Jacqueline Abranches, PhD
Associate Professor
Department:
DN-ORAL BIOLOGY
Business Phone:
(352) 273-6672
Business Email:
jabranches@dental.ufl.edu
About Jacqueline Abranches
Dr. Abranches obtained her M.Sc and Ph.D. in Microbiology and Immunology from the Federal University of Rio de Janeiro in Brazil. She did her post-doctoral training at University of Rochester and University of Florida. In 2007, she became a Research Associate Professor and, along with Dr. Jose Lemos, established the Lemos-Abranches Research Group whose research interests involve microbe-microbe and host-pathogen interactions, and microbial physiology and pathogenesis. In 2014, she became a tenure-track Assistant Professor at the University of Rochester. In 2015, the Lemos-Abranches research group relocated to the University of Florida. Dr. Abranches main research interests involve host-pathogen and microbe-microbe interactions, clinical translational-studies, molecular microbiology and microbial physiology.
Related Links:
Teaching Profile
Courses Taught
2016-2024
DEN5127 Infectious Diseases
2016-2018,2022
DEN8290 Special Topics
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2016
DEN6681 Craniofacial Pathobiology
2021-2025
GMS6162 Oral Microbiology and Immunology
2021
GMS6003 Fundamentals of Graduate Research and Professional Development
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-6615-7348
Publications
Academic Articles
2024
Post-translational modification by the Pgf glycosylation machinery modulates Streptococcus mutans OMZ175 physiology and virulence.
Molecular microbiology.
122(2):133-151
[DOI] 10.1111/mmi.15190.
[PMID] 37972006.
2023
Catalase produced by Candida albicans protects Streptococcus mutans from H2O2 stress-one more piece in the cross-kingdom synergism puzzle.
mSphere.
8(5)
[DOI] 10.1128/msphere.00295-23.
[PMID] 37607054.
2023
Involvement of the Streptococcus mutans PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division.
Glycobiology.
33(3):245-259
[DOI] 10.1093/glycob/cwad004.
[PMID] 36637425.
2022
Amyloid Aggregates Are Localized to the Nonadherent Detached Fraction of Aging Streptococcus mutans Biofilms.
Microbiology spectrum.
10(4)
[DOI] 10.1128/spectrum.01661-22.
[PMID] 35950854.
2022
Quantitative Analysis of Biofilm Removal Following Instrumentation with TRUShape and Vortex Blue File Systems: Microbiological Study.
Frontiers in bioscience (Scholar edition).
14(3)
[DOI] 10.31083/j.fbs1403018.
[PMID] 36137981.
2022
ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication.
PLoS pathogens.
18(8)
[DOI] 10.1371/journal.ppat.1010477.
[PMID] 35939512.
2021
Amyloid Aggregation of Streptococcus mutans Cnm Influences Its Collagen-Binding Activity.
Applied and environmental microbiology.
87(21)
[DOI] 10.1128/AEM.01149-21.
[PMID] 34406827.
2021
Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-90198-3.
[PMID] 34031498.
2021
c-di-AMP Is Essential for the Virulence of Enterococcus faecalis.
Infection and immunity.
89(11)
[DOI] 10.1128/IAI.00365-21.
[PMID] 34424750.
2021
Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals.
Clinical oral investigations.
25(6):3535-3542
[DOI] 10.1007/s00784-020-03676-9.
[PMID] 33170373.
2021
Increased Oxidative Stress Tolerance of a Spontaneously Occurring perR Gene Mutation in Streptococcus mutans UA159.
Journal of bacteriology.
203(8)
[DOI] 10.1128/JB.00535-20.
[PMID] 33526613.
2021
Zinc import mediated by AdcABC is critical for colonization of the dental biofilm by Streptococcus mutans in an animal model.
Molecular oral microbiology.
36(3):214-224
[DOI] 10.1111/omi.12337.
[PMID] 33819383.
2020
Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213.
mSphere.
5(5)
[DOI] 10.1128/mSphere.00863-20.
[PMID] 33055259.
2020
Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.
mSphere.
5(1)
[DOI] 10.1128/mSphere.00764-19.
[PMID] 31915219.
2020
PepO is a target of the two-component systems VicRK and CovR required for systemic virulence of Streptococcus mutans.
Virulence.
11(1):521-536
[DOI] 10.1080/21505594.2020.1767377.
[PMID] 32427040.
2020
Phenotypic and Genotypic Characterization of Streptococcus mutans Strains Isolated from Endodontic Infections.
Journal of endodontics.
46(12):1876-1883
[DOI] 10.1016/j.joen.2020.09.002.
[PMID] 32919986.
2020
Regulatory circuits controlling Spx levels in Streptococcus mutans.
Molecular microbiology.
114(1):109-126
[DOI] 10.1111/mmi.14499.
[PMID] 32189382.
2019
The Biology of Streptococcus mutans.
Microbiology spectrum.
7(1)
[DOI] 10.1128/microbiolspec.gpp3-0051-2018.
[PMID] 30657107.
2018
Biology of Oral Streptococci.
Microbiology spectrum.
6(5)
[DOI] 10.1128/microbiolspec.gpp3-0042-2018.
[PMID] 30338752.
2018
Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-23170-3.
[PMID] 29549320.
2018
CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.
Journal of bacteriology.
200(23)
[DOI] 10.1128/JB.00141-18.
[PMID] 30201780.
2018
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a dpr Mutant Strain of Streptococcus mutans.
Journal of bacteriology.
200(14)
[DOI] 10.1128/JB.00062-18.
[PMID] 29735760.
2018
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans.
Molecular oral microbiology.
33(3):257-269
[DOI] 10.1111/omi.12222.
[PMID] 29524318.
2017
A New Perspective of an Old Villain: Revisiting Biomarkers of Caries Development.
EBioMedicine.
25:14-15
[DOI] 10.1016/j.ebiom.2017.10.022.
[PMID] 29111263.
2017
Collagen-binding proteins of Streptococcus mutans and related streptococci.
Molecular oral microbiology.
32(2):89-106
[DOI] 10.1111/omi.12158.
[PMID] 26991416.
2017
Ex vivo Model of Human Aortic Valve Bacterial Colonization.
Bio-protocol.
7(11)
[DOI] 10.21769/BioProtoc.2316.
[PMID] 32699810.
2017
Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence.
Virulence.
8(1):18-29
[DOI] 10.1080/21505594.2016.1195538.
[PMID] 27260618.
2017
Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.
Molecular oral microbiology.
32(2):142-153
[DOI] 10.1111/omi.12160.
[PMID] 27037617.
2017
Pro-inflammatory Analysis of Macrophages in Contact with Titanium Particles and Porphyromonas gingivalis.
Brazilian dental journal.
28(4):428-434
[DOI] 10.1590/0103-6440201701382.
[PMID] 29160393.
2017
The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.
Molecular oral microbiology.
32(5):419-431
[DOI] 10.1111/omi.12183.
[PMID] 28382721.
2017
Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-16367-5.
[PMID] 29167560.
2015
Lectin Binding Analysis of Streptococcus mutans Glycoproteins.
Bio-protocol.
5(7)
[DOI] 10.21769/BioProtoc.1431.
[PMID] 29644253.
2015
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
Infection and immunity.
83(5):2001-10
[DOI] 10.1128/IAI.03022-14.
[PMID] 25733523.
2015
Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans.
Journal of bacteriology.
197(13):2160-2170
[DOI] 10.1128/JB.00118-15.
[PMID] 25897032.
2015
Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans.
PloS one.
10(4)
[DOI] 10.1371/journal.pone.0124969.
[PMID] 25905865.
2015
Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.
Molecular oral microbiology.
30(6):496-517
[DOI] 10.1111/omi.12110.
[PMID] 26042838.
2014
Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.
Molecular oral microbiology.
29(1):11-23
[DOI] 10.1111/mom.12041.
[PMID] 24103776.
2014
Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence.
Journal of bacteriology.
196(15):2789-97
[DOI] 10.1128/JB.01783-14.
[PMID] 24837294.
2014
The cell wall-targeting antibiotic stimulon of Enterococcus faecalis.
PloS one.
8(6)
[DOI] 10.1371/journal.pone.0064875.
[PMID] 23755154.
2013
Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response.
mBio.
4(5):e00646-13
[DOI] 10.1128/mBio.00646-13.
[PMID] 24065631.
2013
Phenotypic heterogeneity of genomically-diverse isolates of Streptococcus mutans.
PloS one.
8(4)
[DOI] 10.1371/journal.pone.0061358.
[PMID] 23613838.
2013
Psr is involved in regulation of glucan production, and double deficiency of BrpA and Psr is lethal in Streptococcus mutans.
Microbiology (Reading, England).
159(Pt 3):493-506
[DOI] 10.1099/mic.0.063032-0.
[PMID] 23288544.
2013
Streptococcus mutans: a new Gram-positive paradigm?
Microbiology (Reading, England).
159(Pt 3):436-445
[DOI] 10.1099/mic.0.066134-0.
[PMID] 23393147.
2012
BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.
Applied and environmental microbiology.
78(8):2914-22
[DOI] 10.1128/AEM.07823-11.
[PMID] 22327589.
2012
Global transcriptional analysis of the stringent response in Enterococcus faecalis.
Microbiology (Reading, England).
158(Pt 8):1994-2004
[DOI] 10.1099/mic.0.060236-0.
[PMID] 22653948.
2012
The Spx regulator modulates stress responses and virulence in Enterococcus faecalis.
Infection and immunity.
80(7):2265-75
[DOI] 10.1128/IAI.00026-12.
[PMID] 22508863.
2011
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.
Infection and immunity.
79(6):2277-84
[DOI] 10.1128/IAI.00767-10.
[PMID] 21422186.
2011
Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.
Molecular oral microbiology.
26(1):2-18
[DOI] 10.1111/j.2041-1014.2010.00581.x.
[PMID] 21214869.
2011
Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans.
Microbiology (Reading, England).
157(Pt 10):2880-2890
[DOI] 10.1099/mic.0.052407-0.
[PMID] 21816882.
2010
Characterization of the Streptococcus sobrinus acid-stress response by interspecies microarrays and proteomics.
Molecular oral microbiology.
25(5):331-42
[DOI] 10.1111/j.2041-1014.2010.00580.x.
[PMID] 20883222.
2010
Protocols to study the physiology of oral biofilms.
Methods in molecular biology (Clifton, N.J.).
666:87-102
[DOI] 10.1007/978-1-60761-820-1_7.
[PMID] 20717780.
2010
Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.
Journal of bacteriology.
192(10):2546-56
[DOI] 10.1128/JB.00028-10.
[PMID] 20233935.
2009
Inactivation of VicK affects acid production and acid survival of Streptococcus mutans.
Journal of bacteriology.
191(20):6415-24
[DOI] 10.1128/JB.00793-09.
[PMID] 19684142.
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology.
24(2):141-5
[DOI] 10.1111/j.1399-302X.2008.00487.x.
[PMID] 19239641.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research.
21(1):17-20
[DOI] 10.1177/0895937409335593.
[PMID] 19710079.
2009
Role of Clp proteins in expression of virulence properties of Streptococcus mutans.
Journal of bacteriology.
191(7):2060-8
[DOI] 10.1128/JB.01609-08.
[PMID] 19181818.
2009
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis.
Journal of bacteriology.
191(7):2248-56
[DOI] 10.1128/JB.01726-08.
[PMID] 19168608.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology.
190(7):2340-9
[DOI] 10.1128/JB.01237-07.
[PMID] 18223086.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology.
190(15):5291-9
[DOI] 10.1128/JB.00288-08.
[PMID] 18539745.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology.
190(1):28-36
[PMID] 17951382.
2007
Membrane composition changes and physiological adaptation by Streptococcus mutans signal recognition particle pathway mutants.
Journal of bacteriology.
189(4):1219-30
[PMID] 17085548.
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology.
65(6):1568-81
[PMID] 17714452.
2006
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.
Journal of bacteriology.
188(11):3748-56
[PMID] 16707667.
2006
Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
Antimicrobial agents and chemotherapy.
50(2):542-6
[PMID] 16436708.
2006
Osmotic stress responses of Streptococcus mutans UA159.
FEMS microbiology letters.
255(2):240-6
[PMID] 16448501.
2005
Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules.
FEMS microbiology letters.
253(2):251-7
[PMID] 16243456.
2005
Responses of cariogenic streptococci to environmental stresses.
Current issues in molecular biology.
7(1):95-107
[PMID] 15580782.
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology.
186(19):6383-90
[PMID] 15375118.
2004
Galactose metabolism by Streptococcus mutans.
Applied and environmental microbiology.
70(10):6047-52
[PMID] 15466549.
2003
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system.
Applied and environmental microbiology.
69(8):4760-9
[PMID] 12902269.
2002
Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats.
Oral microbiology and immunology.
17(6):337-43
[PMID] 12485324.
2002
Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments.
Oral microbiology and immunology.
17(2):119-24
[PMID] 11929560.
2002
Repressed respiration of oral streptococci grown in biofilms.
Current microbiology.
44(4):262-6
[PMID] 11910496.
Grants
Sep 2024
ACTIVE
Functional amyloid formation in streptococcus mutans
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2024
ACTIVE
Exploring the role of C. albicans oxidative stress pathways in S. mutans reactive oxygen species tolerance
Role: Other
Funding: NATL INST OF HLTH NIDCR
Sep 2023
ACTIVE
Mechanisms of Metal Ion Homeostasis of Oral Streptococci
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2022
– Aug 2024
Exploring the role of catalase in synergism between Candida albicans and Streptococcus mutans
Role: Other
Funding: AMERICAN ACADEMY OF CARIOLOGY
Jan 2022
ACTIVE
To develop a vaccine for Streptococcus mutants
Role: Principal Investigator
Funding: VAXCYTE
Jul 2019
ACTIVE
Intracellular Invasion by Streptococcus mutans: Significance in Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
May 2018
– Apr 2021
Significance of metal homeostasis to bacterial pathogenesis in chronic wounds
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2018
– Dec 2020
Regulatory Nucleotides of Enterococcus faecalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2017
– Apr 2019
Association of Streptococcus mutans and Candida albicans in early childhood caries recurrence
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Apr 2017
– Jun 2023
Miscellaneous Donors Project
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015
– Jun 2017
Start up funds for Dr. J Abranches, Oral Biology
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM
Contact Details
Phones:
- Business:
- (352) 273-6672
Emails:
- Business:
- jabranches@dental.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100424
GAINESVILLE FL 32610 - Business Street:
-
BD 205 D5-33B
GAINESVILLE FL 326100001