on salivary gland epithelial cells.
Clinical and experimental rheumatology. 36 Suppl 112(3):31-40 [PMID] 28421993.
2018
MicroRNAs in Autoimmune Sjögren’s Syndrome
Genomics & Informatics. 16(4) [DOI] 10.5808/gi.2018.16.4.e19.
2017
The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System.
Current drug delivery. 14(4):581-586 [DOI] 10.2174/1567201813666161013150648. [PMID] 27739377.
2017
Uncovering stem cell differentiation factors for salivary gland regeneration by quantitative analysis of differential proteomes.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0169677. [PMID] 28158262.
2016
Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review.
Stem cells international. 2016 [DOI] 10.1155/2016/9305986. [PMID] 26798366.
2016
Sjögren’s syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-0987-0. [PMID] 27142093.
2015
Comparison of peri-implant bone formation around injection-molded and machined surface zirconia implants in rabbit tibiae.
Dental materials journal. 34(4):508-15 [DOI] 10.4012/dmj.2015-024. [PMID] 26235717.
2015
Mouse Models of Primary Sjogren’s Syndrome
Current Pharmaceutical Design. 21(18):2350-2364
2014
Identification of regulatory factors for mesenchymal stem cell-derived salivary epithelial cells in a co-culture system.
PloS one. 9(11) [DOI] 10.1371/journal.pone.0112158. [PMID] 25402494.
2014
Microrna-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule Cd80 Expression and Increases Autoreactive T Cell Activation in Sjogren’s Syndrome.
Arthritis & Rheumatology. 66(10, SI)
2013
Autoantibodies Against Muscarinic Type 3 Receptor in Sjogren’s Syndrome Inhibit Aquaporin 5 Trafficking
PLoS One. 8(1) [DOI] 10.1371/journal.pone.0053113. [PMID] 23382834.
2013
Interleukin-7 enhances the Th1 response to promote the development of Sjögren’s syndrome-like autoimmune exocrinopathy in mice.
Arthritis and rheumatism. 65(8):2132-42 [DOI] 10.1002/art.38007. [PMID] 23666710.
2012
Animal models in autoimmune diseases: lessons learned from mouse models for Sjögren’s syndrome.
Clinical reviews in allergy & immunology. 42(1):35-44 [DOI] 10.1007/s12016-011-8288-5. [PMID] 22105703.
2012
Muscarinic Type 3 Receptor Induces Cytoprotective Signaling in Salivary Gland Cells Through Epidermal Growth Factor Receptor Transactivation
Molecular Pharmacology. 82(1):115-124 [DOI] 10.1124/mol.111.077354. [PMID] 22511543.
2011
A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren’s syndrome.
Arthritis and rheumatism. 63(10):3116-25 [DOI] 10.1002/art.30450. [PMID] 21567383.
2011
Ligneous gingivitis associated with plasminogen deficiency: a challenge in diagnosis.
Journal of investigative and clinical dentistry. 2(3):207-11 [DOI] 10.1111/j.2041-1626.2011.00066.x. [PMID] 25426793.
2011
Loss of PKCδ results in characteristics of Sjögren’s syndrome including salivary gland dysfunction.
Oral diseases. 17(6):601-9 [DOI] 10.1111/j.1601-0825.2011.01819.x. [PMID] 21702866.
2010
CIP2A expression and localization in oral carcinoma and dysplasia.
Cancer biology & therapy. 10(7):694-9 [DOI] 10.4161/cbt.10.7.12895. [PMID] 21068540.
2010
Epigenetics in autoimmune disorders: highlights of the 10th Sjögren’s syndrome symposium.
Autoimmunity reviews. 9(9):627-30 [DOI] 10.1016/j.autrev.2010.05.011. [PMID] 20452464.
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology. 88(2):205-12 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2010
Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats.
Journal of periodontology. 81(10):1481-7 [DOI] 10.1902/jop.2010.100019. [PMID] 20572766.
2010
Periodontal Disease and the Oral-Systemic Connection: “Is It All the Rage?”
Quintessence International. 41:229-237
2010
Periodontal disease and the oral-systemic connection: “is it all the RAGE?”.
Quintessence international (Berlin, Germany : 1985). 41(3):229-37 [PMID] 20213024.
2009
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s syndrome before disease onset.
Immunology and cell biology. 87(1):81-90 [DOI] 10.1038/icb.2008.70. [PMID] 18936772.
2009
MicroRNA in autoimmunity and autoimmune diseases.
Journal of autoimmunity. 32(3-4):189-94 [DOI] 10.1016/j.jaut.2009.02.012. [PMID] 19303254.
2009
Rage Expression and Nf-Kappa B Activation Attenuated By Extracellular Domain of Rage in Human Salivary Gland Cell Line
Journal of Cellular Physiology. 221(2):430-434 [DOI] 10.1002/jcp.21873. [PMID] 19591173.
2008
Decreased Levels of Soluble Receptor for Advanced Glycation End Products in Patients With Primary Sjogren’S Syndrome
Rheumatology International. 28(8):771-776 [DOI] 10.1007/s00296-008-0529-4. [PMID] 18231794.
2008
Salivary Dysfunction and Quality of Life in Sjogren Syndrome – a Critical Oral-Systemic Connection
Journal of the American Dental Association. 139:291-299
2002
Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update.
Critical Reviews in Oral Biology and Medicine. 13(1):5-16 [PMID] 12097234.
1989
Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
The Journal of infectious diseases. 159(5):959-65 [PMID] 2540249.
In Print
The novel Florida Scoring System for stratifying children suspected of Sjögren’s disease: the first data-driven analysis applied to a rare prospective pediatric cohort
The Lancet Rheumatology.
In Print
Unveiling novel transcriptomic profiles and interplay of immune subsets in rare condition of autoimmune childhood Sjögren’s disease
Communications Biology. 7(1) [DOI] 10.1038/s42003-024-06124-6. [PMID] 38641668.

Grants

Sep 2023 ACTIVE
PKR sensing of mitochondrial dsRNA in childhood Sjogrens disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2022 ACTIVE
Phase I/IIa Clinical Trial Using Localized and Systemic Delivery of the P2X7 Receptor Antagonist AZD9056 for the Treatment of Salivary Gland Dysfunction in Sj?grens Syndrome Patients
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NIAID
Sep 2021 ACTIVE
Cytoplasmic mitochondrial dsRNA in pediatric Sj?grens syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2021 – Jul 2023
Innate Immunity in the Sj?grens syndrome mouse model
Role: Principal Investigator
Funding: MITOBRIDGE
Mar 2021 ACTIVE
Targeting P2 receptors to restore salivary and lacrimal gland function in sjogren's syndrome
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NIDCR
Oct 2020 – Sep 2021
STING in Sjogren's syndrome
Role: Principal Investigator
Funding: MITOBRIDGE
Sep 2020 – Dec 2023
Integrated transcriptomic profiling of recurrent parotitis in pediatric Sj?grens syndrome for assessment of mitochondrial RNA regulators
Role: Principal Investigator
Funding: SJOGRENS SYNDROME FOU
Sep 2020 – Aug 2022
Mechanisms and therapeutic modulation of T cell autoimmune responses in Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Sep 2016 – Aug 2020
Facilitation of stem cell differentiation in severely injured salivary glands
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2020
Regulation and Function of Interleukin-7 in Primary Sjogren's Syndrome
Role: Principal Investigator
Funding: FORSYTH INSTITUTE via NATL INST OF HLTH NIDCR
Feb 2016 – Jan 2017
IDENTIFICATION OF SALIVARY EPITHELIAL PRECURSOR INDUCINGFACTORS
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Jul 2010 – Jun 2016
Expression and function of microRNA in autoimmune Sjogren's Syndrome
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR

Education

Health and wellbeing coach
2023 · Duke University
Clinical Fellowship in Oral Oncology and Oral Medicine
2012 · University of Florida
PhD in Biomedical Sciences w/ Immunology Conc.
2001 · University of Florida
DDS
1993 · Yonsei University College of Dentistry

Contact Details

Student Assistant:
Addresses:
Business Mailing:
PO Box 100414
GAINESVILLE FL 32610
Business Street:
1395 Center Drive, R#D8-42
GAINESVILLE FL 32610