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Kesavalu Lakshmyya, B.V.Sc., M.Sc., S.C.C.

Kesavalu Lakshmyya

Department of Periodontology

Associate Professor

Phone: 352-273-6500

Email: kesavalu@dental.ufl.edu

Room D11-24

PO Box 100434

Gainesville, FL 32610-0434

Education

  • B.V.Sc., Veterinary Medicine and Surgery, Madras University, 1971
  • S.C.C., Advanced Statistics, Institute of Agricultural Research Statistics, New Delhi, 1975
  • M.Sc., Medical Microbiology, All India Institute of Medical Sciences, New Delhi, 1979

Previous Positions

  • Associate Research Professor, Department of Oral Health Science, University of Kentucky, Lexington, KY 2003-2006
  • Assistant Research Professor, Department of Oral Health Science, University of Kentucky, Lexington, KY 2000-2003
  • Assistant Research Professor, Department of Periodontics, College of Dentistry, University of Texas Health Science Center at San Antonio, TX 1999-2000

Lab Staff and Students

 

Main Interests

  •  Association between periodontal disease and cardiovascular disease (Clinical study)
  • Association between periodontal pathogens and atherosclerosis  (Basic study)
  • Association between periodontal pathogens and Rheumatoid arthritis  (Basic study)
  • Association between periodontal pathogens and Alzheimer’s disease  (Basic study)
  • The Caries bacterium Streptococcus mutansand atherosclerosis (Basic study)
  • Role of microRNA in periodontal disease and cardiovascular disease
  • The link between periodontal pathogens, microRNA, and Sjogren’s syndrome
  • Pathogenesis of Osteonecrosis of Jaw (ONJ).

Selected Publications

  • Rivera, M., Ju-Youn Lee, M. Aneja, V. Goswami, L. Liu, I. Velsko, S. Chukkapalli, I. Bhattacharyya, H. Chen, A. R. Lucas, and L. Kesavalu*. 2013. Polymicrobial Infection induced periodontitis and atherosclerosis in ApoE-/- mice. PLOS ONE. 8(2):e57178. PMID: 23451182.
  • Nahid, M.A., B. Yao, P. R. Dominguez-Gutierrez, L. Kesavalu, M. Satoh, and E. K. L. Chan. 2013. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J. Immunol. Dec 21. [Epub ahead of print]. PMID: 23264652.
  • Aguirre, J. I., M. P. Akhter, D. B. Kimmel, J. E. Pingel, A. Williams, M. Jorgensen, L. Kesavalu, and T. J. Wronski. 2012. Oncologic doses of Zoledronic acid induce osteonecrosis of jaw-like lesions in rice rats (oryzomys palustris) with periodontitis. J. Bone. Min. Res. May 23. [Epub ahead of print]. PMID: 22623376.
  • Kesavalu, L.,* A. Lucas, R. K. Verma, L. Liu, E. Dai, and A. Fox. 2012. Increased atherogenesis during Streptococcus mutans OMZ175 infection in ApoEnull mice. J. Dent. Res. 91:255-260. PMID: 22262633.
  • Aguirre, J. I., M. P. Akhter, D. B. Kimmel, J. Pingel, X. Xia, A. Williams, M. Jorgensen, K. Edmonds, J-Y. Lee, M. K. Reinhard, A. H. Battles, L. Kesavalu, T. J. Wronski. 2011. Enhanced alveolar bone loss in a model for non-invasive periodontitis in rice rats. Oral. Dis. 18(5):459-468. PMID: 22233442.
  • Bakthavatchalu, V., A. Meka, S. Sathishkumar, R. K. Verma, I. Bhattacharyya, C. M. Lopez, B. F. Boyce, H. V. Baker, J. L. Ebersole, and L. Kesavalu*. 2011. Polymicrobial periodontal pathogens transcriptomes in soft tissues and calvarial bone. Mol. Oral. Microbiol. 26: 303-320. PMID: 21896157.
  • Md, A. Nahid, M. Rivera, A. Lucas, E. K. L. Chan, and L. Kesavalu*. 2011. Polymicrobial infection with periodontal pathogens specifically enhances the expression of miR-146a in ApoEnull mice. Infect. Immun. 79:1597-1605. “SPOTLIGHT” Article of Significant Interest. PMID: 21263019.
  • Bainbridge, B., R. K. Verma, C. Eastman, B. Yehia, M. Rivera, K. Mofatt, I. Bhattacharyya, R. J. Lamont and L. Kesavalu. 2010. Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in infection, inflammation, immune response and induction of alveolar bone resorption in rats. Infect. Immun. 78:4560-4569. PMID: 20805334.
  • Bakthavatchalu, V., A. Meka, S. Sathishkumar, C. M. Lopez, R. K. Verma, I. Bhattacharyya, B. F. Boyce, H. V. Baker, J. L. Ebersole, L. Kesavalu*. 2010. Tannerella forsythia infection-induced tissue and bone transcriptome profiles. Mol. Oral. Microbiol. 25: 317-330. PMID: 20883221.
  • Ebersole, J. L., S. Michelle, S. C. Holt, L. Kesavalu, L. Chu, and D. Cappelli. 2010. Systemic inflammatory responses in progressing periodontitis during pregnancy in a baboon model. Clin. Experimental. Immunol. 162:550-559. PMID: 21070210.

Current Research

  • Association between periodontal disease and cardiovascular disease – Clinical study.
  • Periodontal pathogens and induction of periodontal disease and atherosclerosis in ApoE-/- mouse model.
  • Caries pathogen Streptococcus mutans role in atherosclerosis in ApoE-/- mouse model.
  • Polymicrobial periodontal disease and localization of periodontal pathogens in periodontium.
  • Association between periodontal pathogens and rheumatoid arthritis in DBA1 mouse model.
  • Association between periodontal pathogens and Alzheimer’s disease in humans and animal model.