Jacqueline Abranches

Jacqueline Abranches, Ph.D.

Associate Professor

Department: DN-ORAL BIOLOGY
Business Phone: (352) 273-6672
Business Email: jabranches@dental.ufl.edu

About Jacqueline Abranches

Dr. Abranches obtained her M.Sc and Ph.D. in Microbiology and Immunology from the Federal University of Rio de Janeiro in Brazil. She did her post-doctoral training at University of Rochester and University of Florida. In 2007, she became a Research Associate Professor and, along with Dr. Jose Lemos, established the Lemos-Abranches Research Group whose research interests involve microbe-microbe and host-pathogen interactions, and microbial physiology and pathogenesis. In 2014, she became a tenure-track Assistant Professor at the University of Rochester. In 2015, the Lemos-Abranches research group relocated to the University of Florida. Dr. Abranches main research interests involve host-pathogen and microbe-microbe interactions, clinical translational-studies, molecular microbiology and microbial physiology.

Publications

2021
Amyloid Aggregation of Streptococcus mutans Cnm Influences Its Collagen-Binding Activity.
Applied and environmental microbiology. 87(21) [DOI] 10.1128/AEM.01149-21. [PMID] 34406827.
2021
Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-90198-3. [PMID] 34031498.
2021
c-di-AMP Is Essential for the Virulence of Enterococcus faecalis.
Infection and immunity. 89(11) [DOI] 10.1128/IAI.00365-21. [PMID] 34424750.
2021
Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals.
Clinical oral investigations. 25(6):3535-3542 [DOI] 10.1007/s00784-020-03676-9. [PMID] 33170373.
2021
Increased Oxidative Stress Tolerance of a Spontaneously Occurring perR Gene Mutation in Streptococcus mutans UA159.
Journal of bacteriology. 203(8) [DOI] 10.1128/JB.00535-20. [PMID] 33526613.
2021
Zinc import mediated by AdcABC is critical for colonization of the dental biofilm by Streptococcus mutans in an animal model.
Molecular oral microbiology. 36(3):214-224 [DOI] 10.1111/omi.12337. [PMID] 33819383.
2020
Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213.
mSphere. 5(5) [DOI] 10.1128/mSphere.00863-20. [PMID] 33055259.
2020
Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.
mSphere. 5(1) [DOI] 10.1128/mSphere.00764-19. [PMID] 31915219.
2020
PepO is a target of the two-component systems VicRK and CovR required for systemic virulence of Streptococcus mutans.
Virulence. 11(1):521-536 [DOI] 10.1080/21505594.2020.1767377. [PMID] 32427040.
2020
Phenotypic and Genotypic Characterization of Streptococcus mutans Strains Isolated from Endodontic Infections.
Journal of endodontics. 46(12):1876-1883 [DOI] 10.1016/j.joen.2020.09.002. [PMID] 32919986.
2020
Regulatory circuits controlling Spx levels in Streptococcus mutans.
Molecular microbiology. 114(1):109-126 [DOI] 10.1111/mmi.14499. [PMID] 32189382.
2019
The Biology of Streptococcus mutans.
Microbiology spectrum. 7(1) [DOI] 10.1128/microbiolspec.GPP3-0051-2018. [PMID] 30657107.
2018
Biology of Oral Streptococci.
Microbiology spectrum. 6(5) [DOI] 10.1128/microbiolspec.GPP3-0042-2018. [PMID] 30338752.
2018
Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-23170-3. [PMID] 29549320.
2018
CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.
Journal of bacteriology. 200(23) [DOI] 10.1128/JB.00141-18. [PMID] 30201780.
2018
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a dpr Mutant Strain of Streptococcus mutans.
Journal of bacteriology. 200(14) [DOI] 10.1128/JB.00062-18. [PMID] 29735760.
2018
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans.
Molecular oral microbiology. 33(3):257-269 [DOI] 10.1111/omi.12222. [PMID] 29524318.
2017
A New Perspective of an Old Villain: Revisiting Biomarkers of Caries Development.
EBioMedicine. 25:14-15 [DOI] 10.1016/j.ebiom.2017.10.022. [PMID] 29111263.
2017
Collagen-binding proteins of Streptococcus mutans and related streptococci.
Molecular oral microbiology. 32(2):89-106 [DOI] 10.1111/omi.12158. [PMID] 26991416.
2017
Ex vivo Model of Human Aortic Valve Bacterial Colonization.
Bio-protocol. 7(11) [DOI] 10.21769/BioProtoc.2316. [PMID] 32699810.
2017
Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence.
Virulence. 8(1):18-29 [DOI] 10.1080/21505594.2016.1195538. [PMID] 27260618.
2017
Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.
Molecular oral microbiology. 32(2):142-153 [DOI] 10.1111/omi.12160. [PMID] 27037617.
2017
Pro-inflammatory Analysis of Macrophages in Contact with Titanium Particles and Porphyromonas gingivalis.
Brazilian dental journal. 28(4):428-434 [DOI] 10.1590/0103-6440201701382. [PMID] 29160393.
2017
The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.
Molecular oral microbiology. 32(5):419-431 [DOI] 10.1111/omi.12183. [PMID] 28382721.
2017
Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-16367-5. [PMID] 29167560.
2015
Lectin Binding Analysis of Streptococcus mutans Glycoproteins.
Bio-protocol. 5(7) [DOI] 10.21769/BioProtoc.1431. [PMID] 29644253.
2015
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
Infection and immunity. 83(5):2001-10 [DOI] 10.1128/IAI.03022-14. [PMID] 25733523.
2015
Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans.
Journal of bacteriology. 197(13):2160-2170 [DOI] 10.1128/JB.00118-15. [PMID] 25897032.
2015
Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans.
PloS one. 10(4) [DOI] 10.1371/journal.pone.0124969. [PMID] 25905865.
2015
Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.
Molecular oral microbiology. 30(6):496-517 [DOI] 10.1111/omi.12110. [PMID] 26042838.
2014
Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.
Molecular oral microbiology. 29(1):11-23 [DOI] 10.1111/mom.12041. [PMID] 24103776.
2014
Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence.
Journal of bacteriology. 196(15):2789-97 [DOI] 10.1128/JB.01783-14. [PMID] 24837294.
2014
The cell wall-targeting antibiotic stimulon of Enterococcus faecalis.
PloS one. 8(6) [DOI] 10.1371/journal.pone.0064875. [PMID] 23755154.
2013
Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response.
mBio. 4(5):e00646-13 [DOI] 10.1128/mBio.00646-13. [PMID] 24065631.
2013
Phenotypic heterogeneity of genomically-diverse isolates of Streptococcus mutans.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0061358. [PMID] 23613838.
2013
Psr is involved in regulation of glucan production, and double deficiency of BrpA and Psr is lethal in Streptococcus mutans.
Microbiology (Reading, England). 159(Pt 3):493-506 [DOI] 10.1099/mic.0.063032-0. [PMID] 23288544.
2013
Streptococcus mutans: a new Gram-positive paradigm?
Microbiology (Reading, England). 159(Pt 3):436-445 [DOI] 10.1099/mic.0.066134-0. [PMID] 23393147.
2012
BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.
Applied and environmental microbiology. 78(8):2914-22 [DOI] 10.1128/AEM.07823-11. [PMID] 22327589.
2012
Global transcriptional analysis of the stringent response in Enterococcus faecalis.
Microbiology (Reading, England). 158(Pt 8):1994-2004 [DOI] 10.1099/mic.0.060236-0. [PMID] 22653948.
2012
The Spx regulator modulates stress responses and virulence in Enterococcus faecalis.
Infection and immunity. 80(7):2265-75 [DOI] 10.1128/IAI.00026-12. [PMID] 22508863.
2011
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.
Infection and immunity. 79(6):2277-84 [DOI] 10.1128/IAI.00767-10. [PMID] 21422186.
2011
Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.
Molecular oral microbiology. 26(1):2-18 [DOI] 10.1111/j.2041-1014.2010.00581.x. [PMID] 21214869.
2011
Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans.
Microbiology (Reading, England). 157(Pt 10):2880-2890 [DOI] 10.1099/mic.0.052407-0. [PMID] 21816882.
2010
Characterization of the Streptococcus sobrinus acid-stress response by interspecies microarrays and proteomics.
Molecular oral microbiology. 25(5):331-42 [DOI] 10.1111/j.2041-1014.2010.00580.x. [PMID] 20883222.
2010
Protocols to study the physiology of oral biofilms.
Methods in molecular biology (Clifton, N.J.). 666:87-102 [DOI] 10.1007/978-1-60761-820-1_7. [PMID] 20717780.
2010
Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.
Journal of bacteriology. 192(10):2546-56 [DOI] 10.1128/JB.00028-10. [PMID] 20233935.
2009
Inactivation of VicK affects acid production and acid survival of Streptococcus mutans.
Journal of bacteriology. 191(20):6415-24 [DOI] 10.1128/JB.00793-09. [PMID] 19684142.
2009
Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.
Oral microbiology and immunology. 24(2):141-5 [DOI] 10.1111/j.1399-302X.2008.00487.x. [PMID] 19239641.
2009
Opportunities for disrupting cariogenic biofilms.
Advances in dental research. 21(1):17-20 [DOI] 10.1177/0895937409335593. [PMID] 19710079.
2009
Role of Clp proteins in expression of virulence properties of Streptococcus mutans.
Journal of bacteriology. 191(7):2060-8 [DOI] 10.1128/JB.01609-08. [PMID] 19181818.
2009
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis.
Journal of bacteriology. 191(7):2248-56 [DOI] 10.1128/JB.01726-08. [PMID] 19168608.
2008
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans.
Journal of bacteriology. 190(7):2340-9 [DOI] 10.1128/JB.01237-07. [PMID] 18223086.
2008
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Journal of bacteriology. 190(15):5291-9 [DOI] 10.1128/JB.00288-08. [PMID] 18539745.
2008
Role of RelA of Streptococcus mutans in global control of gene expression.
Journal of bacteriology. 190(1):28-36 [PMID] 17951382.
View on: PubMed
2007
Membrane composition changes and physiological adaptation by Streptococcus mutans signal recognition particle pathway mutants.
Journal of bacteriology. 189(4):1219-30 [PMID] 17085548.
View on: PubMed
2007
Three gene products govern (p)ppGpp production by Streptococcus mutans.
Molecular microbiology. 65(6):1568-81 [PMID] 17714452.
View on: PubMed
2006
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.
Journal of bacteriology. 188(11):3748-56 [PMID] 16707667.
View on: PubMed
2006
Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
Antimicrobial agents and chemotherapy. 50(2):542-6 [PMID] 16436708.
View on: PubMed
2006
Osmotic stress responses of Streptococcus mutans UA159.
FEMS microbiology letters. 255(2):240-6 [PMID] 16448501.
View on: PubMed
2005
Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules.
FEMS microbiology letters. 253(2):251-7 [PMID] 16243456.
View on: PubMed
2005
Responses of cariogenic streptococci to environmental stresses.
Current issues in molecular biology. 7(1):95-107 [PMID] 15580782.
View on: PubMed
2004
Adaptive acid tolerance response of Streptococcus sobrinus.
Journal of bacteriology. 186(19):6383-90 [PMID] 15375118.
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2004
Galactose metabolism by Streptococcus mutans.
Applied and environmental microbiology. 70(10):6047-52 [PMID] 15466549.
View on: PubMed
2003
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system.
Applied and environmental microbiology. 69(8):4760-9 [PMID] 12902269.
View on: PubMed
2002
Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats.
Oral microbiology and immunology. 17(6):337-43 [PMID] 12485324.
View on: PubMed
2002
Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments.
Oral microbiology and immunology. 17(2):119-24 [PMID] 11929560.
View on: PubMed
2002
Repressed respiration of oral streptococci grown in biofilms.
Current microbiology. 44(4):262-6 [PMID] 11910496.
View on: PubMed

Grants

Jul 2019 ACTIVE
Intracellular Invasion by Streptococcus mutans: Significance in Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
May 2018 – Apr 2021
Significance of metal homeostasis to bacterial pathogenesis in chronic wounds
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2018 – Dec 2020
Regulatory Nucleotides of Enterococcus faecalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2017 – Apr 2019
Association of Streptococcus mutans and Candida albicans in early childhood caries recurrence
Role: Principal Investigator
Funding: COLGATE-PALMOLIVE CO
Apr 2017 ACTIVE
Miscellaneous Donors Project
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015 – Jun 2017
Start up funds for Dr. J Abranches, Oral Biology
Role: Principal Investigator
Funding: UF COLLEGE OF DENTISTRY SEED PROGRAM

Teaching Profile

Courses Taught
2016-2021
DEN5127 Infectious Diseases
2016-2018
DEN8290 Special Topics
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2016
DEN6681 Craniofacial Pathobiology
2021
GMS6162 Oral Microbiology and Immunology
2021
GMS6003 Fundamentals of Graduate Research and Professional Development

Contact Details

Phones:
Business:
(352) 273-6672
Emails: