Shannon Wallet, Ph.D.

Dr. Shannon WalletAssociate Professor & Associate Dean for Faculty Affairs

Department of Oral Biology
1395 Center Drive, D11-23
Box 100424
Gainesville, FL 32610-0424
Phone: 352-273-8370
Laboratory: 352-273-8135




  • UNC at Chapel Hill, Chapel Hill, NC: Ph.D. – Curriculum of Oral Biology, 2000-2005
  • Duke University, Durham, NC: Clinical Laboratory Science Certification, 1994-1995
  • North Carolina State University, Raleigh, NC: Bachelor of Science – Medical Technology, 1991-1995

Previous Positions

  • 07/16 – present Associate Dean for Faculty Affairs
  • 01/15 – present Associate Professor – Department of Oral Biology Chair: Robert Burne, PhD
  • 07/13 – 01/15 Associate Professor – Department of Periodontology Department Chair: Ikramuddin Aukhil, BDS, MS
  • 09/06-06/13: Assistant Professor University of Florida-Department of Periodontology
    Department Chair: Ikramuddin Aukhil, B.D.S., M.S.
  • 11/05-08/06: Scientific Consultant University of North Carolina at Chapel Hill
    Dental Research Center (DRC), Comprehensive Center for Inflammatory Disease (CCID)
  • 04/05-11/05: Post-doctoral Fellow University of Pittsburgh School of Medicine
    Principal Investigator: Chad Steele, PhD. Department of Pediatrics
  • 2000-2005: Ph.D. Candidate University of North Carolina at Chapel Hill
    Dissertation advisor: Roland Tisch, PhD. Department of Microbiology and Immunology
  • 1999-2000: Research Assistant Duke University Medical Center
    Supervisor: Nancy Reinsmoen, PhD. Immunology Transplant Laboratory
  • 1995-2000: Medical Technologist Duke University Medical Center
    Supervisor: Mary Lee Campbell, MT (ASCP) Transfusion Services Laboratory

Main Interests

The research interests of the SM Wallet Laboratory are focused on mechanisms associated with altered innate immune functions, which lead to dysregulated adaptive immunity. Through independent and collaborative research programs, the laboratory has been involved, at some level, in investigating the basic biology of health, multiple autoimmune conditions, autoinflammation, sepsis, exercise induced inflammation, and, most recently, cancer. A major focus for the laboratory is understanding intestinal immune regulation under conditions of health versus disease, in the context of type 1 diabetes. Investigations into these interactions have been hindered by a lack of robust primary cell culture techniques, which the SM Wallet laboratory has most recently been able to overcome. The laboratory also studies altered immunological mechanisms which lead to tissue destruction in the context of periodontal disease. Here, through funding from the NIDCR and American Diabetes Association (ADA), they have demonstrated that oral epithelial cells play a central role in regulating oral inflammation and its resolution. In addition, the laboratory has begun to decipher osteoclast specific mechanisms associated with excessive bone destruction observed in periodontal disease of individuals with type 1 diabetes. The SM Wallet laboratory also investigates the subversion of immunity involved in pancreatic cancer. Through funding from the UF-sponsored Team Science Project (UF TSP) and American Cancer Society Career Development Awards (ACS CDA), they have generated data allowing them to develop personalized targeting nanomedicines as well as to decipher the mechanisms associated with pancreatic cancer specific suppression of the innate immune system, allowing for the progression of disease and metastases. Dr. SM Wallet is keen to utilize her expertise and information generated by her laboratory to bring together multiple research communities with the goal of advancing human health.


Selected Publications

  •  Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George T, Brusko T, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet S. Human pancreatic cancer cells induce a MyD88-dependent stromal response to promote a tumor-tolerant immune microenvironment. Cancer Res. 2016 Nov 18. pii: canres.1765.2016. [Epub ahead of print] PubMed PMID: 27864347.
  • Ribeiro-Dasilva MC, Fillingim RB, Wallet SM. Estrogen-Induced Monocytic Response Correlates with Temporomandibular Disorder Pain: A Case Control Study. J Dent Res. 2016 Nov 16. pii: 0022034516678599. [Epub ahead of print] PubMed PMID: 27856968.
  • Mesia R, Gholami F, Huang H, Clare-Salzler M, Aukhil I, Wallet SM, Shaddox LM. Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis. BMJ Open Diabetes Res Care. 2016 Sep 8;4(1):e000260. doi: 10.1136/bmjdrc-2016-000260. PubMed PMID: 27651910; PubMed Central PMCID: PMC5020743.
  • Ebersole JL, Graves CL, Gonzalez OA, Dawson D 3rd, Morford LA, Huja PE, Hartsfield JK Jr, Huja SS, Pandruvada S, Wallet SM. Aging, inflammation, immunity and periodontal disease. Periodontol 2000. 2016 Oct;72(1):54-75. doi: 10.1111/prd.12135. Review. PubMed PMID: 27501491.
  • Delitto D, Wallet SM, Hughes SJ. Targeting tumor tolerance: A new hope for pancreatic cancer therapy? Pharmacol Ther. 2016 Oct;166:9-29. doi: 1016/j.pharmthera.2016.06.008. PubMed PMID: 27343757.
  • Pham K, Delitto D, Knowlton AE, Hartlage ER, Madhavan R, Gonzalo DH, Thomas RM, Behrns KE, George TJ Jr, Hughes SJ, Wallet SM, Liu C, Trevino JG. Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture. Am J Pathol. 2016 Jun;186(6):1537-46. doi: 0.1016/j.ajpath.2016.02.009. PubMed PMID: 27102771; PubMed Central PMCID: PMC4901138.
  • Shaddox LM, Spencer WP, Velsko IM, Al-Kassab H, Huang H, Calderon N, Aukhil I, Wallet SM. Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque. J Clin Periodontol. 2016 Sep;43(9):746-53. doi: 10.1111/jcpe.12560. PubMed PMID: 27037664; PubMed Central PMCID: PMC4975966.
  • Allin N, Cruz-Almeida Y, Velsko I, Vovk A, Hovemcamp N, Harrison P, Huang H, Aukhil I, Wallet SM, Shaddox LM. Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. J Dent Res. 2016 Jun;95(6):635-41. doi: 10.1177/0022034516631973. PubMed PMID: 26917438; PubMed Central PMCID: PMC4924542.
  • Delitto D, Zhang D, Han S, Black BS, Knowlton AE, Vlada AC, Sarosi GA, Behrns KE, Thomas RM, Lu X, Liu C, George TJ, Hughes SJ, Wallet SM, Trevino JG. Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment. Clin Cancer Res. 2016 Apr 1;22(7):1787-99. doi: 10.1158/1078-0432.CCR-15-1256. PubMed PMID: 26667487; PubMed Central PMCID: PMC4818664.
  • Kalash D, Vovk A, Huang H, Aukhil I, Wallet SM, Shaddox LM. Influence of Periodontal Therapy on Systemic Lipopolysaccharides in Children with Localized Aggressive Periodontitis. Pediatr Dent. 2015 Sep-Oct;37(5):35-40. PubMed PMID: 26531074; PubMed Central PMCID: PMC4634009.
  • Jones MK, Grau KR, Costantini V, Kolawole AO, de Graaf M, Freiden P, Graves CL, Koopmans M, Wallet SM, Tibbetts SA, Schultz-Cherry S, Wobus CE, Vinjé J, Karst SM. Human norovirus culture in B cells. Nat Protoc. 2015 Dec;10(12):1939-47. doi: 10.1038/nprot.2015.121. PubMed PMID: 26513671; PubMed Central PMCID: PMC4689599.
  • Delitto D, Black BS, Sorenson HL, Knowlton AE, Thomas RM, Sarosi GA, Moldawer LL, Behrns KE, Liu C, George TJ, Trevino JG, Wallet SM, Hughes SJ. The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival. BMC Cancer. 2015 Oct 24;15:783. doi: 10.1186/s12885-015-1820-x. PubMed PMID: 26498838; PubMed Central PMCID: PMC4619553.
  • Cruz-Almeida Y, Aguirre M, Sorenson HL, Tighe P, Wallet SM, Riley JL 3rd. Age differences in cytokine expression under conditions of health using experimental pain models. Exp Gerontol. 2015 Dec;72:150-6. doi: 10.1016/j.exger.2015.09.017. PubMed PMID: 26456458; PubMed Central PMCID: PMC4664177.
  • Delitto D, Perez C, Han S, Gonzalo DH, Pham K, Knowlton AE, Graves CL, Behrns KE, Moldawer LL, Thomas RM, Liu C, George TJ Jr, Trevino JG, Wallet SM, Hughes SJ. Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer. Cancer Immunol Immunother. 2015 Dec;64(12):1553-63. doi: 10.1007/s00262-015-1760-y. PubMed PMID: 26423423.
  • Han S, Delitto D, Zhang D, Sorenson HL, Sarosi GA, Thomas RM, Behrns KE, Wallet SM, Trevino JG, Hughes SJ. Primary outgrowth cultures are a reliable source of human pancreatic stellate cells. Lab Invest. 2015 Nov;95(11):1331-40. doi: 10.1038/labinvest.2015.117. PubMed PMID: 26322418.
  • Rody WJ Jr, Wijegunasinghe M, Holliday LS, McHugh KP, Wallet SM. Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth. Angle Orthod. 2016 Mar;86(2):187-92. doi: 10.2319/032415-195.1. PubMed PMID: 26154939.
  • Delitto D, Pham K, Vlada AC, Sarosi GA, Thomas RM, Behrns KE, Liu C, Hughes SJ, Wallet SM, Trevino JG. Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements. Am J Pathol. 2015 May;185(5):1297-303. doi: 10.1016/j.ajpath.2015.01.016. PubMed PMID: 25770474; PubMed Central PMCID:PMC4419203.
  • Phillips NA, Welc SS, Wallet SM, King MA, Clanton TL. Protection of intestinal injury during heat stroke in mice by interleukin-6 pretreatment. J Physiol. 2015 Feb 1;593(3):739-52; discussion 753. doi: 10.1113/jphysiol.2014.283416. PubMed PMID: 25433073; PubMed Central PMCID: PMC4324717.
  • Lu S, Zeumer L, Sorensen H, Yang H, Ng Y, Yu F, Riva A, Croker B, Wallet S, Morel L. The murine Pbx1-d lupus susceptibility allele accelerates mesenchymal stem cell differentiation and impairs their immunosuppressive function. J Immunol. 2015 Jan 1;194(1):43-55. PubMed PMID: 25416808.
  • Jones MK, Watanabe M, Zhu S, Graves CL, Keyes LR, Grau KR, Gonzalez-Hernandez MB, Iovine NM, Wobus CE, Vinjé J, Tibbetts SA, Wallet SM, Karst SM. Enteric bacteria promote human and mouse norovirus infection of B cells. Science. 2014 Nov 7;346(6210):755-9. doi: 10.1126/science.1257147. PubMed PMID: 25378626; PubMed Central PMCID: PMC4401463.
  • Graves CL, Harden SW, LaPato M, Nelson M, Amador B, Sorenson H, Frazier CJ, Wallet SM. A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function. J Immunol Methods. 2014 Dec 1;414:20-31. doi: 10.1016/j.jim.2014.08.002. PubMed PMID: 25193428; PubMed Central PMCID: PMC4384334.
  • Neiva KG, Calderon NL, Alonso TR, Panagakos F, Wallet SM. Type 1 diabetes-associated TLR responsiveness of oral epithelial cells. J Dent Res. 2014 Feb;93(2):169-74. doi: 10.1177/0022034513516345. PubMed PMID: 24334435.
  • Catalfamo DL, Britten TM, Storch DL, Calderon NL, Sorenson HL, Wallet SM. Hyperglycemia induced and intrinsic alterations in type 2 diabetes-derived osteoclast function. Oral Dis. 2013 Apr;19(3):303-12. doi: 10.1111/odi.12002. PubMed PMID: 24079914; PubMed Central PMCID: PMC3800028.
  • Wallet MA, Calderon Nl, Alonso TR, Choe CS, Catalfamo Dl, Lalane CJ, NeivaKG, Panagakos F, Wallet SM. Triclosan alters antimicrobial and inflammatoryresponses of epithelial cells. Oral Dis. 2013 Apr;19(3):296-302. doi:10.1111/odi.12001. PubMed PMID: 24079913; PubMed Central PMCID: PMC3800022.
  • Reyes L, Eiler-McManis E, Rodrigues PH, Chadda AS, Wallet SM, Bélanger M,Barrett AG, Alvarez S, Akin D, Dunn WA Jr, Progulske-Fox A. Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells. PLoS One. 2013 Sep 12;8(9):e74230. doi: 10.1371/journal.pone.0074230. PubMed PMID: 24069284; PubMed Central PMCID: PMC3772042.
  • Shaddox LM, Gonçalves PF, Vovk A, Allin N, Huang H, Hou W, Aukhil I, Wallet SM. LPS-induced inflammatory response after therapy of aggressive periodontitis. J Dent Res. 2013 Aug;92(8):702-8. doi: 10.1177/0022034513495242. PubMed PMID:23788609; PubMed Central PMCID: PMC3711573.
  • Knowlton AE, Fowler LJ, Patel RK, Wallet SM, Grieshaber SS. Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an
    infection model. PLoS One. 2013;8(1):e54022. doi: 10.1371/journal.pone.0054022. PubMed PMID: 23308295; PubMed Central PMCID: PMC3538680.
  • Cruz-Almeida Y, King CD, Wallet SM, Riley JL 3rd. Immune biomarker response depends on choice of experimental pain stimulus in healthy adults: a preliminary study. Pain Res Treat. 2012;2012:538739. doi: 10.1155/2012/538739. PubMed PMID: 23213513; PubMed Central PMCID: PMC3508574.
  • Catalfamo DL, Calderon NL, Harden SW, Sorenson HL, Neiva KG, Wallet SM. Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts. J Cell Physiol. 2013 Feb;228(2):349-61. doi: 10.1002/jcp.24138. PubMed PMID: 22718269; PubMed Central PMCID: PMC3470828.
  • Welc SS, Phillips NA, Oca-Cossio J, Wallet SM, Chen DL, Clanton TL. Hyperthermia increases interleukin-6 in mouse skeletal muscle. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C455-66. doi: 10.1152/ajpcell.00028.2012. PubMed PMID: 22673618; PubMed Central PMCID: PMC3422986.
  • Toro EJ, Zuo J, Ostrov DA, Catalfamo D, Bradaschia-Correa V, Arana-Chavez V, Caridad AR, Neubert JK, Wronski TJ, Wallet SM, Holliday LS. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J Biol Chem. 2012 May 18;287(21):17894-904. doi: 10.1074/jbc.M111.280511. PubMed PMID: 22474295; PubMed Central PMCID: PMC3366803.
  • Koutouzis T, Catania D, Neiva K, Wallet SM. Innate immune receptor expression in peri-implant tissues of patients with different susceptibility to periodontal diseases. J Periodontol. 2013 Feb;84(2):221-9. doi: 10.1902/jop.2012.120061. PubMed PMID: 22468681.
  • Amir J, Waite M, Tobler J, Catalfamo DL, Koutouzis T, Katz J, Wallet SM. The role of hyperglycemia in mechanisms of exacerbated inflammatory responses within the oral cavity. Cell Immunol. 2011;272(1):45-52. doi:10.1016/j.cellimm.2011.09.008. PubMed PMID: 21996642; PubMed Central PMCID:PMC3221011.
  • Shaddox LM, Wiedey J, Calderon NL, Magnusson I, Bimstein E, Bidwell JA, Zapert EF, Aukhil I, Wallet SM. Local inflammatory markers and systemic endotoxin in aggressive Periodontitis. J Dent Res. 2011 Sep;90(9):1140-4. doi:10.1177/0022034511413928. PubMed PMID: 21730256; PubMed Central PMCID:PMC3169885.
  • Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL. Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011 Jul;79(7):2746-54. doi: 10.1128/IAI.01291-10. PubMed PMID: 21518789; PubMed Central PMCID: PMC3191971.
  • Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O’Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011 Jan 1;186(1):195-202. doi: 10.4049/jimmunol.1002104. PubMed PMID: 21106855; PubMed Central PMCID: PMC3771366.
  • Verma RK, Bhattacharyya I, Sevilla A, Lieberman I, Pola S, Nair M, Wallet SM, Aukhil I, Kesavalu L. Virulence of major periodontal pathogens and lack of humoral immune protection in a rat model of periodontal disease. Oral Dis. 2010 Oct;16(7):686-95. doi: 10.1111/j.1601-0825.2010.01678.x. PubMed PMID: 20846155.
  • Aris JP, Elios MC, Bimstein E, Wallet SM, Cha S, Lakshmyya KN, Katz J. Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats. J Periodontol. 2010 Oct;81(10):1481-7. doi: 10.1902/jop.2010.100019. PubMed PMID: 20572766.
  • Wallet MA, Wallet SM, Guiulfo G, Sleasman JW, Goodenow MM. IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. Cell Immunol. 2010;262(2):84-8. doi: 10.1016/j.cellimm.2010.02.013. PubMed PMID: 20299009; PubMed Central PMCID: PMC2891046.
  • Katz J, Wallet S, Cha S. Periodontal disease and the oral-systemic connection: “is it all the RAGE?”. Quintessence Int. 2010 Mar;41(3):229-37. PubMed PMID: 20213024.
  • Shaddox L, Wiedey J, Bimstein E, Magnuson I, Clare-Salzler M, Aukhil I, Wallet SM. Hyper-responsive phenotype in localized aggressive periodontitis. J Dent Res. 2010 Feb;89(2):143-8. doi: 10.1177/0022034509353397. PubMed PMID: 20042739; PubMed Central PMCID: PMC3096871.
  • Pauley KM, Satoh M, Pauley BA, Dominguez-Gutierrez PR, Wallet SM, Holliday LS, Cha S, Reeves WH, Chan EK. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells. Immunol Cell Biol. 2010 Feb;88(2):205-12. doi: 10.1038/icb.2009.84. PubMed PMID: 19918258; PubMed Central PMCID: PMC2824770.
  • Mans JJ, von Lackum K, Dorsey C, Willis S, Wallet SM, Baker HV, Lamont RJ, Handfield M. The degree of microbiome complexity influences the epithelial response to infection. BMC Genomics. 2009 Aug 18;10:380. doi: 10.1186/1471-2164-10-380. PubMed PMID: 19689803; PubMed Central PMCID: PMC2736203.
  • Koutouzis T, Haber D, Shaddox L, Aukhil I, Wallet SM. Autoreactivity of serum immunoglobulin to periodontal tissue components: a pilot study. J Periodontol. 2009 Apr;80(4):625-33. doi: 10.1902/jop.2009.080422. PubMed PMID: 19335083; PubMed Central PMCID: PMC3594842.