Robert A Burne

Robert A Burne,

Associate Dean For Research

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-8847
Business Email: rburne@dental.ufl.edu

About Robert A Burne

Robert Burne, Ph.D. received his Ph.D. in microbiology and immunology from the University of Rochester where he served on faculty from 1990 to 2001 before joining UF in 2001 as professor and chair of the Department of Oral Biology. Burne is an internationally-respected researcher and educator who has published over 150 peer-reviewed papers on the genetics, physiology and virulence of bacteria. He has served on numerous editorial boards and NIH study sections, is PI/co-PI on three NIH R01 awards, and is the program director for an NIDCR-funded Institutional Pre- and Post-doctoral Training Program. He received the Hatton Award and Distinguished Scientist Award from the International Association for Dental Research; the Wallace O. Fenn and the Alumni Achievement Awards from the University of Rochester School of Medicine & Dentistry; and is a Fellow of the American Association for the Advancement of Science.

Publications

2021
A single system detects and protects the beneficial oral bacterium Streptococcus sp. A12 from a spectrum of antimicrobial peptides.
Molecular microbiology. 116(1):211-230 [DOI] 10.1111/mmi.14703. [PMID] 33590560.
2021
Direct interactions with commensal streptococci modify intercellular communication behaviors of Streptococcus mutans.
The ISME journal. 15(2):473-488 [DOI] 10.1038/s41396-020-00789-7. [PMID] 32999420.
2021
Molecular mechanisms controlling fructose-specific memory and catabolite repression in lactose metabolism by Streptococcus mutans.
Molecular microbiology. 115(1):70-83 [DOI] 10.1111/mmi.14597. [PMID] 32881130.
2021
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans.
Nature chemical biology. 17(5):576-584 [DOI] 10.1038/s41589-021-00745-2. [PMID] 33664521.
2021
Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-PTS Show Enhanced Post-Exponential Phase Fitness.
Journal of bacteriology. [DOI] 10.1128/JB.00375-21. [PMID] 34460310.
2021
Subpopulation behaviors in lactose metabolism by Streptococcus mutans.
Molecular microbiology. 115(1):58-69 [DOI] 10.1111/mmi.14596. [PMID] 32881164.
2021
The Route of Sucrose Utilization by Streptococcus mutans Affects Intracellular Polysaccharide Metabolism.
Frontiers in microbiology. 12 [DOI] 10.3389/fmicb.2021.636684. [PMID] 33603728.
2020
Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii.
Applied and environmental microbiology. 87(1) [DOI] 10.1128/AEM.01459-20. [PMID] 33097515.
2020
In Vivo Colonization with Candidate Oral Probiotics Attenuates Colonization and Virulence of Streptococcus mutans.
Applied and environmental microbiology. [DOI] 10.1128/AEM.02490-20. [PMID] 33277269.
2020
Peptides encoded in the Streptococcus mutans RcrRPQ operon are essential for thermotolerance.
Microbiology (Reading, England). 166(3):306-317 [DOI] 10.1099/mic.0.000887. [PMID] 31935187.
2020
Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function.
PLoS pathogens. 16(3) [DOI] 10.1371/journal.ppat.1008344. [PMID] 32150575.
2020
Site-Specific Profiling of the Dental Mycobiome Reveals Strong Taxonomic Shifts during Progression of Early-Childhood Caries.
Applied and environmental microbiology. 86(7) [DOI] 10.1128/AEM.02825-19. [PMID] 31953340.
2019
Amino Sugars Modify Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.
Applied and environmental microbiology. 85(10) [DOI] 10.1128/AEM.00370-19. [PMID] 30877119.
2019
Arginine Metabolism in Supragingival Oral Biofilms as a Potential Predictor of Caries Risk.
JDR clinical and translational research. 4(3):262-270 [DOI] 10.1177/2380084419834234. [PMID] 31039043.
2019
Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans.
Molecular microbiology. 112(5):1388-1402 [DOI] 10.1111/mmi.14367. [PMID] 31403729.
2019
Erratum for Underhill et al., “Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence”.
mSphere. 4(1) [DOI] 10.1128/mSphere.00042-19. [PMID] 30760611.
2019
Essential Roles of the sppRA Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by Streptococcus mutans.
Journal of bacteriology. 201(2) [DOI] 10.1128/JB.00586-18. [PMID] 30348833.
2019
Fluorescence Tools Adapted for Real-Time Monitoring of the Behaviors of Streptococcus Species.
Applied and environmental microbiology. 85(15) [DOI] 10.1128/AEM.00620-19. [PMID] 31101614.
2019
Metabolic Profile of Supragingival Plaque Exposed to Arginine and Fluoride.
Journal of dental research. 98(11):1245-1252 [DOI] 10.1177/0022034519869906. [PMID] 31454264.
2019
Novel Probiotic Mechanisms of the Oral Bacterium Streptococcus sp. A12 as Explored with Functional Genomics.
Applied and environmental microbiology. 85(21) [DOI] 10.1128/AEM.01335-19. [PMID] 31420345.
2019
Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness.
Antimicrobial agents and chemotherapy. 63(7) [DOI] 10.1128/AAC.00161-19. [PMID] 31036688.
2018
Competence inhibition by the XrpA peptide encoded within the comX gene of Streptococcus mutans.
Molecular microbiology. 109(3):345-364 [DOI] 10.1111/mmi.13989. [PMID] 29802741.
2018
Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model.
Environmental microbiology reports. 10(1):12-22 [DOI] 10.1111/1758-2229.12600. [PMID] 29124888.
2018
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a Dpr Mutant Strain of Streptococcus Mutans
Journal of bacteriology. 200(14) [DOI] 10.1128/JB.00062-18. [PMID] 29735760.
2018
Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.
Caries research. 52(1-2):88-101 [DOI] 10.1159/000479091. [PMID] 29258070.
2018
Genome-Wide Screens Reveal New Gene Products That Influence Genetic Competence in Streptococcus mutans.
Journal of bacteriology. 200(2) [DOI] 10.1128/JB.00508-17. [PMID] 29109185.
2018
Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159.
mSphere. 3(1) [DOI] 10.1128/mSphere.00031-18. [PMID] 29435491.
2018
Getting to Know “The Known Unknowns”: Heterogeneity in the Oral Microbiome.
Advances in dental research. 29(1):66-70 [DOI] 10.1177/0022034517735293. [PMID] 29355408.
2018
Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence.
mSphere. 3(5) [DOI] 10.1128/mSphere.00444-18. [PMID] 30381353.
2018
Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.
Trends in microbiology. 26(3):229-242 [DOI] 10.1016/j.tim.2017.09.008. [PMID] 29097091.
2018
Preferred Hexoses Influence Long-Term Memory in and Induction of Lactose Catabolism by Streptococcus mutans.
Applied and environmental microbiology. 84(14) [DOI] 10.1128/AEM.00864-18. [PMID] 29752268.
2018
Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci.
mSystems. 3(6) [DOI] 10.1128/mSystems.00158-18. [PMID] 30574560.
2018
Streptococcus mutans.
Journal of Bacteriology. 200(23) [DOI] 10.1128/JB.00141-18. [PMID] 30201780.
2018
Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence.
Molecular microbiology. 110(6):914-930 [DOI] 10.1111/mmi.13992. [PMID] 29873131.
2017
CcpA and CodY Coordinate Acetate Metabolism in Streptococcus mutans.
Applied and environmental microbiology. 83(7) [DOI] 10.1128/AEM.03274-16. [PMID] 28130304.
2017
Coordinated Regulation of the EIIMan and fruRKI Operons of Streptococcus mutans by Global and Fructose-Specific Pathways.
Applied and environmental microbiology. 83(21) [DOI] 10.1128/AEM.01403-17. [PMID] 28821551.
2017
Effects of Arginine on Streptococcus mutans Growth, Virulence Gene Expression, and Stress Tolerance.
Applied and environmental microbiology. 83(15) [DOI] 10.1128/AEM.00496-17. [PMID] 28526785.
2017
Intercellular Communication via the comX-Inducing Peptide (XIP) of Streptococcus mutans.
Journal of bacteriology. 199(21) [DOI] 10.1128/JB.00404-17. [PMID] 28808131.
2017
Microbiomes of Site-Specific Dental Plaques from Children with Different Caries Status.
Infection and immunity. 85(8) [DOI] 10.1128/IAI.00106-17. [PMID] 28507066.
2017
Oxidative Stressors Modify the Response of Streptococcus mutans to Its Competence Signal Peptides.
Applied and environmental microbiology. 83(22) [DOI] 10.1128/AEM.01345-17. [PMID] 28887419.
2017
RNA-Seq Reveals Enhanced Sugar Metabolism in Streptococcus mutans Co-cultured with Candida albicans within Mixed-Species Biofilms.
Frontiers in microbiology. 8 [DOI] 10.3389/fmicb.2017.01036. [PMID] 28642749.
2016
A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans.
Applied and environmental microbiology. 82(7):2187-201 [DOI] 10.1128/AEM.03887-15. [PMID] 26826230.
2016
Amino Sugars Enhance the Competitiveness of Beneficial Commensals with Streptococcus mutans through Multiple Mechanisms.
Applied and environmental microbiology. 82(12):3671-82 [DOI] 10.1128/AEM.00637-16. [PMID] 27084009.
2016
An Essential Role for (p)ppGpp in the Integration of Stress Tolerance, Peptide Signaling, and Competence Development in Streptococcus mutans.
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.01162. [PMID] 27516759.
2016
Effects of Carbohydrate Source on Genetic Competence in Streptococcus mutans.
Applied and environmental microbiology. 82(15):4821-4834 [DOI] 10.1128/AEM.01205-16. [PMID] 27260355.
2016
Growth of Streptococcus mutans in Biofilms Alters Peptide Signaling at the Sub-population Level.
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.01075. [PMID] 27471495.
2016
Sucrose- and Fructose-Specific Effects on the Transcriptome of Streptococcus mutans, as Determined by RNA Sequencing.
Applied and environmental microbiology. 82(1):146-56 [DOI] 10.1128/AEM.02681-15. [PMID] 26475108.
2015
A unique open reading frame within the comX gene of Streptococcus mutans regulates genetic competence and oxidative stress tolerance.
Molecular microbiology. 96(3):463-82 [DOI] 10.1111/mmi.12948. [PMID] 25620525.
2015
Bidirectional signaling in the competence regulatory pathway of Streptococcus mutans.
FEMS microbiology letters. 362(19) [DOI] 10.1093/femsle/fnv159. [PMID] 26363019.
2015
Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms.
Caries research. 49(2):165-76 [DOI] 10.1159/000365296. [PMID] 25634570.
2015
Conserved and divergent functions of RcrRPQ in Streptococcus gordonii and S. mutans.
FEMS microbiology letters. 362(16) [DOI] 10.1093/femsle/fnv119. [PMID] 26229070.
2015
Genetics and Physiology of Acetate Metabolism by the Pta-Ack Pathway of Streptococcus mutans.
Applied and environmental microbiology. 81(15):5015-25 [DOI] 10.1128/AEM.01160-15. [PMID] 25979891.
2015
NagR Differentially Regulates the Expression of the glmS and nagAB Genes Required for Amino Sugar Metabolism by Streptococcus mutans.
Journal of bacteriology. 197(22):3533-44 [DOI] 10.1128/JB.00606-15. [PMID] 26324448.
2015
Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms.
PloS one. 10(7) [DOI] 10.1371/journal.pone.0133886. [PMID] 26222384.
2015
Post-transcriptional regulation by distal Shine-Dalgarno sequences in the grpE-dnaK intergenic region of Streptococcus mutans.
Molecular microbiology. 98(2):302-17 [DOI] 10.1111/mmi.13122. [PMID] 26172310.
2015
Regulation of competence and gene expression in Streptococcus mutans by the RcrR transcriptional regulator.
Molecular oral microbiology. 30(2):147-159 [DOI] 10.1111/omi.12079. [PMID] 25146832.
2015
Sharply Tuned pH Response of Genetic Competence Regulation in Streptococcus mutans: a Microfluidic Study of the Environmental Sensitivity of comX.
Applied and environmental microbiology. 81(16):5622-31 [DOI] 10.1128/AEM.01421-15. [PMID] 26070670.
2015
The Streptococcus mutans irvA gene encodes a trans-acting riboregulatory mRNA.
Molecular cell. 57(1):179-90 [DOI] 10.1016/j.molcel.2014.11.003. [PMID] 25574948.
2014
Discovery of novel peptides regulating competence development in Streptococcus mutans.
Journal of bacteriology. 196(21):3735-45 [DOI] 10.1128/JB.01942-14. [PMID] 25135217.
2014
Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans.
Journal of oral microbiology. 6 [DOI] 10.3402/jom.v6.24878. [PMID] 25317251.
2014
Growth phase and pH influence peptide signaling for competence development in Streptococcus mutans.
Journal of bacteriology. 196(2):227-36 [DOI] 10.1128/JB.00995-13. [PMID] 24163340.
2014
Modification of gene expression and virulence traits in Streptococcus mutans in response to carbohydrate availability.
Applied and environmental microbiology. 80(3):972-85 [DOI] 10.1128/AEM.03579-13. [PMID] 24271168.
2014
Phylogenomics and the dynamic genome evolution of the genus Streptococcus.
Genome biology and evolution. 6(4):741-53 [DOI] 10.1093/gbe/evu048. [PMID] 24625962.
2014
Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.
Journal of bacteriology. 196(13):2355-66 [DOI] 10.1128/JB.01493-14. [PMID] 24748612.
2014
The effect of arginine on oral biofilm communities.
Molecular oral microbiology. 29(1):45-54 [DOI] 10.1111/omi.12044. [PMID] 24289808.
2014
The pH-dependent expression of the urease operon in Streptococcus salivarius is mediated by CodY.
Applied and environmental microbiology. 80(17):5386-93 [DOI] 10.1128/AEM.00755-14. [PMID] 24951785.
2014
Uptake and metabolism of N-acetylglucosamine and glucosamine by Streptococcus mutans.
Applied and environmental microbiology. 80(16):5053-67 [DOI] 10.1128/AEM.00820-14. [PMID] 24928869.
2013
A galactose-specific sugar: phosphotransferase permease is prevalent in the non-core genome of Streptococcus mutans.
Molecular oral microbiology. 28(4):292-301 [DOI] 10.1111/omi.12025. [PMID] 23421335.
2013
Comprehensive mutational analysis of sucrose-metabolizing pathways in Streptococcus mutans reveals novel roles for the sucrose phosphotransferase system permease.
Journal of bacteriology. 195(4):833-43 [DOI] 10.1128/JB.02042-12. [PMID] 23222725.
2013
Core-gene-encoded peptide regulating virulence-associated traits in Streptococcus mutans.
Journal of bacteriology. 195(12):2912-20 [DOI] 10.1128/JB.00189-13. [PMID] 23603743.
2013
Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans.
Molecular biology and evolution. 30(4):881-93 [DOI] 10.1093/molbev/mss278. [PMID] 23228887.
2013
Gene regulation by CcpA and catabolite repression explored by RNA-Seq in Streptococcus mutans.
PloS one. 8(3) [DOI] 10.1371/journal.pone.0060465. [PMID] 23555977.
2013
Oral arginine metabolism may decrease the risk for dental caries in children.
Journal of dental research. 92(7):604-8 [DOI] 10.1177/0022034513487907. [PMID] 23640952.
2013
Phenotypic heterogeneity of genomically-diverse isolates of Streptococcus mutans.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0061358. [PMID] 23613838.
2012
BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.
Applied and environmental microbiology. 78(8):2914-22 [DOI] 10.1128/AEM.07823-11. [PMID] 22327589.
2012
Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance.
BMC microbiology. 12 [DOI] 10.1186/1471-2180-12-187. [PMID] 22937869.
2012
Microfluidic study of competence regulation in Streptococcus mutans: environmental inputs modulate bimodal and unimodal expression of comX.
Molecular microbiology. 86(2):258-72 [DOI] 10.1111/j.1365-2958.2012.08187.x. [PMID] 22845615.
2012
Progress dissecting the oral microbiome in caries and health.
Advances in dental research. 24(2):77-80 [DOI] 10.1177/0022034512449462. [PMID] 22899685.
2012
Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.
International journal of oral science. 4(3):135-40 [DOI] 10.1038/ijos.2012.54. [PMID] 22996271.
2012
Transcriptional organization and physiological contributions of the relQ operon of Streptococcus mutans.
Journal of bacteriology. 194(8):1968-78 [DOI] 10.1128/JB.00037-12. [PMID] 22343297.
2012
Two gene clusters coordinate galactose and lactose metabolism in Streptococcus gordonii.
Applied and environmental microbiology. 78(16):5597-605 [DOI] 10.1128/AEM.01393-12. [PMID] 22660715.
2011
A transcriptional regulator and ABC transporters link stress tolerance, (p)ppGpp, and genetic competence in Streptococcus mutans.
Journal of bacteriology. 193(4):862-74 [DOI] 10.1128/JB.01257-10. [PMID] 21148727.
2011
Caries risk pyramid: a practical biological approach to caries management by risk assessment.
Puerto Rico health sciences journal. 30(4):165-6 [PMID] 22263295.
View on: PubMed
2011
Genetic analysis of the functions and interactions of components of the LevQRST signal transduction complex of Streptococcus mutans.
PloS one. 6(2) [DOI] 10.1371/journal.pone.0017335. [PMID] 21364902.
2011
Nonfluoride Caries-Preventive Agents Executive Summary of Evidence-Based Clinical Recommendations
Journal of the American Dental Association. 142:1065-1071
2011
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.
Infection and immunity. 79(6):2277-84 [DOI] 10.1128/IAI.00767-10. [PMID] 21422186.
2011
The EIIABMan phosphotransferase system permease regulates carbohydrate catabolite repression in Streptococcus gordonii.
Applied and environmental microbiology. 77(6):1957-65 [DOI] 10.1128/AEM.02385-10. [PMID] 21239541.
2011
The major autolysin of Streptococcus gordonii is subject to complex regulation and modulates stress tolerance, biofilm formation, and extracellular-DNA release.
Journal of bacteriology. 193(11):2826-37 [DOI] 10.1128/JB.00056-11. [PMID] 21478346.
2011
Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans.
FEMS microbiology letters. 320(2):110-7 [DOI] 10.1111/j.1574-6968.2011.02293.x. [PMID] 21521360.
2011
Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.
Molecular oral microbiology. 26(1):2-18 [DOI] 10.1111/j.2041-1014.2010.00581.x. [PMID] 21214869.
2011
Urease activity as a risk factor for caries development in children during a three-year study period: a survival analysis approach.
Archives of oral biology. 56(12):1560-8 [DOI] 10.1016/j.archoralbio.2011.06.017. [PMID] 21784411.
2011
Urease activity in dental plaque and saliva of children during a three-year study period and its relationship with other caries risk factors.
Archives of oral biology. 56(11):1282-9 [DOI] 10.1016/j.archoralbio.2011.04.015. [PMID] 21616477.
2010
Biofilm formation and virulence expression by Streptococcus mutans are altered when grown in dual-species model.
BMC microbiology. 10 [DOI] 10.1186/1471-2180-10-111. [PMID] 20398271.
2010
Protocols to study the physiology of oral biofilms.
Methods in molecular biology (Clifton, N.J.). 666:87-102 [DOI] 10.1007/978-1-60761-820-1_7. [PMID] 20717780.
2010
Seryl-phosphorylated HPr regulates CcpA-independent carbon catabolite repression in conjunction with PTS permeases in Streptococcus mutans.
Molecular microbiology. 75(5):1145-58 [DOI] 10.1111/j.1365-2958.2009.07029.x. [PMID] 20487301.
2010
The effect of sucrose on plaque and saliva urease levels in vivo.
Archives of oral biology. 55(3):249-54 [DOI] 10.1016/j.archoralbio.2009.12.007. [PMID] 20096398.
2010
The Streptococcus mutans Cid and Lrg systems modulate virulence traits in response to multiple environmental signals.
Microbiology (Reading, England). 156(Pt 10):3136-3147 [DOI] 10.1099/mic.0.039586-0. [PMID] 20671018.
2010
Utilization of lactose and galactose by Streptococcus mutans: transport, toxicity, and carbon catabolite repression.
Journal of bacteriology. 192(9):2434-44 [DOI] 10.1128/JB.01624-09. [PMID] 20190045.
2009
AguR is required for induction of the Streptococcus mutans agmatine deiminase system by low pH and agmatine.
Applied and environmental microbiology. 75(9):2629-37 [DOI] 10.1128/AEM.02145-08. [PMID] 19270124.
2009
Changes in biochemical and phenotypic properties of Streptococcus mutans during growth with aeration.
Applied and environmental microbiology. 75(8):2517-27 [DOI] 10.1128/AEM.02367-08. [PMID] 19251884.
2009
Correlations of oral bacterial arginine and urea catabolism with caries experience.
Oral microbiology and immunology. 24(2):89-95 [DOI] 10.1111/j.1399-302X.2008.00477.x. [PMID] 19239634.
2009
Distribution, regulation and role of the agmatine deiminase system in mutans streptococci.
Oral microbiology and immunology. 24(1):79-82 [DOI] 10.1111/j.1399-302X.2008.00459.x. [PMID] 19121075.
2009
Inactivation of VicK affects acid production and acid survival of Streptococcus mutans.
Journal of bacteriology. 191(20):6415-24 [DOI] 10.1128/JB.00793-09. [PMID] 19684142.
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology. 24(2):141-5 [DOI] 10.1111/j.1399-302X.2008.00487.x. [PMID] 19239641.
2009
Multiple two-component systems modulate alkali generation in Streptococcus gordonii in response to environmental stresses.
Journal of bacteriology. 191(23):7353-62 [DOI] 10.1128/JB.01053-09. [PMID] 19783634.
2009
Multiple two-component systems of Streptococcus mutans regulate agmatine deiminase gene expression and stress tolerance.
Journal of bacteriology. 191(23):7363-6 [DOI] 10.1128/JB.01054-09. [PMID] 19783635.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research. 21(1):17-20 [DOI] 10.1177/0895937409335593. [PMID] 19710079.
2009
Transcriptional regulation of the cellobiose operon of Streptococcus mutans.
Journal of bacteriology. 191(7):2153-62 [DOI] 10.1128/JB.01641-08. [PMID] 19168613.
2008
A model of efficiency: stress tolerance by Streptococcus mutans.
Microbiology (Reading, England). 154(Pt 11):3247-3255 [DOI] 10.1099/mic.0.2008/023770-0. [PMID] 18957579.
2008
cadDX operon of Streptococcus salivarius 57.I.
Applied and environmental microbiology. 74(5):1642-5 [DOI] 10.1128/AEM.01878-07. [PMID] 18165364.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology. 190(7):2340-9 [DOI] 10.1128/JB.01237-07. [PMID] 18223086.
2008
Characteristics of biofilm formation by Streptococcus mutans in the presence of saliva.
Infection and immunity. 76(9):4259-68 [DOI] 10.1128/IAI.00422-08. [PMID] 18625741.
2008
Environmental and growth phase regulation of the Streptococcus gordonii arginine deiminase genes.
Applied and environmental microbiology. 74(16):5023-30 [DOI] 10.1128/AEM.00556-08. [PMID] 18552185.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology. 190(15):5291-9 [DOI] 10.1128/JB.00288-08. [PMID] 18539745.
2008
Multiple sugar: phosphotransferase system permeases participate in catabolite modification of gene expression in Streptococcus mutans.
Molecular microbiology. 70(1):197-208 [DOI] 10.1111/j.1365-2958.2008.06403.x. [PMID] 18699864.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology. 190(1):28-36 [PMID] 17951382.
View on: PubMed
2007
Biofilm formation in an in vitro model of cochlear implants with removable magnets.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 136(4):583-8 [PMID] 17418256.
View on: PubMed
2007
Biofilm formation in cochlear implants with cochlear drug delivery channels in an in vitro model.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 136(4):577-82 [PMID] 17418255.
View on: PubMed
2007
Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans.
Journal of bacteriology. 189(17):6293-302 [PMID] 17616606.
View on: PubMed
2007
Effects of oxygen on virulence traits of Streptococcus mutans.
Journal of bacteriology. 189(23):8519-27 [PMID] 17921307.
View on: PubMed
2007
Impact of engineered surface microtopography on biofilm formation of Staphylococcus aureus.
Biointerphases. 2(2):89-94 [DOI] 10.1116/1.2751405. [PMID] 20408641.
2007
Physiologic effects of forced down-regulation of dnaK and groEL expression in Streptococcus mutans.
Journal of bacteriology. 189(5):1582-8 [PMID] 17172345.
View on: PubMed
2007
The oligopeptide (opp) gene cluster of Streptococcus mutans: identification, prevalence, and characterization.
Oral microbiology and immunology. 22(4):277-84 [PMID] 17600541.
View on: PubMed
2007
The relationship between dental caries status and dental plaque urease activity.
Oral microbiology and immunology. 22(1):61-6 [PMID] 17241172.
View on: PubMed
2007
The Seventh International Conference on the Genetics of Streptococci, Lactococci, and Enterococci.
Journal of bacteriology. 189(4):1209-18 [PMID] 17012391.
View on: PubMed
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology. 65(6):1568-81 [PMID] 17714452.
View on: PubMed
2006
A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.
Molecular microbiology. 62(1):187-200 [PMID] 16987177.
View on: PubMed
2006
Characterization of cis-acting sites controlling arginine deiminase gene expression in Streptococcus gordonii.
Journal of bacteriology. 188(3):941-9 [PMID] 16428398.
View on: PubMed
2006
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.
Journal of bacteriology. 188(11):3748-56 [PMID] 16707667.
View on: PubMed
2006
Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
Antimicrobial agents and chemotherapy. 50(2):542-6 [PMID] 16436708.
View on: PubMed
2006
Influence of BrpA on critical virulence attributes of Streptococcus mutans.
Journal of bacteriology. 188(8):2983-92 [PMID] 16585759.
View on: PubMed
2006
Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159.
Infection and immunity. 74(3):1631-42 [PMID] 16495534.
View on: PubMed
2006
Organization of heat shock dnaK and groE operons of the nosocomial pathogen Enterococcus faecium.
Research in microbiology. 157(2):162-8 [PMID] 16376055.
View on: PubMed
2006
Osmotic stress responses of Streptococcus mutans UA159.
FEMS microbiology letters. 255(2):240-6 [PMID] 16448501.
View on: PubMed
2006
Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159.
Journal of bacteriology. 188(3):834-41 [PMID] 16428386.
View on: PubMed
2006
Streptococcus mutans: fructose transport, xylitol resistance, and virulence.
Journal of dental research. 85(4):369-73 [PMID] 16567561.
View on: PubMed
2006
The atlA operon of Streptococcus mutans: role in autolysin maturation and cell surface biogenesis.
Journal of bacteriology. 188(19):6877-88 [PMID] 16980491.
View on: PubMed
2005
A hypothetical protein of Streptococcus mutans is critical for biofilm formation.
Infection and immunity. 73(5):3147-51 [PMID] 15845523.
View on: PubMed
2005
Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules.
FEMS microbiology letters. 253(2):251-7 [PMID] 16243456.
View on: PubMed
2005
Responses of cariogenic streptococci to environmental stresses.
Current issues in molecular biology. 7(1):95-107 [PMID] 15580782.
View on: PubMed
2005
Role of HtrA in growth and competence of Streptococcus mutans UA159.
Journal of bacteriology. 187(9):3028-38 [PMID] 15838029.
View on: PubMed
2005
Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation.
Infection and immunity. 73(1):219-25 [PMID] 15618157.
View on: PubMed
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology. 186(19):6383-90 [PMID] 15375118.
View on: PubMed
2004
Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.
Journal of bacteriology. 186(6):1902-4 [PMID] 14996823.
View on: PubMed
2004
Bacterial biofilms may contribute to persistent cochlear implant infection.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 25(6):953-7 [PMID] 15547425.
View on: PubMed
2004
Characterization of the arginine deiminase operon of Streptococcus rattus FA-1.
Applied and environmental microbiology. 70(3):1321-7 [PMID] 15006749.
View on: PubMed
2004
Control of expression of the arginine deiminase operon of Streptococcus gordonii by CcpA and Flp.
Journal of bacteriology. 186(8):2511-4 [PMID] 15060059.
View on: PubMed
2004
Effects of RelA on key virulence properties of planktonic and biofilm populations of Streptococcus mutans.
Infection and immunity. 72(3):1431-40 [PMID] 14977948.
View on: PubMed
2004
Galactose metabolism by Streptococcus mutans.
Applied and environmental microbiology. 70(10):6047-52 [PMID] 15466549.
View on: PubMed
2004
LuxS-mediated signaling in Streptococcus mutans is involved in regulation of acid and oxidative stress tolerance and biofilm formation.
Journal of bacteriology. 186(9):2682-91 [PMID] 15090509.
View on: PubMed
2004
RegM is required for optimal fructosyltransferase and glucosyltransferase gene expression in Streptococcus mutans.
FEMS microbiology letters. 240(1):75-9 [PMID] 15500982.
View on: PubMed
2004
Transcriptional analysis of the groE and dnaK heat-shock operons of Enterococcus faecalis.
Research in microbiology. 155(4):252-8 [PMID] 15142622.
View on: PubMed
2003
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system.
Applied and environmental microbiology. 69(8):4760-9 [PMID] 12902269.
View on: PubMed
2003
Identification and characterization of the nickel uptake system for urease biogenesis in Streptococcus salivarius 57.I.
Journal of bacteriology. 185(23):6773-9 [PMID] 14617641.
View on: PubMed
2003
Role of urease enzymes in stability of a 10-species oral biofilm consortium cultivated in a constant-depth film fermenter.
Infection and immunity. 71(12):7188-92 [PMID] 14638814.
View on: PubMed
2002
Analysis of cis- and trans-acting factors involved in regulation of the Streptococcus mutans fructanase gene (fruA).
Journal of bacteriology. 184(1):126-33 [PMID] 11741852.
View on: PubMed
2002
cis-Acting elements that regulate the low-pH-inducible urease operon of Streptococcus salivarius.
Microbiology (Reading, England). 148(Pt 11):3599-3608 [DOI] 10.1099/00221287-148-11-3599. [PMID] 12427950.
2002
Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans.
Applied and environmental microbiology. 68(3):1196-203 [PMID] 11872468.
View on: PubMed
2002
Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1.
Applied and environmental microbiology. 68(11):5549-53 [PMID] 12406748.
View on: PubMed
2002
Pathways for lactose/galactose catabolism by Streptococcus salivarius.
FEMS microbiology letters. 209(1):75-9 [PMID] 12007657.
View on: PubMed
2002
Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans.
Journal of bacteriology. 184(22):6357-66 [PMID] 12399506.
View on: PubMed
2001
Biofilm acid/base physiology and gene expression in oral bacteria.
Methods in enzymology. 337:403-15 [PMID] 11398446.
View on: PubMed
2001
Characterization of two operons that encode components of fructose-specific enzyme II of the sugar:phosphotransferase system of Streptococcus mutans.
FEMS microbiology letters. 205(2):337-42 [PMID] 11750824.
View on: PubMed
2001
Construction of a new integration vector for use in Streptococcus mutans.
Plasmid. 45(1):31-6 [PMID] 11319929.
View on: PubMed
2001
Effects of mutating putative two-component systems on biofilm formation by Streptococcus mutans UA159.
FEMS microbiology letters. 205(2):225-30 [PMID] 11750807.
View on: PubMed
2001
Genetic and physiologic analysis of the groE operon and role of the HrcA repressor in stress gene regulation and acid tolerance in Streptococcus mutans.
Journal of bacteriology. 183(20):6074-84 [PMID] 11567008.
View on: PubMed
2001
Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate.
Microbiology (Reading, England). 147(Pt 10):2841-2848 [DOI] 10.1099/00221287-147-10-2841. [PMID] 11577162.
2001
Roles of fructosyltransferase and levanase-sucrase of Actinomyces naeslundii in fructan and sucrose metabolism.
Infection and immunity. 69(9):5395-402 [PMID] 11500409.
View on: PubMed
2000
Alkali production by oral bacteria and protection against dental caries.
FEMS microbiology letters. 193(1):1-6 [PMID] 11094270.
View on: PubMed
2000
Analysis of urease expression in Actinomyces naeslundii WVU45.
Infection and immunity. 68(12):6670-6 [PMID] 11083780.
View on: PubMed
2000
Bacterial ureases in infectious diseases.
Microbes and infection. 2(5):533-42 [PMID] 10865198.
View on: PubMed
2000
Characterization of recombinant, ureolytic Streptococcus mutans demonstrates an inverse relationship between dental plaque ureolytic capacity and cariogenicity.
Infection and immunity. 68(5):2621-9 [PMID] 10768953.
View on: PubMed
2000
Characterization of the fructosyltransferase gene of Actinomyces naeslundii WVU45.
Journal of bacteriology. 182(13):3649-54 [PMID] 10850978.
View on: PubMed
2000
Dual functions of Streptococcus salivarius urease.
Journal of bacteriology. 182(16):4667-9 [PMID] 10913107.
View on: PubMed
2000
Inactivation of the ptsI gene encoding enzyme I of the sugar phosphotransferase system of Streptococcus salivarius: effects on growth and urease expression.
Microbiology (Reading, England). 146 ( Pt 5):1179-1185 [DOI] 10.1099/00221287-146-5-1179. [PMID] 10832646.
2000
Molecular cloning, purification and immunological responses of recombinants GroEL and DnaK from Streptococcus pyogenes.
FEMS immunology and medical microbiology. 28(2):121-8 [PMID] 10799801.
View on: PubMed
2000
Regulation of urease gene expression by Streptococcus salivarius growing in biofilms.
Environmental microbiology. 2(2):169-77 [PMID] 11220303.
View on: PubMed
1999
Genetic and physiologic characterization of urease of Actinomyces naeslundii.
Infection and immunity. 67(2):504-12 [PMID] 9916052.
View on: PubMed
1999
Physiologic homeostasis and stress responses in oral biofilms.
Methods in enzymology. 310:441-60 [PMID] 10547811.
View on: PubMed
1999
Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression.
Journal of bacteriology. 181(9):2863-71 [PMID] 10217779.
View on: PubMed
1998
Oral streptococci… products of their environment.
Journal of dental research. 77(3):445-52 [PMID] 9496917.
View on: PubMed
1998
Streptococcus salivarius urease expression: involvement of the phosphoenolpyruvate:sugar phosphotransferase system.
FEMS microbiology letters. 165(1):117-22 [PMID] 9711847.
View on: PubMed
1998
Transcriptional regulation of the Streptococcus salivarius 57.I urease operon.
Journal of bacteriology. 180(21):5769-75 [PMID] 9791132.
View on: PubMed
1997
Analysis of gene expression in Streptococcus mutans in biofilms in vitro.
Advances in dental research. 11(1):100-9 [PMID] 9524447.
View on: PubMed
1997
Construction and characterization of a recombinant ureolytic Streptococcus mutans and its use to demonstrate the relationship of urease activity to pH modulating capacity.
FEMS microbiology letters. 151(2):205-11 [PMID] 9228755.
View on: PubMed
1997
Genetic and transcriptional analysis of flgB flagellar operon constituents in the oral spirochete Treponema denticola and their heterologous expression in enteric bacteria.
Infection and immunity. 65(6):2041-51 [PMID] 9169730.
View on: PubMed
1997
Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidification.
Molecular microbiology. 25(2):329-41 [PMID] 9282745.
View on: PubMed
1996
Analysis of Streptococcus salivarius urease expression using continuous chemostat culture.
FEMS microbiology letters. 135(2-3):223-9 [PMID] 8595861.
View on: PubMed
1996
Cariogenicity of Streptococcus mutans strains with defects in fructan metabolism assessed in a program-fed specific-pathogen-free rat model.
Journal of dental research. 75(8):1572-7 [PMID] 8906125.
View on: PubMed
1996
Streptococcus salivarius urease: genetic and biochemical characterization and expression in a dental plaque streptococcus.
Infection and immunity. 64(2):585-92 [PMID] 8550211.
View on: PubMed
1995
DnaK expression in response to heat shock of Streptococcus mutans.
FEMS microbiology letters. 131(3):255-61 [PMID] 7557337.
View on: PubMed
1995
Identification of a fliG homologue in Treponema denticola.
Gene. 161(1):69-73 [PMID] 7642139.
View on: PubMed
1995
Molecular analysis of the urease of Streptococcus salivarius strain 57.1.
Developments in biological standardization. 85:387-92 [PMID] 8586207.
View on: PubMed
1995
Regulation of fructan degradation by Streptococcus mutans.
Developments in biological standardization. 85:323-31 [PMID] 8586197.
View on: PubMed
1994
Differential localization of the Streptococcus mutans GS-5 fructan hydrolase enzyme, FruA.
FEMS microbiology letters. 121(2):243-9 [PMID] 7926677.
View on: PubMed
1994
Use of transposons to dissect pathogenic strategies of gram-positive bacteria.
Methods in enzymology. 235:405-26 [PMID] 8057913.
View on: PubMed
1993
Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model.
Infection and immunity. 61(9):3811-7 [PMID] 8359902.
View on: PubMed
1993
Streptococcus mutans fructosyltransferase (ftf) and glucosyltransferase (gtfBC) operon fusion strains in continuous culture.
Infection and immunity. 61(4):1259-67 [PMID] 8454329.
View on: PubMed
1992
Characteristics and cariogenicity of a fructanase-defective Streptococcus mutants strain.
Infection and immunity. 60(9):3673-81 [PMID] 1500176.
View on: PubMed
1992
Characterization of the Streptococcus mutans GS-5 fruA gene encoding exo-beta-D-fructosidase.
Infection and immunity. 60(11):4621-32 [PMID] 1398976.
View on: PubMed
1989
Cloning and expression in Escherichia coli of the genes of the arginine deiminase system of Streptococcus sanguis NCTC 10904.
Infection and immunity. 57(11):3540-8 [PMID] 2530176.
View on: PubMed
1987
Expression, purification, and characterization of an exo-beta-D-fructosidase of Streptococcus mutans.
Journal of bacteriology. 169(10):4507-17 [PMID] 3308844.
View on: PubMed
1986
Cloning and expression of a Streptococcus mutans glucosyltransferase gene in Bacillus subtilis.
Gene. 47(2-3):201-9 [PMID] 2951298.
View on: PubMed
1986
Tight genetic linkage of a glucosyltransferase and dextranase of Streptococcus mutans GS-5.
Journal of dental research. 65(12):1392-401 [PMID] 2946734.
View on: PubMed

Grants

Sep 2020 ACTIVE
Arginine metabolism in periodontal health and diseases
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Sep 2018 – Sep 2019
Ecological Consequences of Cell-Cell Signaling on Interbacterial Competition
Role: Other
Funding: NATL INST OF HLTH NIDCR
Sep 2018 ACTIVE
Oral Microbiomes and Dental Caries in a Human Immunodeficiency Virus Infected Population
Role: Principal Investigator
Funding: CLEMSON UNIV via NATL INST OF HLTH NIDCR
Aug 2018 – Aug 2020
Investigation of the probiotic mechanisms of action of Streptococcus A12
Role: Other
Funding: NATL INST OF HLTH NIDCR
Jul 2018 ACTIVE
Gene Regulation and Physiology of Streptococcus mutans
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2016 – Jun 2021
Comprehensive Training Program in Oral Biology
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Jul 2016 – Jun 2021
Comprehensive Training Program in Oral Biology
Role: Other
Funding: NATL INST OF HLTH NIDCR
Mar 2016 ACTIVE
Probiotics that moderate PH and antagonize pathogens to promote oral health
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Nov 2015 – Nov 2017
The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride
Role: Project Manager
Funding: COLGATE-PALMOLIVE CO
Jul 2015 – Jun 2021
Genetics and Physiology of Oral Biofilms
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2014 – Aug 2017
Effects of arginine on virulence-related properties of cariogenic Streptococcus mutans
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Dec 2013 – Aug 2020
Environmental regulation of gene expression dissected by microfluidics
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
May 2013 – Jul 2018
Gene Regulation and Physiology of Streptococcus mutans
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2011 – Dec 2016
Comprehensive Training Program in Oral Biology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2011 – Jun 2016
R90-Comprehensive Training Program in Oral Biology
Role: Principal Investigator
Funding: NATL INST OF HLTH
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Patents

Issued May 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions
#9,655,839
Published January 2017
Probiotic Arginolytic Oral Compositions and Methods of Making and Using Probiotic Arginolytic Oral Compositions (CIP of 13295)
#US-2017-0136074-A1
Issued November 2015
Methods for Predicting and Preventing Cardiovascular Disease
#9,176,135
Published January 2007
Recombinant Alkalinizing Bacteria
#US-2007-0212311-A1

Teaching Profile

Courses Taught
2010,2012-2016,2016-2021,2021
DEN8290 Special Topics
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
MCB4911 Supervised Research in Microbiology and Cell Science
2018
PHY7980 Research for Doctoral Dissertation
2017
EGN4912 Engineering Directed Independent Research
2011-2015
DEN5127 Infectious Diseases
2011,2014
DEN5013 Found Professionalism
2013-2014
DEN6681 Craniofacial Pathobiology
2011-2012
GMS6161 Introduction to Oral Biology II

Contact Details

Phones:
Business:
(352) 273-8847
Emails: