Shannon Holliday, Ph.D.

Shannon Holliday. Ph.D.

Department of Orthodontics

Research Areas

  • Basic Science
  • Exosomes in bone remodeling

Main Interests

  • Activation of osteoclastic bone resorption
  • Structure, transport, and function of vacuolar H+ ATPase
  • Cytoskeletal dynamics in osteoclasts
  • MicroRNAs and RNA interference in dental physiology and pathophysiology.


  • Holliday, L.S. 2012. Vacuolar H+-ATPase: Targeting a “Housekeeping” Enzyme for Drug Development. Curr. Prot. Peptide Sci.  13: 105-106.
  • Toro, E. J., D. A. Ostrov, T. J. Wronski, and L. S. Holliday. 2012. Rational identification of a novel V-ATPase-directed inhibitor of bone resorption. Curr. Prot. Peptide Sci.  13: 180-191. Invited Review.
  • Toro, E. J., J.  Zuo, D. Catalfamo, V. Bradaschia-Correa, V. Arana-Chavez, R. Donatelli, J.K. Neubert, T.J. Wronski, D. A. Ostrov, S.M. Wallet2 and L. S. Holliday. 2012. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J. Biol Chem.  287:17894-17904.
  • Kim SS, DW Kwon, I Im, YD Kim, DS Hwang, LS Holliday, RE Donatelli, WS Son, ES Jun. 2012. Differentiation and characteristics of undifferentiated mesenchymal stem cells originating from adult premolar periodontal ligaments. Korean J Orthod.42(6):307-317.
  • Holliday, L.S., Huynh, N., Zuo, J., E.J. Toro. 2013. Mechanisms controlling vacuolar H+-adenosine triphosphatase activity:targets for the development of new therapeutic agents for the management of osteoporosis. Research and Reports in Biochem. 3:1-17. Invited Review.
  • Toro, E.J., Zuo, J.,  Guiterrez, A.,  La Rosa R, Gawron, A. ,  Bradaschia-Correa, V., Arana-Chavez, V.,  Dolce, C., Rivera, M. F., Lakshmyya, K., Bhattacharyya, I.,  Neubert, J.K., and Holliday, L.S. 2013. Bis-enoxacin inhibits bone resorption and orthodontic tooth movement. J. Dent Res.  92(10):925-931.
  • Rodriguez, D., E., Thula,T., Toro E. J., Yeh, Y-W.,  Holt, C., Holliday, L. S., and Gower L.  B. 2014. Multifunctional role of osteopontin in directing intrafibular mineralization of collagen and activation of osteoclasts. ACTA Biomaterialia. 10(1):494-507.
  • Holliday, L.S. 2014. V-ATPase: An essential multitasking enzyme in physiology and pathophysiology.  New Journal of Science. 2014. Article ID 675430, 21 pages.
  • Neiva, K,  Catalfamo, D., Holliday, L. S., Wallet, S. M., and R.Pileggi. 2014. Propolis decreases LPS-induced inflammatory mediators in pulp cells and osteoclasts. Dental Traum. Epub Feb 6.
  • Rivera, M.F., Lee, J.-Y., Chukkapalli, S., Velsko I., Bhattacharyya, I. ,. Toro, E.J., Holliday, L. S. , and K. Lakshmyya . 2014. Bis-enoxacin blocks rat alveolar bone loss in polymicrobial periodontitis. PLOS One, 9(3):e92119. PMID:24638087.
  • Rody, W.J., Holliday, L. S., McHugh, K.P., Wallet, S.M., Spicer, V., Krokhin, O.,  2014. Mass spectrometry anlaysis of gingival crevicular fluid in the presence of external root resorption. AJO-DO.  145(6):787-798. PMID: 24880850.
  • Oktay, S, Chukkapalli, S. S., Rivera, M. F., Velsko, I. M., Holliday, L. S., Kesavalu, L. 2014. Periodontitis in Rats Induces Systemic Oxidative Stress which is Controlled by Bone-targeted Antiresorptives. J. Periodontol. In press July 28, 2014.