Abdel A Alli, PhD, MPH
Associate Professor
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About Abdel A Alli
The two main areas of focus of my research program include 1) investigating the role of extracellular vesicles in intercellular communication and intracellular signaling associated with pathophysiology and 2) investigating the role of proteases, adaptor proteins, and lipids in the regulation of epithelial transport mechanisms in the pathogenesis of disease (e.g. hypertension, cystic fibrosis, diabetic kidney disease, cardiovascular disease) over a 24 hour cycle.
Teaching Profile
Courses Taught
Research Profile
My laboratory uses a multidisciplinary approach to investigate mechanisms of disease. We have established protocols/methods for measuring 1) single channel activity of ion channels in cultured cells and in native tissue by electrophysiology, 2) density of membrane proteins by protein biochemistry, enrichment of lipids/proteins within extracellular vesicles and membrane preparations by lipidomics/proteomics, 3) uptake of extracellular vesicles and expression of various constructs by microscopy, and 4) effect of extracellular vesicles loaded with small molecule drugs by pharmacological approaches.
Publications
Academic Articles
Grants
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AB SCIEX QTRAP 7500 LC MS/MS
Active
- Role:
- Other
- Funding:
- NATL INST OF HLTH OD
-
Mechanisms of morbidity after correcting aortic coarctations of varying severity
Active
- Role:
- Co-Investigator
- Funding:
- MEDICAL COLLEGE OF WISCONSIN via NATL INST OF HLTH NHLBI
-
Targeting ferroptosis in renal tubular epithelial cells to improve outcomes of lupus nephritis
Active
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NIDDK
-
Southeastern Coastal Center for Agricultural Health & Safety (SCCAHS)
Active
- Role:
- Project Manager
- Funding:
- CTRS FOR DISEASE CONTROL AND PREVENTION
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Mechanisms of morbidity after correcting aortic coarctations of varying severity
- Role:
- Principal Investigator
- Funding:
- MEDICAL COLLEGE OF WISCONSIN via NATL INST OF HLTH NHLBI
-
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Active
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIDDK
-
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NCATS
-
Exosomal cargo and cystic fibrosis in children
- Role:
- Principal Investigator
- Funding:
- UF FOUNDATION
-
Mechanisms of morbidity after correcting aortic coarctations of varying severity
- Role:
- Principal Investigator
- Funding:
- MARQUETTE UNIV via NATL INST OF HLTH NHLBI
-
Calicum, MARCKS, and PIP2 regulation of ENaC
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIDDK
Contact Details
- Business:
- (352) 273-7877
- Business:
- aalli@ufl.edu
- Business Mailing:
-
MG42
PO Box 100274
GAINESVILLE FL 32610