Jacqueline Abranches

Jacqueline Abranches, PhD

Associate Professor

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-6672
Business Email: jabranches@dental.ufl.edu

About Jacqueline Abranches

Dr. Abranches obtained her M.Sc and Ph.D. in Microbiology and Immunology from the Federal University of Rio de Janeiro in Brazil. She did her post-doctoral training at University of Rochester and University of Florida. In 2007, she became a Research Associate Professor and, along with Dr. Jose Lemos, established the Lemos-Abranches Research Group whose research interests involve microbe-microbe and host-pathogen interactions, and microbial physiology and pathogenesis. In 2014, she became a tenure-track Assistant Professor at the University of Rochester. In 2015, the Lemos-Abranches research group relocated to the University of Florida. Dr. Abranches main research interests involve host-pathogen and microbe-microbe interactions, clinical translational-studies, molecular microbiology and microbial physiology.

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Teaching Profile

Courses Taught
2016-2024
DEN5127 Infectious Diseases
2016-2018,2022
DEN8290 Special Topics
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2016
DEN6681 Craniofacial Pathobiology
2021-2025
GMS6162 Oral Microbiology and Immunology
2021
GMS6003 Fundamentals of Graduate Research and Professional Development

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-6615-7348

Publications

2023
Catalase produced by Candida albicans protects Streptococcus mutans from H 2 O 2 stress—one more piece in the cross-kingdom synergism puzzle
mSphere. 8(5) [DOI] 10.1128/msphere.00295-23. [PMID] 37607054.
2023
Involvement of the Streptococcus mutans PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division.
Glycobiology. 33(3):245-259 [DOI] 10.1093/glycob/cwad004. [PMID] 36637425.
2023
Post‐translational modification by the Pgf glycosylation machinery modulates Streptococcus mutansOMZ175 physiology and virulence
Molecular Microbiology. [DOI] 10.1111/mmi.15190. [PMID] 37972006.
2022
Amyloid Aggregates Are Localized to the Nonadherent Detached Fraction of Aging Streptococcus mutans Biofilms
Microbiology Spectrum. 10(4) [DOI] 10.1128/spectrum.01661-22. [PMID] 35950854.
2022
Quantitative Analysis of Biofilm Removal Following Instrumentation with TRUShape and Vortex Blue File Systems: Microbiological Study.
Frontiers in bioscience (Scholar edition). 14(3) [DOI] 10.31083/j.fbs1403018. [PMID] 36137981.
2022
ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication.
PLoS pathogens. 18(8) [DOI] 10.1371/journal.ppat.1010477. [PMID] 35939512.
2021
Amyloid Aggregation of Streptococcus mutans Cnm Influences Its Collagen-Binding Activity
Applied and Environmental Microbiology. 87(21) [DOI] 10.1128/aem.01149-21.
2021
Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-90198-3. [PMID] 34031498.
2021
c-di-AMP Is Essential for the Virulence of Enterococcus faecalis
Infection and Immunity. 89(11) [DOI] 10.1128/iai.00365-21.
2021
Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals.
Clinical oral investigations. 25(6):3535-3542 [DOI] 10.1007/s00784-020-03676-9. [PMID] 33170373.
2021
Increased Oxidative Stress Tolerance of a Spontaneously Occurring perR Gene Mutation in Streptococcus mutans UA159.
Journal of bacteriology. 203(8) [DOI] 10.1128/JB.00535-20. [PMID] 33526613.
2021
Zinc import mediated by AdcABC is critical for colonization of the dental biofilm by Streptococcus mutans in an animal model
Molecular Oral Microbiology. 36(3):214-224 [DOI] 10.1111/omi.12337. [PMID] 33819383.
2020
Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213.
mSphere. 5(5) [DOI] 10.1128/mSphere.00863-20. [PMID] 33055259.
2020
Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.
mSphere. 5(1) [DOI] 10.1128/mSphere.00764-19. [PMID] 31915219.
2020
PepO is a target of the two-component systems VicRK and CovR required for systemic virulence of Streptococcus mutans.
Virulence. 11(1):521-536 [DOI] 10.1080/21505594.2020.1767377. [PMID] 32427040.
2020
Phenotypic and Genotypic Characterization of Streptococcus mutans Strains Isolated from Endodontic Infections
Journal of Endodontics. 46(12):1876-1883 [DOI] 10.1016/j.joen.2020.09.002. [PMID] 32919986.
2020
Regulatory circuits controlling Spx levels in Streptococcus mutans
Molecular Microbiology. 114(1):109-126 [DOI] 10.1111/mmi.14499. [PMID] 32189382.
2019
The Biology of Streptococcus mutans.
Microbiology spectrum. 7(1) [DOI] 10.1128/microbiolspec.GPP3-0051-2018. [PMID] 30657107.
2018
Biology of Oral Streptococci.
Microbiology spectrum. 6(5) [DOI] 10.1128/microbiolspec.GPP3-0042-2018. [PMID] 30338752.
2018
Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-23170-3. [PMID] 29549320.
2018
CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.
Journal of bacteriology. 200(23) [DOI] 10.1128/JB.00141-18. [PMID] 30201780.
2018
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a dpr Mutant Strain of Streptococcus mutans.
Journal of bacteriology. 200(14) [DOI] 10.1128/JB.00062-18. [PMID] 29735760.
2018
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans
Molecular Oral Microbiology. 33(3):257-269 [DOI] 10.1111/omi.12222. [PMID] 29524318.
2017
A New Perspective of an Old Villain: Revisiting Biomarkers of Caries Development.
EBioMedicine. 25:14-15 [DOI] 10.1016/j.ebiom.2017.10.022. [PMID] 29111263.
2017
Collagen-binding proteins of Streptococcus mutans and related streptococci.
Molecular oral microbiology. 32(2):89-106 [DOI] 10.1111/omi.12158. [PMID] 26991416.
2017
Ex vivo Model of Human Aortic Valve Bacterial Colonization.
Bio-protocol. 7(11) [DOI] 10.21769/BioProtoc.2316. [PMID] 32699810.
2017
Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence.
Virulence. 8(1):18-29 [DOI] 10.1080/21505594.2016.1195538. [PMID] 27260618.
2017
Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.
Molecular oral microbiology. 32(2):142-153 [DOI] 10.1111/omi.12160. [PMID] 27037617.
2017
Pro-inflammatory Analysis of Macrophages in Contact with Titanium Particles and Porphyromonas gingivalis.
Brazilian dental journal. 28(4):428-434 [DOI] 10.1590/0103-6440201701382. [PMID] 29160393.
2017
The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.
Molecular oral microbiology. 32(5):419-431 [DOI] 10.1111/omi.12183. [PMID] 28382721.
2017
Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-16367-5. [PMID] 29167560.
2015
Lectin Binding Analysis of Streptococcus mutans Glycoproteins.
Bio-protocol. 5(7) [DOI] 10.21769/BioProtoc.1431. [PMID] 29644253.
2015
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
Infection and immunity. 83(5):2001-10 [DOI] 10.1128/IAI.03022-14. [PMID] 25733523.
2015
Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans.
Journal of bacteriology. 197(13):2160-2170 [DOI] 10.1128/JB.00118-15. [PMID] 25897032.
2015
Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans.
PloS one. 10(4) [DOI] 10.1371/journal.pone.0124969. [PMID] 25905865.
2015
Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.
Molecular oral microbiology. 30(6):496-517 [DOI] 10.1111/omi.12110. [PMID] 26042838.
2014
Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.
Molecular oral microbiology. 29(1):11-23 [DOI] 10.1111/mom.12041. [PMID] 24103776.
2014
Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence.
Journal of bacteriology. 196(15):2789-97 [DOI] 10.1128/JB.01783-14. [PMID] 24837294.
2014
The cell wall-targeting antibiotic stimulon of Enterococcus faecalis.
PloS one. 8(6) [DOI] 10.1371/journal.pone.0064875. [PMID] 23755154.
2013
Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response.
mBio. 4(5):e00646-13 [DOI] 10.1128/mBio.00646-13. [PMID] 24065631.
2013
Phenotypic heterogeneity of genomically-diverse isolates of Streptococcus mutans.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0061358. [PMID] 23613838.
2013
Psr is involved in regulation of glucan production, and double deficiency of BrpA and Psr is lethal in Streptococcus mutans.
Microbiology (Reading, England). 159(Pt 3):493-506 [DOI] 10.1099/mic.0.063032-0. [PMID] 23288544.
2013
Streptococcus mutans: a new Gram-positive paradigm?
Microbiology (Reading, England). 159(Pt 3):436-445 [DOI] 10.1099/mic.0.066134-0. [PMID] 23393147.
2012
BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.
Applied and environmental microbiology. 78(8):2914-22 [DOI] 10.1128/AEM.07823-11. [PMID] 22327589.
2012
Global transcriptional analysis of the stringent response in Enterococcus faecalis.
Microbiology (Reading, England). 158(Pt 8):1994-2004 [DOI] 10.1099/mic.0.060236-0. [PMID] 22653948.
2012
The Spx regulator modulates stress responses and virulence in Enterococcus faecalis.
Infection and immunity. 80(7):2265-75 [DOI] 10.1128/IAI.00026-12. [PMID] 22508863.
2011
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.
Infection and immunity. 79(6):2277-84 [DOI] 10.1128/IAI.00767-10. [PMID] 21422186.
2011
Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.
Molecular oral microbiology. 26(1):2-18 [DOI] 10.1111/j.2041-1014.2010.00581.x. [PMID] 21214869.
2011
Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans.
Microbiology (Reading, England). 157(Pt 10):2880-2890 [DOI] 10.1099/mic.0.052407-0. [PMID] 21816882.
2010
Characterization of the Streptococcus sobrinus acid-stress response by interspecies microarrays and proteomics.
Molecular oral microbiology. 25(5):331-42 [DOI] 10.1111/j.2041-1014.2010.00580.x. [PMID] 20883222.
2010
Protocols to study the physiology of oral biofilms.
Methods in molecular biology (Clifton, N.J.). 666:87-102 [DOI] 10.1007/978-1-60761-820-1_7. [PMID] 20717780.
2010
Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.
Journal of bacteriology. 192(10):2546-56 [DOI] 10.1128/JB.00028-10. [PMID] 20233935.
2009
Inactivation of VicK affects acid production and acid survival of Streptococcus mutans.
Journal of bacteriology. 191(20):6415-24 [DOI] 10.1128/JB.00793-09. [PMID] 19684142.
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology. 24(2):141-5 [DOI] 10.1111/j.1399-302X.2008.00487.x. [PMID] 19239641.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research. 21(1):17-20 [DOI] 10.1177/0895937409335593. [PMID] 19710079.
2009
Role of Clp proteins in expression of virulence properties of Streptococcus mutans.
Journal of bacteriology. 191(7):2060-8 [DOI] 10.1128/JB.01609-08. [PMID] 19181818.
2009
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis.
Journal of bacteriology. 191(7):2248-56 [DOI] 10.1128/JB.01726-08. [PMID] 19168608.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology. 190(7):2340-9 [DOI] 10.1128/JB.01237-07. [PMID] 18223086.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology. 190(15):5291-9 [DOI] 10.1128/JB.00288-08. [PMID] 18539745.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology. 190(1):28-36 [PMID] 17951382.
2007
Membrane composition changes and physiological adaptation by Streptococcus mutans signal recognition particle pathway mutants.
Journal of bacteriology. 189(4):1219-30 [PMID] 17085548.
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology. 65(6):1568-81 [PMID] 17714452.
2006
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.
Journal of bacteriology. 188(11):3748-56 [PMID] 16707667.
2006
Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
Antimicrobial agents and chemotherapy. 50(2):542-6 [PMID] 16436708.
2006
Osmotic stress responses of Streptococcus mutans UA159.
FEMS microbiology letters. 255(2):240-6 [PMID] 16448501.
2005
Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules.
FEMS microbiology letters. 253(2):251-7 [PMID] 16243456.
2005
Responses of cariogenic streptococci to environmental stresses.
Current issues in molecular biology. 7(1):95-107 [PMID] 15580782.
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology. 186(19):6383-90 [PMID] 15375118.
2004
Galactose metabolism by Streptococcus mutans.
Applied and environmental microbiology. 70(10):6047-52 [PMID] 15466549.
2003
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system.
Applied and environmental microbiology. 69(8):4760-9 [PMID] 12902269.
2002
Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats.
Oral microbiology and immunology. 17(6):337-43 [PMID] 12485324.
2002
Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments.
Oral microbiology and immunology. 17(2):119-24 [PMID] 11929560.
2002
Repressed respiration of oral streptococci grown in biofilms.
Current microbiology. 44(4):262-6 [PMID] 11910496.

Grants

Sep 2023 ACTIVE
Mechanisms of Metal Ion Homeostasis of Oral Streptococci
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2022 ACTIVE
Exploring the role of catalase in synergism between Candida albicans and Streptococcus mutans
Role: Other
Funding: AMERICAN ACADEMY OF CARIOLOGY
Jan 2022 ACTIVE
To develop a vaccine for Streptococcus mutants
Role: Principal Investigator
Funding: VAXCYTE
Jul 2019 ACTIVE
Intracellular Invasion by Streptococcus mutans: Significance in Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
May 2018 – Apr 2021
Significance of metal homeostasis to bacterial pathogenesis in chronic wounds
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2018 – Dec 2020
Regulatory Nucleotides of Enterococcus faecalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2017 – Apr 2019
Association of Streptococcus mutans and Candida albicans in early childhood caries recurrence
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Apr 2017 – Jun 2023
Miscellaneous Donors Project
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015 – Jun 2017
Start up funds for Dr. J Abranches, Oral Biology
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM

Contact Details

Phones:
Business:
(352) 273-6672
Emails:
Addresses:
Business Mailing:
PO Box 100424
GAINESVILLE FL 32610
Business Street:
BD 205 D5-33B
GAINESVILLE FL 326100001