Cytologic Smear


suspected herpetic lesions, candidiasis, leukoplakic lesions that rub off, erythematous lesions (Persistent erythematous lesions should be biopsied.)


  1. Using a pencil, label the frosted end of a microscope slide with the patient’s name.
  2. Remove cells from the oral mucosa with a Cytobrush or tongue blade and spread them evenly on the microscope slide.
  3. Repeat procedure on a second microscope slide.
  4. Spray the slides lightly with a fixative. (Aquanet hairspray works well.)
  5. Submit both slides to the pathologist with a provisional diagnosis.