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UF Health University of Florida

College of Dentistry

UNIVERSITY of FLORIDA

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Robert A Burne

Robert A Burne

Associate Dean For Research

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8847
Business Email: rburne@dental.ufl.edu

About Robert A Burne

Robert Burne, Ph.D. received his Ph.D. in microbiology and immunology from the University of Rochester where he served on faculty from 1990 to 2001 before joining UF in 2001 as professor and chair of the Department of Oral Biology. Burne is an internationally-respected researcher and educator who has published over 150 peer-reviewed papers on the genetics, physiology and virulence of bacteria. He has served on numerous editorial boards and NIH study sections, is PI/co-PI on three NIH R01 awards, and is the program director for an NIDCR-funded Institutional Pre- and Post-doctoral Training Program. He received the Hatton Award and Distinguished Scientist Award from the International Association for Dental Research; the Wallace O. Fenn and the Alumni Achievement Awards from the University of Rochester School of Medicine & Dentistry; and is a Fellow of the American Association for the Advancement of Science.

Publications

2020
Direct interactions with commensal streptococci modify intercellular communication behaviors of Streptococcus mutans
The ISME journal
2020
Subpopulation behaviors in lactose metabolism by Streptococcus mutans
Molecular Microbiology
2020
Site-specific profiling of the dental mycobiome reveals strong taxonomic shifts during progression of early childhood caries
Applied and Environmental Microbiology
2020
Molecular Mechanisms Controlling Fructose-Specific Memory and Catabolite Repression in Lactose Metabolism by Streptococcus mutans
Molecular Microbiology
2020
Peptides encoded in the Streptococcus mutans RcrRPQ operon are essential for thermotolerance
Microbiology (Reading, England)
2020
Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function
PLOS Pathogens
2019
Amino Sugars Modify Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans
Applied and Environmental Microbiology
2019
Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans
Molecular Microbiology
2019
Erratum for Underhill et al., “Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence”
Msphere
2019
Essential Roles of the sppRA Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by Streptococcus mutans
Journal of Bacteriology
2019
Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness
Antimicrobial Agents and Chemotherapy
2018
Streptococcus mutans.
Journal of Bacteriology
2018
Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci
MSystems
2018
Preferred Hexoses Influence Long-Term Memory in and Induction of Lactose Catabolism By Streptococcus Mutans
Applied and Environmental Microbiology
2018
Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments
Trends in Microbiology
2018
Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence
Msphere
2018
Genome-Wide Screens Reveal New Gene Products That Influence Genetic Competence in Streptococcus Mutans
2018
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a Dpr Mutant Strain of Streptococcus Mutans
Journal of bacteriology
2018
Differential Oxidative Stress Tolerance of Streptococcus Mutans Isolates Affects Competition in An Ecological Mixed-Species Biofilm Model
Environmental Microbiology Reports
2018
Competence Inhibition By the Xrpa Peptide Encoded Within the Comx Gene of Streptococcus Mutans
Molecular Microbiology
2018
Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159
Msphere
2017
Ccpa and Cody Coordinate Acetate Metabolism in Streptococcus Mutans
Applied and Environmental Microbiology
2017
Effects of Arginine on Streptococcus Mutans Growth, Virulence Gene Expression, and Stress Tolerance
Applied and Environmental Microbiology
2017
Intercellular Communication Via the Comx-Inducing Peptide (Xip) of Streptococcus Mutans
Journal of bacteriology
2017
Microbiomes of Site-Specific Dental Plaques From Children With Different Caries Status
Infection and Immunity
2017
Oxidative Stressors Modify the Response of Streptococcus mutans to Its Competence Signal Peptides
Applied and Environmental Microbiology
2017
Rna-Seq Reveals Enhanced Sugar Metabolism in Streptococcus Mutans Co-Cultured With Candida Albicans Within Mixed-Species Biofilms
Frontiers in Microbiology
2016
Growth of Streptococcus Mutans in Biofilms Alters Peptide Signaling at the Sub-Population Level
Frontiers in microbiology
2016
Sucrose- and Fructose-Specific Effects on the Transcriptome of Streptococcus Mutans, As Determined By RNa Sequencing
Applied and Environmental Microbiology
2016
An Essential Role for (P)Ppgpp in the Integration of Stress Tolerance, Peptide Signaling, and Competence Development in Streptococcus Mutans
Frontiers in Microbiology
2016
A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans
Applied and Environmental Microbiology
2016
Effects of Carbohydrate Source on Genetic Competence in Streptococcus mutans
Applied and Environmental Microbiology
2015
Bidirectional Signaling in the Competence Regulatory Pathway of Streptococcus Mutans
Fems Microbiology Letters
2015
Conserved and Divergent Functions of Rcrrpq in Streptococcus Gordonii and S. Mutans
Fems Microbiology Letters
2015
NagR Differentially Regulates the Expression of the glmS and nagAB Genes Required for Amino Sugar Metabolism by Streptococcus mutans
Journal of Bacteriology
2015
Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions With Streptococcus Mutans Biofilms
PLoS One
2015
Post-Transcriptional Regulation By Distal Shine-Dalgarno Sequences in the Grpe-Dnak Intergenic Region of Streptococcus Mutans
Molecular microbiology
2015
Regulation of Competence and Gene Expression in Streptococcus Mutans By the Rcrr Transcriptional Regulator
Molecular oral microbiology
2015
The Streptococcus Mutans Irva Gene Encodes a Trans-Acting Riboregulatory Mrna
Molecular Cell
2015
A Unique Open Reading Frame Within the Comx Gene of Streptococcus Mutans Regulates Genetic Competence and Oxidative Stress Tolerance
Molecular microbiology
2014
Uptake and Metabolism of N-Acetylglucosamine and Glucosamine By Streptococcus Mutans
Applied and Environmental Microbiology
2014
The pH-dependent expression of the urease operon in Streptococcus salivarius is mediated by CodY
Applied and Environmental Microbiology
2014
The Effect of Arginine On Oral Biofilm Communities
Molecular oral microbiology
2014
Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery
Journal of Bacteriology
2014
Modification of gene expression and virulence traits in Streptococcus mutans in response to carbohydrate availability
Applied and Environmental Microbiology
2014
Growth Phase and Ph Influence Peptide Signaling for Competence Development in Streptococcus Mutans
Journal of bacteriology
2014
Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans
Journal of oral microbiology
2014
Discovery of novel peptides regulating competence development in Streptococcus mutans
Journal of Bacteriology
2014
Phylogenomics and the Dynamic Genome Evolution of the Genus Streptococcus
Genome Biology and Evolution
2013
A Galactose-Specific Sugar:Phosphotransferase Permease Is Prevalent in the Non-Core Genome of Streptococcus Mutans
Molecular oral microbiology
2013
Comprehensive Mutational Analysis of Sucrose-Metabolizing Pathways in Streptococcus Mutans Reveals Novel Roles for the Sucrose Phosphotransferase System Permease
Journal of bacteriology
2013
Core-Gene-Encoded Peptide Regulating Virulence-Associated Traits in Streptococcus Mutans
Journal of bacteriology
2013
Evolutionary and Population Genomics of the Cavity Causing Bacteria Streptococcus Mutans
Molecular Biology and Evolution
2013
Gene Regulation By Ccpa and Catabolite Repression Explored By Rna-Seq in Streptococcus Mutans
PLoS One
2013
Oral Arginine Metabolism May Decrease the Risk for Dental Caries in Children
Journal of dental research
2013
Phenotypic Heterogeneity of Genomically-Diverse Isolates of Streptococcus Mutans
PLoS One
2012
Brpa Is Involved in Regulation of Cell Envelope Stress Responses in Streptococcus Mutans
Applied and Environmental Microbiology
2012
Identification of the Streptococcus Mutans Lytst Two-Component Regulon Reveals Its Contribution To Oxidative Stress Tolerance
BMC microbiology
2012
Microfluidic Study of Competence Regulation in Streptococcus Mutans: Environmental Inputs Modulate Bimodal and Unimodal Expression of Comx
Molecular microbiology
2012
Transcriptional Organization and Physiological Contributions of the Relq Operon of Streptococcus Mutans
Journal of bacteriology
2012
Two Gene Clusters Coordinate Galactose and Lactose Metabolism in Streptococcus Gordonii
Applied and Environmental Microbiology
2012
Progress Toward Understanding the Contribution of Alkali Generation in Dental Biofilms To Inhibition of Dental Caries
International Journal of Oral Science
2011
A Transcriptional Regulator and Abc Transporters Link Stress Tolerance, (P)Ppgpp, and Genetic Competence in Streptococcus Mutans
Journal of bacteriology
2011
Caries Risk Pyramid: a Practical Biological Approach To Caries Management By Risk Assessment
Puerto Rico health sciences journal
2011
Genetic Analysis of the Functions and Interactions of Components of the Levqrst Signal Transduction Complex of Streptococcus Mutans
PLoS One
2011
Nonfluoride Caries-Preventive Agents Executive Summary of Evidence-Based Clinical Recommendations
Journal of the American Dental Association
2011
The Collagen-Binding Protein Cnm Is Required for Streptococcus Mutans Adherence To and Intracellular Invasion of Human Coronary Artery Endothelial Cells
Infection and Immunity
2011
The Eiiab(Man) Phosphotransferase System Permease Regulates Carbohydrate Catabolite Repression in Streptococcus Gordonii
Applied and Environmental Microbiology
2011
The Major Autolysin of Streptococcus Gordonii Is Subject To Complex Regulation and Modulates Stress Tolerance, Biofilm Formation, and Extracellular-Dna Release
Journal of bacteriology
2011
Transcriptional Repressor Rex Is Involved in Regulation of Oxidative Stress Response and Biofilm Formation By Streptococcus Mutans
Fems Microbiology Letters
2011
Transcriptome Analysis of Luxs-Deficient Streptococcus Mutans Grown in Biofilms
Molecular oral microbiology
2011
Urease Activity as a Risk Factor for Caries Development in Children During a Three-Year Study Period: a Survival Analysis Approach
Archives of oral biology
2011
Urease Activity in Dental Plaque and Saliva of Children During a Three-Year Study Period and Its Relationship With Other Caries Risk Factors
Archives of oral biology
2010
Utilization of Lactose and Galactose By Streptococcus Mutans: Transport, Toxicity, and Carbon Catabolite Repression
Journal of bacteriology
2010
The Effect of Sucrose On Plaque and Saliva Urease Levels in Vivo
Archives of oral biology
2010
The Streptococcus Mutans Cid and Lrg Systems Modulate Virulence Traits in Response To Multiple Environmental Signals
Microbiology
2010
Seryl-Phosphorylated Hpr Regulates Ccpa-Independent Carbon Catabolite Repression in Conjunction With Pts Permeases in Streptococcus Mutans
Molecular microbiology
2010
Biofilm Formation and Virulence Expression By Streptococcus Mutans Are Altered When Grown in Dual-Species Model
BMC microbiology
2009
Agur Is Required for Induction of the Streptococcus Mutans Agmatine Deiminase System By Low Ph and Agmatine
Applied and Environmental Microbiology
2009
Changes in Biochemical and Phenotypic Properties of Streptococcus Mutans During Growth With Aeration
Applied and Environmental Microbiology
2009
Correlations of Oral Bacterial Arginine and Urea Catabolism With Caries Experience
Oral microbiology and immunology
2009
Distribution, Regulation and Role of the Agmatine Deiminase System in Mutans Streptococci
Oral microbiology and immunology
2009
Inactivation of Vick Affects Acid Production and Acid Survival of Streptococcus Mutans
Journal of bacteriology
2009
Invasion of Human Coronary Artery Endothelial Cells By Streptococcus Mutans Omz175
Oral microbiology and immunology
2009
Multiple Two-Component Systems Modulate Alkali Generation in Streptococcus Gordonii in Response To Environmental Stresses
Journal of bacteriology
2009
Multiple Two-Component Systems of Streptococcus Mutans Regulate Agmatine Deiminase Gene Expression and Stress Tolerance
Journal of bacteriology
2009
Opportunities for disrupting cariogenic biofilms.
Advances in Dental Research
2009
Transcriptional Regulation of the Cellobiose Operon of Streptococcus Mutans
Journal of bacteriology
2008
Role of Rela of Streptococcus Mutans in Global Control of Gene Expression
Journal of bacteriology
2008
Multiple Sugar: Phosphotransferase System Permeases Participate in Catabolite Modification of Gene Expression in Streptococcus Mutans
Molecular microbiology
2008
Global Regulation By (P)Ppgpp and Cody in Streptococcus Mutans
Journal of bacteriology
2008
Environmental and Growth Phase Regulation of the Streptococcus Gordonii Arginine Deiminase Genes
Applied and Environmental Microbiology
2008
A Model of Efficiency: Stress Tolerance By Streptococcus Mutans
Microbiology
2008
Ccpa Regulates Central Metabolism and Virulence Gene Expression in Streptococcus Mutans
Journal of bacteriology
2008
Caddx Operon of Streptococcus Salivarius 57.I
Applied and Environmental Microbiology
2008
Characteristics of Biofilm Formation By Streptococcus Mutans in the Presence of Saliva
Infection and Immunity
2007
Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans
Journal of Bacteriology
2007
Effects of oxygen on virulence traits of Streptococcus mutans
Journal of Bacteriology
2006
A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans
Molecular Microbiology
2006
Characterization of cis-acting sites controlling arginine deiminase gene expression in Streptococcus gordonii
Journal of Bacteriology
2006
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans
Journal of Bacteriology
2006
Influence of BrpA on critical virulence attributes of Streptococcus mutans
Journal of Bacteriology
2006
Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159
Infection and Immunity
2006
Osmotic stress responses of Streptococcus mutans UA159
Fems Microbiology Letters
2006
The atlA operon of Streptococcus mutans: role in autolysin maturation and cell surface biogenesis
Journal of Bacteriology
2005
Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation
Infection and Immunity
2005
Responses of cariogenic streptococci to environmental stresses.
Current Issues in Molecular Biology
2005
Role of HtrA in growth and competence of Streptococcus mutans UA159
Journal of Bacteriology
2004
Bacterial biofilms may contribute to persistent cochlear implant infection.
The American Journal of Otology
2004
Galactose metabolism by Streptococcus mutans
Applied and Environmental Microbiology
2004
LuxS-mediated signaling in Streptococcus mutans is involved in regulation of acid and oxidative stress tolerance and biofilm formation
Journal of Bacteriology
2004
RegM is required for optimal fructosyltransferase and glucosyltransferase gene expression in Streptococcus mutans
Fems Microbiology Letters
2003
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system
Applied and Environmental Microbiology
2003
Identification and characterization of the nickel uptake system for urease biogenesis in Streptococcus salivarius 57.I
Journal of Bacteriology
2002
Analysis of cis- and trans-acting factors involved in regulation of the Streptococcus mutans fructanase gene (fruA)
Journal of Bacteriology
2002
Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans
Applied and Environmental Microbiology
2002
Pathways for lactose/galactose catabolism by Streptococcus salivarius
Fems Microbiology Letters

Grants

Sep 2020 ACTIVE
Arginine metabolism in periodontal health and diseases
NATL INST OF HLTH NIDCR · Project Manager
Sep 2018 – Sep 2019
Ecological Consequences of Cell-Cell Signaling on Interbacterial Competition
NATL INST OF HLTH NIDCR · Mentor
Sep 2018 ACTIVE
Oral Microbiomes and Dental Caries in a Human Immunodeficiency Virus Infected Population
CLEMSON UNIV · Principal Investigator
Aug 2018 – Aug 2020
Investigation of the probiotic mechanisms of action of Streptococcus A12
NATL INST OF HLTH NIDCR · Mentor
Jul 2018 ACTIVE
Gene Regulation and Physiology of Streptococcus mutans
NATL INST OF HLTH NIDCR · Principal Investigator
Apr 2017 ACTIVE
OoR CTSI Institutional Matching Support
UF DIV OF SPONSORED RES MATCHING FUNDS · Project Manager
Jul 2016 ACTIVE
Comprehensive Training Program in Oral Biology
NATL INST OF HLTH NIDCR · Project Manager
Jul 2016 ACTIVE
Comprehensive Training Program in Oral Biology
NATL INST OF HLTH NIDCR ·
Mar 2016 ACTIVE
Probiotics that moderate PH and antagonize pathogens to promote oral health
NATL INST OF HLTH NIDCR · Principal Investigator
Nov 2015 – Nov 2017
The Metabolomics of Oral Biofilms exposed to Arginine an
COLGATE-PALMOLIVE CO · Project Manager
Nov 2015 ACTIVE
Miscellaneous Donors
MISCELLANEOUS DONORS · Project Manager
Jul 2015 ACTIVE
Genetics and Physiology of Oral Biofilms
NATL INST OF HLTH NIDCR · Principal Investigator
Aug 2014 – Aug 2017
Effects of arginine on virulence-related properties of c
COLGATE-PALMOLIVE CO · Principal Investigator
Dec 2013 – Aug 2020
Environmental regulation of gene expression dissected by microfluidics
NATL INST OF HLTH NIDCR · Project Manager
May 2013 – Jul 2018
Gene Regulation and Physiology of Streptococcus mutans
NATL INST OF HLTH NIDCR · Principal Investigator
Jul 2011 – Dec 2016
Comprehensive Training Program in Oral Biology
NATL INST OF HLTH NIDCR · Principal Investigator
Jul 2011 – Jun 2016
R90-Comprehensive Training Program in Oral Biology
NATL INST OF HLTH · Principal Investigator
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
UF RESEARCH FOU · Project Manager

Patents

Published January 2007
Recombinant Alkalinizing Bacteria
#US-2007-0212311-A1
Issued November 2015
Methods for Predicting and Preventing Cardiovascular Disease
#9,176,135
Published January 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions (CIP of 13295)
#US-2017-0136074-A1
Issued May 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions
#9,655,839

Contact Details

Phones:
Business:
(352) 273-8847
Emails:
Business:
rburne@dental.ufl.edu