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Kevin P. McHugh, M.S., Ph.D.

Kevin P. McHugh, M.S., Ph.D.

Department of Periodontology

Associate Professor

Education

  • Ph.D., Genetics and Cell Biology, Florida State University, Tallahassee, Fla., 1994
  • M.S., Genetics and Cell Biology, Florida State University, Tallahassee, Fla.,  1987
  • B.S., Biology, Florida State University, Tallahassee, Fla., 1982

Previous Positions

  • Associate Professor of Periodontics, College of Dentistry, University of Florida, Gainesville, Fla. (2011-present)
  • Clinical Research Investigator, Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, Mass. (2008 -2011)
  • Assistant Professor of Orthopaedic Surgery, Harvard Medical School, Boston, Mass. (2007-2011)
  • Instructor, Department of Medicine, Harvard Medical School, Boston, Mass. (2004-2007)
  • Research Associate, Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass. (2004-2007)
  • Instructor, Department of Orthopaedic Surgery, Harvard Medical School, Boston, Mass. (2000-2004)
  • Research Associate, Department of Orthopaedic Surgery, Children’s Hospital, Boston, Mass. (2000-2004)
  • Individual NRSA Fellow (NIAMS), Department of Pathology, Barnes-Jewish Hospital, St. Louis, Miss. (1995-1999)
    Sponsor: Steven L. Teitelbaum, M.D.
  •  Post-doctoral Fellow, Department of Pathology, Barnes-Jewish Hospital and Washington University Medical School, St. Louis MO. (1994-1998)
  • NIH Fellow, Department of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Miss. (1994-1995)
    Program Director: Louis V. Avioli, M.D.

Selected Publications

  • Goldring SR, Purdue PE, Crotti TN, Shen Z, Flannery MR, McHugh KP.  Bone remodeling in inflammatory arthritis. Annals of Rheumatic Diseases 2012 (in press).
  • Crotti TN, O’Sullivan RP, Shen Z, Flannery MR, Fajardo RJ, Ross FP, Goldring SR, McHugh KP. . Bone matrix regulates osteoclast differentiation and annexin A8 gene expression. J Cell Physiol. 2011, 226(12):3413-21.
  • McHugh KP, Shen Z, Crotti TN, Flannery MR, O’Sullivan RP, Purdue PE, Goldring SR. The role of cell-substrate interaction in regulating osteoclast activation: potential implications in targeting bone loss in rheumatoid arthritis. Ann Rheum Dis. 2010 Jan; 69:83-85.
  • Ji JD, Park-Min KH, Shen Z, Fajardo RJ, Goldring SR, McHugh KP, Ivashkiv LB. Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J Immunol. 2009 Dec 1; 183(11):7223-33.
  • Curtin P, McHugh KP, Zhou HY, Flückiger R, Goldhaber P, Oppenheim FG, Salih E. Modulation of bone resorption by phosphorylation state of bone sialoprotein. Biochemistry. 2009 Jul 28; 48(29):6876-86.
  • Ishii J, Kitazawa R, Mori K, McHugh KP, Morii E, Kondo T, Kitazawa S. Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF. J Cell Biochem. 2008 Oct 15; 105(3):896-904.
  • Yang Q, McHugh KP, Patntirapong S, Gu X, Wunderlich L, Hauschka PV. VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and beta3-integrin. Matrix Biol. 2008 Sep; 27(7):589-99.
  • Haraguchi M, Okubo T, Miyashita Y, Miyamoto Y, Hayashi M, Crotti TN, McHugh KP, Ozawa M. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. J Biol Chem. 2008 Aug 29; 283(35):23514-23.
  • Crotti TN, Sharma SM, Fleming JD, Flannery MR, Ostrowski MC, Goldring SR, McHugh KP. PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter. J Cell Physiol. 2008 Jun; 215(3):636-44.
  • McHugh KP. Osteoimmunology in skeletal cell biology and disease. Autoimmunity. 2008 Apr; 41(3):181-2.
  • Paruchuri V, Prasad A, McHugh K, Bhat HK, Polyak K, Ganju RK. S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS One. 2008; 3(3):e1741.
  • Shen Z, Crotti TN, Flannery MR, Matsuzaki K, Goldring SR, McHugh KP. A novel promoter regulates calcitonin receptor gene expression in human osteoclasts. Biochim Biophys Acta. 2007 Nov-Dec; 1769(11-12):659-67.
  • McHugh KP, Shen Z, Crotti TN, Flannery MR, Fajardo R, Bierbaum BE, Goldring SR. Role of cell-matrix interactions in osteoclast differentiation. Adv Exp Med Biol. 2007; 602:107-11.
  • Cuetara BL, Crotti TN, O’Donoghue AJ, McHugh KP. Cloning and characterization of osteoclast precursors from the RAW264.7 cell line. In Vitro Cell Dev Biol Anim. 2006 Jul-Aug; 42(7):182-8.
  • Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR. The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther. 2006; 8(3):R70.
  • Crotti TN, Flannery M, Walsh NC, Fleming JD, Goldring SR, McHugh KP. NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation. Gene. 2006 May 10; 372:92-102.
  • Crotti TN, Flannery M, Walsh NC, Fleming JD, Goldring SR, McHugh KP. NFATc1 directly induces the human beta3 integrin gene in osteoclast differentiation. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):335-7.
  • Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, Teitelbaum SL. A Glanzmann’s mutation in beta 3 integrin specifically impairs osteoclast function. J Clin Invest. 2001 May; 107(9):1137-44.
  • McHugh KP, Kitazawa S, Teitelbaum SL, Ross FP. Cloning and characterization of the murine beta(3) integrin gene promoter: identification of an interleukin-4 responsive element and regulation by STAT-6. J Cell Biochem. 2001 Mar 26; 81(2):320-32.
  • Solomon KR, Adolphson LD, Wank DA, McHugh KP, Hauschka PV. Caveolae in human and murine osteoblasts. J Bone Miner Res. 2000 Dec; 15(12):2391-401.
  • Cheng SL, Lai CF, Fausto A, Chellaiah M, Feng X, McHugh KP, Teitelbaum SL, Civitelli R, Hruska KA, Ross FP, Avioli LV. Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells. J Cell Biochem. 2000 Mar; 77(2):265-76.
  • McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest. 2000 Feb; 105(4):433-40.
  • Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S, Hynes RO. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999 Jan; 103(2):229-38.