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Robert M. Caudle

Robert M. CaudleDepartment of Oral & Maxillofacial Surgery

Neuroscience Division

Professor

Phone: 352-273-6767
E-Mail: caudle@ufl.edu

Education

  • Ph.D., University of Illinois at Chicago, 1988
  • B.A., Humboldt State University, 1981

Main Interests

My research focuses on the molecular and physiological processes that initiate and maintain chronic pain. In particular, we are examining alterations in the function of the N-Methyl-D-Aspartate (NMDA) class of excitatory amino acid receptor in the spinal cord and the vanilloid receptor – the protein responsible for detecting the burning sensation produced by hot chili peppers – in the periphery following persistent stimulation. The NMDA receptor performs the function of an amplifier in the spinal cord to enhance pain signals, whereas the vanilloid receptor detects pain from heat, inflammation, and chemicals throughout the body. These studies examine changes in the phosphorylation status of these two receptors and alterations in subunits and splice variants as a result of painful experiences. These studies also examine the interaction of the NMDA receptor and vanilloid receptor with endogenous neuropeptides that are released during chronic pain. The ultimate goal of our work is to develop novel strategies to avoid the induction of chronic pain and new therapies to treat chronic pain once it is established.

Publications

  • Neubert, J.K.,Widmer, C.G., Malphurs, W., Rossi, H.L., Vierck, C.J., and  Caudle, R.M.: Use of a Novel Thermal Operant Behavioral Assay for Characterization of Orofacial Pain Sensitivity, Pain, 116(3) (2005) 386-395.
  • Neubert, J.K., Mannes, A.J., Keller, J., Wexel, M., Iadarola, M.J. and Caudle, R.M.: Peripheral Targeting of the Trigeminal Ganglion via the Infraorbital Foramen as a Therapeutic Strategy. Brain Res Brain Res Protoc. 15(3) (2005) 119-126.
  • Mannes, A.J., Brown, D.C., Keller, J., Cordes, L., Eckenhoff, R.G., Caudle, R.M., Iadarola, M.J. and Meng, Q.C.: Measurement of Resiniferatoxin in Serum Samples by High-Performance Liquid Chromatography, J Chromatogr B Analyt Technol Biomed Life Sci. 823(2) (2005) 184-188.
  • Caudle, R.M., Perez, F.M., Del Valle-Pinero, A.Y., and Iadarola, M.J.: Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation, Mol Pain, 1 (2005) 25. PMC1208948
  • Zhou, Q, Caudle, R.M., Price, D.D., Del Valle-Pinero, A.Y., and Verne, G.N.: Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats. Mol Pain, 2(1) (2006) 3. PMC1402265
  • Caudle, R.M.: Memory in astrocytes: a hypothesis, Theor Biol Med Model. 3 (2006) 2.PMC1360660
  • Neubert, J.K., Rossi, H.L., Malphurs, W., Vierck, C.J., Caudle, R.M.: Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay. Behavioural Brain Research 170(2) (2006) 308-315.
  • Zhou, Q, Caudle, R.M., Moshiree, B., Price D.D., and Verne, G.N.: Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis. Neurosci. Lett. 406(3) (2006) 250-255.
  • Rossi HL, Vierck CJ Jr, Caudle RM, Neubert JK.: Characterization of cold sensitivity and thermal preference using an operant orofacial assay. Mol Pain. 2(1) (2006) 37. PMC1764875
  • Katz, J., Yoon, T.Y.H., Mao, S., Lamont, R.J., and Caudle, R.M.: Expression of the Receptor of Advanced Glycation End Products in the Gingival Tissue of Smokers With Generalized Periodontal Disease and After Nornicotine Induction in Primary Gingival Epithelial Cells. J. Periodontol, 78 (2007) 736-741.
  • Del Valle-Pinero AY, Suckow SK,  Zhou Q, Perez FM, Verne GN and Caudle RM:Expression of the N-methyl-D-aspartate Receptor NR1 Splice Variants and NR2 Subunit Subtypes in the Rat Colon. Neuroscience, 147 (2007) 164-173.PMC2048573
  • Zhou, Q., Price, D.D., Caudle, R.M. and Verne, G.N.: Visceral and somatic hypersensitivity in subset of rats following TNBS-induced colitis. Pain 134(1-2) (2008) 9-15. PMC2807887
  • Caudle, R.M., Mannes, A.J., Keller, J., Perez, F.M., Suckow, S.K., and Neubert, J.K.: Sensitization of Spinal Cord Nociceptive Neurons with a Conjugate of Substance P and Cholera Toxin. BMC Neuroscience 8 (2007) 30.PMC1878491
  • Zhou, Q., Price, D.D., Caudle, R.M. and Verne, G.N.: Visceral and somatic hypersensitivity in TNBS induced colitis in rats. Digestive Diseases and Sciences 53(2) (2008) 429-435. PMC2807888
  • Neubert, J.K., Rossi, H.L., Pogar, J., Jenkins, A.C. and Caudle, R.M.: Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors. Behavioral and Brain Functions 3(1) (2007) 49. PMC2045099
  • Stewart, C., Cha, S., Caudle, R.M., Berg, K. and Katz, J.:Decreased levels of soluble receptor for advanced glycation end products in patients with primary Sjögren’s syndrome. Rheumatol Int. 28(8) (2008) 771-776.
  • Suckow, S. K. and Caudle, R.M.: Identification and Immunohistochemical Characterization of Colospinal Afferent Neurons (CANs) in the Rat. Neuroscience 153(3) (2008) 803-813.
  • Crabtree M., Pileggi R., Bhattacharyya I., Caudle R., Perez F., Riley J., Vertucci F. and Katz J.: RAGE mRNA Expression and Its Correlation with Nuclear Factor Kappa Beta mRNA Expression in Inflamed Human Periradicular Tissues. J Endod. 34(6) (2008) 689-692. PMC2685146
  • Neubert JK, King C, Malphurs W, Wong F, Weaver JP, Jenkins AC, Rossi HL and Caudle RM.: Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior. Mol Pain. 4(1) (2008) 43.PMC2584042
  • Khan J, Benoliel R, Herzberg U, Mannes AJ, Caudle RM, Young A, Eliav E.: Bite force and pattern measurements for dental pain assessment in the rat. Neurosci. Lett. 447 (2008) 175–178. PMC2642734
  • Zhou Q, Price DD, Caudle RM, Verne GN.: Spinal NMDA NR1 Subunit Expression Following Transient TNBS Colitis. Brain Res. 1279 (2009) 109-20.PMC2743074
  • Rossi HL, Vierck CJ Jr, Caudle RM, Yezierski RP, Neubert JK.: Dose-Dependent Effects of Icilin on Thermal Preference in the Hindpaw and Face of Rats. J Pain. 10(6) (2009) 646-53. PMC2731548
  • Suckow SK, Caudle RM: NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity. Mol Pain. 5 (2009) 54. PMC2758842
  • Caudle RM, King C, Nolan TA, Suckow SK, Vierck CJ Jr, Neubert JK: Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin. J Pain. 11(9) (2010) 838-46. PMC2930122
  • Nolan TA, Caudle RM, Neubert JK: Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning. Behav Brain Res. 216(2) (2011) 723-5. PMC2981637
  • Nolan TA, Hester J, Bokrand-Donatelli Y, Caudle RM, Neubert JK.: Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain. Behav Brain Res. 217(2) (2011) 477-80. PMC3010421
  • Suckow SK, Anderson EM, Caudle RM.: Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon. Neurogastroenterol Motil. 24(3): (2012) e125-35.  PMC3276722
  • Anderson EM, Del Valle-Pinero AY, Suckow SK, Nolan TA, Neubert JK, Caudle RM.: Morphine and MK-801 administration leads to alternative N-methyl-d-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay. Neuroscience. 214 (2012) 14-27. PMC3371179
  • Anderson EM, Neubert JK, Caudle RM.: Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-d-aspartate receptor 1 splice variants in the amygdala. Neuroscience. 223 (2012) 45-55.
  • Nolan TA, Price DD, Caudle RM, Murphy NP, Neubert JK.: Placebo-induced analgesia in an operant pain model in rats. Pain. 153(10)(2012) 2009-16. PMC3445785
  • Rossi HL, Jenkins AC, Kaufman J, Bhattacharyya I, Caudle RM, Neubert JK.: Characterization of bilateral trigeminal constriction injury using an operant facial pain assay. Neuroscience. 224 (2012) 294-306. PMC3468660
  • King CD, Goodin B, Kindler LL, Caudle RM, Edwards RR, Gravenstein N, Riley JL 3rd, Fillingim RB.: Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.  J Behav Med. 36(3)(2013) 315-27. PMC3774309
  • Rossi HL, Luu AK, Kothari SD, Kuburas A, Neubert JK, Caudle RM, Recober A.: Effects of diet-induced obesity on motivation and pain behavior in an operant assay. Neuroscience. 235C (2013) 87-95. PMC3607444
  • Anderson EM, Mills R, Nolan TA, Jenkins AC, Mustafa G, Lloyd C, Caudle RM, Neubert JK.: Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior. J Vis Exp. 2013, 10;(76).
  • Mustafa G, Anderson EM, Bokrand-Donatelli Y, Neubert JK, Caudle RM.: Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A. Pain. 2013, 154(11):2547-53. PMC3808523
  • Anderson EM, Jenkins AC, Caudle RM, Neubert JK.: The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. PLoS One. 2014, 9(2):e89137. PMC3928399
  • Murphy NP, Mills RH, Caudle RM, Neubert JK.: Operant Assays for Assessing Pain in Preclinical Rodent Models: Highlights from an Orofacial Assay. Curr Top Behav Neurosci. 2014;20:121-45.
  • Del Valle-Pinero AY, Sherwin LB, Anderson EM, Caudle RM, Henderson WA: Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis. World J Gastroenterol 2015; 21(1): 155-163
  • Katz, J. Bhattacharyya, I., Farkhondeh-Kish, F., Perez, F.M., Caudle, R.M., Heft, M.: Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabtes pateints with chronic periodontal disease: a study utlizing immunohistochemistry and RT-PCR.J.Clin.Periodontol., 32 (2005) 40-44.
  • Katz, J., Caudle, R.M., Bhattacharyya, I., Stewart, C.M., Cohen, D.M.: Receptor for advanced glycation end products (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine. J. Periodontol, 76 (2005) 130-133.
  • Rau, K.K, Caudle, R.M., Johnson, R.D. and Cooper, B.Y.: Diverse expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia. J. Chem. Neuroanatomy, 29(4) (2005) 255-264.
  • Neubert, J.K.,Widmer, C.G., Malphurs, W., Rossi, H.L., Vierck, C.J., andCaudle, R.M.: Use of a Novel Thermal Operant Behavioral Assay for Characterization of Orofacial Pain Sensitivity, Pain, 116(3) (2005) 386-395.
  • Neubert, J.K., Mannes, A.J., Keller, J., Wexel, M., Iadarola, M.J. and Caudle, R.M.: Peripheral Targeting of the Trigeminal Ganglion via the Infraorbital Foramen as a Therapeutic Strategy. Brain Res Brain Res Protoc. 15(3) (2005) 119-126.
  • Mannes, A.J., Brown, D.C., Keller, J., Cordes, L., Eckenhoff, R.G., Caudle, R.M., Iadarola, M.J. and Meng, Q.C.: Measurement of Resiniferatoxin in Serum Samples by High-Performance Liquid Chromatography, J Chromatogr B Analyt Technol Biomed Life Sci. 823(2) (2005)
    184-188.
  • Caudle, R.M., Perez, F.M., Del Valle-Pinero, A.Y., and Iadarola, M.J.: Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation, Mol Pain, 1 (2005) 25.
  • Zhou, Q, Caudle, R.M., Price, D.D., Del Valle-Pinero, A.Y., and Verne, G.N.: Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.Mol Pain, 2(1) (2006) 3.
  • Caudle, R.M.: Memory in astrocytes: a hypothesis,
    Theor Biol Med Model. 3 (2006) 2.
  • Neubert, J.K., Rossi, H.L., Malphurs, W., Vierck, C.J., Caudle, R.M.: Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay. Behavioural Brain Research 170(2) (2006) 308-315.
  • Zhou, Q, Caudle, R.M., Moshiree, B., Price D.D., and Verne, G.N.: Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis. Neurosci. Lett. 406(3) (2006) 250-255.
  • Rossi HL, Vierck CJ Jr, Caudle RM, Neubert JK.: Characterization of cold sensitivity and thermal preference using an operant orofacial assay. Mol Pain. 2(1) (2006) 37.
  • Caudle, R.M., Mannes, A.J., Benoliel, R., Eliav, E., and Iadarola, M.J.: Intrathecally administered cholera toxin blocks allodynia and hyperalgesia in persistent pain models. J. Pain. 2 (2001) 118-127.
  • Olah Z, Szabo T, Karai L, Hough C, Fields RD, Caudle RM, Blumberg PM, Iadarola MJ: Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. J Biol Chem 276(14) (2001) 11021-11030.
  • Caudle, R.M. and Mannes, A.J.: Dynorphin: Friend or Foe? Pain 87(3) (2000) 235-239.
  • Benoliel R, Tanaka M, Caudle RM, Iadarola MJ: Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord. Neurosci Lett 291(2) (2000) 61-64.
  • Eliav, E., Herzberg, U. and Caudle, R.M.: GR89,696 blocks hyperalgesia and allodynia in rat models of peripheral neuritis and neuropathy. Pain 79 (1999) 255-264.
  • Benoliel, R., Eliav, E., Mannes, A.J., Caudle, R.M., Leeman, S. and ladarola, M.J.: Actions of intrathecal diphtheria toxin?substance P fusion protein on models of acute and chronic pain. Pain 79 (1999) 243-253.

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